Osteoporosis in the aging population: the male perspective

References

• Orwoll ES, Klein RF. Osteoporosis in men. Endocr Rev 1995;16:87–115
   PubMed Web of Science ®Google Scholar
• Seeman E. Osteoporosis in men. Baillière’s Clin Rheumatol 1997;11:613–29
   PubMed Web of Science ®Google Scholar
• Bilezikian JP. Osteoporosis in men. J Clin Endo- crinol Metab 1999;84:3431–4
   PubMed Web of Science ®Google Scholar
• Kaufman JM, Johnell O, Abadie E, et al. Back- ground for studies on the treatment of male osteo- porosis: state of the art. Ann Rheum Dis 2000; 59:765–72
   PubMedGoogle Scholar
• Vanderschueren D, Boonen S, Bouillon R. Osteo- porosis and osteoporotic fractures in men: a clinical perspective. Baillière’s Clin Endocrinol Metab 2000; 14:299–315
   PubMed Web of Science ®Google Scholar
• De Laet C, van Hout BA, Burger H, Hofman A, Pols HAP. Bone density and risk of hip fracture in men and women: cross sectional analysis. Br Med J 1997;315:221–5
   PubMed Web of Science ®Google Scholar
• Nydegger V, Rizzoli R, Rapin CH, Vasey H, Bonjour JPh. Epidemiology of fractures of the proximal femur in Geneva: incidence, clinical and social aspects. Osteoporos Int 1991;2:42–7
   PubMed Web of Science ®Google Scholar
• Maggi S, Kelsey JL, Litvak J, Heyse SP. Incidence of hip fractures in the elderly: a cross-national analysis. Osteoporosis Int 1991;1:232–41
   PubMedGoogle Scholar
• Johnell O, Nilsson Be, Obrant KJ, Sernbo I. Age and sex pattern of hip fracture – changes in 30 years. Acta Orthop Scand 1984;55:290–2
   PubMedGoogle Scholar
• Melton LJ III, Kan SH, Wahner HW, Riggs BI. Lifetime fracture risk: an approach to hip fracture risk assessment based on bone mineral and age. J Clin Epidemiol 1988;41:985–94
   PubMedGoogle Scholar
• Oden A, Dawson A, Dere W, Johnell O, Jonsson B, Kanis JA. Lifetime risk of hip fractures is under- estimated. Osteoporos Int 1998;8:599–603
   PubMed Web of Science ®Google Scholar
• Cooper C, Campion G, Melton III LJ. Hip fractures in the elderly: a world-wide projection. Osteoporos Int 1992;2:285–9
   PubMed Web of Science ®Google Scholar
• Cooper C, Atkinson EJ, O’Fallon WL, Melton III LJ. Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res 1992;7:221–7
   Google Scholar
• Bengner U, Johnell O, Redlund-Johnell I. Changes in incidence and prevalence of vertebral fractures during 30 years. Calcif Tissue Int 1988; 42:293–6
   PubMed Web of Science ®Google Scholar
• O’Neill TW, Felsenberg D, Varlow J, et al. The prevalence of vertebral deformity in European men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res 1996;11:1010–18
   PubMed Web of Science ®Google Scholar
• Johnell O. The socioeconomic burden of fractures: today and in the 21st century. Am J Med 1997; 103(Suppl 2A):205–55
   Google Scholar
• Felsenberg D, Lunt M, Armbrecht G, et al. Rates and determinants of vertebral fracture incidence in European men and women. J Bone Miner Res 1999; 14(Suppl 1): S159:abstr1105
   Google Scholar
• Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA. Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. Br Med J 1994;309:691–5
   PubMed Web of Science ®Google Scholar
• Sernbo I, Johnell O. Consequences of a hip fracture: a prospective study over 1 year. Osteoporos Int 1993;3:148–53
   PubMed Web of Science ®Google Scholar
• Cooper C, Atkinson EJ, Jacobsen SJ, O’Fallon WM, Melton III LJ. Population-based study of survival after osteoporotic fractures. Am J Epidemiol 1993;137:1001–5
