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Original Articles

A Comparison of Nonlinear Mixed-Model Analyses for a Pediatric Pharmacokinetic Study

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Pages 465-478 | Published online: 02 Feb 2007

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  • Samara , E. , Granneman , R. ( 1997 ). Role of population pharmacokinetics in drug development . Clin. Pharmacokinet . 32 ( 4 ): 294 – 312 . [CSA]
  • Davidian , M. , Giltinan , D. ( 1995 ). Nonlinear Models for Repeated Measurement Data. Monographs on Statistics and Applied Probability. New York : Chapman and Hall .
  • Pinheiro , J. C. , Bates , D. M. ( 2000 ). Mixed-effects models in S and S-PLUS. In: Statistics and Computing. New York : Springer-Verlag .
  • Pinheiro , J. C. , Bates , D. M. ( 1995 ). Approximations to the log-likelihood function in the nonlinear mixed effects model . J. Comput. Graph. Statist. 4 ( 1 ): 12 – 35 .
  • U.S. Food and Drug Administration (FDA). ( 1999 ). Guidance for Industry, Population Pharmacokinetics. http://www.fda.gov/cder/guidance/index.htm .

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