6
Views
5
CrossRef citations to date
0
Altmetric
Original Article

A Vascular Connection to Alzheimer's Disease

&
Pages 207-220 | Published online: 10 Jul 2009

References

  • Aoyama K, Matsubara K, Fujikawa Y, Nagahiro Y, Shimizu K, Umegae N, Hayase N, Shiono H, Kabaya-shi S. (2000). Nitration of manganese superoxide dis-mutase in cerebrospinal fluids is a marker for perox-initrite-mediated oxidative stress in neurodegenera�tive diseases. Ann Neurol 47:524–527.
  • Bush AL, Martins RN, Rumble B, Moir R, Fuller S, Milward E, Currie J, Ames D, Weidemann A, Fischer P, Multhaup G, Beyreuther K, Masters LL. (1990). The amyloid precursor protein of Alzheimer�s disease is released by human platelets. J Biol Chem 265: 15977–15983.
  • Chabrier P-E, Demerle'-Pallardy C, Auguet M. (1999). Nitric oxide synthases: targets for therapeutic strategies in neurological diseases. Cell Mol Life Sci 55:1029–1035.
  • Chambers R, Zweifach BW. (1944). The topography and function of mesenteric capillary circulation. Am J Anat 75:173–205.
  • Chen M, Inestrosa NC, Ross GS, Fernandez HL. (1995). Platelets are the primary resource of amyloid beta-peptide in human blood. Biochem Biophys Res Commun 213:96–103.
  • Davies TA, Billingslea A, Johnson R, Greenberg S, Ortiz M, Long H, Sgro K, Tibbles H, Seetoo K, Rath-bun W, Schonhorn J, Rimons ER. (1997). Stimulus responses and amyloid precursor protein processing in DAMI megakaryocytes. J Lab Clin Med 130:21–32.
  • de la Torre JC. (1994). Impaired brain microcircula�tion may trigger Alzheimer�s disease. Neurosci Biobe-hav Rev 18:397–401.
  • de la Torre JL, Hachinski V. (Eds.) (1997). Cerebro�vascular pathology in Alzheimer�s disease. Ann NY Acad Sci 826:1–523.
  • de la Torre JC, Mussivand T. (1993). Can disturbed brain circulation cause Alzheimer�s disease? Neurol Res 15:146–153.
  • Frangione B. (1989). Systemic and cerebral amyloid�osis. Ann Med 21:69–72.
  • Frasher WG Jr. (1973). Attached floating cat mesen�tery preparation for vital microscopy. Microvasc Res 5:376–383.
  • Hensley K, Maidt ML, Yu Z, Sang H, Markesbery WR, Floyd RA. (1988). Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J Neu-rosci 18:8126–8132.
  • Jancso G, Domoki F, Santha P, Varga J, Fischer J, Orosz K, Penke B, Becskei A, Dux M, Toth L. (1998). (3-Amyloid (1-42) peptide impairs blood-brain bar�rier function after intracarotid infusion in rats. Neu-rosci Lett 253:139–141.
  • Kalaria RN. (1993). Cerebral microvasculature and immunological factors in Alzheimer�s disease. Clin Neurosci 1:204–211.
  • Kalaria RN. (1996). Cerebral vessels in ageing and Alzheimer�s disease. Pharmacol Ther 72:193–214.
  • Kalaria RN. (1999). The blood-brain barrier and ce�rebrovascular pathology in Alzheimer�s disease. Ann NY Acad Sci 893:113–125.
  • Kalaria RN, Hedera P. (1995). Differential degenera�tion of the cerebral microvasculature in Alzheimer�s disease. NeuroReport 6:477–480.
  • Kalaria RN, Hedera P. (1996). (3-amyloid vasoactiv-ity in Alzheimer�s disease. Lancet 347:1492–1493.
  • Kalaria RN, Ince P. (Eds.) (2000). Vascular factors in Alzheimer�s disease. Ann NY Acad Sci 903:1–556.
  • Kang J, Lemaire H, Unterbeck A, Salbaum JM, Mas�ters CL, Grzeschik K, Multhaup K, Beyreuther K, Muller-Hill B. (1987). The precursor of Alzheimer�s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733–736.
  • Knopman D, Boland LL, Mosley T, Howard G, Liao D, Szoklo M, McGovern P, Folsom AR. (2001). Car- diovascular risk factors and cognitive decline in middle-aged adults. Neurology 56:42–48.