   PubMed Web of Science ®Google Scholar
• Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA. Mortality after all major types of osteoporotic fracture in men and women: an obser- vational study. Lancet 1999;353:878–82
   PubMed Web of Science ®Google Scholar
• Poor G, Atkinson EJ, O’Fallon WM, Melton LJ III. Determinants of reduced survival following hip fractures in men. Clin Orthopaed Rel Res 1999; 319:260–5
   Google Scholar
• Schurch MA, Rizzoli R, Mermillod B, et al. A prospective study on socioeconomic aspects of fractures of the proximal femur. J Bone Miner Res 1996;11:1935–42
   PubMed Web of Science ®Google Scholar
• Reginster JY, Gillet P, Sedrine WB, et al. Direct costs of hip fractures in patients over 60 years of age in Belgium. Pharmacoeconomics 1999;15:507–14
   PubMed Web of Science ®Google Scholar
• Orwoll ES, Oviatt SK, McClung MR, Deftos LJ, Sexton G. The rate of bone mineral loss in normal men and the effects of calcium and cholecalciferol supplementation. Ann Intern Med 1990;5:645–52
   Google Scholar
• Jones G, Nguyen T, Sambrook PN, Kelly PJ, Gilbert C, Eisman J. Symptomatic fracture inci- dence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). Osteo- poros Int 1994;4:277–82
   PubMed Web of Science ®Google Scholar
• Burger H, de Laet CEDH, van Daele PLA, et al. Risk factors for increased bone loss in an elderly population. The Rotterdam study. Am J Epidemiol 1998;147:871–9
   PubMed Web of Science ®Google Scholar
• Orwoll E. Assessing bone density in men. J Bone Miner Res 2000;15:1867–70
   PubMed Web of Science ®Google Scholar
• Melton LJ III, Atkinson EJ, O’Connor MK, O’Fallon WM, Riggs BL. Bone density and frac- ture risk in men. J Bone Miner Res 1998;13:1915–23
   PubMed Web of Science ®Google Scholar
• Legrand E, Chappard D, Pascaretti C, et al. Bone mineral density and vertebral fractures in men. Osteoporos Int 1999;10:265–70
   PubMedGoogle Scholar
• Gärdsell P, Johnell O, Nilsson BE. The predictive value of forearm bone mineral content measure- ments in men. Bone 1990;11:229–32
   PubMedGoogle Scholar
• Ross PD, Lombardi A, Freedholm D. The assess- ment of bone mass in men. In Orwoll E, ed. Osteo- porosis in Men. New York: Academic Press, 1999: 505–25
   Google Scholar
• Nguyen T, Sambrook P, Kelly P, Jones G, Lord S, Freund J. Prediction of osteoporotic fractures by postural instability and bone density. Br Med J 1993; 307:1111–15
   PubMed Web of Science ®Google Scholar
• De Laet C, van Hout BA, Burger H, Weel AeAM, Hofman A, Pols HAP. Hip fracture prediction in elderly men and women: validation in the Rotterdam study. J Bone Miner Res 1998;13:1587–93
   PubMed Web of Science ®Google Scholar
• Chang S, Suominen H, Sakari-Rantala R, Kaukkanen P, Avikainen V, Heikkinen E. Calcaneal bone mineral density predicts fracture occurrence. A five-year follow-up study in elderly people. J Bone Miner Res 1997;12:1075–82
   PubMedGoogle Scholar
• Seeman E. The structural basis of bone fragility in men. Bone 1999;25:143–7
   PubMed Web of Science ®Google Scholar
• Melton LJ, Atkinson EJ, O’Connor MK, O’Fallon WM, Riggs BL. Bone density and fracture risk in men. J Bone Miner Res 1998;13:1915–23
   PubMed Web of Science ®Google Scholar
• Nguyen TV, Eisman JA, Kelly PJ, Sambrook PN. Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol 1996,144:255–62
   Google Scholar
