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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 22, 2005 - Issue 3
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Original

Inverse Blood Pressure Rhythm of Transgenic Hypertensive TGR(mREN2)27 Rats: Role of Norepinephrine and Expression of Tyrosine‐Hydroxylase and Reuptake1‐Transporter

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Pages 473-488 | Received 24 Feb 2005, Accepted 03 Apr 2005, Published online: 07 Jul 2009

References

  • Ackermann H. BIAS–Biometrische Analyse von Stichproben. Epsilon‐Verlag, Hochheim‐Darmstadt 1997
  • Böhm M., Castellano M., Flesch M., Maack C., Moll M., Paul M., Schiffer F., Zolk O. Chamber‐specific alterations of norepinephrine uptake sites in cardiac hypertrophy. Hypertension 1998; 32: 831–837
  • Brasch H., Sieroslawski L., Dominiak P. Angiotensin ll increases norepinephrine release form atria by acting on angiotensin suptype 1 receptors. Hypertension 1993; 22: 699–704
  • Chevillard C., Barden N., Saavedra J. M. Twenty‐four hour rhythm in monoamine oxidase activity in specific areas of the rat brain stem. Brain Res. 1983; 223: 205–209
  • Feldberg W., Lewis G. P. The action of peptides on the adrenal medulla. Releases of adrenalin by bradykinin and angiotensin. J. Physiol. 1964; 171: 98–108
  • Ferrario M. C. Neurogenic actions of angiotensin ll. Hypertension 1983; 5(Suppl V)V73–V79
  • Gelband C. H., Sumners C., Lu D., Raizada M. K. Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling. Regul. Pept. 1998; 73: 141–147
  • Kaschina E., Unger T. Angiotensin AT1/2 receptors: regulation, signalling and function. Blood Press. 2003; 12: 70–88
  • Khairallah P. A. Action of angiotensin on adrenergic nerve endings: inhibition of norepinephrine uptake. Fed. Proc. 1972; 31: 1351–1357
  • Kline R. L., Chow K. Z., Mercer P. F. Does enhanced sympathetic tone contribute to angiotensin hypertension in rats. Eur. J. Pharmacol. 1990; 184: 109–118
  • Lemmer B., Saller R. Influence of light and darkness on the turnover of noradrenaline in the rat heart. Naunyn‐Schmiedeberg's Arch. Pharmacol. 1974; 282: 75–84
  • Lemmer B., Wenda K. Diurnal rhythms in the noradrenaline turnover and motility after reserpine and 6‐hydroxydopamine. Pharmac. Biochem. Behav. 1979; 10: 361–368
  • Lemmer B., Portaluppi F. Chronopharmacology of cardiovascular diseases. Handbook of Experimental Pharmacology: Physiology and Pharmacology of Biological Rhythms, P. Redfern, B. Lemmer. Springer, New York 1997; 125: 251–297
  • Lemmer B., Mattes A., Böhm M., Ganten D. Circadian blood pressure variation in transgenic hypertensive rats. Hypertension 1993; 22: 97–101
  • Lemmer B., Witte K., Schänzer A., Findeisen A. Circadian rhythms in the renin‐angiotensin‐system and adrenal steroids may contribute to the inverse blood pressure rhythm in hypertensive TGR(mREN‐2)27 rats. Chronobiol. Int. 2000; 17: 645–658
  • Lemmer B., Rueff T., Reiter S., Huser L., Hauptfleisch S., Witte K. Influence of circadian time and age on glomerular angiotensin II receptors in normotensive Sprague‐Dawley and transgenic hypertensive TGR(mREN2)27 rats. Chronobiol. Int. 2001; 18: 447–459
  • Lemmer B., Witte K., Enzminger H., Schiffer S., Hauptfleisch S. Transgenic TGR(mREN2)27 rats as a model for disturbed circadian organisation at the level of the brain, the heart, and the kidneys. Chronobiol. Int. 2003; 20: 711–738
  • Lu D., Yu K., Paddy M. R., Rowland N. E., Raizada M. K. Regulation of norepinephrine transport system by angiotensin II in neuronal cultures of normotensive and spontaneously hypertensive rat brains. Endocrinology 1996; 137: 763–772
  • Mullins J. J., Peters J., Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse ren‐2 gen. Nature 1990; 344: 541–544
  • Nickenig G., Laufs U., Schnabel P., Knorr A., Paul M., Böhm M. Down‐regulation of aortic and cardiac AT1‐receptor gene expression in transgenic (mRen‐2)27 rats. Brit. J. Pharmacol. 1997; 121: 134–140
  • Pons M., Schnecko A., Witte K., Lemmer B., Waterhouse J. M., Cambar J. Circadian rhythms in renal functions in hypertensive TGR(mRen2)27 rats and their normotensive controls. Am. J. Physiol. Reg. Integrat. Comp. Physiol. 1996; 40: R1002–R1008
  • Schiffer S., Pummer S., Witte K., Lemmer B. Cardiovascular regulation in TGR(mREN2)27 rats: 24h variation in plasma catecholamines, angiotensin peptides and in telemetric heart rate variability. Chronobiol. Int. 2000; 18: 461–474
  • Spät A., Hunyady L. Control of aldosterone secretion: a model for convergence in cellular signaling pathways. Physiol. Rev. 2004; 84: 489–539
  • Tokita Y., Franco‐Saenz R., Mulrow P. J., Ganten D. Effects of nephrectomy and adreanlectomy on the renin‐angiotensin system of transgenic rats TGR(mRen2)27. Endocrinology 1994; 134: 253–257
  • Touitou Y., Portaluppi F., Smolensky M. H., Rensing L. Ethical principles and standards for the conduct of human and animal biological rhythm research. Chronobiol. Int. 2004; 21: 161–170
  • Witte K., Lemmer B. Development of inverse circadian blood pressure pattern in transgenic hypertensive TGR(mREN2)27 rats. Chronobiol. Int. 1999; 16: 293–303
  • Witte K., Huser L., Knotter B., Heckmann M., Schiffer S., Lemmer B. Normalisation of blood pressure in hypertensive TGR(mREN2)27 rats by amlodipine vs. enalapril: effects on cardiac hypertrophy and signal transduction pathways. Naunyn‐Schmiedeberg's Arch. Pharmacol. 2001; 363: 101–109
  • Witte K., Schnecko A., Buijs R. M., Vliet J., van der, Scalbert E., Delagrange Ph., Guardiola‐Lemaître B., Lemmer B. Effects of SCN‐lesions on circadian blood pressure rhythm in normotensive and transgenic hypertensive rats. Chronobiol. Int. 1998; 15: 135–145
  • Yu K., Lu D., Rowland N. E., Raizada M. K. Angiotensin II regulation of tyrosine hydroxylase gene expression in the neuronal cultures of normotensive and spontaneously hypertensive rats. Endocrinology 1996; 137: 3566–3576
  • Zhao Y., Bader M., Kreutz R., Fernandez‐Alfonso, Zimmermann F., Ganten U., Metzger R., Ganten D., Mullins J. J., Peters J. Ontogenetic regulation of mouse Ren‐2d renin gene in transgenic hypertensive rats, TGR(mREN2)27. Am. J. Physiol. 1993; 265: E699–E707
  • Zimmerman B. G. Actions of angiotensin on adrenergic nerve endings. Fed. Proc. 1978; 37: 199–202

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