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Research Article

Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis

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Pages 715-757 | Published online: 26 Nov 2002

REFERENCES

  • De Haro L., Prost N., Perringue C., Arditti J., David J.M., Drouet G., Thomas M., Valli M. Intoxications par Champignons: Expérience du Centre Anti-Poisons de Marseille en 1994 et 1998. Bull. Épidémiol. Hebdomadaire 1999; 30: 1–8
  • Jacobs J., VonBehren J., Kreutzer R. Serious Mushroom Poisonings in California Requiring Hospital Admission, 1990–1994. West. J. Med. 1996; 165: 283–288
  • Litovitz T.L., Clark L.R., Soloway R.A. 1993 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 1994; 12(5)546–584
  • Litovitz T.L., Felberg L., Soloway R.A., Ford M., Geller R. 1994 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 1995; 13(5)551–597
  • Litovitz T.L., Felberg L., White S., Klein-Schwartz W. 1995 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 1996; 14(5)487–537
  • Litovitz T.L., Smilkstein M., Felberg L., Klein-Schwartz W., Berlin R., Morgan J.L. 1996 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 1997; 15(5)447–500
  • Litovitz T.L., Klein-Schwartz W., Dyer K.S., Shannon M., Lee S., Powers M. 1997 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 1998; 16(5)443–497
  • Litovitz T.L., Klein-Schwartz W., Caravati E.M., Youniss J., Crouch B., Lee S. 1998 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 1999; 17(5)535–587
  • Litovitz T.L., Klein-Schwartz W., White S., Cobaugh D.J., Youniss J., Drab A., Benson B.E. 1999 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am. J. Emerg. Med. 2000; 18(5)517–574
  • Persson H.E., Sjöberg G.K., Haines J.A., Pronczuk de Carbino J. Poisoning Severity Score. Grading of Acute Poisoning. Clin. Toxicol. 1998; 36(3)205–213
  • Trestail J.H. Mushroom Poisoning in the United States—An Analysis of 1989 United States Poison Center Data. Clin. Toxicol. 1991; 29(4)459–465
  • Bresinsky A., Besl H. A Colour Atlas of Poisonous Fungi. Wolfe Publishing Ltd., Stuttgart, Germany 1990; 295
  • Fanton L., Perrot D., Miras A., Achache P., Malicier D. Intoxications par les Champignons. Rev. Prat. 1995; 45: 1327–1332
  • Faulstich H., Zilker T. Amatoxins. Handbook of Mushroom Poisoning, Diagnosis and Treatment, D.G. Spoerke, B.H. Rumack. CRC Press, Inc., Boca Raton 1994; 233–248
  • Godfrank L.R. Mushrooms: Toxic and Hallucinogenic. Godfrank's Toxicologic Emergencies, L.R. Godfrank. Appleton & Lange, Norwalk, CT 1998; 1205–1219
  • Jaeger A., Vale J.A. Intoxications Aiguës. Elsevier, Paris 1999; 393–415
  • Kohn R., Motovska Z. Otrava Hubami—Klasifikacia, Symptomatoza a Liecba (Mushroom Poisoning—Classification, Symptomatology and Treatment). Vnitr. Lék. 1997; 43(4)230–233
  • Lambert H. Le Syndrome Phalloïdien. Les Intoxications Aiguës, Collection Anesthésie et Réanimation d'Aujourd'hui. Arnette, Paris, France 1993; 495–517
  • Lambert H., Larcan A. Intoxications par les Champignons. Encyclopédie Médico-Chirurgicale. Elsevier Publishers/Editions Scientifiques et Médicales, Paris, France 1989; Vol. 3: 1–14
  • Larcan A. A Propos de la Néphropathie Phalloïdienne. Presse Méd. 1999; 28(5)231
  • Vetter J. Toxins of Amanita phalloides (Review). Toxicon 1998; 36(1)13–24
  • Wiernikowski A., Sczepanek M. Zatrucie Muchomoren Sromotnikowym—Rozpoznawanie, Klinika, Leczenie (Amanita phalloides Poisoning—Diagnosis, Clinical Course, Treatment). Przegl. Lék. 1999; 56(6)450–454
  • Zachoval R., Günther C., Scheurlen C., Klüppelberg U.G., Zilker T., Pape G.R. Ein 27Jähriger Patient mit Wäßrigen Durchfällen, Ubelkeit und Erbrechen 10 h nach Genuß Eines Pilzgerichtes. Internist 1994; 35: 385–391
