Simultaneous Separation and Purification of Microcystin LR, RR, YR by Using Supercritical Fluid Extraction and Column Chromatography

References

• Carmichael , W. W. , Beasley , V. R. , Bunner , D. L. , Eloff , J. N. , Falconer , I. , Gorham , P. , Harada , K.‐I. , Krishnamurthy , T. , Yu , M.‐J. , Moore , R. E. , Rinehart , K. , Runnegar , M. , Skulberg , O. M. and Watanabe , M. 1988 . Naming of cyclic heptapeptide toxins of cyanobacteria (blue‐green algae) . Toxicon. , 26 : 971
   Google Scholar
• Sivonen , K. , Namlcoshi , M. , Evans , W. R. , Fardig , M. , Carmichael , W. W. and Rinegart , K. L. 1992 . Chem. Res. Toxicol. , 5 : 464
   Google Scholar
• Namikoshi , M. , Rinehart , K. L. , Sakai , R. , Stoots , R. R. , Dahlem , A. M. , Beasley , V. , Carmichael , W. W. and Evans , W. R. 1992 . J. Org. Chem. , 57 : 866
   Google Scholar
• Carmichael , W. W. 1988 . Toxins of Freshwater Algae: Handbook of Natural Toxins Vol. 3 , 121 New York : Marcel Dekker .
   Google Scholar
• Namikoshi , M. , Rinehart , D. L. , Sakai , R. , Sivonen , K. and Carmichael , W. W. 1990 . Identification of 12 hepatotoxins from a Homer lake bloom of the cyanobacteria Microcystis aeruginosa, Microcystis viridis, Microcystis wesenbergii; nine new microcystins . J. Org. Chem. , 55 : 613
   Google Scholar
• Sivonen , K. , Carmichael , W. W. , Namikoshi , M. , Rinehart , K. L. , Dahlem , A. M. and Niemela , S. I. 1991 . Isolation and characterization of hepatotoxic microcystin homologues from the filamentous freshwater cyanobacterium Nostoc sp . Appl. Environ. Microbiol. , 56 : 2650
   Google Scholar
• Botes , D. P. , Tuinman , A. A. , Wessels , P. L. , Voljoen , C. C. , Kruger , H. , Williams , D. , Sanikarn , S. , Smith , R. J. and Hammand , S. J. 1984 . The structure of cyanoginosin‐LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa . J. Chem. Soc., Perkin Trans. , 55 : 2311
   Google Scholar
• Kusumi , T. , Ooi , T. , Watanabe , M. M. , Takahashi , H. and Kakisawa , H. 1987 . Cyanoviridin RR, a toxin from the cyanobacterium (blue‐green alga) Microcystis viridis . Tetrahedron Lett. , 28 : 4695
   Google Scholar
• Lahti , K. and Hiisvirta , L. 1989 . Water Supply , 7 : 149
   Google Scholar
• Keijola , A. M. , Himberg , K. , Esala , A. L. , Sivonen , K. and Hiisvirta , L. 1988 . Toxicol. Assass , 3 : 643
   Google Scholar
• Watanabe , M. F. , Harada , K.‐I. and Fujiki , H. 1994 . “ Waterbloom of Bluegreen Algae and Their Toxins ” . Tokyo, , Japan : University of Tokyo Press .
   Google Scholar
• Sugaya , Y. , Yasuno , M. and Yanai , T. 1990 . Effect of toxin Microcystis viridis and isolated toxin on goldfish . Jpn. J. Limnol. , 51 : 149
   Google Scholar
• Erikson , J. E. , Meriluoto , J. A.O. and Lindholm , T. 1989 . Hydrobiologia , 183 : 211
   Google Scholar
• MacKintosh , C. , Beattie , K. A. , Klumpp , S. , Cohen , P. and Codd , G. A. 1990 . FEBS Lett. , 264 : 187
   Google Scholar
• Matsushima , R. , Yoshizawa , S. , Watanabe , M. F. , Harada , K.‐I. , Furusawa , M. , Carmichael , W. W. and Fujiki , H. 1990 . In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts . Biochem. Biophys. Res. Commun. , 171 : 867
   Google Scholar
• Falconer , I. R. , Jackson , A. R.B. , Langely , J. and Runnegar , M. T.C. 1981 . Liver pathology in mice in poisoning by the blue‐green alga Microcystis aeruginosa . Aust. J. Biol. Sci. , 34 : 179
   Google Scholar
• Harada , K.‐I. , Matsuura , K. , Suzuki , M. , Oka , H. , Watanabe , M. F. , Oishi , S. , Dahlem , A. M. , Beasley , V. R. and Carmichael , W. W. 1988 . J. Chromatogr. , 448 : 275
   Google Scholar
• Namakoshi , M. , Sivonen , K. , Evans , W. R. , Sun , F. , Carmichael , W. W. and Rinehart , K. L. 1992 . Toxicon , 30 : 1473
   Google Scholar
• Pyo , D. and Shin , H. 1999 . Supercritical fluid extraction of microcystins from cyanobacteria . Anal. Chem. , 71 : 4772
   Google Scholar