Adaptations of the Renal Microcirculation to Hypertension

REFERENCES

• Abassi ZA, Ellahharn S, Winaver J, Hoffman A. (2001). The intrarenal endothelin system and hy-pertension. News Physiol Sci 16:152–156.
   Google Scholar
• Abdi A, Johns EJ. (1996). Importance of the renin-angiotensin system in the generation of kidney fail-ure in renovascular hypertension. J Hypertension 14:1131–1137.
   Google Scholar
• Adbi A, Johns EJ. (1997). The effect of angiotensin II receptor antagonists on kidney function in two-kidney, two-clip Goldblatt hypertensive rats. Eur J Pharmacol 331:185–192.
   Google Scholar
• Arniri F, Garcia R. (1997). Renal angiotensin II re-ceptor regulation in two-kidney, one clip hyperten-sive rats: effect of ACE inhibition. Hypertension 30: 337–344.
   Google Scholar
• Andersen BT, Jackson EK, Romero GG. (2001). An-giotensin II signaling to phospholipase D in renal microvascular smooth muscle cells in SHR. Hyper-tension 37:635–639.
   Google Scholar
• Anderson WP, Kett MM, Stevenson KM, Edgley AJ, Denton KM, Fitzgerald SM. (2000). Renovascular hypertension: structural changes in the renal vascu-lature. Hypertension 36:648–652.
   Google Scholar
• Bataillard A, Lo M, Sassard J. (2000). Renal circu-lation in genetic experimental hypertension. In: Ad-vances in Organ Biology (Anderson WP, Evans RG, and Stevenson KM, Eds.) JAI Press. Stamford, CT, 9:317–329.
   Google Scholar
• Beenen OHM, Mathy MJ, Pfaffendorf M, van Zweiten PA. (1996). Vascular responsiveness in iso-lated perfused kidneys of diabetic hypertensive rats. J Hypertension 14:1125–1130.
   Google Scholar
• Bell PD, Mashburn N, Unlap MT. (2000). Renal so-dium/calcium exchange: a vasodilator that is defec-tive in salt-sensitive hypertension. Acta Physiol Scand 168:209–214.
   Google Scholar
• Bell PD, Peti-Peterdi J. (1999). Angiotensin II stimulates macula densa basolateral sodium/ hydrogen exchange via Type 1 angiotensin II recep-tors. J Am Soc Nephrol 10:S225–S229.
   Google Scholar
• Bernard N, Sacquet J, Benzoni D, Sassard J. (2000). Cyclooxygenase 1 and 2 and thromboxane synthase in kidneys of Lyon hypertensive rats. Am J Hyper-tension 13:404–409.
   Google Scholar
• Bidani AK, Schwartz MM, Lewis EJ. (1987). Renal autoregulation and vulnerability to hypertensive in-jury in remnant kidney. Am J Physiol Renal Physiol 252:F1003–F1010.
   Google Scholar
• Boberg U, Persson AEG. (1986). Increased tubulo-glomerular feedback activity in Milan hypertensive rats. Am J Physiol Renal Physiol 250:F967–F974.
   Google Scholar
• Bosse, HM, Bachmann S. (1997). Imrnunohisto-chemically detected protein nitration indicates sites of renal nitric oxide release in Goldblatt hyperten-sion. Hypertension 30:948–952.
   PubMed Web of Science ®Google Scholar
• Braam B, Navar LG, Mitchell KD. (1995). Modula-tion of tubuloglomerular feedback by angiotensin II type 1 receptors during the development of Gold-blatt hypertension. Hypertension 25:1232–1237.
   PubMedGoogle Scholar
• Brannstrom K, Morsing P, Arendshorst W. (1999). Candesartan normalizes exaggerated tubuloglo - merular feedback activity in young spontaneously hypertensive rats. J Am Soc Nephrol 10:S213–S219.
   Google Scholar
• Cachofeiro V, Nasjletti A. (1991). Increased vascu-lar responsiveness to bradykinin in kidneys of spon-taneously hypertensive rats: effect of Nw-nitro-L-arginine. Hypertension 18:683–688.
   PubMed Web of Science ®Google Scholar
• Cervenka L, Kramer HJ, Maly J, Heller J. (2001). Role of nNOS in regulation of renal function in an-giotensin II-induced hypertension. Hypertension 38: 280–285.
