The Microcirculation and Inflammation: Site of Action for Glucocorticoids

References

• Ahluwalia A. (1998). Topical glucocorticoids and the skin-mechanism of action: an update. Med In-flamm 7:183–193.
   Google Scholar
• Ahluwalia A, Flower RJ. (1993). Topical betameth-asone-17-valerate inhibits heat-induced vasodila-don in man. Br J Dermatol 128:45–48.
   Google Scholar
• Ahluwalia A, Flower RJ. (1993). Effect of chronic capsaicin and guanethidine treatment on skin blood flow of the rat. Agents Actions 38:C16–C18.
   Google Scholar
• Ahluwalia A, Buckingham JC, Croxtall JD, Flower RJ, Goulding NJ, Perretti M. (1996). The biology of annexin I. In: Annexins: Molecular Structure to Cel-lular Function. (BA Seaton, Ed.) R.G. Landes. Aus-tin, TX. 161-199.
   Google Scholar
• Ahluwalia A, Peers SH, Flower RJ. (1992). Steroid inhibition of oedema formation in the rat skin. Br J Pharmacol 106:628–631.
   Google Scholar
• Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, Verity A, Perretti M. (1998). Endogenous monocyte chemoattractant protein-1 recruits mono-cytes in the zymosan peritonitis model. J Leukoc Biol 63:108–116.
   PubMed Web of Science ®Google Scholar
• Andersson SE, Kallstrom L, Malm M, Miller-Larsson A, Axelsson B. (1995). Inhibition of nitric oxide synthase reduces sephadex-induced oedema formation in the rat lung: dependence on intact adrenal function. Inflamm Res 44:418–422.
   Google Scholar
• Appleton I, Tomlinson A, Willoughby DA. (1996). Induction of cyclo-oxygenase and nitric oxide syn-thase in inflammation. Adv Pharmacol 35:27–79.
   PubMedGoogle Scholar
• Ashton N, Cook C. (1952). In vivo observations of the effects of cortisone upon the blood vessels in rabbit ear chambers. Br J Exp Pathol 33:445–450.
   PubMedGoogle Scholar
• Barnes PJ. (1998). Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci 94: 557–572.
   PubMed Web of Science ®Google Scholar
• Barnes PJ, Karin M. (1997). Nuclear factor-KB a pivotal transcription factor in chronic inflammatory diseases. New Engl J Med 336:1066–1071.
   PubMed Web of Science ®Google Scholar
• Berti E, Cerri A, Marzano AV, Richelda R, Bianchi B, Caputo R. (1998). Mometasone furoate decreases adhesion molecule expression in psoriasis. Eur J Dermatol 8:421–426.
   Google Scholar
• Bjork J, Goldschrnidt T, Smedegard G, Arfors KE. (1985). Methylprednisolone acts at the endothelial cell level reducing inflammatory responses. Acta Physiol Scand 123:221–224.
   Google Scholar
• Bollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G, Larcan A. (1998). Reversal of late sep-tic shock with supraphysiologic doses of hydrocor-tisone. Grit Care Med 26:645–650.
   PubMed Web of Science ®Google Scholar
• Borregaard N, Cowland JB. (1997). Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89:3503–3521.
   PubMed Web of Science ®Google Scholar
• Bournpas DT. (1996). A novel action of glucocorti-coids-NF-KB inhibition. Br J Rheumatol 35:709–710.
   Google Scholar
• Bourke E, Moynagh PN. (1999). Antiinflamrnatory effects of glucocorticoids in brain cells, independent of NF-KB. J Immunol 163:2113–2119.
   Google Scholar
• Briegel J, Forst H, Schelling G, Kilger E, Kuprat G, Hemmer B, Hummel T, Lenhart A, Heyduck M, Stoll C, Peter K (1999). Stress doses of hydrocorti-sone reverse hyperdynarnic shock: a prospective, randomized, double-blind, single-center study. Grit Care Med 27:723–732.
   PubMed Web of Science ®Google Scholar
• Brostjan C, Anrather J, Csizmadia V, Natarajan G, and Winkler H. (1997). Glucocorticoids inhibit E-selectin expression by targeting NF-KB and not ATF/c-Jun. J Immunol 158:3836–3844.
