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Artificial Cells, Blood Substitutes, and Biotechnology Volume 31, 2003 - Issue 3
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Original

Analysis of Polyethylene‐glycol‐polylactide Nano‐Dimension Artificial Red Blood Cells in Maintaining Systemic Hemoglobin Levels and Prevention of Methemoglobin Formation

Thomas M. S. Chang Artificial Cells and Organs Research Centre and MSSS‐FRSQ Research Group (equipe) on Blood Substitutes in Transfusion Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6
, F.R.S.C. , O.C. , M.D. , Ph.D. , F.R.C.P.C.,
Douglas Powanda Artificial Cells and Organs Research Centre and MSSS‐FRSQ Research Group (equipe) on Blood Substitutes in Transfusion Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6
, M.Sc. &
W. P. Yu Artificial Cells and Organs Research Centre and MSSS‐FRSQ Research Group (equipe) on Blood Substitutes in Transfusion Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, H3G 1Y6
, Ph.D.
Pages 231-247 | Published online: 11 Jul 2009

References

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  • Chang T. M.S. Semipermeable microcapsules. Science 1964; 146(3643)524–525
  • Chang T. M.S. Stabilization of enzymes by microencapsulation with a concentrated protein solution or by microencapsulation followed by cross‐linking with glutaraldehyde. Biochem. Biophys. Res. Commun. 1971; 44(6)1531–1536
  • Chang T. M.S. Biodegradable semipermeable microcapsules containing enzymes, hormones, vaccines, and other biologicals. J. Bioeng. 1976; 1: 25–32
  • Chang T. M.S. Monograph on “Blood Substitutes: Principles, Methods, Products and Clinical Trials”. Basel Karger, Texas Landes 1997; Vol. 1, (free viewing on www.artcell.mcgill.ca)
  • Chang T. M.S. Oxygen carriers. Curr. Opin. Invest. Drugs 2002; 3(8)1187–1190, (free viewing on www.artcell.mcgill.ca)
  • Chang T. M.S., Yu W. P.. Biodegradable Polymer Membrane Containing Hemoglobin for Blood Substitutes. U.S.A. Patent 5670173, September 23, 1997
  • Chang T. M.S., Yu W. P.. Biodegradable Polymeric Nanocapsules and Uses Thereof. U.S. Provisional Patent Application. No 60/316,001, August 31, 2001
  • Chang T. M.S., Powanda D., Yu W. P.. Biodegradable Polymeric Nanocapsules and Uses Thereof. International Patent Application No. PCT/CA02/01331, August 2002
  • D'Agnillo F., Chang T. M.S. Polyhemoglobin‐superoxide dismutase‐catalase as a blood substitute with antioxidant properties. Nature Biotechnol. 1998; 16(7)667–671
  • Gould S. A., Moore E. E., Hoyt D. B., Burch J. M., Haenel J. B., Garcia J., DeWoskin R., Moss G. S. The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. J. Am. Coll. Surg. 1998; 187: 113–120
  • Sprung J., Kindscher J. D., Wahr J. A., Levy J. H., Monk T. G., Moritz M. W., O'Hara P. J. The use of bovine hemoglobin glutamer‐250 (Hemopure) in surgical patients: results of a multicenter, randomized, single‐blinded trial. Anesth. Analg. 2002; 94(4)799–808
  • Squires J. E. Artificial blood. Science 2002; 295(5557)1002–1005
  • Yu W. P., Chang T. M.S. Nano‐dimension red blood cell substitutes based on a novel ultrathin polyethylene‐glycol‐polylactide copolymer membrane nanocapsules containing hemoglobin and enzymes, (submitted)

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