  • Fineschi V., Di Paolo M., Centini F. Histological Criteria for Diagnosis of Amanita phalloides Poisoning. J. Forensic Sci. 1996; 41(2)429–432
  • Ammirati J.F., Traquair J.A., Horgen P.A. Poisonous Mushrooms of Canada Including Other Inedible Fungi. Fitzhenry & Whiteside, Markham, Canada 1985; 396
  • Lincoff G.H. National Audubon Society Field Guide to North American Mushrooms. Alfred A. Knopf, New York 1998; 926
  • Enjalbert F., Cassanas G., Andary C. Variation in Amounts of Main Phallotoxins in Amanita phalloides. Mycologia 1989; 81(2)266–271
  • Enjalbert F., Gallion C., Jehl F., Monteil H., Faulstich H. Simultaneous Assay for Amatoxins and Phallotoxins in Amanita phalloides Fr. by High-Performance Liquid Chromatography. J. Chromatogr. A 1992; 598: 227–236
  • Enjalbert F., Gallion C., Jehl F., Monteil H., Faulstich H. Amatoxins and Phallotoxins in Amanita Species: High-Performance Liquid Chromatographic Determination. Mycologia 1993; 85(4)579–584
  • Wieland T. The Toxic Peptides from Amanita Mushrooms. Int. J. Pept. Protein Res. 1983; 22: 257–276
  • Wieland T., Faulstich H. Peptide Toxins from Amanita. Handbook of Natural Toxins, R.F. Keeler, A.T. Tu. Marcel Dekker, Inc., New York 1983; Vol. 1: 585–635
  • Faulstich H., Wieland T. New Aspects of Amanitin and Phalloidin Poisoning. Natural Toxins II. Advances in Experimental Medicine and Biology, B.R. Singh, A.T. Tu. Plenum Press, New York 1996; 309–314
  • Wieland T., Faulstich H. Fifty Years of Amanitin. Experientia 1991; 47: 1186–1193
  • Courtecuisse R., Duhem B. Guide des Champignons de France et d'Europe. Delachaux et Niestlé, Lausanne, Switzerland 2000; 476
  • Logemann H., Argueta J., Guzman G., Montoya Bello L., Bandela Munoz V., Leon Chocooj R. Evenamiento Mortal por Hongos en Guatemala. Rev. Mex. Micol. 1987; 3: 211–216
  • Trestail J.H. Mushroom Poisoning Case Registry: North American Mycological Association Report 1991. McIlvainea 1992; 10(2)51–59
  • Benjamin D.R. Mushrooms Poisons and Panaceas. Freeman, W.H. and Company, New York 1995; 422
  • Besl H. Amatoxins in Greenhouses, Galerina sulciceps, a Tropical Toxic Mushroom. Z. Mykol. 1981; 47(2)253–256, (Received 1982)
  • Singer R. The Agaricales in Modern Taxonomy. Koeltz Scientific Books, Koenigstein, Germany 1986; 981
  • Muraoka S., Fukamachi N., Mizumoto K., Shinozawa T. Detection and Identification of Amanitins in the Wood-Rotting Fungi Galerina fasciculata and Galerina helvoliceps. Appl. Environ. Microbiol. 1999; 65(9)4207–4210
  • Muraoka S., Shinozawa T. Effective Production of Amanitins by Two-Step Cultivation of the Basidiomycete, Galerina fasciculata GF-060. J. Biosci. Bioeng. 2000; 89(1)73–76
  • Pond S.M., Olson K.R., Woo O.F., Osterloh J.D., Ward R.E., Kaufman D.A., Moody R.R. Amatoxin Poisoning in Northern California, 1982–1983. West. J. Med. 1986; 145(2)204–209
  • Piqueras J. Nuevas Aportaciones al Conocimiento de la Etiologia, Fisiopatologia, Clinica y Terapeutica de las Intoxicaciones por Hongos Macromicetos Hepatotoxicos (Amanitas y Lepiotas). Universitat de Barcelona, Spain 1988; 519
  • Klan J. Prehleb hub Obsahujicich Amanitiny a Faloidiny (the Survey of Fungi Containing Amanitins and Phalloidins). Cas. Lék. Cesk. 1993; 132(15)449–451
  • Esteve-Ravantos F., Altés A. Tres Interesantes Lepiotas Toxicas en la Provincia de Madrid. Bol. Soc. Micol. Madrid 1990; 14: 161–168
  • Besl H., Mack P., Schmid-Heckel H. Gifpilze in den Gattungen Galerina und Lepiota (New Toxic Fungi in the Genera Galerina and Lepiota). Z. Mykol. 1984; 50(2)183–192
  • Gérault A. Les Champignons Supérieurs et Leurs Intoxications. Le Genre Lepiota (au sens Ancien Classique). Université de Rennes, France 1976; 302
  • Gérault A., Girre L. Recherches Toxicologiques sur le Genre Lepiota Fries. C. R. Acad. Sci. Paris 1975; 280(25)2841–2843
  • Gérault A., Girre L. