Analytical Techniques for Ecstasy

References

• Steele , T. D. , McCann , U. D. and Ricaurte , G. A. 1994 . 3,4 Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans . Addiction , 89 : 539 – 551 .
   Google Scholar
• Shulgin , A. and Shulgin , A. 1995 . Pihkal, A Chemical Love Story Berkeley, CA : Transform Press .
   Google Scholar
• Freeman , S. and Alder , J. F. 2002 . Arylethylamines psychotropic recreational drugs: a chemical perspective . Eur. J. Med. Chem. , 37 : 527 – 539 .
   Google Scholar
• Cole , J. C. and Sumnall , H. R. 2003 . Altered states: the clinical effects of ecstasy . Pharmacol. Therap. , 98 : 35 – 58 .
   Google Scholar
• Baggott , M. , Heiferts , B. , Jones , R. T. , Mendelson , J. , Sferios , E. and Zhender , J. 2000 . Chemical analysis of ecstasy pills . J. Amer. Med. Assoc. , 248 : 2190 – 2198 .
   Google Scholar
• Nichols , D. E. 1986 . Differences between the mechanisms of action of MDMA, MDBD and the classical hallucinogens. Identification of a new therapeutic class; entactogens . J. Psychoactive Drugs. , 18 : 305 – 313 .
   Google Scholar
• Moore , K. A. , Mozayani , A. , Fierro , M. F. and Poklis , A. 1996 . Distribution of 3,4‐methylenedioxymethamphetamine (MDMA) and 3,4 methylenedioxyamphetamine (MDA) stereoisomers in a fatal poisoning . Forensic Sci. Int. , 83 : 111 – 119 .
   Google Scholar
• O'Connor , B. 1994 . Hazards associated with the recreational drug “Ecstasy . British J. Hospital Medicine , 52 : 507 – 514 .
   Google Scholar
• Fineschi , V. and Masti , A. 1994 . Fatal poisoning by MDMA and MDEA: a case report . Int. J. Legal Medicine , 108 : 272 – 275 .
   Google Scholar
• Forrest , A. R.W. 1995 . A fatal overdose with MDMA Derivatives . Forensic Sci. Int. , 64 : 57 – 59 .
   Google Scholar
• Henry , J. A. , Jeffreys , K. J. and Dawling , S. 1992 . Toxicity and deaths from 3,4‐methylenedioxymethamphetamine, (“Ecstasy”) . Lancet , 340 : 384 – 387 .
   Google Scholar
• Doydon , S. 2001 . The many faces of ecstasy . Curr. Opin. Paediatr. , 13 : 170 – 176 .
   Google Scholar
• Hegadoren , K. M. , Baker , G. B. and Bourine , M. 1999 . 3,4‐Methylenedioxy analogues of amphetamine: defining the risks to humans . Neurosci. Biobehav. Rev. , 23 : 539 – 553 .
   Google Scholar
• De La Torre , R. , Farre , M. , Ortuno , J. , Mas , M. , Brenneisen , R. , Roset , P. N. , Segura , J. and Cami , J. 2000 . Non‐linear pharmacokinetics of MDMA (Ecstasy) in humans . Br. J. Clin. Pharmacol. , 49 : 104 – 109 .
   Google Scholar
• Fitzgerald , R. L. , Blanke , R. V. , Glennon , R. A. , Yousif , M. , Roscrans , J. A. and Poklis , A. 1989 . Determination of 3,4 methylenedioxyamphetamine and 3,4 methylenedioxymethamphetamine enantiomers in whole blood . J. Chromatogr. , 490 : 59 – 69 .
   Google Scholar
• Schmidt , C. J. 1987 . Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine . J. Pharmacol. Exp. Ther. , 240 : 1 – 7 .
   Google Scholar
• Maurer , H. H. , Bickerboeller‐Friedrich , J. , Kramer , T. and Peters , F. T. 2000 . Toxicokinetics and analytical toxicology of amphetamine‐derived designer drugs (“Ecstasy”) . Toxicol. Lett. , 112–113 : 133 – 142 .
   Google Scholar
• Ensslin , H. K. , Kovar , K.‐A. and Maurer , H. H. 1996 . Toxicological detection of the designer drug 3,4 methylenedioxyethyleamphetamine (MDE, “Eve”) and its metabolites in urine by gas chromatography‐mass spectrometry and fluorescence polarization immunoassay . J. Chromatogr. B , 683 : 189 – 197 .