   PubMed Web of Science ®Google Scholar
• Burke-Gaffney A, Hellewell PG. (1996). Regulation of ICA1VI-1 by dexarnethasone in a human vascular endothelial cell line EA.hy926. Am J Physiol 270:C552–0561.
   Google Scholar
• Burns AR, Walker DC, Brown ES, Thurmon LT, Bowden RA, Keese CR, Simon SI, Entman ML, Smith CW. (1997). Neutrophil transendothelial mi-gration is independent of tight junctions and occurs preferentially at tricellular corners. J Immunol 159: 2893–2903.
   PubMed Web of Science ®Google Scholar
• Burton JL, Kehrli ME Jr, Kapil S, Horst RL. (1995). Regulation of L-selectin and CD18 on bovine neu-trophils by glucocorticoids: effect of cortisol and dexarnethasone. J Leukoc Biol 57:317–325.
   PubMed Web of Science ®Google Scholar
• Buttgereit F, Wehling M, Burmester, G-R. (1998). A new hypothesis of modular glucocorticoid action. Arthr Rheum 41:761–767.
   PubMed Web of Science ®Google Scholar
• Caldenhoven E, Liden J, Wissink S, van de Stolpe A, Raaijmakers J, Koenderman L, Okret S, Gustafsson J-A, van der Saag PT. (1995). Negative cross-talk between RelA and the glucocorticoid receptor: a pos-sible mechanism for the antiinflarnrnatory action of glucocorticoids. Mol Endocrinol 9:401–412.
   PubMedGoogle Scholar
• Casale TB, Abbas MK (1990). Comparison of leu-kotriene B4-induced neutrophil migration through different cellular barriers. Am J Physiol 258:C639–C647.
   Google Scholar
• Caterina MJ, Schumacher MA, Tominago M, Rosen TA, Levine JD, Julius D. (1998). The capsaicin re-ceptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824.
   Google Scholar
• Cato ACB, Wade E. (1996). Molecular mechanisms of anti-inflammatory action of glucocorticoids. BioEssays 18:371–378.
   PubMed Web of Science ®Google Scholar
• Collins PD, Jose PJ, Williams TJ. (1991). The se-quential generation of neutrophil chemoattractant proteins in acute inflammation in the rabbit in vivo. Relationship between C5a and proteins with the characteristics of IL-8/neutrophil-activating protein 1. J Immunol 146:677–684.
   Google Scholar
• Cooke JP, Dzau VJ. (1997). Nitric oxide synthase. Role in the genesis of vascular disease. Ann Rev Med 48:489–509.
   Google Scholar
• Cronstein BN, Kimmel SC, Levin RI, Martiniuk F, Weissmann G. (1992). A mechanism for the antiin-flarnrnatory effects of corticosteroids: the glucocor-ticoid receptor regulates leukocyte adhesion to en-dothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 89: 9991–9995.
   PubMed Web of Science ®Google Scholar
• Das AM, Lim LHK, Flower RJ, Perretti M. (1997). Dexarnethasone reduces cell surface levels of CD1lb on human eosinophils. Med Inflamm 6:363–367.
   Google Scholar
• Davenpeck KL, Zagorski J, Schleimer RP, Bochner BS. (1998). Lipopolysaccharide-induced leukocyte rolling and adhesion in the rat mesenteric microcir-culation: regulation by glucocorticoids and role of cytokines. J Immunol 161:6861–6870.
   PubMedGoogle Scholar
• Euzger H, Flower RJ, Goulding NJ, Perretti M. (1999). Differential modulation of annexin I bind-ing sites on monocytes and neutrophils. Med In-flamm 8:53–62.
   Google Scholar
• Fantuzzi G, Ghezzi P. (1993). Glucocorticoids as cytokine inhibitors: role in neuroendocrine control and therapy of inflammation. Med Inflamm 2:263–270.
   PubMedGoogle Scholar
• Farsky SP, Sannomiya P, Garcia-Leme J. (1995). Secreted glucocorticoids regulate leukocyte-endothelial interactions in inflammation. A direct vital microscopic study. J Leukoc Biol 57:379–386.
   PubMed Web of Science ®Google Scholar
• Filep JC, Delalandre A, Payette Y, Foldes-Filep E. (1997). Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutro-phils. hils Circulation 96:295–301.
   PubMed Web of Science ®Google Scholar
• Flower RJ. (1988). Lipocortin and the mechanism of action of the glucocorticoids. Br J Pharmacol 94: 987–1015.
