Genetic Epidemiology?Science and Ethics on Familial Cancers,

References

• Lander E, Schork N. Genetic dissection of complex traits. Science 1994; 265: 2037–48.
   PubMed Web of Science ®Google Scholar
• Risch N, Merikangas K. The future of genetic studies of complex diseases. Science 1996; 273: 1516–7.
   PubMed Web of Science ®Google Scholar
• Goldgar D, Easton D. Optimal strategies for mapping com-plex diseases in the presence of multiple loci. Am J Hum Genet 1997; 60: 1222–32.
   PubMedGoogle Scholar
• Easton D. Familial risks of cancer. Eur J Cancer 1999; 35: 1043–5.
   PubMedGoogle Scholar
• Easton D. How many more breast cancer predisposition genes are there? Breast Cancer Res 1999; 1: 14–7.
   PubMedGoogle Scholar
• Ponder B. Genetic testing for cancer risk. Science 1997; 278: 1050–4.
   PubMedGoogle Scholar
• Hansson M. Ethical management of hereditary cancer infor-mation. Acta Oncol 1999; 38: 305–8.
   PubMed Web of Science ®Google Scholar
• Schonmann A. From make believe to doomsday eve: or should we patent genes? Med Law 1998; 17: 455–76.
   PubMedGoogle Scholar
• Syrjäkoski K, Vahteristo P, Eerola H, et al. Population-based study of BRCA1 and BRCA2 mutations in 1035 unselected Finnish breast cancer patients. J Natl Cancer Inst 2000; 92: 1529–31.
   Google Scholar
• Ford D, Easton D, Stratton M, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 1998; 62: 676–89.
   PubMed Web of Science ®Google Scholar
• Kainu T, Hank Juo S-H, Desper R, et al. Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus. Proc Natl Acad Sci 2000; 97: 9603 �8.
   Google Scholar
• Peto J, Collins N, Barfoot R, etal. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 1999; 91: 943�9.
   Google Scholar
• Cui J, Hopper J. Why are the majority of hereditary cases of early-onset breast cancer sporadic? A simulation study. Cancer Epidemiol Biomarkers Prev 2000; 9: 805�12.
   Google Scholar
• Lichtenstein P, Holm N, Verkasalo P, et al. Environmental and heritable factors in the causation of cancer. N Engl J Med 2000; 343: 78�85.
   Google Scholar
• IARC. Cancer: causes, occurrence and control. Lyon: IARC, 1990.
   Google Scholar
• Ahlbom A, Lichtenstein P, Malmström H, Feychting M, Hemminki K, Pedersen NL. Cancer in twins: genetic and nongenetic familial risk factors. J Natl Cancer Inst 1997; 89: 287 �93.
   PubMedGoogle Scholar
• Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH. Systematic population-based assessment of cancer risk in . rst-degree relatives of cancer probands. J Natl Cancer Inst 1994; 86: 1600�7.
   Google Scholar
• Hemminki K, Vaittinen P, Kyyronen P. Age-specific familial risks in common cancers of the offspring. Int J Cancer 1998; 78: 172 �5.
   PubMedGoogle Scholar
• Hemminki K, Vaittinen P. Familial cancers in a nation-wide family-cancer database: age distribution and prevalence. Eur J Cancer 1999; 35: 1109 �11.
   Google Scholar
• Salovaara R, Loukola A, Kristo P, et al. Population-based molecular detection of hereditary nonpolyposis colorectal acancer. J Clin Oncol 2000; 18: 2193�200.
   Google Scholar
• Xu J, Meyers D, Freije D, et al. Evidence for a prostate cancer susceptibility locus on the X chromosome. Natl Genet 1998; 20: 175�9.
   Google Scholar
• Grönberg H, Smith J, Emanuelsson M, et al. In Swedish families with hereditary prostate cancer, linkage to the HPC1
   Google Scholar
• Easton D. The inherited component of cancer. Br Med Bull 1994; 50: 527�35.
