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Original Article

Adaptation of Ion Channels in the Microcirculation to Exercise Training

DOUGLAS K. BOWLES Department of Veterinary Biomedical Sciences and Dalton Cardiovascular Research Center University of Missouri, Columbia, MO USA
Pages 24-40 | Received 16 Feb 1999, Accepted 10 Mar 1999, Published online: 14 Aug 2009

  • (1995). Physical Activity and Cardiovascular Health. NIH Consens Statement Dec 18-20(13):1–33.
  • Aiello EA, Clement-Chomienne 0, Sontag DP, Walsh MP, Cole WC. (1996). Protein kinase C in-hibits delayed rectifier IC+ current in rabbit vascular smooth muscle cells. Am J Physiol Heart Circ Phys-iol 271:H109–H119.
  • Aiello EA, Walsh MP, Cole WC. (1995). Phosphor-ylation by protein kinase A enhances delayed recti-fier IC+ current in rabbit vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 268:H926–H934.
  • Armstrong RB, Delp MD, Goljan EF, Laughlin M H. (1987). Distribution of blood flow in muscles of miniature swine during exercise. J Appl Physiol 62: 1285–1298.
  • Asano M, Masuzawaito K, Matsuda T, Suzuki Y, Oyarna H, Shibuya M, Sugita K. (1993). Functional role of charybdotoxin-sensitive IC+ channels in the resting state of cerebral, coronary and mesenteric arteries of the dog. J Pharmacol Exp Ther 267: 1277–1285.
  • Asano M, Nomura Y, Ito K, Uyarna Y, Irnaizurni Y, Watanabe M. (1995). Increased function of voltage-dependent Ca ++ channels and Ca'-activated channels in resting state of femoral arteries from spontaneously hypertensive rats at prehypertensive stage. J Pharmacol Exp Ther 275:775–783.
  • Bean BP, Sturek M, Puga A, Hermsmeyer K. (1986). Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs. Circ Res 59:229–235.
  • Benham CD, Bolton TB. (1986). Spontaneous tran-sient outward currents in single visceral and vascu-lar smooth muscle cells of the rabbit. J Physiol (Loud) 381:385–406.
  • Benham CD, Tsien RW. (1988). Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery. J Physiol (Loud) 404:767–784.
  • Bielefeldt K. (1999). Molecular diversity of voltage-sensitive calcium channels in smooth muscle cells. Journal of Laboratory & Clinical Medicine 133(5): 469–477.
  • Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Co-hen RA. (1994). Nitric oxide directly activates cal-cium-dependent potassium channels in vascular smooth muscle. Nature 368:850–853.
  • Bolton TB, MacKenzie I, Aaronson PI. (1988). Volt-age-dependent calcium channels in smooth muscle cells. J Cardiovasc Pharmacol 12 Suppl. 6:S3–S7.
  • Bonev AD, Jaggar JH, Rubart M, Nelson MT. (1997). Activators of protein kinase C decrease Ca2+ spark frequency in smooth muscle cells from cere-bral arteries. Am J Physiol Cell Physiol 273(6 Pt 1):C2090–C2095.
  • Bowles DK, Hu Q, Laughlin MH, Sturek M. (1997). Heterogeneity of L-type calcium current density in coronary smooth muscle. Am J Physiol Heart Circ Physiol 273 (42 ) :H2083–H2089.
  • Bowles DK, Hu Q, Laughlin MH, Sturek M. (1998). Exercise training increases L-type calcium current density in coronary smooth muscle. Am J Physiol Heart Circ Physiol 275(44):H2159–H2169.
  • Bowles DK, Laughlin M H, Sturek M. (1995). Exer-cise training alters the Ca2+ and contractile re-sponses of coronary arteries to endothelin. J Appl Physiol 78:1079–1087.
  • Bowles DK, Laughlin M H, Sturek M. (1998). Exer-cise training increases K+ channel contribution to regulation of coronary arterial tone. J Appl Physiol 84(4):1225–1233.
  • Brayden JE. (1996). Potassium channels in vascular smooth muscle. Clin Exp Pharmacol Physiol 23: 1069–1076.
  • Brayden JE, Nelson MT. (1992). Regulation of ar-terial tone by activation of calcium-dependent po-tassium channels. Science 256:532–535.
