REFERENCES
- Arndt H, Smith CW, Granger DN. (1993). Leuko-cyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats. Hypertension 21: 667–673.
- Auch-Schwelk W, Katu sic ZS, Vanhoutte PM. (1989) Contractions to oxygen-derived free radicals are aug-mented in aorta of the spontaneously hypertensive rat. Hypertension 13(6 Pt 2):859–864.
- Belisle B, Abo A. (2000). N-Formyl peptide receptor ligation induces rac-dependent actin reorganization through Gbeta gamma subunits and class Ia phos-phoinositide 3-kinases. J Biol Chem 275:26225–26232.
- Bolton SJ, Perry VH. (1998). Differential blood-brain barrier breakdown and leucocyte recruitment follow-ing excitotoxic lesions in juvenile and adult rats. Exp Neurology 154:231–240.
- Cosentino F, Patton S, d'Uscio LV, Werner ER, Werner-Felrnayer G, Moreau P, Malinski T, Liischer TF. (1998). Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. J Clin Invest 101:1530–1537.
- Escolar JD, Mateos J, Alfaro E, Escolar MA, Miliana C, Roche P. (1993). Goodpasture's syndrome in ag-ing. An experimental study on the rat. I. Histology Histopathology 8:599–608.
- Hibino M, Okurnura K, Iwarna Y, Mokuno S, Osanai H, Matsui H, Toki Y, Ito T. (1999). Oxygen-derived free radical-induced vasoconstriction by throm-boxane A2 in aorta of the spontaneously hypertensive rat. J Cardiovasc Pharmacol 33:605–610.
- Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominic-zak AF, Hamilton CA. (1999). Superoxide anion pro-duction is increased in a model of genetic hyperten-sion: role of the endothelium. Hypertension 33:1353–1358.
- Kumar KV, Das UN. (1993). Are free radicals in-volved in the pathobiology of human essential hyper-tension? Free Rad Res Corn 19:59–66.
- Kurose I, Wolf R, Cerwinka W, Granger DN. (1999). Microvascular responses to ischemia/reperfusion in normotensive and hypertensive rats. Hypertension 34:212–216.
- Lacy F, Kailasam MT, O'Connor DT, Schmid-Schönbein GW, Parmer RJ. (2000). Plasma hydrogen peroxide production in human essential hypertension: role of heredity, gender, and ethnicity. Hypertension 36:878–884.
- Lacy F, O'Connor DT, Schmid-Schönbein GW. (1998). Plasma hydrogen peroxide production in hy-pertensives and normotensive subjects at genetic risk of hypertension. J Hypertension 16:291–303.
- McIntyre M, Bohr DF, Dominiczak AF. (1999). En-dothelial function in hypertension: the role of super-oxide anion. Hypertension 34:539–545.
- Nakazono K, Watanabe N, Matsuno K, Sasaki J, Sato T, Inoue M. (1991). Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad. Sci USA 88:10045–10048.
- Ofosu -Appiah W, Sfeir G, Smith D, Richard T. (1997). Neutrophil-mediated damage to vascular en-dothelium in the spontaneously hypertensive rat. Clin Immunol Immunopathol 83:293–301.
- Ohashi KL, Tung DK-L, Wilson J, Zweifach BW, Schmid-Schönbein GW. (1996). Transvascular and interstitial migration of neutrophils in rat mesentery. Microcirculation 3:199–210.
- Ohtsuki T, Matsumoto M, Suzuki K, Taniguchi N, Karnada T. (1995). Mitochondrial lipid peroxi dation and superoxide dismutase in rat hypertensive target organs. Am J Physiol 268:H1418–H1421.
- Prabha PS, Das UN, Koratkar R, Sagar PS, Ramesh G. (1990). Free radical generation, lipid peroxi dation and essential fatty acids in uncontrolled essential hy-pertension. Prostaglandins Leukot Essent Fatty Acids 41:27–33.
- Sagar S, Kallo IJ, Kaul N, Ganguly NK, Sharma BK. (1992). Oxygen free radicals in essential hyperten-sion. Mol Cell Biochem 111:103–108.