   Google Scholar
• Hemminki K, Vaittinen P, Dong C, Easton D. Sibling risks in cancer: clues to recessive or X-linked genes? Br J Cancer 2001; 84: 388 �41.
   Google Scholar
• Hemminki K, Dong C, Vaittinen P. Familial risks in cervix cancer: is there a hereditary component? Int J Cancer 1999; 82: 775�81.
   Google Scholar
• Lynch H, Smyrk T. Hereditary nonpolyposis colorectal cancer (Lynch syndrome). Cancer 1996; 78: 1149�67.
   Google Scholar
• Aamio M, Sankila R, Pukkala E, et al. Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Can-cer 1999; 81: 214–8.
   PubMedGoogle Scholar
• Hemminki K, Vaittinen P. Familial breast cancer in the Family-Cancer Database. Int J Cancer 1998; 77: 386–91.
   PubMedGoogle Scholar
• Hemminki K, Vaittinen P, Easton D. Familial cancer risks to offspring from mothers with two primary breast cancers: leads to cancer syndromes. Int J Cancer 2000; 88: 87–91.
   Google Scholar
• Vaittinen P, Hemminki K. Risk factors and age-incidence relationships for contralateral breast cancer. hit J Cancer 2000; 88: 998–1002.
   PubMed Web of Science ®Google Scholar
• Hemminki K, Dong C. Familial prostate cancer from the Family-Cancer Database. Eur J Cancer 2000; 36: 229–34.
   PubMedGoogle Scholar
• Hemminki K, Vaittinen P, Dong C. Endometrial cancer in the Family-Cancer Database. Cancer Epidemiol Biomarkers Prey 1999; 8: 1005–10.
   Google Scholar
• Hemminki K, Lönnstedt I, Vaittinen P. A population-based study of familial cutaneous melanoma. Melanoma Res 2001; in press.
   Google Scholar
• Hemminki K, Dong C. Familial relationships in squamous cell carcinoma of the skin. Epidemiology 2000; 11: 309–14.
   PubMedGoogle Scholar
• Pharoah P, Day N, Duffy S, Easton D, Ponder B. Family history and the risk of breast cancer: a systematic review and meta-analysis. Int J Cancer 1997; 71: 800–9.
   Google Scholar
• Stratton J, Pharoah P, Smith S, Easton D, Ponder B. A systematic review and meta-analysis of family history and risk of ovarian cancer. Br J Obstet Gynaecol 1998; 105: 493–9.
   Google Scholar
• Narod S. Genetic epidemiology of prostate cancer. Biochim Biophys Acta 1999; 1423: F1–F13.
   Google Scholar
• Rapley E, Crockford G, Teare D, et al. Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. Na-ture Genet 2000; 24: 197–200.
   PubMed Web of Science ®Google Scholar
• Fearon ER. Human cancer syndromes: clues to the origin and nature of cancer. Science 1997; 278: 1043–50.
   PubMed Web of Science ®Google Scholar
• Cairns P, Sidransky D. Bladder cancer. In: Vogelstein B, Kinzler K, eds. The genetic basis of human cancer. New York: McGraw-Hill, 1998: 639–45.
   Google Scholar
• The Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst 1999; 91: 1310–6.
   PubMed Web of Science ®Google Scholar
• Dong C, Hemminki K. Second primary neoplasms in 633964 cancer patients in Sweden, 1958–1996. hit J Cancer 2001 in press.
   Google Scholar
• Dong C, Hemminki K. Multiple primary cancers at colon, breast and skin (melanoma) as models for polygenic cancers. Int J Cancer 2001; 92.
   PubMedGoogle Scholar
• Hemminki K, Mutanen P. Genetic epidemiology of multi-stage carcinogenesis. Mut Res 2001; 473: 11–21.
   PubMed Web of Science ®Google Scholar
• Kinzler K, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87: 159–70.
   PubMed Web of Science ®Google Scholar