• Fujiwara S, Kasagi F, Yamada M, Kodama K. Risk factors for hip fracture in a Japanese cohort. J Bone Miner Res 1997;12:998–1004
   PubMed Web of Science ®Google Scholar
• Kanis J, Johnell O, Gullberg B, et al. Risk factors for hip fracture in men from Southern Europe: the MEDOS study. Osteoporos Int 1999;9:45–54
   PubMed Web of Science ®Google Scholar
• Poor G, Atkinson EJ, O’Fallon WM, Melton III LJ. Predictors of hip fractures in elderly men. J Bone Miner Res 1995;10:1900–7
   PubMed Web of Science ®Google Scholar
• Grisso JA, Kelsey JL, O’Brien LA, et al. Risk factors for hip fracture in men. Hip Fracture Study Group. Am J Epidemiol 1997;145:786–93
   PubMed Web of Science ®Google Scholar
• Mussolino ME, Looker AC, Madans JH, Langlois JA, Orwoll ES. Risk factors for hip fracture in white men: the NHANES I epidemiologic follow-up study. J Bone Miner Res 1998;13:918–24
   PubMed Web of Science ®Google Scholar
• Nyquist F, Gardsell P, Sernbo I, Jeppsson JO, Johnell O. Assessment of sex hormones and bone mineral density in relation to occurrence of fracture in men: a prospective population-based study. Bone 1998;22:147–51
   PubMedGoogle Scholar
• Seeman E, Melton LJ III, O’Fallon WM, Riggs BL. Risk factors for spinal osteoporosis in men. Am J Med 1983;75:977–83
   PubMed Web of Science ®Google Scholar
• Hoidrup S, Gronbaek M, Gottschau A, Lauritzen JM, Schroll M. Alcohol intake, beverage prefer- ence, and risk of hip fracture in men and women. Am J Epidemiol 1999;149:993–1001
   PubMed Web of Science ®Google Scholar
• Langdahl BL, Ralston SH, Grant SF, Eriksen EF. An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic fractures in both men and women. J Bone Miner Res 1998;13:1684–9
   Google Scholar
• Stanley HL, Schmitt BP, Poses RM, Deiss WP. Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc 1991;39:766–71
   PubMed Web of Science ®Google Scholar
• Eastell R, Boyle IT, Compston J, et al. Manage- ment of male osteoporosis: report of the UK Consensus Group. Q J Med 1998;91:71–92
   Google Scholar
• Jackson JA, Riggs M, Spiekerman AM. Testoster- one deficiency as a risk factor for hip fractures in men: a case-control study. Am J Med Sci 1992; 304:4–8
   PubMed Web of Science ®Google Scholar
• Boonen S, Vanderschueren D, Cheng XG, et al. Age-related (type II) femoral neck osteoporosis in men: biochemical evidence for both hypo- vitaminosis D- and androgen deficiency-induced bone resorption. J Bone Miner Res 1997;12:2119–26
   PubMed Web of Science ®Google Scholar
• Kaufman JM, Vermeulen A. Declining gonadal function in elderly men. Baillieres Clin Endocrinol Metab 1997;11:289–309
   PubMed Web of Science ®Google Scholar
• Ferrini R, Barrett-Connor. Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fraction in community- dwelling men. Am J Epidemiol 1998;147:750–4
   PubMed Web of Science ®Google Scholar
• Van Den Beld AW, De Jong FH, Grobbee DE, Pols HA, Lamberts SWJ. Measures of bioavailable serum testosterone and estradiol and their relation- ships with muscle strength bone density, and body composition in elderly men. J Clin Endocrinol Metab 2000;85:3276–82
   PubMed Web of Science ®Google Scholar
• Stepan JJ, Lachman M, Zverina J, Pacovsky V, Baylink DJ. Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling. J Clin Endocrinol Metab 1989; 69:523–7
   PubMed Web of Science ®Google Scholar