   Google Scholar
• Forsyth KID, Talbot V. (1992). Role of glucocorti-coids in neutrophil and endothelial adhesion mol-ecules expression and function. Med Inflamm 1:101–106.
   Google Scholar
• Foty RA, Corbett SA, Schwarzbauer JE, Steinberg MS. (1998). Dexarnethasone up-regulates cadherin expression and cohesion of HT-1080 human fibro-sarcoma cells. Cancer Res 15:3586–3589.
   Google Scholar
• Gallin JI, Goldstein IM, Snyderman R. (1992). Overview. In: Inflammation: Basic Principles and Clinical Correlates. (JI Gallin and IM Goldstein, Eds.) Raven Press Ltd. New York. 1–4.
   Google Scholar
• Getting SJ, Flower RJ, Perretti M. (1997). Inhibition of neutrophil and monocyte recruitment by endog-enous and exogenous lipocortin 1. Br J Pharmacol 120:1075–1082.
   Google Scholar
• Goulding NJ, Pan L, Wardwell K, Guyre VC, Guyre PM. (1996). Evidence for specific annexin I-binding proteins on human monocytes. Biochem J 316:593–597.
   Google Scholar
• Granger DN, Kubes P. (1994). The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 55:662–675.
   PubMed Web of Science ®Google Scholar
• Green PG, Strausbaugh HJ, Levine JD. (1999). An-nexin I is a local mediator in neural-endocrine feed-back control of inflammation. J Neurophysiol 80: 3120–3126.
   Google Scholar
• Gulbenkian S, Wharton J. (1993). Pattern of inner-vation of sensory afferent systems in the circulation: irnrnunocytochemistry and ultrastructure. In: Vas-cular Innervation and Receptor Mechanisms. (L Ed-vinsson and R Uddman, Eds.) Academic Press, Inc. San Diego. 247-262.
   Google Scholar
• Haines KA., Kolasinski SL, Cronstein BN, Reibman J, Gold LI, Weissmann G. (1993). Chemoattraction of neutrophils by substance P and transforming growth factor-P1 is inadequately explained by cur-rent models of lipid remodeling. J Immunol 151: 1491–1499.
   PubMed Web of Science ®Google Scholar
• Hartne11 A, Kay BA, Wardlaw AJ. (1992). Interleu-kin-3-induced up-regulation of CR3 expression on human eosinophils is inhibited by dexamethasone. Immunology 77:488–493.
   Google Scholar
• Hench PS, Kendall EC, Slocurnb CH, Polley HE. (1949). The effect of the adrenal cortex (17-hydroxy-11-de-hydrocortisone: compound E) and of pituitary adrenocorticotropic hormone on rheu-matoid arthritis; preliminary report. Proc Staff Meet Mayo Clin 24:181–197.
   PubMed Web of Science ®Google Scholar
• Henricks P, Nijkarnp FP. (1998). Pharmacological modulation of cell adhesion molecules. Eur J Phar-macol 344:1–13.
   PubMed Web of Science ®Google Scholar
• Herschrnan HR. (1994). Regulation of prostaglan-din synthase-1 and prostaglandin synthase-2. Can-cer Met Reviews 13:241–256.
   Google Scholar
• Hill GE, Alonso A, Thiele GM, Robbins RA. (1994). Glucocorticoids blunt neutrophil CD1lb upregula-don during cardiopulmonary bypass in humans. Anesth Analg 79:23–27.
   Google Scholar
• Hordijk PL, Anthony E, Mul FPJ, Rientsma R, ()o-men LCJM, Roos D. (1999). Vascular-endothelial-cadherin modulates endothelial monolayer perme-ability. J Cell Sci 112:1915–1923.
   Google Scholar
• Hinshaw LB. (1996). Sepsis/septic shock: participa-tion of the microcirculation. Grit Care Med 24: 1072–1078.
   PubMed Web of Science ®Google Scholar
• Hughes JM, Sewell WA, Black JL, Armour CL. (1996). Effect of dexarnethasone on expression of adhesion molecules on CD4+ lymphocytes. Am J Physiol 271:L79–L84.
   Google Scholar
• Ishikawa H, Mori Y, Tsurufuji S. (1969). The char-acteristic feature of glucocorticoids after local appli-cation with reference to leucocyte migration and protein exudation. Eur J Pharmacol 7:201–205.