   Google Scholar
• Chatziantoniou C, Arendshorst WJ. (1993). Angio-tensin receptor sites in renal vasculature of rats de-veloping genetic hypertension. Am J Physiol Renal Physiol 265:F853–F862.
   Google Scholar
• Chatziantoniou C, Daniels FH, Arendshorst WJ. (1990). Exaggerated renal vascular reactivity to an-giotensin and thromboxane in young genetically hy-pertensive rats. Am J Physiol Renal Physiol 259:F372–F382.
   Google Scholar
• Chatziantoniou C, Ruan X, Arendshorst WJ. (1993). Interactions of cAlVIP-mediated vasodilators with angiotensin II in rat kidney during hypertension. Am J Physiol Renal Physiol 265:F845–F852.
   Google Scholar
• Chin SY, Pandey KN, Shi SJ, Kobori H, Moreno C, Navar LG. (1999). Increased activity and protein expression of calcium-dependent nitric oxide syn-thases in the renal cortex of angiotensin II-infused hypertensive rats. Am J Physiol Renal Physiol 277:F797–F804.
   Google Scholar
• Cowley AW, Roman RJ. (1996). The role of the kid-ney in hypertension. J Am Med Assoc 275:1581–1589.
   PubMed Web of Science ®Google Scholar
• Cserp G, Abraham G, Tolins JP, Simon G. (1996). Different vascular responses to subpressor angioten-sin II administration in the mesenteric and renal circulation of rats. Am J Hypertension 9:385–392.
   Google Scholar
• Dilley JR, Arendshorst WJ. (1984). Enhanced tabu-loglomerular feedback activity in rats developing spontaneous hypertension. Am J Physiol Renal Phys-iol 247:F672–F679.
   Google Scholar
• Dubey RK, Roy A, Overbeck HW. (1992). Culture of renal arteriolar smooth muscle cells mitogenic re-sponses to angiotensin II. Circ Res 71:1143–1152.
   PubMed Web of Science ®Google Scholar
• Eng E, Veniant M, Floege J, Fingerle J, Alpers CE, Menard J, Clozel JP, Johnson RJ. (1994). Renal pro-liferative and phenotypic changes in rats with two-kidney, one-clip Goldblatt hypertension. Am J Hy-pertension 7:177–185.
   PubMed Web of Science ®Google Scholar
• Epstein M, Sowers JR. (1992). Diabetes mellitus and hypertension. Hypertension 19:403–418.
   PubMed Web of Science ®Google Scholar
• Farina NK, Hodgson WC, Widdop RE. (1996). Vas-cular reactivity to angiotensin II in blood-perfused kidneys of hypertensive diabetic rats. Eur J Phar-macol 310:185–191.
   Google Scholar
• Fink GD, Brody MJ. (1979). Renal vascular resis-tance and reactivity in the spontaneously hyperten-sive rat. Am J Physiol Renal Physiol 237:F128–F132.
   Google Scholar
• Foley, RN, Parfrey PS, Harnett JD, Kent GM, Mur-ray DC, Barre PE. (1996). Impact of hypertension on cardiomyopathy, morbidity and mortality in end-stage renal disease. Kidney Int 49:1379–1385.
   PubMed Web of Science ®Google Scholar
• Gebremedhin D, Ma YH, Irnig JD, Harder DR, Ro-man RJ. (1993). Role of cytochrome P-450 in el-evating renal vascular tone in spontaneously hyper-tensive rats. J Vasc Res 30:53–60.
   PubMed Web of Science ®Google Scholar
• Gorbea-Oppliger VJ, Fink GD. (1995). Cerebroven-tricular injection of angiotensin II antagonist: effects on blood pressure responses to central and systemic angiotensin II. J Pharmacol Exp Ther 273:611–616.
   Google Scholar
• Griffin KA, Churchill PC, Picken M, Webb RC, Kurtz TW, Bidani AK. (2001). Differential salt-sensitivity in the pathogenesis of renal damage in SHR and stroke prone SHR. Am J Hypertension 14: 311–320.
   Google Scholar
• Haas JA, Krier JD, Bolterman RJ, Romero JC. (1999). Low-dose angiotensin II increases free iso-prostane levels in plasma. Hypertension 33:983–986.
