Vascular Dysfunction Induced by AGE is Mediated by VEGF via Mechanisms Involving Reactive Oxygen Species, Guanylate Cyclase, and Protein Kinase C

References

• Bierhaus A, Chevion S, Chevion M, Hofmann M, Que-henberger P, Illmer T, Luther T, Berentshtein E, Tritschler H, Mu¨ller M, Wahl P, Ziegler R, Nawroth PP. (1997). Advanced glycation end product-induced activation of NF-KB is suppressed by a-lipoic acid in cultured endothelial cells. Diabetes 46:1481–1490.
   PubMed Web of Science ®Google Scholar
• Bjercke RJ, Cook G, Rychlik N, Gjika HB, Vunakis HV, Langone JJ. (1986). Stereospecific monoclonal antibodies to nicotine and cotinine and their use in enzyme-linked immunosorbent assays. J Immunol Meth 90:203–213.
   PubMedGoogle Scholar
• Bonnardel-Phu E, Wautier J-L, Schmidt AM, Avila C, Vicaut E. (1999). Acute modulation of albumin mi¬crovascular leakage by advanced glycation end prod¬ucts in microcirculation of diabetic rats in vivo. Dia¬betes 48:2052–2058.
   PubMed Web of Science ®Google Scholar
• Brownlee M, Cerami A, Vlassara H. (1988). Ad¬vanced glycation endproducts in tissue and the bio¬chemical basis of diabetic complications. N Engl J Med 318:1315–1321.
   PubMed Web of Science ®Google Scholar
• Brownlee M. (1995). Advanced protein glycosylation in diabetes and aging. Annu Rev Med 46:223–234.
   PubMed Web of Science ®Google Scholar
• Chappey O, Dosquet C, Wautier M-P, Wautier J-L. (1997). Advanced glycation end products, oxidant stress and vascular lesions. Eur J Clin Invest 27:97–108.
   PubMed Web of Science ®Google Scholar
• Craven PA, Davidson CM, DeRubertis FR. (1990). Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes 39:667–674.
   PubMed Web of Science ®Google Scholar
• Curry FE. (1992). Modulation of venular microvessel permeability by calcium influx into endothelial cells. FASEB J 6:2456–2466.
   Google Scholar
• Giardino I, Fard AK, Hatchell DL, Brownlee M. (1998). Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes 47:1114–1120.
   PubMed Web of Science ®Google Scholar
• He P, Zeng M, Curry FE. (1998). cGMP modulates basal and activated microvessel permeability inde¬pendently of [Ca2+]i. Am J Physiol 274:H1865–H1874.
   Google Scholar
• Hirata C, Nakano K, Nakamura N, Kitagawa Y, Shigeta H, Hasegawa G, Ogata M, Ideda T, Sawa H, Nakamura K, Ienaga K, Obayashi H, Kondo M. (1997). Advanced glycation end products induce ex¬pression of vascular endothelial growth factor by reti-nal Mu¨ller cells. Biochem Biophys Res Commun 236: 712–715.
   PubMed Web of Science ®Google Scholar
• Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL. (1996). Ame¬lioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272:728–731.
   PubMed Web of Science ®Google Scholar
• Kilzer P, Chang K, Marvel J, Kilo C, Williamson JR. (1985). Tissue differences in vascular permeability changes induced by histamine. Microvasc Res 30: 270–285.
   PubMedGoogle Scholar
• Kilzer P, Chang K, Marvel J, Rowold E, Jaudes P, Ullensvang S, Kilo C, Williamson JR. (1985). Albu¬min permeation of new vessels is increased in diabetic rats. Diabetes 34:333–336.
   Google Scholar
• Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Yan SD, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM. (1999). N -(Carboxymethyl)lysine ad-ducts of proteins are ligands for receptor for advanced gylcation end products that activate cell signaling pathways and modulate gene expression. J Biol Chem 274:31740–31749.
   PubMed Web of Science ®Google Scholar
• KoyaD, King GL. (1998). Protein kinase C activation and the development of diabetic complications. Dia¬betes 47:859–866.
   Google Scholar
• Ku DD, Zaleski JK, Liu S, Brock TA. (1993). Vascu¬lar endothelial growth factor induces EDRF- dependent relaxation in coronary arteries. Am J Phys-iol 265:H586–H592.
   PubMed Web of Science ®Google Scholar
• Kuroki M, Voest EE, Amano S, Beerepoot LV, Takashima S, Tolentino M, Kim RY, Rohan RM, Colby KA, Yeo K-T, Adamis AP. (1996). Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. J Clin Invest 98:495–504.
   Web of Science ®Google Scholar
• Lopez JJ, Laham RJ, Carrozza JP, Tofukuji M, Sellke FW, Bunting S, Simons M. (1997). Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response. Am J Physiol 273:H1317–H1323.
   Google Scholar
• Loske C, Neumann A, Cunningham AM, Nichol K, Schinzel R, Riederer P, Mu¨nch G. (1998). Cytotoxic-ity of advanced glycation endproducts is mediated by oxidative stress. J Neural Transm 105:1005–1015.