  • Biilbring E, Tomita T. (1987). Catecholarnine ac-tion on smooth muscle. Pharmacol Rev 39:49–96.
  • Campbell KP, Leung AT, Sharp AH. (1988). The biochemistry and molecular biology of the dihydro-pyridine-sensitive calcium channel. Trends Neurosci 11:425–430.
  • Chen Q, Cannell M, Van Breemen C. (1992). The superficial buffer barrier in vascular smooth muscle. Can J Physiol Pharmacol 70:509–514.
  • Chien AJ, Gao T, Perez-Reyes E, Hosey MM. (1998) . Membrane targeting of L -type calcium channels. Role of palrnitoylation in the subcellular localization of the beta2a subunit. J Biol Chem 273(36) :23590–23597.
  • Chilian WM, Layne SM, Eastharn CL, Marcus ML. (1989). Heterogeneous microvascular coronary a -adrenergic vasoconstriction. Circ Res 64:376–388.
  • Cole WC, Clement-Chomienne 0, Aiello EA. (1996). Regulation of 4 arninopyridine-sensitive, delayed rectifier K+ channels in vascular smooth muscle by phosphorylation. Biochem Cell Biol 74: 439–447.
  • Cox RH, Petrou S. (1999). Ca2+ influx inhibits volt-age-dependent and augments Ca2+-dependent K+ currents in arterial myocytes. Am J Physiol Cell Physiol 277(46):C51–C63.
  • Dart C, Standen NB. (1993). Adenosine-activated potassium current in smooth muscle cells isolated from the pig coronary artery. J Physiol (Loud) 471: 767–786.
  • Dart C, Standen NB. (1995). Activation of ATP-dependent K+ channels by hypoxia in smooth muscle cells isolated from the pig coronary artery. J Physiol (Loud) 483:29–39.
  • Davidoff AJ, Maki TM, Ellingsen 0, Marsh JD. (1997). Expression of calcium channels in adult car-diac myocytes is regulated by calcium. J Molecular Cell Cardiol 29(7):1791–1803.
  • Davis MJ. (1993). Myogenic response gradient in an arteriolar network. Am J Physiol Heart Circ Physiol 264:H2168–H2179.
  • Davis MJ, Donovitz JA, Hood JD. (1992). Stretch-activated single-channel and whole cell currents in vascular smooth muscle cells. Am J Physiol Cell Physiol 262:C1083–C1088.
  • De Jongh KS, Murphy BJ, Colvin AA, Hell JW, Ta-kahashi M, Cameral' WA. (1996). Specific phos-phorylation of a site in the full-length form of the al subunit of the cardiac L-type calcium channel by adenosine 3 ',5 ' -cyclic monopho sphate- dependent protein kinase. Biochem 35:10392–10402.
  • DeLorme EM, Rabe CS, McGee RJ. (1988). Regu-lation of the number of functional voltage-sensitive Ca ++ channels on PC12 cells by chronic changes in membrane potential. J Pharmacol Exp Ther 244: 838–843.
  • Dodd-o JM, Gwirtz PA. (1996). Coronary al - adrenergic constrictor tone varies with intensity of exercise. Med Sci Sports Exerc 28:62–71.
  • Ekelund LG, Haskell WL, Johnson JL, Whaley FS, Criqui, MH, Sheps DS. (1988). Physical fitness as a predictor of cardiovascular mortality in asymptom-atic North American men. The Lipid Research Clin-ics Mortality Follow-up Study. N Engl J Med 319(21):1379–1384.
  • Fleischrnann BK, Murray RK, Kotlikoff MI. (1994). Voltage window for sustained elevation of cytosolic calcium in smooth muscle cells. Proceedings of the Natl Acad Sci USA 91:11914–11918.
  • Fomina AF, Levitan ES. (1997). Control of Ca2+ channel current and exocytosis in rat lactotrophs by basally active protein kinase C and calcineurin. Neuroscience 78 (2 ) :523–531.
  • Fomina AF, Levitan ES, Takirnoto K. (1996). Dexa-methasone rapidly increases calcium channel sub-unit messenger RNA expression and high voltage-activated calcium current in clonal pituitary cells. Neuroscience 72 (3 ) :857–862.