   Google Scholar
• Fucci , N. , De Giovanni , N. and Chiarotti , M. 2003 . Simultaneous detection of some drugs of abuse in saliva samples by SPME technique . Forensic Sci. Int. , 134 : 40 – 45 .
   Google Scholar
• Talwar , D. , Watson , I. D. and Stewart , M. J. 1999 . Routine analysis of amphetamine class drugs as their naphthoquinone derivatives in human urine by high‐performance liquid chromatography . J. Chromatogr. B , 735 : 229 – 241 .
   Google Scholar
• Campins‐Falco , P. , Molins‐Legua , C. , Hernandez , T. H. and Sevillano Cabeza , A. 1995 . Improved amphetamine and methamphetamine determination in urine by normal‐phase high performance liquid chromatography with sodium 1,2 naphthoquinone 4‐sulfonate as derivatising agent and solid‐phase extraction for sample clean up . J. Chromatogr. B , : 235 – 245 .
   Google Scholar
• Herraez‐Hernandez , R. , Campins‐Falco , P. and Verdu Andres , J. 2001 . Sensitive determination of methylenedioxylated amphetamines by liquid chromatography . Analyst , 126 : 581 – 586 .
   Google Scholar
• Sadeghipour , F. and Veuthey , J.‐L. 1997 . Sensitive and selective determination of methylenedioxylated amphetamines by high‐performance liquid chromatography with fluorimetric detection . J. Chromatogr. A , 787 : 137 – 143 .
   Google Scholar
• Sadeghipour , F. , Giroud , C. , Rivier , L. and Veuthey , J.‐L. 1997 . Rapid determination of amphetamines by high‐performance liquid chromatography with UV detection . J. Chromatogr. A , 761 : 71 – 78 .
   Google Scholar
• Mancinelli , R. , Gentili , S. , Guiducci , M. S. and Macchia , T. 1999 . Simple and reliable high‐performance liquid chromatography fluorimetric procedure for the determination of amphetamine‐derived designer drugs . J. Chromatogr. B , 735 : 243 – 253 .
   Google Scholar
• Segura , M. , Ortuno , J. , McLure , J. A. , Pujadas , M. , Pizarro , N. , Farre , M. , Llebaria , A. , Joglar , J. , Segura , J. and de la Torre , R. 2002 . High performance liquid chromatography with electrochemical detection applied to the analysis of 3,4 dihydroxymethamphetamine in human plasma and urine . J. Chromatogr. B , 769 : 313 – 321 .
   Google Scholar
• Brunnenberg , M. and Kovar , K.‐A. 2001 . Stereospecific analysis of ecstasy like N‐ethyl 3,4 methylenedioxyamphetamine and its metabolites in humans . J. Chromatogr. B , 751 : 9 – 18 .
   Google Scholar
• Pellegrini , M. , Rosati , F. , Pacifici , R. , Zuccaro , R. , Rosmolo , F. S. and Lopez , A. 2002 . Rapid screening method for determination of Ecstasy and amphetamines in urine samples using gas chromatography‐chemical ionisation mass spectrometry . J. Chromatogr. B , 769 : 243 – 251 .
   Google Scholar
• Marquet , P. , Lacassie , E. , Battu , C. , Faubert , H. and Lachatre , G. 1997 . Simultaneous determination of amphetamine and its analogs in human whole blood by gas chromatography‐mass spectrometry . J. Chromatogr. B , 700 : 77 – 82 .
   Google Scholar
• Ortuno , J. , Pizzaro , N. , Farre , M. , Mas , M. , Segura , J. , Cami , J. , Brenneisen , R. and De la Torre , R. 1999 . Quantification of 3,4 methylenedioxymethamphetamine and its metabolites in plasma and urine by gas chromatography with nitrogen–phospherous detection . J. Chromatogr. B , 723 : 221 – 232 .
   Google Scholar
• Moeller , M. R. , Steinmeyer , S. and Kraemer , T. 1998 . Determination of drugs of abuse in blood . J. Chromatogr. B , 713 : 91 – 109 .