   Google Scholar
• Kanse SM, Takahashi K, Warren JIB, Ghatei M, Bloom SR. (1991). Glucocorticoids induce endothe-lin release from vascular smooth muscle cells but not endothelial cells. Eur J Pharmacol 199:99–101.
   PubMed Web of Science ®Google Scholar
• Kim KM, Kim DK, Park YM, Kim C-K, Na DS. (1994). Annexin-I inhibits phospholipase A2 by specific interaction, not by substrate depletion. FEBS Left 343:251–255.
   PubMed Web of Science ®Google Scholar
• Kimberly RP. (1991). Mechanism of action, dosage schedule, and side effects of steroid therapy. Curr Op Rheumatol 3:373–379.
   Google Scholar
• Kirwan JR. (1995). The effect of glucocorticoids on joint destruction in rheumatoid arthritis. New Engl J Med 333:142–146.
   PubMed Web of Science ®Google Scholar
• Konno S, Tsurufuji S. (1983). Induction of zymo-san-air-pouch inflammation in rats, and its charac-terization with reference to the effects of anti-complementary and anti-inflammatory agents. Br J Pharmacol 80:269–277.
   Google Scholar
• Leech M, Hutchinson P, Holdsworth SR, Morand EF. (1998). Endogenous glucocorticoids modulate neutrophil migration and synovial P-selectin but not neutrophil phagocytic or oxidative function in ex- perirnental arthritis. Clin Exp Immunol 112:383–388.
   PubMedGoogle Scholar
• Lim LHK, Perretti M, Flower RJ, Das AM. (2000). Glucocorticoid receptor activation reduces Cd1lb and CD49d levels on murine eosinophils: characteri-sation and functional relevance. Am J Resp Mol Biol Cell (in press).
   Google Scholar
• Lim LHK, Solito E, Russo-Marie F, Flower RJ, Per-retti M. (1998). Promoting detachment of neutro-phils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci USA 95:14535–14539.
   Google Scholar
• Lyons CR. (1995). The role of nitric oxide in in-flammation. Adv Immunol 60:323–371.
   PubMed Web of Science ®Google Scholar
• Maggi CA. (1991). The pharmacology of the effer-ent function of sensory nerves. J Anton Pharmacol 11:173–208.
   PubMedGoogle Scholar
• Mancuso F, Flower RJ, Perretti M. (1995). Leuko-cyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the ham-ster post-capillary venule. Involvement of endog-enous lipocortin 1. J Immunol 155:377–386.
   PubMed Web of Science ®Google Scholar
• Masferrer JL, Zweifel BS, Seibert K, Needleman P. (1990). Selective regulation of cellular cyclooxygen-ase by dexarnethasone and endotoxin in mice. J Clin Invest 866:1375–1379.
   Google Scholar
• Masferrer JL, Srinivasa T, Zweifel BS, Seibert P, Gilbert RS, Herschrnan HR. (1994). In vivo gluco-corticoids regulate cyclooxygenase-2 but not cyclo-oxygenase-1 in peritoneal macrophages. J Pharma-col Exp Ther 270:1340–1344.
   PubMed Web of Science ®Google Scholar
• Matteo R De, May CN. (1999). Inhibition of pros-taglandin and nitric oxide synthesis prevents corti-sol-induced renal vasodilatation in sheep. Am J Physiol 45:R1125–R1131.
   Google Scholar
• May CN, Bednarik JA. (1995). Regional hemody-namic and endocrine effects of aldosterone and cor-tisol in conscious sheep: comparison with the effects of corticotrophin. Hypertension 26:294–300.
   Google Scholar
• McKenzie AW, Stoughton RD. (1962). Method for comparing percutaneous absorption of steroids. Arch Dermatol 86:608–610.
   Web of Science ®Google Scholar
• Mendelsohn FAO, Lloyd CJ, Kachel C, Funder JW. (1982). Induction by glucocorticoids of angiotensin converting enzyme production from bovine endothe-lial cells in culture and rat lung in vivo. J Clin Invest 70:684–692.
   PubMed Web of Science ®Google Scholar
• Mori N, Hone Y, Gerritsen ME, Anderson DC, Granger DN. (1999). Anti-inflammatory drugs and endothelial cell adhesion molecule expression in mu-rine vascular beds. Gut 44:186–195.