   Google Scholar
• Hayakawa H, Coffee K, Raij L. (1997). Endothelial dysfunction and cardiorenal injury in experimental salt-sensitive hypertension. Circulation 96:2407–2413.
   PubMed Web of Science ®Google Scholar
• Hayakawa H, Hirata Y, Suzuki E, Sugimoto T, Mat-suoka H, Kikuchi K, Nagano T, Hirobe M. (1993). Mechanisms for altered endothelium-dependent va-sorelaxation in isolated kidneys from experimental hypertensive rats. Am J Physiol Heart Circ Physiol 264:H1535–H1541.
   Google Scholar
• Hayashi K, Epstein M, Loutzenhiser R. (1989). Pressure-induced vasoconstriction of renal mi-crovessels in normotensive and hypertensive rats: studies in the isolated perfused hydronephrotic kid-ney. Circ Res 65:1475–1484.
   Google Scholar
• Hayashi K, Suzuki H, Saruta T. (1995). Nitric oxide modulates but does not impair myogenic vasocon-striction of the afferent arteriole in spontaneously hypertensive rats: studies in the isolated perfused hydronephrotic kidney. Hypertension 25:1212–1219.
   Google Scholar
• Hirata Y, Hayakawa H, Suzuki E, Kimura K, Kiku-chi K, Nagano T, Hirobe M, Omata M. (1995). Di-rect measurements of endothelium-derived nitric oxide release by stimulation of endothelin receptors in rat kidney and its alteration in salt-induced hy-pertension. Circulation 91:1229–1235.
   Google Scholar
• Holla VR, Adas F, Imig JD, Zhao X, Price E, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH. (2001). Alterations in the regulation of androgen-sensitive Gyp 4a monooxygenases cause hyperten-sion. Proc Natl Acad Sci USA 98:5211–5216.
   PubMed Web of Science ®Google Scholar
• Honeck H, Gross V, Erdmann B, Kargel E, Neun-aber R, Milia AF, Schneider W, Luft FC, Schunck WF . (2000 ) . Cytochrome P450 - dependent renal arachidonic acid metabolism in deoxycorticosterone acetate-salt hypertensive mice. Hypertension 36: 610–616.
   PubMed Web of Science ®Google Scholar
• Hoshino J, Sakarnaki T, Nakamura T, Kobayashi M, Kato M, Sakarnoto H, Kurashina T, Yagi A, Sato K, Ono Z. (1994). Exaggerated vascular response due to endothelial dysfunction and role of the renin-angiotensin system at early stage of renal hyperten-sion in rats. Circ Res 74:130–138.
   PubMedGoogle Scholar
• Ichihara A, Irnig JD, Inscho EW, Navar LG. (1998). Interactive nitric oxide-angiotensin II influences on renal microcirculation in angiotensin II-induced hy-pertension. Hypertension 31:1255–1260.
   Google Scholar
• Ichihara A, Inscho EW, Irnig JD, Michel RE, Navar LG. (1997). Role of renal nerves in afferent arterio-lar reactivity in angiotensin-induced hypertension. Hypertension 29:442–449.
   Google Scholar
• Imig JD. (2000). Afferent arteriolar reactivity to an-giotensin II is enhanced during the early phase of angiotensin II-induced hypertension. Am J Hyper-tension 13:810–818.
   PubMed Web of Science ®Google Scholar
• Imig JD, Falck JR, Gebremedhin D, Harder DR, Ro-man RJ. (1993). Elevated renovascular tone in young spontaneously hypertensive rats: role of cyto-chrome P450. Hypertension 22:357–364.
   PubMed Web of Science ®Google Scholar
• Imig JD, Falck JR, Inscho EW. (1999). Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory re-sponsiveness. Br J Pharmacol 127:1399–1405.
   Google Scholar
• Imig JD, Falck JR, Wei S, Capdevila JH. (2001). Enhanced renal microvascular responsiveness to an-giotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12 -epoxyeico satrienoic acid. J Hypertension 19:983–992.
   Google Scholar
• Imig JD, Navar LG, Roman RJ, Reddy KK, Falck JR. (1996). Actions of epoxygenase metabolites on the preglomerular vasculature. J Am Soc Nephrol 7: 2364–2370.