   Google Scholar
• Kraemer , T. and Maurer , H. H. 1998 . Determination of amphetamine, methamphetamine and amphetamine‐derived designer drugs or medicaments in blood and urine . J. Chromatogr. B , 713 : 163 – 187 .
   Google Scholar
• Navarro , M. , Pichini , S. , Farre , M. , Ortuno , J. , Roset , P. N. , Segura , J. and de la Torre , R. 2001 . Usefulness of saliva for measurement of 3,4 methyledioxymethamphetamine and its metabolites: correlation with plasma drug concentrations and effect on salivary pH . Clin. Chem. , 47 : 1788 – 1795 .
   Google Scholar
• Kintz , P. and A Samyn , N. 1999 . Determination of ecstasy components in alternative biological specimens . J. Chromatogr. B , 733 : 137 – 143 .
   Google Scholar
• Palhol , F. , Lamoureux , C. , Chabrillat , M. and Naulet , N. 2004 . 15N/14N Isotopic ratio and statistical analysis: an effecient way of linking seized ecstasy tablets . Anal. Chim. Acta. , 510 : 1 – 8 .
   Google Scholar
• Piette , V. and Parmentier , F. 2002 . Analysis of illicit amphetamine seizures by capillary zone electrophoresis . J. Chromatogr. A , 979 : 345 – 352 .
   Google Scholar
• Frost , M. , Kohler , H. and Blaschke , G. 1996 . Analysis of “Ecstasy” by capillary electrophoresis . Int. J. Legal Med. , 109 : 53 – 57 .
   Google Scholar
• Chung , Y.‐L. , Tsung , L. J. and Cheng‐Huang , L. 2001 . One‐line identification of 3,4 methylenedioxymethamphetamine in human urine by non‐aqueous capillary electrphoresis–fluorescence spectroscopy at 77K . J. Chromatogr. B , 759 : 219 – 226 .
   Google Scholar
• Fang , C. , Chung , Y. L. , Ju‐Tsung , L. and Lin , C. H. 2002 . Rapid analysis of 3,4 methylenedioxymethamphetamine: a comparison of non‐aqueous capillary electrophoresis/fluorescence detection with GC/MS . Forensic Sci. Int. , 125 : 142 – 148 .
   Google Scholar
• Lanz , M. , Brenneisen , R. and Thormann , W. 1997 . Enantioselective determination of 3,4 methylenedioxymethamphetamine and two of its metabolites in human urine by cyclodextrin‐modified capillary zone electrophoresis . Electrophoresis , 18 : 1035 – 1043 .
   Google Scholar
• Boatto , G. , Faedda , M. V. , Pau , A. , Asproni , B. , Menconi , S. and Cerri , R. 2002 . Determination of amphetamines in human whole blood by capillary electrophoresis with photodiode array detection . J. Pharmaceut. Biomed. Anal. , 28 : 1073 – 1080 .
   Google Scholar
• Tagliaro , F. , Turrina , S. , Pisi , P. , Smith , F. P. and Marigo , M. 1998 . Determination of illicit and/or abused drugs and compounds of forensic interest in biosamples by capillary electrophoretic/electrokinetic methods . J. Chromatogr. B , 713 : 27 – 49 .
   Google Scholar
• Geiser , L. , Cherkaoui , S. and Veuthey , J.‐L. 2000 . Simultaneous analysis of stone amphetamine derivatives in urine by nonaqueous capillary electrophoresis coupled to electrospray ionization mass spectrometry . Journal D, Chromatogr. A , 895 : 111 – 121 .
   Google Scholar
• Budd , R. D. 1981 . Amphetamine EMIT‐structure versus reactivity . Clin. Toxicol. , 18 : 91 – 110 .
   Google Scholar
• Suttijitpaisal , P. and Ratanabanangkoon , K. 1992 . Immunoassays of amphetamine: immunogen structure vs antibody specificity . Asian Pac. J. Allergy Immunol. , 10 : 159 – 164 .
   Google Scholar
• Henderson , D. R. , Friedman , S. B. , Harris , J. D. , Manning , W. B. and Zoccoli , M. A. 1986 . CEDIA™ a new homogeneous immunoassay system . Clin. Chem. , 32 : 1637 – 1641 .