  • Franco-Obregon A, Lopez-Barneo J. (1996). Differ-ential oxygen sensitivity of calcium channels in rab-bit smooth muscle cells of conduit and resistance pulmonary arteries. J Physiol (Loud) 491(2):511–518.
  • Fukurnitsu T, Hayashi H, Tokuno H, Tomita T. (1990). Increase in calcium channel current by [3-a-drenoceptor agonists in single smooth muscle cells isolated from porcine coronary artery. Br J Pharma-col 100:593–599.
  • Ganitkevich VY, Isenberg G. (1990). Contribution of two types of calcium channels to membrane con-ductance of single myocytes from guinea-pig coro-nary artery. J Physiol (Loud) 426:19–42.
  • Ganitkevich VY, Isenberg G. (1996). Dissociation of subsarcolemmal from global cytosolic [Ga2+] in myocytes from guinea-pig coronary artery. J Physiol (Loud) 490:305–318.
  • Gelband CH, Hume JR. (1995). [Ca2+]j inhibition of K+ channels in canine renal artery: Novel mecha- nism for agonist-induced membrane depolarization. Circ Res 77:121–130.
  • Gelband CH, Ishikawa T, Post ym, Keef KB, Hume JR. (1993). Intracellular divalent cations block smooth muscle IC+ channels. Circ Res 73:24–34.
  • Gerster U, Neuhuber B, Groschner K, Striessnig J, Flucher BE. (1999). Current modulation and mem- brane targeting of the calcium channel alpha(1c) Subunit are independent functions of the beta sub-unit. Journal of Physiology-London 517(2):353–368.
  • Groschner K, Schuhrnann K, Mieskes G, Baumgart-ner W, Romanin C. (1996). A type 2A phosphatase- sensitive phosphorylation site controls modal gating of L-type Ca2+ channels in human vascular smooth-muscle cells. Biochem J 318:513–517.
  • Guia A, Wan X, Courtemanche M, Leblanc N. (1999 ) . Local Ca2+ entry through L -type Ca2+ channels activates Ca2+-dependent IC+ channels in rabbit coronary myocytes. Circ Res 84:1032–1042.
  • Haller H, Lindschau C, Quass P, Distler A, Luft FC. (1995). Differentiation of vascular smooth muscle cells and the regulation of protein kinaseCircRes 76:21–29.
  • Haskell WL, Sims C, Myll J, Bortz W1VI, St. Goar FG, Alderman EL. (1993). Coronary artery size and di-lating capacity in ultradistance runners. Circulation 87:1076–1082.
  • Hill MA, Davis MJ, Song J, Zou H. (1996). Calcium dependence of indolactarn-mediated contractions in resistance vessels. J Pharmacol Exp Ther 276:867–874.
  • Hille B. (1984). Ionic Channels of Excitable Mem-branes. Sunderland: Sinauer.
  • Hosey WV, Chien AJ, Puri TS. (1996). Structure and regulation of L-type calcium channels - A cur-rent assessment of the properties and roles of chan-nel subunits. Trends Cardiovasc Med 6:265–273.
  • Hughes AD. (1995). Calcium channels in vascular smooth muscle cells. J Vasc Res 32:353–370.
  • lijima K, Lin L, Nasjletti A, Goligorsky MS. (1991). Intracellular ramification of endothelin signal. Am J Physiol Cell Physiol 260:C982–C992.
  • Inoue Y, Oike M, Nakao K, Kitamura K, Kuriyarna H. (1990). Endothelin augments unitary calcium channel currents on the smooth muscle cell mem-brane of guinea-pig portal vein. J Physiol (Loud) 423:171–191.
  • Ishikawa T, Hume JR, Keef KB. (1993). Regulation of Ca channels by cAlVIP and cGMP in vascular smooth muscle cells. Circ Res 73:1128–1137.
  • Ishizaka H, Kuo L. (1996). Acidosis-induced coro-nary arteriolar dilation is mediated by ATP-sensitive potassium channels in vascular smooth muscle. Circ Res 78:50–57.
  • Izzard AS, Bund SJ, Heagerty AM. (1996). Myo-genic tone in mesenteric arteries from spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 270:H1–H6.