   PubMed Web of Science ®Google Scholar
• Lu M, Kuroki M, Amano S, Tolentino M, Keough K, Kin I, Bucala R, Adamis AP. (1998). Advanced gly-cation end products increase retinal vascular endo-thelial growth factor expression. J Clin Invest 101: 1219–1224.
   PubMed Web of Science ®Google Scholar
• Lundberg C, Gerdin B. (1984). The inflammatory reaction in an experimental model of open wounds in the rat. The effect of arachidonic acid metabolites. Eur J Pharmacol 97:229–238.
   Google Scholar
• Mayhan WG. (1999). VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/ cGMP-dependent pathway. Am J Physiol 276:C1148- C1153.
   Google Scholar
• Murata T, Nagai R, Ishibashi T, Inomata H, Ikeda K, Horiuchi S. (1997). The relationship between accu¬mulation of advanced glycation end products and ex¬pression of vascular endothelial growth factor in hu¬man diabetic retinas. Diabetologia 40:764–769.
   PubMed Web of Science ®Google Scholar
• Nyengaard JR, Chang K, Berhorst S, Reiser KM, Williamson JR, Tilton RG. (1997). Discordant effects of guanidines on renal structure and function and on regional vascular dysfunction and collagen changes in diabetic rats. Diabetes 46:94–106.
   Google Scholar
• Reiser KM, Hennessy SM, Last JA. (1987). Analysis of age-associated changes in collagen crosslinking in the skin and lung in monkeys and rats. Biochem Bio-phys Acta 926:339–348.
   PubMedGoogle Scholar
• Reiser KM, Amigable MA, Last JA. (1992). Nonen-zymatic glycation of type I collagen: the effects of aging on preferential glycation. J Biol Chem 267: 24207–24216.
   PubMed Web of Science ®Google Scholar
• Reiser KM. (1994). Influence of age and long-term dietary restriction on enzymatically mediated crosslinks and nonenzymatic glycation of collagen in mice. J Gerontol Biol Sci 49:B71–B79.
   Google Scholar
• Ruderman NB, Williamson JR, Brownlee M. (1992). Glucose and diabetic vascular disease. FASEB J 6: 2905–2914.
   PubMed Web of Science ®Google Scholar
• Schmidt AM, Hori O, Brett J, Yan SD, Wautier J-L, Stern D. (1994). Cellular receptors for advanced gly- cation end products. Implications for induction of oxidant stress and cellular dysfunction in the patho-genesis of vascular lesions. Arterioscler Thromb 14: 1521–1528.
   Google Scholar
• Schmidt AM, Hori O, Chen JX, Li JF, Crandall J, Zhang J, Cao R, Yan SD, Brett J, Stern D. (1995). Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascu¬lar cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. J Clin Invest 96:1395–1403.
   PubMed Web of Science ®Google Scholar
• Shasby DM, Lind SE, Shasby SS, Goldsmith JC, Hun-ninghake GW. (1985). Reversible oxidant-induced increases in albumin transfer across cultured endo-thelium: alterations in cell shape and calcium homeo-stasis. Blood 65:605–614.
   PubMed Web of Science ®Google Scholar
• Siflinger-Birnboim A, Lum H, Del Vecchio PJ, Malik AE. (1996). Involvement of Ca2+ in the H2O2-induced increase in endothelial permeability. Am J Physiol 270:L973–L978.
   Google Scholar
• Singh AK, Mo W, Dunea G, Arruda JAL. (1998). Effect of glycated proteins on the matrix of glomeru-lar epithelial cells. J Am Soc Nephrol 9:802–810.
   PubMed Web of Science ®Google Scholar
• Smith MA, Taneda S, Richey PL, Miyata S, Yan SD, Stern D, Sayre LM, Monnier VM, Perry G. (1994). Advanced Maillard reaction end products are associ¬ated with Alzheimer’s disease pathology. Proc Natl Acad Sci 91:5710–5714.
   PubMed Web of Science ®Google Scholar
• Soulis T, Thallas V, Youssef S, Gilbert RE, McWilliam BG, Murray-McIntosh RP, Cooper ME. (1997). Advanced glycation end products and their receptors co-localise in rat organs susceptible to dia¬ betic microvascular injury. Diabetologia 40:619–628.
   PubMed Web of Science ®Google Scholar
• Stitt AW, He C, Vlassara H. (1999). Characterization of the advanced glycation end-product receptor com¬plex in human vascular endothelial cells. Biochem Biophys Res Commun 256:549–556.
   PubMed Web of Science ®Google Scholar
• Sun M, Yokoyama M, Ishiwata T, Asano G. (1998). Deposition of advanced glycation end products (AGE) and expression of the receptor for AGE in car¬diovascular tissue of the diabetic rat. Int J Exp Path 79:207–222.