   Google Scholar
• Armbruster , D. A. , Hubster , E. C. , Kauffman , M. S. and Ramon , M. K. 1995 . Cloned enzyme donor immunoassay (CEDIA) for drugs‐of‐abuse screening . Clin. Chem. , 41 : 92 – 98 .
   Google Scholar
• Loor , R. , Lingenfelter , C. , Wason , P. P. , Tang , K. and Davoudzadeh , D. 2002 . Multiplex assay of amphetamine, methamphetamine, and ecstasy drug using CEDIA technology . J. Anal. Toxicol. , 26 : 267 – 273 .
   Google Scholar
• Dasgupta , A. , Saldana , S.W. , Kinnaman , G. , Smith , M. and Johansen , K. 1993 . Analytical perfomance of EMIT II monoclonal amphetamine/methamphetamine assay: more specificity than EMIT with monoclonal amphetamine/methamphetamine assay . Clin. Chem. , 39 : 104 – 108 .
   Google Scholar
• Cody , J. T. 1990 . Detection of D ,L‐amphetamine, D ,L‐methamphetamine and illicit amphetamine analogues using diagnostic products corporations' amphetamine and metamphetamine radioimmunoassay . J. Anal. Toxicol. , 14 : 321 – 324 .
   Google Scholar
• Cody , J. T. and Schwarzhoff , R. 1993 . Fluorescence polarization immunoassay detection of amphetamine, methamphetamine and illicit amphetamine analogues . J. Anal. Toxicol. , 17 : 26 – 30 .
   Google Scholar
• Kunsman , G. W. , Manno , J. E. , Cockerham , K. R. and Manno , B. R. 1990 . Application of the Syva EMIT and Abbott TDx amphetamine immunoassays to the detection of 3,4 methylenedioxymethamphetamine (MDMA) and 3,4 methylenedioxyethamphetamine (MDEA) in urine . J. Anal. Toxicol. , 14 : 149 – 153 .
   Google Scholar
• Dunsman , G. W. , Levine , B. , Kuhlman , J. J. , Jones , R. L. , Hughes , R. O. , Fujiyama , C. I. and Smith , M. L. 1996 . MDA_MDMA concentrations in urine specimens . J. Anal. Toxicol. , 20 : 517 – 521 .
   Google Scholar
• Polkis , A. , Hall , K. V. , Eddleton , R. A. , Fitzgerald , R. L. , Saady , J. J. and Bogema , S. C. 1993 . EMIT‐dau. Monoclonal amphetamine assay. Stereoselectivity and clinical evaluation . Forensic Sci. Int. , 59 : 49 – 62 .
   Google Scholar
• Ruanguttikarn , W. and Moody , D. E. 1998 . Comparison of three commercial amphetamine immunoassays for detection of methamphetamine, methylenedioxyamphetamine, methylenedioxymethamphetamine, and methylenedioxyethylamphetamine . J. Anal. Toxicol. , 12 : 229 – 233 .
   Google Scholar
• D'Nicuola , J. , Jones , R. , Levine , B. and Smith , M. L. 1992 . Evaluation of six commercial amphetamine immunoassays for cross reactivity to phenylpropanolamine and ephedrine in urine . J. Anal. Toxicol. , 16 : 211 – 213 .
   Google Scholar
• Kerrigan , S. and Phillips , W. H. 2001 . Comparison of ELISAs for Opiates, methamphetamine, cocaine metabolite, benzodiazepines, phenylcyclidine and cannabinoids in whole blood and urine . Clin. Chem. , 47 : 540 – 547 .
   Google Scholar
• Ward , C. , McNally , A. J. , Rusyniak , D. and Salmone , S. J. 1994 . 125I Radioimmunoassay for the dual detection of amphetamine and methamphetamine . J. Forensic Sci. , 39 : 1486 – 1496 .
   Google Scholar
• Ramseier , A. , Caslavaska , J. and Thormann , W. 1998 . Screening for urinary amphetamine and analogs by capillary electrophoretic immunoassays and confirmation by capillary electrophoresis with on‐column multiwavelength absorbance detection . Electrophoresis , 19 : 2956 – 2966 .
   Google Scholar
• Butler , D. , Pravda , M. and Guilbault , G. G. in press . An electrochemical sensor for ecstasy . Anal. Chem. Acta. ,
   Google Scholar