  • Jackson WF. (1998). Potassium channels and regu-lation of the microcirculation. Microcirculation-London 5(2-3):85–90.
  • Jackson WF, Blair KL. (1998). Characterization and function of Ca2+-activated IC+ channels in arte-riolar muscle cells. Am J Physiol Heart Circ Physiol 43(1):H 27–34.
  • Jones CJ, Kuo L, Davis MJ, Chilian WM. (1993). Distribution and control of coronary microvascular resistance. Advances in Experimental Medicine and Biology 346:181–188.
  • Jones CJH, Kuo L, Davis MJ, Chilian WM. (1995). Regulation of coronary blood flow: Coordination of heterogeneous control mechanisms in vascular mi-crodomains. Cardiovasc Res 29:558–596.
  • Jones CJH, Kuo L, Davis MJ, DeFily DV, Chilian WM. (1995). Role of nitric oxide in the coronary microvascular responses to adenosine and increased metabolic demand. Circulation 91:1807–1813.
  • Kaczorowski GJ, Knaus HG, Leonard RJ, McManus OB, Garcia ML. (1996). High-conductance calcium-activated potassium channels; Structure, pharma-cology, and function. J Bioenerg Biomembr 28:255–267.
  • Knot HJ, Nelson MT. (1995). Regulation of mem-brane potential and diameter by voltage-dependent IC+ channels in rabbit myogenic cerebral arteries. Am J Physiol Heart Circ Physiol 269:H348–H355.
  • Knot HJ, Nelson MT. (1998). Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure. J Physiol (Loud) 508(Pt 1):199–209.
  • Knot HJ, Standen NB, Nelson MT. (1998). Ryano-dine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+-dependent IC+ channels. J Physiol (Lond) 508\(Pt 1):211–221.
  • Knot HJ, Zimmermann PA, Nelson MT. (1996). Ex-tracellular K+-induced hyperpolarizations and dila-tations of rat coronary and cerebral arteries involve inward rectifier IC+ channels. J Physiol (Loud) 492: 419–430.
  • Koh SD, Sanders KM. (1996). Modulation of Ca2+ current in canine colonic myocytes by cyclic nucleo-tide-dependent mechanisms. Am J Physiol Cell Physiol 271:C794–C803.
  • Koh SD, Sanders KIM, Carl A. (1996). Regulation of smooth muscle delayed rectifier IC+ channels by pro-tein kinase A. Pflugers Arch 432:401–412.
  • Koller A, Huang A, Sun D, Kaley G. (1995). Exer-cise training augments flow-dependent dilation in rat skeletal muscle arterioles: Role of endothelial ni-tric oxide and prostaglandins. Circ Res 76:544–550.
  • Korzick DH, Thorne PK, Bowles DK, et al. (1999). Enhanced myogenic constriction by exercise train-ing in porcine coronary resistance arteries is medi- ated by PKC -dependent mechanisms. Med Sci Sports Exerc 31:(5)S52 (Abstract).
  • Kurne H, Takai A, Tokuno H, Tomita T. (1989). Regulation of Ca2+-dependent Ktchannel activity in tracheal myocytes by phosphorylation. Nature 341:152–154.
  • Kuo L, Davis MJ, Cannon MS, Chilian WM. (1992). Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restora-tion of endothelium-dependent responses by L-Arginine. Circ Res 70:465–476.
  • Kuo L, Davis MJ, Chilian WM. (1995). Longitudinal gradients for endothelium-dependent and -indepen-dent vascular responses in the coronary microcircu-lation. Circulation 92:518–525.
  • Lash ym. (1998). Training-induced alterations in contractile function and excitation-contraction cou-pling in vascular smooth muscle [Review]. Med Sci Sports Exerc 30(1):60–66.
  • Laughlin M H. (1994). Effects of exercise training on coronary circulation: introduction. Med Sci Sports Exerc 26:1226–1229.
  • Laughlin MH, McAllister RM. (1992). Exercise training-induced coronary vascular adaptation. J Appl Physiol 73:2209–2225.
  • Laughlin MH, Oltrnan CL, Bowles DK. (1998). Ex-ercise training-induced adaptations in the coronary circulation. Med Sci Sports Exerc 30(3):352–360.
