50
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Iron-Mediated Cardiotoxicity Develops Independently of Extracellular Hydroxyl Radicals in Isolated Rat Hearts

, , &
Pages 19-28 | Published online: 22 Feb 1999

REFERENCES

  • Vernon D D, Banner W, Jr, Dean J M. Hemodynamic effects of experimental iron poisoning. Ann Emerg Med 1989; 18: 863–866
  • Anderson A C. Iron poisoning in children. Curr Opin Pediatr 1994; 6: 289–294
  • Stohs S J, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 1995; 18: 321–336
  • Meneghini R. Iron homeostasis, oxidative stress, and DNA damage. Free Radic Biol Med 1997; 23: 783–792
  • Lesnefsky E J. Tissue iron overload and mechanisms of iron-catalyzed oxidative injury. Adv Exp Med Biol 1994; 366: 129–146
  • Carmine T C, Evans P, Bruchelt G, et al. Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: Implications for therapeutic management. Cancer Lett 1995; 94: 219–226
  • Evans P J, Evans R W, Bomford A, Williams R, Halliwell B. Metal ions catalytic for free radical reactions in the plasma of patients with fulminant hepatic failure. Free Radic Res 1994; 20: 139–144
  • Bonkovsky H L, Ponka P, Bacon B R, Drysdale J, Grace N D, Tavill A S. An update on iron metabolism: Summary of the fifth international conference on disorders of iron metabolism. Hepatology 1996; 24: 718–729
  • Link G, Pinson A, Hershko C. Identification of thiolic sarcolemmal proteins as a primary target of iron toxicity in cultured heart cells. Adv Exp Med Biol 1994; 356: 267–276
  • Moreb J, Hershko C, Hasin Y. Effects of acute iron loading on contractility and spontaneous beating rate of cultured rat myocardial cells. Basic Res Cardiol 1988; 83: 360–368
  • Artman M, Olson R D, Boucek R J, Jr, Boerth R C. Depression of contractility in isolated rabbit myocardium following exposure to iron: Role of free radicals. Toxicol Appl Pharmacol 1984; 72: 324–332
  • Lesnefsky E J, Allen K G, Carrea F P, Horwitz L D. Iron-catalyzed reactions cause lipid peroxidation in the intact heart. J Mol Cell Cardiol 1992; 24: 1031–1038
  • Artman M, Olson R D, Boerth R C. Depression of myocardial contractility in acute iron toxicity in rabbits. Toxicol Appl Pharmacol 1982; 66: 329–337
  • Tenenbein M, Kopelow M L, deSa J. Myocardial failure and shock in iron poisoning. Human Toxicol 1988; 7: 281–284
  • Goldhaber J I, Weiss J N. Oxygen free radicals and cardiac reperfusion abnormalities. Hypertension 1992; 20: 118–127
  • Kadiiska M B, Burkitt M J, Xiang Q H, Mason R P. Iron supplementation generates hydroxyl radical in vivo: An ESR spin-trapping investigation. J Clin Invest 1995; 96: 1653–1657
  • Halliwell B, Gutteridge J M. Biologically relevant metal ion-dependent hydroxyl radical generation. An update. FEBS Lett 1992; 307: 108–112
  • Obata T, Hosokawa H, Yamanaka Y. In vivo monitoring of norepinephrine and hydroxyl free radical generation by ferrous iron in the myocardium with a microdialysis technique. Comp Biochem Physiol C 1993; 106: 635–638
  • Obata T, Yamanaka Y. Effect of iron (II) on the generation of hydroxyl free radicals in rat myocardium. Biochem Pharrnacol 1996; 51: 1411–1413
  • Gunther T, Vormann J, Hollriegl V. Effects of magnesium and iron on lipid peroxidation in cultured hepatocytes. Mol Cell Biochem 1995; 144: 141–145