   Google Scholar
• Nakagawa M, Bondy GP, Waisman D, Minshall D, Hogg JC, van Eeden SF. (1999). The effect of glu-cocorticoids on the expression of L-selectin on poly-morphonuclear leukocyte. Blood 93:2730–2737.
   PubMed Web of Science ®Google Scholar
• Nakarnoto H, Suzuki Y, Kageyama A, Ohishi A, Mu-rakarni M, Naitoh M, Saruta T. (1991). Characteri-sation of alterations of hemodynarnics and neuroen- docrine hormones in dexamethasone induced hyper-tension in dogs. Clin Exp Hypertens A13:587–606.
   Google Scholar
• Naray-fejes-Toth A, Fejes-toth G, Fischer C, Frolich JC. (1984). Effect of dexamethasone on in vivo pros-tanoid production in the rabbit. J Clin Invest 74: 120–123.
   Google Scholar
• Nikolaizik WH, Preece MA, Warner JO. (1997). One year follow-up study of endocrine and lung function of asthmatic children on inhaled budesonide. Eur Respir J 10:2596–2601.
   Google Scholar
• Oda T, Katori M. (1992). Inhibition site of dexa-methasone on extravasaton of polymorphonuclear leukocytes in the hamster cheek pouch microcircu-lation. J Leukoc Biol 52:337–342.
   Google Scholar
• O'Leary EC, Marder P, Zuckerman SH. (1996). Glucocorticoid effects in an endotoxin-induced rat pulmonary inflammation model: differential effects on neutrophil influx, integrin expression, and in-flammatory mediators. Am J Respir Cell Mol Biol 15:97–106.
   PubMed Web of Science ®Google Scholar
• Panes J, Perry M, Granger DN. (1999). Leukocyte-endothelial cell adhesion: avenues for therapeutic intervention. Br J Pharmacol 126:537–550.
   Google Scholar
• Perretti M. (1998). Lipocortin 1 and chemokine modulation of granulocyte and monocyte accumu-lation in experimental inflammation. Gen Pharma-col 31:545–552.
   PubMedGoogle Scholar
• Perretti M, Flower RJ (1996). Measurement of lipo-cortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation. Br J Pharmacol 118:605–610.
   Google Scholar
• Perretti M, Christian H, Wheller SK, Aiello I, Mu-gridge KG, Morris JF, Flower RJ, Goulding NJ. (2000). Annexin I is stored within gelatinase gran-ules of human neutrophils and mobilised on the cell surface upon adhesion but not phagocytosis. Cell Biol Int (in press).
   Google Scholar
• Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon, R, Flower RJ. (1996). Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nature Med 22:1259–1262.
   Google Scholar
• Perretti M, Wheller SK, Flower RJ, Wahid S, Pitzalis C. (1999). Modulation of cellular annexin I in hu-man leukocytes infiltrating DTH skin reactions. J Leukoc Biol 65:583–589.
   Google Scholar
• Perretti M, Wheller SK, Harris JG, Flower RJ. (1996). Modulation of ICA1VI-1 levels on U-937 cells and mouse macrophages by interleukin-143 and dexamethasone. Biochem Biophys Res Commun 223:112–117.
   PubMedGoogle Scholar
• Persson NH, Erlansson M, Berggvist D, Takolander R, Svensjo E. (1987). Terbutaline and budesonide as inhibitors of postischaemic permeability increase. Acta Physiol Scand 129:517–524.
   Google Scholar
• Petersen LJ, Kristensen JK. (1990). Local sympa-thetic reflex control of blood flow in human skin following topical corticosteroid treatment. Scand J Clin Lab Invest 50:199–201.
   PubMed Web of Science ®Google Scholar
• Piedirnonte G, McDonald DM, Nadel JA. (1991). Neutral endopeptidase and kininase II mediate glu-cocorticoid inhibition of neurogenic inflammation in rat trachea. J Clin Invest 88:40–44.
   Google Scholar
• Pitzalis C, Pipitone N, Bajocchi G, Hall M, Goulding N, Lee A, Kingsley G, Lanchbury J, Panay G. (1997). Corticosteroids inhibit lymphocyte binding to endothelium and intercellular adhesion: an addi-tional mechanism for their anti-inflammatory and irnrnunosuppressive effect. J Immunol 158:5007–5016.
