Genetics of Hypertension: Lessons Learnt from Mendelian and Polygenic Syndromes

References

• Botstein D, Risch N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nat Genet 2003; 33(suppl)228–237, [PUBMED], [INFOTRIEVE]
   Google Scholar
• Alberts M J. Genetic aspects of cerebrovascular disease. Stroke 1991; 22: 276–280, [PUBMED], [INFOTRIEVE]
   Google Scholar
• Lifton R P, Gharavi A G, Geller D S. Molecular mechanisms of human hypertension. Cell 2001; 104: 545–556, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Lifton R P, Dluhy R G, Powers M, Rich G M, Cook S, Ulick S, Lalouel J M. A chimaeric 11 beta‐hydroxylase/aldosterone synthase gene causes glucocorticoid‐remediable aldosteronism and human hypertension. Nature 1992; 355: 262–265, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Shimkets R A, Lifton R P, Canessa C M. The activity of the epithelial sodium channel is regulated by clathrin‐mediated endocytosis. J Biol Chem 1997; 272: 25537–25541, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Wilson F H, Disse‐Nicodeme S, Choate K A, Ishikawa K, Nelson‐Williams C, Desitter I, Gunel M, Milford D V, Lipkin G W, Achard J M, Feely M P, Dussol B, Berland Y, Unwin R J, Mayan H, Simon D B, Farfel Z, Jeunemaitre X, Lifton R P. Human hypertension caused by mutations in WNK kinases. Science 2001; 293: 1107–1112, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Stewart P M, Corrie J E, Shackleton C H, Edwards C R. Syndrome of apparent mineralocorticoid excess. A defect in the cortisol‐cortisone shuttle. J Clin Invest 1988; 82: 340–349, [PUBMED], [INFOTRIEVE]
   Google Scholar
• Geller D S, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai F T, Sigler P B, Lifton R P. Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 2000; 289: 119–123, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Schuster H, Wienker T E, Bahring S, Bilginturan N, Toka H R, Neitzel H, Jeschke E, Toka O, Gilbert D, Lowe A, Ott J, Haller H, Luft F C. Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nat Genet 1996; 13: 98–100, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Baker E H, Dong Y B, Sagnella G A, Rothwell M, Onipinla A K, Markandu N D, Cappuccio F P, Cook D G, Persu A, Corvol P, Jeunemaitre X, Carter N D, MacGregor G A. Association of hypertension with T594M mutation in beta subunit of epithelial sodium channels in black people resident in London. Lancet 1998; 351: 1388–1392, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Levy D, DeStefano A L, Larson M G, O'Donnell C J, Lifton R P, Gavras H, Cupples L A, Myers R H. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension 2000; 36: 477–483, [PUBMED], [INFOTRIEVE]
   Google Scholar
• Erlich P M, Cui J, Chazaro I, Farrer L A, Baldwin C T, Gavras H, DeStefano A L. Genetic variants of WNK4 in whites and African Americans with hypertension. Hypertension 2003; 41: 1191–1195, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Anderson N H, Dominiczak A F. Genetic analysis of complex traits. Emery and Rimoin's: Principles and Practice of Medical Genetics, D L Rimoin, J M Connor, R E Pyeritz, B R Korf. Churchhill Livingstone. 2002; Vol. 1: 410–424, Chapter 12
   Google Scholar
• Jeunemaitre X, Soubrier F, Kotelevtsev Y V, Lifton R P, Williams C S, Charru A, Hunt S C, Hopkins P N, Williams R R, Lalouel J M. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992; 71: 169–180, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Wang J G, Staessen J A. Genetic polymorphisms in the renin‐angiotensin system: relevance for susceptibility to cardiovascular disease. Eur J Pharmacol 2000; 410: 289–302, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Staessen J A, Wang J G, Ginocchio G, Petrov V, Saavedra A P, Soubrier F, Vlietinck R, Fagard R. The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular‐renal risk. J Hypertens 1997; 15: 1579–1592, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• O'Donnell C J, Lindpaintner K, Larson M G, Rao V S, Ordovas J M, Schaefer E J, Myers R H, Levy D. Evidence for association and genetic linkage of the angiotensin‐converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998; 97: 1766–1772, [PUBMED], [INFOTRIEVE], [CSA]
   Google Scholar
• Higaki J, Baba S, Katsuya T, Sato N, Ishikawa K, Mannami T, Ogata J, Ogihara T. Deletion allele of angiotensin‐converting enzyme gene increases risk of essential hypertension in Japanese men: the Suita Study. Circulation 2000; 101: 2060–2065, [PUBMED], [INFOTRIEVE]
   Google Scholar
• Staessen J A, Wang J G, Brand E, Barlassina C, Birkenhager W H, Herrmann S M, Fagard R, Tizzoni L, Bianchi G. Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population. J Hypertens 2001; 19: 1349–1358, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Barbour V. UK Biobank: a project in search of a protocol?. Lancet 2003; 361: 1734–1738, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Samani N J. Genome scans for hypertension and blood pressure regulation. Am J Hypertens 2003; 16: 167–171, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   Google Scholar
• Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop M, Farrall M, Connell J. Genome‐wide mapping of human loci for essential hypertension. Lancet 2003; 361: 2123, [CROSSREF]
   Google Scholar
• Jacob H J, Kwitek A E. Rat genetics: attaching physiology and pharmacology to the genome. Nat Rev Genet 2002; 3: 33–42, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
   Google Scholar
• Dominiczak A F, Negrin D C, Clark J S, Brosnan M J, McBride M W, Alexander M Y. Genes and hypertension: from gene mapping in experimental models to vascular gene transfer strategies. Hypertension 2000; 35: 164–172, [PUBMED], [INFOTRIEVE], [CSA]
   Google Scholar
• McBride M W, Carr F J, Graham D, Anderson N H, Clark J S, Lee W K, Charchar F J, Brosnan M J, Dominiczak A F. Microarray analysis of rat chromosome 2 congenic strains. Hypertension 2003; 41: 847–853, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar
• Hayes J D, McLellan L I. Glutathione and glutathione‐dependent enzymes represent a co‐ordinately regulated defence against oxidative stress. Free Radic Res 1999; 31: 273–300, [PUBMED], [INFOTRIEVE], [CSA]
   Google Scholar
• Roses A D. Pharmacogenetics and the practice of medicine. Nature 2000; 405: 857–865, [PUBMED], [INFOTRIEVE], [CROSSREF]
   Google Scholar