  • Leblanc N, Wan X, Leung PM. (1994). Physiologi-cal role of Ca2tactivated and voltage-dependent K+ current in rabbit coronary myocytes. Am J Physiol Cell Physiol 266:C1523–C1537.
  • Lee M-Y, Bang H-W, Lim I-J, Uhrn D-Y, Rhee S-D. (1994). Modulation of large conductance calcium-activated K+ channel by membrane-delimited pro-tein kinase and phosphatase activities. Pflugers Ar-chiv European Journal of Physiology 429:150–152.
  • Marrion NV, Tavalin SJ. (1998). Selective activa-tion of Ca2tactivated K+ channels by co-localized Ca2+ channels in hippocampal neurons. Nature 395(6705):900–905.
  • Matsuda JJ, Volk KA, Shibata EF. (1990). Calcium currents in isolated rabbit coronary arterial smooth muscle myocytes. J Physiol (Loud) 427:657–680.
  • McKirnan MD, White FC, Guth BD. (1986). Car-diovascular and metabolic responses to acute and chronic exercise in swine. In: Swine in Biomedical Research. (Turnbleson ME, Ed.) New York: Plenum Press. 1379–1394.
  • Meininger GA, Davis MJ. (1992). Cellular mecha-nisms involved in the vascular myogenic response. Am J Physiol Heart Circ Physiol 263:H647–H659.
  • Michelakis E, Tewari K, Simard ym. (1994). Cal-cium channels in smooth muscle cells from cerebral precapillary arterioles activate at more negative po-tentials than those from basilar artery. Pflugers Arch-Eur J Physiol 426:459–461.
  • Muller ym, Myers PR, Laughlin M H. (1993). Exer- cise training alters myogenic responses in porcine coronary resistance arteries. J Appl Physiol 75: 2677–2682.
  • Muller ym, Myers PR, Laughlin M H. (1994). Vaso-dilator responses of coronary resistance arteries of exercise-trained pigs. Circulation 89:2308–2314.
  • Mundifia-Weilenrnann C, Chang CF, Gutierrez LM, HoseylVEVI. (1991). Demonstration of the phosphor-ylation of dihydropyridine-sensitive calcium chan-nels in chick skeletal muscle and the resultant acti-vation of the channels after reconstitution. J Biol Chem 266:4067–4073.
  • Neher E. (1988). The influence of intracellular cal-cium concentration on degranulation of dialyzed mast cells from rat peritoneum. J Physiol (Lond) 395:193–214.
  • Nelson MT, Cheng H, Rubart M, Santana LF, Bonev AD, Knot HJ, Lederer WJ. (1995). Relaxation of arterial smooth muscle by calcium sparks. Science 270:633–637.
  • Nelson MT, Conway MA, Knot HJ, Brayden JE. (1997). Chloride channel blockers inhibit myogenic tone in rat cerebral arteries. J Physiol (Loud) 502(2):259–264.
  • Nelson MT, Patlak JIB, Worley JF, Standen NB. (1990). Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. Am J Physiol Cell Physiol 259:C3–C18.
  • Nelson MT, Quayle ym. (1995). Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol Cell Physiol 268:C799–C822.
  • Nelson MT, Standen NB, Brayden JE, Worley III JF. (1988). Noradrenaline contracts arteries by activat-ing voltage-dependent calcium channels. Nature 336:382–385.
  • O'Callahan CM, Ptasienski J, Hosey 1VEVI. (1988). Phosphorylation of the 165-kDa dihydropyridine/ phenylalkylarnine receptor from skeletal muscle by protein kinase C. J Biol Chem 263:17342–17349.
  • O'Rourke ST. (1996). Effects of potassium channel blockers on resting tone in isolated coronary arter-ies. J Cardiovasc Pharmacol 27:636–642.
  • Obejero-Paz CA, Auslender M, Scarpa A. (1998). PKC activity modulates availability and long open-ings of L-type Ca2+ channels in A7r5 cells. Am J Physiol Cell Physiol 275(2 Pt 1):C535–0543.
  • Ohya Y, Abe I, Fujii K, Takata Y, Fujishirna M. (1993). Voltage-dependent Ca2+ channels in resis-tance arteries from spontaneously hypertensive rats. Circ Res 73:1090–1099.
