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Journal of Biopharmaceutical Statistics Volume 14, 2004 - Issue 4
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Original Articles

Estimation of the Treatment Difference in Multicenter Trials

Valerii Fedorov Department of Biometrics, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA
,
Byron Jones Statistical Research and Consulting Center, Pfizer Global Research and Development, Sandwich, Kent, UK
,
Matthew Jones School of Mathematics, University of Cardiff, Cardiff, UK
&
Anatoly Zhigljavsky School of Mathematics, University of Cardiff, Cardiff, UK; School of Mathematics, University of Cardiff, Senhennydd Rd., Cardiff, CF24 4AG, UKCorrespondence[email protected]
Pages 1037-1063 | Received 01 Feb 2003, Accepted 01 Apr 2003, Published online: 02 Feb 2007

References

  • Chinchilli , V. M. and Bortey , E. B. 1991 . Testing for consistency in a single multicenter trial . J. Biopharmaceut. Statist. , 1 : 67 – 80 .
  • Dragalin , V. , Fedorov , V. , Jones , B. and Rockhold , F. 2002 . Estimation of the combined response to treatment in multicentre trials . J. Biopharmaceut. Statist. , 11 : 275 – 295 .
  • Fedorov , V. , Jones , B. and Rockhold , F. 2002 . The design and analysis of multicentre trials in the random effect setting . GSK BDS Tech. Rep. , 2002-03
  • Fedorov , V. V. , Montepiedra , G. and Nachtsheim , C. J. 1998 . Optimal design and the model validity range . J. Statist. Plann. Infer. , 72 : 215 – 227 .
  • Johnson , N. L. , Kotz , S. and Kemp , A. W. 1993 . Univariate Discrete Distributions , 2nd New York : John Wiley & Sons .
  • Johnson , N. L. , Kotz , S. and Balakrishnan , N. 1994 . Continuous Univariate Distributions , 2nd New York : John Wiley & Sons .
  • Källén , A. 1997 . Treatment-by-center interaction: What is the issue? . Drug Inform. J. , 31 : 927 – 936 .
  • Lin , Z. 2000 . The number of centres in a multicentre clinical study: Effects on statistical power . Drug Inform. J. , 34 : 379 – 386 .
  • Schwemer , G. 2000 . General linear models for multicenter trials . Control. Clin. Trials , 21 : 21 – 29 .
  • Senn , S. 1997 . Statistical Issues in Drug Development Chichester : John Wiley & Sons .
  • Snapinn , M. S. 1998 . Interpreting interaction: The classical approach . Drug Inform. J. , 32 : 433 – 438 .

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