  • Mattson MP, Rydel RR. (1996). Amyloid ox-tox transducers. Nature 382:674–675.
  • Mayrovitz HN, Tuma RF, Wiedemann MP. (1980). Leukocyte adherence in arterioles following extravas-cular tissue trauma. Microvasc Res 20:264–272.
  • Miyakawa T, Kimura T, Hirata S, Fujise N, Ono T, IshizukaK, Nakabayashi J. (2000). Role of blood ves�sels in producing pathological changes in the brain with Alzheimer�s disease. Ann NY Acad Sci 903:46–54.
  • Naslund J, Haroutunian V, Mohs R, Davis KL, Davies P, Greengard P, Buxbaum JD. (2000). Correlation between elevated levels of amyloid-(3 peptide in the brain and cognitive decline. JAMA 283:1571–1577.
  • Ohkura T, Isse K, Akazawa K, Hamamoto M, Yaoi Y, Hagino N (1994). Evaluation of estrogen treatment in female patients with dementia of the Alzheimer type. Endocr J 41:361–367.
  • Paris D, Parker TA, Town T, Suo Z, Fang C, Hum�phrey J, Crawford F, Mullan M. (1998). Role of per-oxynitrite in the vasoactive and cytotoxic effects of Alzheimer�s (3-amyloid 1–40 peptide. Exp Neurol 152:116–122.
  • Perlmutter LS, Chang Chui H. (1990). Microangiop�athy, the vascular basement membrane and Alzhei�mer�s disease: a review. Brain Res Bull 24:677–686.
  • Petito CK, Levy DE. (1980). The importance of ce�rebral arterioles in alterations of the blood-brain bar�rier. Lab Invest 43:262–268.
  • Rhodin JAG. (1986). Perfusion and superfusion fixa�tion effects on rat mesentery microvascular beds. In�travital and electron microscope analyses. J Submi-crosc Cytol Pathol 18:453–470.
  • Rhodin JAG, Lim SS. (1979). Combined intravital microscopy and electron microscopy of the blind be�ginnings of the mesenteric lymphatic capillaries of the rat mesentery. Acta Physiol Scand Suppl 463:51–58.
  • Rhodin J, Thomas T, Bryant MW, Clark L, Sutton ET. (1999). Animal model of vascular inflammation. J Submicrosc Cytol Pathol 31:305–311.
  • Rhodin J, Thomas T, Bryant MW, Sutton ET. (2000). Animal model of Alzheimer-like vascular pathology and inflammatory reaction. Vascular factors in al-zheimer�s disease. Ann NY Acad Sci 903:345–352.
  • Roher AE. (1993). (3-amyloid (1-42) is a major com�ponent of cerebrovascular amyloid deposits: implica�tions for the pathology of Alzheimer�s disease. Proc Natl Acad Sci USA 90:10836–10840.
  • Sheng JG, Ito K, Skinner RD, Mark RE, Rovnaghi CR, Van Eldik LJ, Griffin ST. (1996). In vivo and in vitro evidence supporting a role for the inflammatory cy�tokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging 17:761–766.
  • Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. (2000). Clearance of Alz- heimer�s amyloid-(3 1–40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106:1489–1499.
  • Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura N, Chiba S, Perry G, Smith MA, Fujimoto S. (2000). Activation of NADPH oxidase in Alzheimer�s disease brains. Biochem Biophys Res Commun 273:5–9.
  • Shinkai Y, Yoshimura M, Ito Y, Odaka A, Suzuki N, Yanagisawa K, Ihara Y. (1995). Amyloid beta-proteins 1-40 and 1-42 (43) in the soluble fraction of extra- and intracranial blood vessels. Ann Neurol 38: 421–448.
  • Smith CCT. (1997). Stimulated release of the (3-amy-loid protein of Alzheimer�s disease by normal human platelets. Neurosci Lett 235:157–159.
  • Sparks DL. (1997). Coronary artery disease, hyper�tension, ApoE, and cholesterol: a link to Alzheimer�s disease? Ann NY Acad Sci 826:128–146.
  • Sparks DL. (1999). Vascular related and mediated alterations in Alzheimer�s disease. Cereb Cortex 14:733–772.
  • Stewart PA, Hayakawa K, Akers MA, Vinters HV. (1992). A morphometric study of the blood-brain barrier in Alzheimer�s disease. Lab Invest 67:734–742.