- Schmid-Schönbein GW, DeLano FA, Costa J, Harris AG. (1999) Parenchymal cell death and leukocyte-endothelial cell interaction in acute experimental in-flammation. In: Ruffolo RR, Jr., Feuerstein GZ, Hunter AJ, Poste G and Metcalf BW, editors. Inflam-matory Cells and Mediators in CNS Diseases. Sydney, Australia: Harwood Academic Publishers.
- Schmid-Schönbein GW, Seiffge D, DeLano FA, Shen K, Zweifach BW. (1991). Leukocyte counts and ac-tivation in spontaneously hypertensive and normo-tensive rats. Hypertension 17:323–330.
- Schnackenberg CG, Welch WJ, Wilcox CS. (1998). Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable su-peroxide dismutase mimetic: role of nitric oxide. Hy-pertension 32:59–64.
- Shen K, Sung KL, Whittemore DE, DeLano FA, Zweifach BW, Schmid-Schönbein GW. (1995). Prop-erties of circulating leukocytes in spontaneously hy-pertensive rats. Biochem Cell Biol 73:491–500.
- Suematsu M, DeLano FA, Poole DC, Engler RL, Mi-yasaka M, Zweifach BW, Schmid-Schönbein GW. (1994). Spatial and temporal correlation between leukocyte behavior and cell injury in postischemic rat skeletal muscle microcirculation. Lab Invest 70:684–695.
- Suematsu M, Schmid-Schönbein GW, Chavez-Chavez RH, Yee TT, Tamatani T, Miyasaka M, DeLano FA, Zweifach BW. (1993). In vivo visualiza-tion of oxidative changes in microvessels during neu-trophil activation. Am J Physiol 264:H881–H891.
- Suematsu M, Suzuki H, DeLano FA, Tarnatani T, Miyasaka M, Forrest M, Zweifach BW, Ishirnura Y, Schmid-Schönbein GW. (1994). Impairment of P-selectin-mediated leukocyte adhesion to venular en-dothelium in spontaneously hypertensive rats. J Clin Invest 96:2009–2016.
- Suzuki H, Miura S, Mori M, Akiba Y, Nagahashi S, Zweifach BW, Ishii H, Schmid-Schönbein GW. (1999). Protective role of adrenal glucocorticoids for gastric mucosa in spontaneously hypertensive rats. J Castroenterol Hepatol 14:364–371.
- Suzuki H, Poole DC, Zweifach BW, Schmid-Schönbein GW. (1995). Temporal correlation be-tween maximum tetanic force and cell death in post-ischemic rat skeletal muscle. J Clin Invest 96:2892–2897.
- Suzuki H, Schmid-Schönbein GW, Suematsu M, DeLano FA, Forrest MJ, Miyasaka M, Zweifach BW. (1994). Impaired leukocyte-endothelial interaction in spontaneously hypertensive rats. Hypertension 24: 719–727.
- Suzuki H, Swei A, Zweifach BW, Schmid-Schönbein GW. (1995). In vivo evidence for microvascular oxi-dative stress in spontaneously hypertensive rats. -Hy-droethidine microfluorography-. Hypertension 25: 1083–1089.
- Suzuki H, Zweifach BW, Forrest MJ, Schmid-Schönbein GW. (1995). Modification of leukocyte ad-hesion in spontaneously hypertensive rats by adrenal corticosteroids. J Leuk Biol 57:20–26.
- Swei A, Lacy F, DeLano FA, Schmid-Schönbein GW. (1997). Oxidative stress in the Dahl hypertensive rat. Hypertension 30:1628–1633.
- Tung DK-L, Bjursten LM, Zweifach BW, Schmid-Schönbein GW. (1997). Leukocyte contribution to parenchymal cell death in an experimental model of inflammation. J Leuk Biol 62:163–175.
- Vaziri ND, Ni Z, Oveisi F, Trnavsky-Hobbs DL. (2000). Effect of antioxidant therapy on blood pres-sure and NO synthase expression in hypertensive rats. Hypertension 36:957–964.
- Welch WJ, Tojo A, Wilcox CS. (2000). Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR. Am J Physiol Renal Physiol 278:F769—F776.
- Wennberg E, Hagberg H, Haljarnae H. (1984). The response of the awake spontaneously hypertensive rats to acute blood loss. Acta Anesth Scand 28:457–461.