   PubMed Web of Science ®Google Scholar
• Tilton RG, Chang K, Pugliese G, Eades DM, Province MA, Sherman WR, Kilo C, Williamson JR. (1989). Prevention of hemodynamic and vascular albumin filtration changes in diabetic rats by aldose reductase inhibitors. Diabetes 38:1258–1270.
   PubMed Web of Science ®Google Scholar
• Tilton RG, Chang K, Nyengaard JR, Van den Enden M, Ido Y, Williamson JR. (1995). Inhibition of sorbi-tol dehydrogenase: effects on vascular and neural dysfunction in streptozocin-induced diabetic rats. Diabetes 44:234–242.
   PubMed Web of Science ®Google Scholar
• Tilton RG, Kawamura T, Chang KC, Ido Y, Bjercke RJ, Stephan CC, Brock TA, Williamson JR. (1997). Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor. J Clin Invest 99:2192–2202.
   PubMed Web of Science ®Google Scholar
• Tilton RG, Chang KC, LeJeune WS, Stephan CC, Brock TA, Williamson JR. (1999). Role for nitric ox¬ide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. Invest Oph-thalmol Vis Sci 40:689–696.
   PubMed Web of Science ®Google Scholar
• Vitek MP, Bhattyacharya K, Glendening JM, Stopa E, Vlassara H, Bucala R, Manogue K, Cerami A. (1994). Advanced glycation endproducts contribute to amy-loidosis in Alzheimer’s disease. Proc Natl Acad Sci 91:4766–4770.
   PubMed Web of Science ®Google Scholar
• Vlassara H, Fuh H, Makita Z, Krungkrai S, Cerami A, Bucala R. (1992). Exogenous advanced glycosyla-tion end products induce complex vascular dysfunc¬tion in normal animals: a model for diabetic and ag¬ing complications. Proc Natl Acad Sci 89:12043–12047.
   PubMed Web of Science ®Google Scholar
• Wautier J-L, Wautier M-P, Schmidt AM, Anderson GM, Hori O, Zoukourian C, Capron L, Chappey O, Yan S-D, Brett J, Guillausseau P-J, Stern D. (1994). Advanced glycation end products (AGEs) on the sur¬face of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications. Proc Natl Acad Sci 91: 7742–7746.
   PubMed Web of Science ®Google Scholar
• Wautier J-L, Zoukourian C, Chappey O, Wautier M-P, Guillausseau P-J, Cao R, Hori O, Stern D, Schmidt AM. (1996). Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble re¬ceptor for advanced gycation end products blocks hy-perpermeability in diabetic rats. J Clin Invest 97:238–243.
   Google Scholar
• Williams B, Gallacher B, Patel H, Orme C. (1997). Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes 46:1497–1503.
   PubMed Web of Science ®Google Scholar
• Williamson JR, Rowold E, Chang K, Marvel J, Tom-linson M, Sherman WR, Ackermann KE, Berger RA, Kilo C. (1986). Sex steroid-dependency of diabetes-induced changes in polyol metabolism, vascular per¬meability and collagen crosslinking. Diabetes 35:20–27.
   Google Scholar
• Williamson JR, Ostrow E, Eades DM, Chang K, Alli¬son W, Kilo C, Sherman WR. (1990). Glucose-induced microvascular functional changes in nondia-betic rats are stereospecific and are prevented by an aldose reductase inhibitor. J Clin Invest 85:1167–1172.
   PubMed Web of Science ®Google Scholar
• Williamson JR, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura T, Nyengaard JR, Van den Enden M, Kilo C, Tilton RG. (1993). Hyperglycemic pseudohy-poxia and diabetic complications. Diabetes 42:801–813.
   PubMed Web of Science ®Google Scholar
• Wolf BA, Williamson JR, Easom RA, Chang K, Sher¬man WR, Turk J. (1990). Diacylglycerol accumula- tion and microvascular abnormalities induced by el¬evated glucose levels. J Clin Invest 87:31–38.
   Google Scholar
• Yamagishi S, Yonekura H, Yamamoto Y, Katsuno K, Sato F, Mita I, Ooka H, Satozawa N, Kawakami T, Nomura M, Yamamoto H. (1997). Advanced glyca-tion end products-driven angiogenesis in vitro. J Biol Chem 272:8723–8730.
   PubMed Web of Science ®Google Scholar
• Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, Stern D. (1994). Enhanced cellu¬lar oxidant stress by the interaction of advanced gly- cation end products with their receptors/binding pro¬teins. J Biol Chem 269:9889–9897.
   PubMed Web of Science ®Google Scholar
• Yang C-W, Vlassara H, Peten EP, He C-J, Striker GE, Striker LJ. (1994). Advanced glycation end products up-regulate gene expression found in diabetic glomer-ular disease. Proc Natl Acad Sci 91:9436–9440.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Granger HJ, Zawieja DC, DeFily DV, Chilian WM. (1993). Histamine increases venular permeabil¬ity via a phospholipase C-NO synthase-guanylate cy-clase cascade. Am J Physiol 264:H1734–H1739.
   Google Scholar