• Goldray D, Weisman Y, Jaccard N, Merdler C, Chen J, Matzkin H. Decreased bone density in elderly men treated with the gonadotropin- releasing hormone agonist decapeptyl (D-Trp6- GnRH). J Clin Endocrinol Metab 1993;76:288–90
   PubMed Web of Science ®Google Scholar
• Kaufman JM. Androgens, bone metabolism and osteoporosis. In Oddens J, Vermeulen A, eds. Androgens and the Aging Male. Carnforth, UK: Parthenon Publishing, 1996:39–60
   Google Scholar
• Clarke BL, Ebeling PR, Jones JD, et al. Changes in quantitative bone histomorphometry in aging healthy men. J Clin Endocrinol Metab 1996;81:2264–70
   PubMed Web of Science ®Google Scholar
• Murphy S, Khaw K, Cassidy A, Compston JE. Sex hormones and bone mineral density in elderly men. Bone Miner 1993;20:133–40
   PubMedGoogle Scholar
• Greendale GA, Edelstein S, Barrett-Connor E. Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study. J Bone Miner Res 1997;12:1833–43
   PubMed Web of Science ®Google Scholar
• Center JR, Nguyen TV, Sambrook PN, Eisman JA. Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab 1999;84:3626–35
   PubMed Web of Science ®Google Scholar
• Ettinger B, Pressman A, Sklarin P, Bauer DC, Cauley JA, Cummings SR. Associations between low levels of serum estradiol, bone density, and fractures among elderly women: the study of osteo- porotic fractures. J Clin Endocrinol Metab 1998;83:2239–43
   PubMed Web of Science ®Google Scholar
• Chapurlat RD, Garnero P, Bréart G, Meunier PJ, Delmas P for the EPIDOS study group. Serum estradiol and sex hormone-binding globulin and the risk of hip fracture in elderly women: the EPIDOS study. J Bone Miner Res 2000;15:1835–41
   PubMed Web of Science ®Google Scholar
• Vanderschueren D, Boonen S, Bouillon R. Action of androgens versus estrogens in male skeletal homeostasis. Bone 1998;23:391–4
   PubMedGoogle Scholar
• Khosla S, Melton III LJ, Atkinson EJ, O’Fallon WM, Klee GG, Riggs BL. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 1998;83:2266–74
   PubMed Web of Science ®Google Scholar
• Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston CC. Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgen. J Clin Invest 1997;100:1755–9
   PubMed Web of Science ®Google Scholar
• Barrett-Connor E, Mueller JE, von Mühlen DG, Laughlin A, Schneider DL, Sartoris DJ. Low levels of estradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000;85:219–23
   PubMed Web of Science ®Google Scholar
• Goemaere S, Toye K, Daems M, et al. Indices of bone turnover in elderly men. European Congress on Osteoporosis, Berlin. Osteoporos Int 1998;8 (Suppl 3):465
   Google Scholar
• Fatayerji D, Eastell R. Age-related changes in bone turnover in men. J Bone Miner Res 1999;14:1203–10
   PubMed Web of Science ®Google Scholar
• Scopacasa F, Horowitz M, Wishart JM, Morris HA, Chatterton BE, Need AG. The relation between bone density, free androgen index, and estradiol in men 60 to 70 years old. Bone 2000; 27:145–9
   PubMed Web of Science ®Google Scholar
• Wishart JM, Need AG, Horowitz M, Morris HA, Nordin BEC. Effect of age on bone density and bone turnover in men. Clin Endocrinol 1995; 42:141–6
   PubMed Web of Science ®Google Scholar
• Vermeulen A. Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedine-C levels. J Clin Endocrinol Metab 1987;64:884–8
   PubMed Web of Science ®Google Scholar
• Van den Saffele J, Goemaere S, De Bacquer D, Kaufman JM. Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency ? Clin Endocrinol 1995;51:81–8
   Google Scholar