   PubMed Web of Science ®Google Scholar
• Imig JD, Roman RJ. (1992). Nitric oxide modulates vascular tone in preglomerular arterioles. Hyperten-sion 19:770–774.
   PubMed Web of Science ®Google Scholar
• Imig JD, Zhao X, Capdevila JH, Morisseau C, Ham-mock BD. (2002). Soluble epoxide hydrolase inhi-bition lowers arterial pressure in angiotensin II hy-pertension. Hypertension 39:690–694.
   PubMed Web of Science ®Google Scholar
• Inscho EW. (2001). P2 receptors in regulation of renal microvascular function. Am J Physiol Renal Physiol 280: F927–F944.
   Google Scholar
• Inscho EW, Carmines PK, Cook AK, Navar LG. (1990). Afferent arteriolar responsiveness to altered perfusion pressure in renal hypertension. Hyperten-sion 15:748–752.
   Google Scholar
• Inscho EW, Irnig JD, Deichmann PC, Cook AK. (1999). Candesartan cilexetil protects against loss of autoregulatory efficiency in angiotensin II-infused rats. J Am Soc Nephrol 10:S178–S183.
   Google Scholar
• Ito A. (1995). Nitric Oxide in the kidney. Curr Opin Nephrol Hypertension 4:23–30.
   Google Scholar
• Jackson EK. (1994). Pertussis toxin normalizes en-hanced renovascular responses to angiotensin II in spontaneously hypertensive rats. Life Sci 54:445–450.
   Google Scholar
• Keen HL, Brands MW, Smith MJ, Shek EW, Hall JE. (1997). Thromboxane is required for full expression of angiotensin hypertension in rats. Hypertension 29:310–314.
   PubMed Web of Science ®Google Scholar
• Kelly JJ, Whitworth JA. (2000). Renal blood flow in human diseases. In: Advances in Organ Biology (Anderson WP, Evans RG, and Stevenson KM, Eds.) JAI Press. Stamford, CT, 9:347–368.
   Google Scholar
• Kett 1VEVI, Alcorn D, Bertram JF, Anderson WP. (1995). Enalapril does not prevent renal arterial hy-pertrophy in spontaneously hypertensive rats. Hy-pertension 25:335–342.
   Google Scholar
• Kihara M, Umemura S, Sugaya T, Toya Y, Yabana M, Kobayashi S, Tamura K, Kadota T, Kishida R, Murakarni K, Fukamizu A, Ishii M. (1998). Expres-sion of neuronal type nitric oxide synthase and renin in the juxtaglomerular apparatus of angiotensin type-la receptor gene-knockout mice. Kidney Int 53:1585–1593.
   Google Scholar
• King AJ, Troy JL, Brenner BM. (1991). Endothe-lium-derived relaxing factor and the vascular reply to systemic hypertension. J Am Soc Nephrol 2:1072–1077.
   Google Scholar
• Kline RL. (1987). Renal nerves and experimental hypertension: evidence and controversy. Can J Physiol Pharmacol 65:1540–1547.
   Google Scholar
• Kost GK, Herzer WA, Li P, Notoya M, Mizuhira V, Inagarni T, Jackson EK. (1996). Angiotensin II-induced structural and functional alterations in spontaneously hypertensive kidney. Am J Physiol Renal Physiol 270:F229–F236.
   Google Scholar
• Kost GK, Jackson EK. (1993). Enhanced renal an-giotensin II subtype 1 receptor responses in the spontaneously hypertensive rat. Hypertension 21: 420–431.
   PubMed Web of Science ®Google Scholar
• Lariviere R, Deng LY, Day R, Sventek P, Thibault G, Schiffrin EL. (1996). Increased endothelin-1 gene expression in the endothelium of coronary ar-teries and endocardiurn in the DOCA-salt hyperten-sive rat. J Mol Cell Cardiol 27:2123–2131.
   Google Scholar
• Majid DSA, Williams A, Navar LG. (1993). Inhibi-tion of nitric oxide synthesis attenuates pressure- induced natriuretic responses in anesthetized dogs. Am J Physiol Renal Physiol 264:F79–F87.
   Google Scholar
• Makita K, Falck JR, Capdevila JH. (1996). Cyto-chrome P450, the arachidonic acid cascade, and hy-pertension: new vistas for an old system. FASER J 10:1456–1463.