  • Pauwels PJ, Van Assouw HP, Leysen JE. (1987). Depolarization of chick myotubes triggers the ap-pearance of (+)-[3H]PN 200-110-binding sites. Mol Pharm 32(6):785–791.
  • Porter VA, Bonev AD, Knot HJ, Heppner TJ, Stevenson AS, Kleppisch T, Lederer WJ, Nelson MT. (1998). Frequency modulation of Ca2+ sparks is in- volved in regulation of arterial diameter by cyclic nucleotides. Am J Physiol Cell Physiol 274(5 Pt 1):C1346–C1355.
  • Post JM, Gelband CH, Hume JR. (1995). [Ca2+]1 inhibition of K+ channels in canine pulmonary ar-tery: Novel mechanism for hypoxia-induced mem-brane depolarization. Circ Res 77:131–139.
  • Pragnell M, Dewaard M, Mori Y, Tanabe T, Snutch TP, Campbell KP. (1994). Calcium channel beta subunit binds to a conserved motif in the i-II cyto-plasmic linker of the alpha(1) -subunit. Nature 368: 67–70.
  • Puri TS, Gerhardstein BL, Zhao XL, Ladner MB, Hosey 1VIVI. (1997). Differential effects of subunit interactions on protein kinase A-and C-mediated phosphorylation of L-type calcium channels. Bio-chemistry 36(31):9605–9615.
  • Quayle JM, Dart C, Standen NB. (1996). The prop-erties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle. J Physiol (Loud) 494:715–726.
  • Quayle JM, Nelson MT, Standen NB. (1997). ATP-sensitive and inwardly rectifying potassium chan-nels in smooth muscle. [Review] [641 refs]. Physiol Rev 77(4):1165–1232.
  • Rasmussen H, Barrett P, Zawalich W, Isales C, Stein P, Smallwood J, McCarthy R, Bollag W. (1989). Cy-cling of Ca2+ across the plasma membrane as a mechanism for generating a Ca2+ signal for cell ac-tivation. Ann N Y Acad Sci 568:73–80.
  • Regensteiner JG, Steiner JF, Hiatt WR. (1996). Ex-ercise training improves functional status in patients with peripheral arterial disease. Journal of Vascular Surgery 23(1):104–115.
  • Rembold CM. (1989). Desensitization of swine ar-terial smooth muscle to transplasmalemrnal Ca2+ J Physiol (Loud) 416:273–290.
  • Rembold CM, Murphy RA. (1988). Myoplasmic [Ca2+] determines myosin phosphorylation and iso-metric stress in agonist-stimulated swine arterial smooth muscle. J Cardiovasc Pharmacol 12 Suppl. 5:S38–S42.
  • Robertson BE, Schubert R, Hescheler J, Nelson MT. (1993). cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol Cell Physiol 265:C299–C303.
  • Rowell LB. (1986). Human Circulation: Regulation During Physical Stress. New York: Oxford Univer-sity Press.
  • Rubin LJ, Jones AW, Laughlin M H. (1994). En-hanced adenosine stimulation of cyclic AMP in coro-nary smooth muscle cells of exercise-trained minia-ture swine. Circulation 90: (4)1-104 (Abstract) .
  • Ruiz-Velasco V, Zhong J, Hume JR, Keef KD. (1998). Modulation of Ca2+ channels by cyclic nucleotide cross activation of opposing protein ki-nases in rabbit portal vein. Circ Res (82):557–565.
  • Schrnid A, Renaud J, Lazdunski M. (1985). Short term and long term effects of P-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle. J Biol Chem 260:13041–13046.
  • Scornik FS, Codina J, Birnbaumer L, Toro L. (1993). Modulation of coronary smooth muscle Kc„ channels by Gset independent of phosphorylation by protein kinase A. Am J Physiol Heart Circ Physiol 265:H1460–H1465.
  • Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. (1994). Chronic exercise in dogs increases coro- nary vascular nitric oxide production and endothe-lial cell nitric oxide synthase gene expression. Circ Res 74:349–353.
  • Song YM, Simard JM. (1995). -Adrenoceptor stimulation activates large-conductance C a2+ - activated K+ channels in smooth muscle cells from basilar artery of guinea pig. Pflugers Arch 430:984–993.