  • Ceccarelli D, Gallesi D, Giovannini F, Ferrali M, Masini A. Relationship between free iron level and rat liver mitochondrial dysfunction in experimental dietary iron overload. Biochirn Biophys Res Commun 1995; 209: 53–59
  • Link G, Pinson A, Hershko C. Iron loading of cultured cardiac myocytes modifies sarcolemmal structure and increases lysosomal fragility. J Lab Clin Med 1993; 121: 127–134
  • Oubidar M, Marie C, Mossiat C, Bralet J. Effects of increasing intracellular reactive iron level on cardiac function and oxidative injury in the isolated rat heart. J Mol Cell Cardiol 1996; 28: 1769–1776
  • Powell S R, Wapnir R A. Adventitious redox-active metals in Krebs-Henseleit buffer can contribute to Langendorff heart experimental results. J Mol Cell Cardiol 1994; 26: 769–778
  • Buettner G R. Use of ascorbate as test for catalytic metals in simple buffers. Methods Enzymol 1990; 186: 125–127
  • Erickson M C, Hultin H O. Influence of histidine on lipid peroxidation in sarcoplasmic reticulum. Arch Biochem Biophys 1992; 292: 427–432
  • Cai Q, Takemura G, Ashraf M. Antioxidative properties of histidine and its effect on myocardial injury during ischemia/reperfusion in isolated rat heart. J Cardiovasc Pharmacol 1995; 25: 147–155
  • Bergmeyer H U, Bernt E. Lactate dehydrogenase. Methods of Enzymatic Analysis, H U Bergmeyer. Academic Press, New York 1974; 574–579
  • Buege J A, Aust S D. Microsomal lipid peroxidation. Oxygen Radicals in Biological Systems, Part B, Oxygen Radicals and Antioxidants, L Packer, A M Glazer. Academic Press, New York 1990; 302–310
  • Marcengill M B, Purl S, Puri S K, Mohanram A, Leonova E, Raymond R M, Watts J A. Antioxidant effects of pyruvate in isolated rat hearts. J Mol Cell Cardiol 1995; 27: 2059–2067
  • Floyd R A, Watson J J, Wong P K. Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products. J Biochem Biophys Methods 1984; 10: 221–235
  • Halliwell B, Kaur H, Ingelman-Sundberg M. Hydroxylation of salicylate as an assay for hydroxyl radicals: A cautionary note. Free Radic Biol Med 1991; 10: 439–441
  • Bolli R, Patel B S, Jeroudi M O, Li X Y, Triana J F, Lai E K, McCay P B. Iron-mediated radical reactions upon reperfusion contribute to myocardial “stunning.”. Am J Physiol 1990; 259: H1901–H1911
  • Takemura G, Onodera T, Ashraf M. Quantification of hydroxyl radical and its lack of relevance to myocardial injury during early reperfusion after graded ischemia in rat hearts. Circ Res 1992; 71: 96–105
  • Lesnefsky E J, Ye J. Exogenous intracellular, but not extracellular, iron augments myocardial reperfusion injury. Am J Physiol 1994; 266: H384–H392
  • Schlag M G, Clarke S, Carson M W, Harris K A, Potter R F. The role of intracellular hydroxyl radicals in ischemia/reperfusion injury. Shock 1997; 8: 65
  • Henderson B R. Iron regulatory proteins 1 and 2. BioEssays 1996; 18: 739–746
  • Link G, Pinson A, Hershko C. Heart cells in culture: A model of myocardial iron overload and chelation. J Lab Clin Mdd 1985; 106: 147–153
  • Parkes J G, Olivieri N F, Templeton D M. Characterization of Fe2+ and Fe3+ transport by iron-loaded cardiac myocytes. Toxicology 1997; 117: 141–151
  • Minotti G, Aust S D. Redox cycling of iron and lipid peroxidation. Lipids 1992; 27: 219–226
  • Tenenbein M. Benefits of parenteral deferoxamine for acute iron poisoning. J Toxicol Clin Toxicol 1996; 34: 485–489

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.