   PubMed Web of Science ®Google Scholar
• Messer-Letienne I, Bernard N, Benzoni D, Sassard J. (1998). Cytochrome P-450-dependent arachidonate metabolites and renal functions in the Lyon hyper-tensive rat. Clin Exp Pharmacol Physiol 25:559–563.
   Google Scholar
• Monneret G, Sassard J, Benzoni D. (1999). Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat. Fundam Clin Pharmacol 13: 226–231.
   Google Scholar
• Moreno C, Maier KG, Hoagland KIM, Yu M, Roman RJ. (2001). Abnormal pressure-natriuresis in hyper-tension: role of cytochrome P450 metabolites of ara-chidonic acid. Am J Hypertension 14:90S–97S.
   Google Scholar
• Mulvany MJ. (1993). Resistance vessel structure and the pathogenesis of hypertension. J Hypertension 11:S7–S12.
   Google Scholar
• Nava E, Linas MT, Gonzalez JD, Salazar FJ. (1996). Nitric oxide synthase activity in renal cortex and medulla of normotensive and spontaneously hyper-tensive rats. Am J Hypertension 9:1236–1239.
   PubMed Web of Science ®Google Scholar
• Navar LG, Ichihara A, Chin SY, Irnig JD. (2000). Nitric oxide-angiotensin II interactions in angioten-sin II dependent hypertension. Acta Physiol Scand 168:139–147.
   PubMedGoogle Scholar
• Navar LG, Inscho EW, Majid DSA, Irnig JD, Harri-son-Bernard LM, Mitchell KID. (1996). Paracrine regulation of the renal microcirculation. Physiol Rev 76:425–536.
   PubMed Web of Science ®Google Scholar
• Navar LG, Ploth DW. (1999). Pathophysiology of renovascular hypertension. In: Hypertension Primer, 2nd Ed (Izzo JL and Black HR, Eds.) Lippincott, Williams & Wilkins, Baltimore, MD. 131–134.
   Google Scholar
• Navar LG, Zou L, Von Thun A, Wang CT, Imig JD, Mitchell KB. (1998). Unraveling the mystery of Goldblatt hypertension. News Physiol Sci 13:170–176.
   PubMedGoogle Scholar
• Node K, Huo Y, Ruan X, Yang B, Spieker M, Ley K, Zeldin DC, Liao JK. (1999). Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 285:1276–1279.
   PubMed Web of Science ®Google Scholar
• Norrelund H, Christensen KL, Sarnani NJ, Kirnber P, Mulvany MJ, Korsgaard N. (1994). Early nar-rowed afferent arteriole is a contributor to the de-velopment of hypertension. Hypertension 24:301–308.
   PubMed Web of Science ®Google Scholar
• Notoya M, Nakamura M, Mizojiri K. (1996). Effects of lisinopril on the structure of renal arterioles. Hy-pertension 27:364–370.
   PubMed Web of Science ®Google Scholar
• Oishi T, Ogura T, Yarnauchi T, Harada K, Ota Z. (1996). Effect of renin-angiotensin inhibition on lomerular injuries in DOCA-salt hypertensive rats. Regulatory Peptides 62:89–95.
   Google Scholar
• Omata K, Abraham NG, Schwartzman ML. (1992). Renal cytochrome P-450-arachidonic acid metabo-lism: localization and hormonal regulation in SHR. Am J Physiol Renal Physiol 262:F591–F599.
   Google Scholar
• Owens GK, Schwartz SM, McCanna M. (1988). Evaluation of medial hypertrophy in resistance ves-sels of spontaneously hypertensive rats. Hyperten-sion 11:198–207.
   PubMed Web of Science ®Google Scholar
• Perry MI, Miller JP, Fornoff JR, Baty JD, Sarnbhi MP, Rutan G, Moskowitz DW, Carmody SE. (1995). Early predictors of 15-year end-stage renal disease in hypertensive patients. Hypertension 25:587–594.
   PubMed Web of Science ®Google Scholar
• Ploth DW, Roy RN, Huang WC, Navar LG. (1981). Impaired renal blood flow and cortical pressure au-toregulation in contralateral kidneys of Goldblatt hypertensive rats. Hypertension 3:67–74.