   PubMed Web of Science ®Google Scholar
• Pitzalis C, Sharrack B, Gray IA, Lee A, Hughes RA. (1997). Comparison of the effects of oral versus in-travenous methylprednisolone regimens on periph-eral blood T lymphocyte adhesion molecule expres-sion, T cell subsets distribution and TNF-a concen-trations in multiple sclerosis. J Neuroimmunol 74: 62–68.
   PubMedGoogle Scholar
• Rascher W, Dietz R, Schomig A, Burkart G, Gross F. (1980). Reversal of corticosterone-induced super-sensitivity of vascular smooth muscle to noradrena-line by arachidonic acid and prostacyclin. Eur J Pharmacol 68:267–273.
   Google Scholar
• Ren P, Feijter AW, Paul DL, Ruch RJ. (1994). En-hancement of liver cell gap junction protein expres-sion by glucocorticoids. Carcinogenesis 15:1807–1813.
   PubMed Web of Science ®Google Scholar
• Sessa WC, Nasjletti A. (1990). Dexarnethasone se-lectively attenuates prostanoid-induced vasocon-strictor responses in vitro. Circ Res 66:383–388.
   PubMed Web of Science ®Google Scholar
• Sessa WC, Lin L, Nasjletti A. (1990). Reciprocal effects of dexamethasone on vasodilatory responses to arachidonic acid and prostanoids in the isolated perfused rabbit kidney. Hypertension 15(SI):193–196.
   Google Scholar
• Schleirner RP, Freeland HS, Peters SP, Brown ICE, Derse CP. (1989). An assessment of the effects of lucorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotri-ene B4 by purified human neutrophils. J Pharmacol Exp Ther 250:598–605.
   Google Scholar
• Schneider AJ, Voerman HJ. (1991). Abrupt hemo-dynamic improvement in late septic shock with physiological doses of glucocorticoids. In ten Care Med 17:436–437.
   Google Scholar
• Solomon LM, Wentzel HE, Greenberg MS. (1965). Studies in the mechanism of steroid vasoconstric-tion. J Invest Dermatol 44:129–131.
   Google Scholar
• Sprung CL, Caralis PV, Marcial EH, Gelbard MA, Long WM, Duncan RC, Tendler MD, Karpf M. (1984). The effects of high-dose corticosteroids in patients with septic shock. A prospective, controlled study. New Engl J Med 311:1137–1143.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Zweifach BW, Forrest MJ, and Schmid-Schönbein GW. (1995). Modification of leukocyte adhesion in spontaneously hypertensive rats by adrenal corticosteroids. J Leukoc Biol 57:20–26.
   Google Scholar
• Szallasi A, Blumberg PM. (1999). Vanilloid (capsa- icin) receptors and mechanisms. Pharmacol Rev 51: 159–211.
   PubMed Web of Science ®Google Scholar
• Tailor A, Das AM, Getting SJ, Flower RJ, Perretti M. (1997). Subacute treatment of rats with dexarneth-asone reduces ICAM-1 levels on circulating mono-cytes Biochem Biophys Res Commun 231:675–678.
   Google Scholar
• Tailor A, Flower RJ, Perretti M. (1997). Dexameth-asone inhibits leukocyte emigration in rat mesenter-ic post-capillary venules: an intravital microscopy study. J Leukoc Biol 62:301–308.
   Google Scholar
• Tailor A, Tomlinson A, Salas A, Panes J, Granger DN, Flower RJ, Perretti M. (1999). Dexamethasone inhibition of leukocyte adhesion to rat mesenteric post-capillary venules: role of intercellular adhesion molecule 1 and KC. Gut 45:705–712.
   PubMed Web of Science ®Google Scholar
• Tessier P, Audette M, Cattaruzzi P, McColl SR. (1993). Up-regulation by tumor necrosis factor al-pha of intercellular adhesion molecule 1 expression and function in synovial fibroblasts and its inhibi-tion by glucocorticoids. Arthr Rheum 11:1528–1539.
   Google Scholar
• Thiele K, Bierhaus A, Autschbach F, Hofman M, Stremmel W, Thiele H, Ziegler R, Nawroth PP. (1999). Cell specific effects of glucocorticoid treat-ment on NF-KBp65/IkBa system in patients with Crohn's disease. Gut 45:693–704.
