REFERENCES
- Mullins J., Peters J., Ganten D. Fulminant hypertension in transgenic rats habouring the mouse Ren-2 gene. Nature 1990; 344: 541–544
- Lemmer B., Mattes A., Böhm M., Ganten D. Circadian blood pressure variation in transgenic hypertensive rats. Hypertension 1993; 22: 98–101
- Lemmer B., Witte K., Makabe T., Ganten D., Mattes A. Effects of enalaprilat on circadian profiles in blood pressure and heart rate of spontaneously and transgenic hypertensive rats. J. Cardiovasc. Pharmacol. 1994; 23: 311–314
- Schnecko A., Witte K., Lemmer B. Effects of the angiotensin II receptor antagonist losartan on 24-hour blood pressure profiles of primary and secondary hypertensive rats. J. Cardiovasc. Pharmacol. 1995; 26: 214–221
- Pons M., Schnecko A., Witte K., Lemmer B., Waterhouse J., Cambar J. Circadian rhythms in renal function in hypertensive TGR(mREN2)27 rats and their normotensive controls. Am. J. Physiol. 1996; 271: R1002–R1009
- Bachmann S., Peters J., Engler E., Ganten D., Mullins J. Transgenic rats carrying the mouse rnin gene—morphological characterization of a low-renin hypertension model. Kidney Int. 1992; 41: 24–36
- Springate J., Feld L., Ganten A. Renal function in hypertensive rats transgenic for mouse renin. Am. J. Physiol. 1993; 266: F731–F737
- Gross V., Lippoldt A., Schneider W., Luft F. Effect of captopril and angiotensin II receptor blockade on pressure natriuresis in transgenic TGR(mREN2)27 rats. Hypertension 1995; 26: 471–479
- Lippoldt A., Gross V., Bohlender J., Ganten U., Luft F. Lifelong angiotensinconverting enzyme inhibition, pressure natriuresis, and renin-angiotensin system gene expression in transgenic (mREN2)27 rats. J. Am. Soc. Nephrol. 1996; 7: 2119–2129
- Nickenig G., Laufs U., Schnabel P., Knorr A., Paul M., Böhm M. Down-regulation of aortic and cardiac AT1 receptor gene expression in transgenic (mRen-2)27 rats. Br. J. Pharmacol. 1997; 121: 134–140
- National Institutes of Health, Guide for the Care and Use of Laboratory Animals, Available on line at: http://www.nap.edu/readingroom/books/labrats
- Lowry O., Rosebrough A., Farr A., Randall R. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265–275
- Mattes A., Witte K., Hohmann W., Lemmer B. PHARMFIT—a non-linear fitting program for pharmacology. Chronobiol. Int. 1991; 8: 460–476
- Ackermann H. BiAS-Biometrische Analysen von Stichproben. Epsilon Verlag Hochheim:, DarmstadtGermany 1997; Vers. 6.0
- Mitchell K., Jacinto S., Mullins J. Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am. J. Physiol. 1997; 273: F246–F253
- Amiri F., Garcia R. Renal angiotensin II receptor regulation in two-kidney, one clip hypertensive rats: effects of ACE inhibition. Hypertension 1997; 33: 337–344
- Zhuo J., Ohishi M., Mendelsohn F. A.O. Roles of AT1 and AT2 receptors in the hypertensive Ren-2 gene transgenic rat kidney. Hypertension 1999; 33: 347–353
- Adams B., Obertone T. S., Wang X., Murphy T. J. Relationship between internalization and mRNA decay in down-regulation of recombinant type 1 angiotensin II receptor (AT1) expression in smooth muscle cells. Mol. Pharmacol. 1999; 55: 1028–1036
- Chansel D., Bizet T., Vandermeersch S., Pham P., Levy B., Ardaillou R. Differential regulation of angiotensin II and losartan binding sites in glomeruli and mesangial cells. Am. J. Physiol. 1994; 266: F384–F393
- Lemmer B., Witte K., Schänzer A., Findeisen A. Circadian rhythms in the reninangiotensin-system and adrenal steroids may contribute to the inverse blood pressure rhythm in hypertensive TGR(mREN-2)27 rats. Chronobiol. Int. 2000; 17: 645–658