   PubMed Web of Science ®Google Scholar
• Pomposiello SI, Carroll MA, Falck JR, McGiff JC. (2001). Epoxyeicosatrienoic acid-mediated renal vaso dilation to arachidonic acid is enhanced in SHR. Hypertension 37:887–893.
   PubMed Web of Science ®Google Scholar
• Rajagopalan S, Kurz A, Munzel T, Tarpey M, Free-man BA, Griendling KK, Harrison DG. (1996). An-giotensin II-mediated hypertension in the rat in-creases superoxide production via membrane NADH/NADPH oxidase activation. J Clin Invest 97: 1916–1923.
   Google Scholar
• Reddi AS, Nirnrnagadda VR, Arora R. (2001). Ef-fect of antihypertensive therapy on renal artery structure in type 2 diabetic rats with hypertension. Hypertension 37:1273–1278.
   PubMedGoogle Scholar
• Ren, YL, Carretero OA, Garvin JL. (2002). Mecha-nism by which superoxide potentiates tubuloglo-merular feedback. Hypertension 39:624–628.
   Google Scholar
• Roald AB, Ofstad J, Iversen BM. (2001). Attenuated buffering of renal perfusion pressure variation in juxtarnedullary cortex in SHR. Am J Physiol Renal Physiol 282:F506–F511.
   Google Scholar
• Roman, RJ. (1990). Alterations in renal medullary hemodynamics and the pressure-natriuretic re-sponse in genetic hypertension. Am J Hypertension 3:893–900.
   PubMed Web of Science ®Google Scholar
• Ruan X, Arendshorst WJ. (1996). Role of protein kinase C in angiotensin II-induced renal vasocon-striction in genetically hypertensive rats. Am J Phys-iol Renal Physiol 270:F945–F952.
   Google Scholar
• Rudd MA, Gripopo RS, Arendshorst WJ. (1986). Acute renal denervation produces a diuresis and na-triuresis in young SHR but not WKY rats. Am J Physiol Renal Physiol 251:F655–F661.
   Google Scholar
• Sabbatini M, Leonardi A, Testa R, Vitaioli L, Amenta F. (2000). Effect of calcium antagonists on glomerular arterioles in spontaneously hypertensive rats. Hypertension 35:775–779.
   PubMed Web of Science ®Google Scholar
• Salomonsson M, Arendshorst WJ. (2001). Norepi-nephrine-induced calcium signaling pathways in af-ferent arterioles of genetically hypertensive rats. Am J Physiol Renal Physiol 281:F264–F2723.
   Google Scholar
• Schiffrin EL. (1999). Role of endothelin-1 in hyper-tension. Hypertension 34:876–881.
   PubMed Web of Science ®Google Scholar
• Schnackenberg CG, Wilcox CS. (1999). Two-week administration of tempol attenuates both hyperten-sion and renal excretion of 8-iso prostaglandin F2. Hypertension 33:424–428.
   PubMed Web of Science ®Google Scholar
• Schnermann JB, Traynor T, Yang T, Huang YG, Oliverio MI, Coffman T, Briggs JP. (1997). Absence of tubuloglomerular feedback responses in AT1A re-ceptor-deficient mice. Am J Physiol Renal Physiol 273:F315–F320.
   Google Scholar
• Schoonrnaker GC, Fallet RW, Carmines PK. (2000). Superoxide anion curbs nitric oxide modulation of afferent arteriolar angiotensin II responsiveness in diabetes mellitus. Am J Physiol Renal Physiol 278:F302–F309.
   Google Scholar
• Sechi LA, Griffen CA, Giacchetti G, Valentin JP, Llorens-Cortes C, Corvol P, Scharnbelan M. (1996). Tissue-specific regulation of type 1 angiotensin II receptor mRNA levels in the rat. Hypertension 28: 403–408.
   Google Scholar
• Shaw LM, Ohanian J, Heagerty AM. (1997). Cal-cium sensitivity and agonist-induced calcium sensi-tization in small arteries of young and adult spon-taneously hypertensive rats. Hypertension 30:442–448.
   Google Scholar
• Sigmon DH, Beierwaltes WH. (1993). Renal nitric oxide and angiotensin II interaction in renovascular hypertension. Hypertension 22:237–242.