• L’Hermite-Balériaux M, Copinschi G, Van Cauter E. Growth hormone and the aging male. Aging Male 1999;2:87–94
   Google Scholar
• Kurland ES, Rosen CJ, Cosman F, et al. Insulin- like growth factor-1 in men with idiopathic osteo- porosis. J Clin Endocrinol Metab 1997;82:2799–805
   PubMedGoogle Scholar
• Johansson AG, Eriksen EF, Lindh E, et al. Reduced serum levels of the growth hormone-dependent insulin-like growth factor binding protein and a negative bone balance at the level of individual remodeling units in idiopathic osteoporosis in men. J Clin Endocrinol Metab 1997;82:2795–8
   PubMedGoogle Scholar
• Ljunghall S, Johansson AG, Burmon P, et al. Low plasma levels of insulin-like growth factor (IGF-I) in male patients with idiopathic osteoporosis. J Int Med 1992;232:59–64
   PubMed Web of Science ®Google Scholar
• Fatayerji D, Mawer EB, Eastell R. The role of insulin-like growth factor I in age-related changes in calcium homeostasis in men. J Clin Endocrinol Metab 2000;85:4657–62
   PubMed Web of Science ®Google Scholar
• Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997;337:670–6
   PubMed Web of Science ®Google Scholar
• Lips P, Graafmans WC, Ooms ME, et al. Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial. Ann Intern Med 1996;124:400–6
   PubMed Web of Science ®Google Scholar
• Devogelaer JP, De Cooman S, Nagant de Deux Chaisnes C. Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study. Maturitas 1992;15:17–23
   PubMed Web of Science ®Google Scholar
• Finkelstein JS, Klibanski A, Neer RM, et al. Increases in bone density during treatment of men with idiopathic hypogonadism. J Clin Endocrinol Metab 1989;69:776–83
   PubMed Web of Science ®Google Scholar
• Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DI, Anderson EJ, Klibanski A. Increase in bone density and lean body mass during testos- terone administration in men with acquired hypo- gonadism. J Clin Endocrinol Metab 1996;81:4358–65
   PubMed Web of Science ®Google Scholar
• Behre HM, Kliesch S, Leitke E, Link TM, Nieschlag E. Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab 1997;82:2386–90
   PubMed Web of Science ®Google Scholar
• Snyder P, Peachey H, Hannoush P, et al. Effect of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 1999;84:1966–72
   PubMed Web of Science ®Google Scholar
• Tenover J. Abstracts of the 80th Annual Meeting of the Endocrine Society. Bethesda MD: Endocrine Society, 1998
   Google Scholar
• Kenny AM, Preswood KM, Marcello KD, Foll PM, Raisz LG. The effect of transdermal testoster- one on bone mineral density (BMD), bone turn- over markers and muscle strength in older men. J Bone Miner Res 1999;14(Suppl): S184(abstr)
   Google Scholar
• Orwoll E, Ettinger M, Weiss S, et al. Alendronate for the treatment of osteoporosis in men. N Engl J Med 2000;343:604–10
   PubMed Web of Science ®Google Scholar
• Ringe JD, Dorst A, Kipshoven C et al. Avoidance of vertebral fractures in men with idiopathic osteo- porosis by a three year therapy with calcium and low-dose intermittent monofluorophosphate. Osteoporos Int 1998;8:47–52
   PubMed Web of Science ®Google Scholar
• Riggs BL, Hodgson SF, O’Fallon WM, et al. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med 1990;322:802–9
   PubMed Web of Science ®Google Scholar
• Kurland E, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP. Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. J Clin Endocrinol Metab 2000;85:3069–76
   PubMed Web of Science ®Google Scholar