   PubMed Web of Science ®Google Scholar
• Tsurufuji S, Sugio K, Takemasa F. (1979). The role of glucocorticoid receptor and gene expression in the anti-inflammatory action of dexarnethasone. Nature 280:408–410.
   PubMed Web of Science ®Google Scholar
• Tsurufuji S, Sugio K, Takemasa F, Yoshizawa S. (1980). Blockade by antiglucocorticoids, actinomy-cin D and cyclohexirnide of anti-inflammatory ac-tion of dexarnethasone against bradykinin. J Phar-macol Exp Therap 212:225–231.
   Google Scholar
• van de Stolpe A, Caldenhoven E, Raaijmakers JAM, van der Saag PT, Koenderman L. (1993). Gluco-corticoid-mediated repression of intercellular adhe-sion molecule-1 expression in human monocytic and bronchial epithelial cell lines. Am J Respir Cell Mol Biol 8:340–347.
   PubMed Web of Science ®Google Scholar
• van de Stolpe A, Caldenhoven E, Stade BG, Koen-derman L, Raaijmakers JAM, Johnson JP, van der Saag PT. (1994). 12-0-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is in-hibited by dexarnethasone. Functional analysis of the human intercellular adhesion molecule-1 pro-moter. J Biol Chem 269:6185–6192.
   PubMed Web of Science ®Google Scholar
• van der Saag PT, Caldenhoven E, van de Stolpe A. (1996). Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-KB transcription factors. Eur Respir J 9\(suppl 22):146s–153s.
   Google Scholar
• Wahl SM, Feldman GM, McCarthy JB. (1996). Regulation of leukocyte adhesion and signalling in inflammation and disease. J Leukoc Biol 59:789–796.
   PubMed Web of Science ®Google Scholar
• Walker BR, Connacher AA, Webb DJ, Edwards CR (1992). Glucocorticoids and blood pressure: a role for the cortisol/cortisone shuttle in the control of vascular tone in man. Clin Sci 83:171–178.
   Web of Science ®Google Scholar
• Wheller SK, Perretti M. (1997). Dexamethasone in-hibits cytokine-induced intercellular adhesion mol-ecule-1 up-regulation on endothelial cell lines. Eur J Pharmacol 331:65–71.
   PubMed Web of Science ®Google Scholar
• Williams TJ, Morley J. (1973). Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature 1282:215–217.
   Google Scholar
• Wuthrich RP, Sekar P. (1993). Effect of dexarneth-asone, 6-mercaptopurine and cyclosporine A on in-tercellular adhesion molecule-1 and vascular adhe-sion molecule-1 expression. Biochem Pharmacol 46: 1349–1353.
   Google Scholar
• Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. (1988). A novel potent vasoconstrictor peptide pro-duced by vascular endothelial cell. Nature 332:411–415.
   PubMed Web of Science ®Google Scholar
• Yoshida N, Yoshikawa T, Nakamura Y, Takenaka S, Sakarnoto K, Manabe H, Nakagawa S, Kondo M. (1997) . Methylprednisolone inhibits neutrophil - endothelial cell interactions induced by interleukin-lp under flow conditions. Life Sci 60:2341–2347.
   Google Scholar
• Yoshirnura T, Matsushima K, Oppenheirn JJ, Leo-nard EJ. (1987). Neutrophil chemotactic factor pro-duced by lipopolysaccharide (LPS)-stimulated hu-man blood mononuclear leukocytes: partial charac-terization and separation from interleukin 1 (IL-1). J Immunol 139:788–793.
   Google Scholar
• Yoshirnura T, Yuhki, N, Moore SK, Appella E, Le-rman MI, Leonard EJ. (1989). Human monocyte chemoattractant protein-1 (MCP-1). Full length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence simi-larity to mouse competence gene JE. FERS Lett 244: 487–493.
   Google Scholar
• Youssef PP, Cormack J, Evill CA, Peter DT, Rob-erts-Thomson PJ, Ahern M, Smith M. (1996). Neu-trophil trafficking into inflamed joints in patients with rheumatoid arthritis, and the effects of meth-ylprednis olone. Arth Rheum 39:216–225.
   Google Scholar
• Zweifach BW. (1961). Functional Behavior of the Microcirculation. Chas. C. Thomas. Springfield, IL. 1–86.
   Google Scholar