  • Stehno-Bittel L, Laughlin MH, Sturek M. (1990). Exercise training alters Ca release from coronary smooth muscle sarcoplasmic reticulurn. Am J Physiol Heart Circ Physiol 259:H643–H647.
  • Stehno-Bittel L, Laughlin MH, Sturek M. (1991). Exercise training depletes sarcoplasmic reticulurn calcium in coronary smooth muscle. J Appl Physiol 71:1764–1773.
  • Stehno-Bittel L, Sturek M. (1992). Spontaneous sarcoplasmic reticulurn calcium release and extru-sion from bovine, not porcine, coronary artery smooth muscle. J Physiol (Loud) 451:49–78.
  • Stone HL. (1983). Control of the coronary circula-tion during exercise. Ann Rev Physiol 45:213–227.
  • Sturek M, Hermsmeyer K. (1986). Calcium and so-dium channels in spontaneously contracting vascu-lar muscle cells. Science 233:475–478.
  • Takimoto K, Li D, Nerbonne JM, Levitan ES. (1997). Distribution, splicing and glucocorticoid- induced expression of cardiac alpha 1C and alpha 1D voltage-gated Ca2+ channel mRNAs. J Molecular Cell Cardiol 29(11):3035–3042.
  • Toro L, Wallner M, Meera P, Tanaka Y. (1998). Maxi-Kc„, a unique member of the voltage-gated K channel superfarnily. News Physiol Sci 13:112–117.
  • Van Breemen C, Chen Q, Laher I. (1995). Superfi-cial buffer barrier function of smooth muscle sarco-plasmic reticulurn. Trends Pharmacol Sci 16:98–105.
  • Wallner M, Meera P, Toro L. (1996). Determinant for 3-subunit regulation in high-conductance volt- age-activated and Ca2+-sensitive K+ channels: An additional transmembrane region at the N terminus. Proc Natl Acad Sci USA 93:14922–14927.
  • Wang J, Wolin MS, Hintze TH. (1993). Chronic ex-ercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ Res 73:829–838.
  • Wang R, Karpinski E, Pang PKT. (1989). Two types of calcium channels in isolated smooth muscle cells from rat tail artery. Am J Physiol Heart Circ Physiol 256:H1361—H1368.
  • Wayman GA, Irnpey S, Wu Z, Kindsvogel W, Pri-chard L, Storm DR. (1994). Synergistic activation of the type I adenylyl cyclase by Ca2+ and Gs-coupled receptors in vivo. J Biol Chem 269:25400–25405.
  • Welling A, Ludwig A, Zimmer S, Klugbauer N, Flockerzi V, Hofmann F. (1997). Alternatively spliced IS6 segments of the alpha lc gene determine the tissue-specific dihydropyridine sensitivit of car-diac and vascular smooth muscle L-type Ca + chan-nels. Circ Res 81(4):526–532.
  • Wellman GC, Bonev AD, Nelson MT, Brayden JE. (1996). Gender differences in coronary artery diam-eter involve estrogen, nitric oxide, and Ca2+-dependent IC+ channels. Circ Res 79:1024–1030.
  • Weidner M-C, Isenberg G. (1994). Stretch effects on whole-cell currents of guinea-pig urinary bladder myocytes. J Physiol (Loud) 480:439–448.
  • Wesselrnan JPM, Vanbavel E, Pfaffendorf M, Spaan JAE. (1996). Voltage-operated calcium channels are essential for the myogenic responsiveness of cannu-lated rat mesenteric small arteries. J Vasc Res 33: 32–41.
  • Wilde DW, Bohr DF. (1998). Dietary fat increases calcium current density in vascular cells but lowers blood pressure in hypertensive (SHRSP) and control rats (WKY) . FASER J 12:(4)A41 (Abstract) .
  • Woodman CR, Muller JM, Laughlin M H, Price EM. (1997). Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs. Am J Physiol Heart Circ Physiol 273(6 Pt 2):H2575—H2579.
  • Yatani A, Seidel CL, Allen J, Brown AM. (1987). Whole-cell and single-channel calcium currents of isolated smooth muscle cells from saphenous vein. Circ Res 60:523–533.

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