  • Strazielle N, Ghersi-Egea J-F, Ghiso J, Dehouck M-P, Frangione B, Patlak C, Fenstermacher J, Gorevic P. (2000). In vitro evidence that (3-amyloidpeptide 1-40 diffuses across the blood-brain barrier and affects its permeability. J Neuropath Exp Neurol 59:29–38.
  • Sutton ET, Hellerman GR, Thomas T. (1997). (3-amyloid induced endothelial necrosis and inhibi�tion of nitric oxide production. Exp Cell Res 230:368–376.
  • Sutton ET, Thomas T, Bryant MW, Landon CS, New�ton CA, Rhodin JAG. (1999). Amyloid-(3 peptide in�duced inflammatory reaction is mediated by the cy�tokines tumor necrosis factor and interleukin-1. J Submicrosc Cytol Pathol 31:313–323.
  • Tanzi, RE. (1989). Molecular genetics of Alzheimer�s disease and the amyloid-(3 peptide precursor gene. Ann Med 21:91–94.
  • Thomas T, Thomas G, McLendon C, Sutton T, Mul�lan M. (1996). (3-amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380:168–171.
  • Thomas T, Sutton ET, Bryant MW, Rhodin JAG. (1997). In vivo vascular damage, leukocyte activation and inflammatory response induced by (3-amyloid. J Submicrosc Cytol Pathol 29:293–304.
  • Thomas T, McLendon C, Sutton ET, Thomas G (1997). Cerebrovascular endothelial dysfunction me�diated by (3-amyloid. NeuroReport 8:1387–1391.
  • Thomas T, Rhodin JAG, Sutton ET, Bryant MW, Price JM. (1999). Estrogen protects peripheral and cerebral blood vessels from toxicity of Alzheimer pep- tide amyloid-(3 and inflammatory reaction. J Submi�crosc Cytol Pathol 31:571–579.
  • Thomas T, Rhodin J. (2000). Vascular actions of es�trogens and Alzheimer�s disease. Vascular factors in Alzheimer�s disease. Ann NY Acad Sci 903:501–509.
  • Thomas T, Bryant MW, Clark L, Garces A, Rhodin J. (2001). Estrogen and raloxifene activities on amy-loid-(3 induced inflammatory reaction. Microvasc Res 61:28–39.
  • Torreilles F, Salman-Tabcheh S, Gur-eacute;rin M-C, Torreilles J. (1999). Neurodegenerative disor�ders: the role of peroxynitrite. Brain Res Rev 30:153–163.
  • van Dyke K. (1997). The possible role of peroxyni�trite in Alzheimer�s disease: a simple hypothesis that could be tested more thoroughly. Med Hypotheses 48: 375–380.
  • Vinters HV, Pardridge WM. (1986). The blood-brain barrier in Alzheimer�s disease. Can J Neurol Sci 13: 446–448.
  • Vinters HV. (1987). Cerebral amyloid angiopathy. A critical review. Stroke 18:311–324.
  • Vinters HV, Secor DL, Read SL, Frazee JG, Tomi-yasu U, Stanley TM, Ferreiro JA, Akers MA. (1994). Microvasculature in brain biopsy specimens from pa�tients with Alzheimer�s disease: an immunohisto-chemical and ultrastructural study. Ultrastruct Pathol 18:333–348.
  • Weller RO, Massey A, Newman TA, Hutchings M, Kuo Y-M, Roher AE. (1998). Cerebral amyloid angi�opathy: (3-amyloid accumulates in putative intersti�tial fluid drainage pathways in Alzheimer�s disease. Am J Pathol 153:725–734.
  • Weller RO, Massey A, Kuo Y-M, Roher AE. (2000). Cerebral amyloid angiopathy: accumulation of Ab in interstitial fluid drainage pathways in Alzheimer�s disease. Ann NY Acad Sci 903:110–117.
  • Wisniewski HM, Kozlowski PB. (1982). Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT). Ann NY Acad Sci 396:119–129.
  • Wisniewski HM, Wegiel J, Wang KC, Lach B. (1992). Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer�s disease. Acta Neuropathol 84:117–127.
  • Yamashita K, MiyakawaT, Katsuragi S. (1991). Vas�cular changes in brains with Alzheimer�s disease. Jpn J Psychiatry Neurol 45:79–84.
  • Yan DS, Chen X, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM. (1996). RAGE and amyloid-(3 pep�tide neurotoxicity in Alzheimer�s disease. Nature 382: 685–691.
  • Zweifach BW. (1954). Direct observation of the mes�enteric circulation in experimental animals. Anat Rec 120:277–288.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.