   PubMed Web of Science ®Google Scholar
• Simon G, Abraham G. (1995). Angiotensin II ad-ministration as an experimental model of hyperten-sion. In: Hypertension: Pathophysiology, Diagnosis,, and Management (Laragh JH and Brenner BM, Eds.) Raven Press. New York, 1423-1435.
   Google Scholar
• Sinai CJ, Miyata M, Tohkin M, Nagata K, Bend JR, Gonzalez FJ. (2000). Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation. J Biol Chem 275:40504–40510.
   Google Scholar
• Sorooshian M, Olsen JL, Meyer TW. (2000). Effect of angiotensin II blockade on renal injury in miner-alo co rticoi d - salt hypertension. Hypertension 36: 569–574.
   Google Scholar
• Sowers JR, Epstein M. (1995). Diabetes mellitus and associated hypertension, vascular disease, and ne-Phropathy: an update. Hypertension 26:869–879.
   PubMed Web of Science ®Google Scholar
• Stevenson KM, Edgley AJ, Bergstrom G, Worthy K, Kett MM, Anderson WP. (2000). Angiotensin II in-fused intrarenally causes preglomerular vascular changes and hypertension. Hypertension 36:839–844.
   Google Scholar
• Stoll M, Cowley AW, Tonellato PJ, Greene AS, Kal-dunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. (2001). A genomic-systems biology map of cardiovascular function. Science 294:1723–1726.
   PubMed Web of Science ®Google Scholar
• Uehara Y, Kawabata Y, Shirahase H, Wada K, Hashizume Y, Morishita S, Numabe A, Iwai J. (1993). Oxygen radical scavengers and renal pro-tection by indaparnide diuretic in salt-induced hy-pertension of Dahl strain rats. J Cardiovasc Phar-macol 22:S42–S46.
   Google Scholar
• Veniant M, Heudes D, Clozel JP, Bruneval P, Me-nard J. (1994). Calcium blockade versus ACE inhi-bition in clipped and unclipped kidneys of 2K-1C rats. Kidney Int 46:421–429.
   PubMed Web of Science ®Google Scholar
• Vyas, SJ, Blaschak CM, Chinoy MR, Jackson EK. (2000). Angiotensin II-induced changes in G-protein expression and resistance of renal microves-sels in young genetically hypertensive rats. Mol Cell Biochem 212:121–129.
   Google Scholar
• Walker WG. (1993). Hypertension-related renal in-jury: a major contributor to end-stage renal disease. Am J Kid Dis 22:164–173.
   Google Scholar
• Welch, WJ, Tojo A, Wilcox CS. (2000). Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR. Am J Physiol Renal Physiol 278:F769–F776.
   Google Scholar
• Welch WJ, Wilcox CS. (2001). AT1 receptor an-tagonist combats oxidative stress and restores nitric oxide signaling in the SHR. Kidney Int 59:1257–1263.
   PubMed Web of Science ®Google Scholar
• Wilcox CS, Welch WJ. (1990). Thromboxane me-diation of the pressor response to infused angioten-sin II. Am J Hypertension 3:242–249.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Tomura Y, Tanaka H, Kajiya F. (2001). In vivo visualization of characteristics of re-nal microcirculation in hypertensive and diabetic rats. Am J Physiol Renal Physiol 281:F571–F577.
   Google Scholar
• Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler M, Ham-mock BD, Zeldin DC, Kroetz DL. (2000). Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87:992–998.
   Google Scholar
• Zhao X, Inscho EW, Falck JR, Imig JD. (2001). The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstric-tion. Am J Physiol Heart Circ Physiol 281:H2089–H2096.
   Google Scholar
• Zou AP, Fleming JT, Falck JR, Jacobs ER, Ge-bremedhin D, Harder DR, Roman RJ. (1996). Ste-reospecific effects of epoxyeicosatrienoic acids on re-nal vascular tone and Ktchannel activity. Am J Physiol Renal Physiol 270:F822–F832.
   Google Scholar
• Zou LX, Irnig JD, von Thun AM, Hymel A, Ono H, Navar LG. (1996). Receptor-mediated intrarenal angiotensin II augmentation in angiotensin II-infused rats. Hypertension 28:669–677.
   PubMed Web of Science ®Google Scholar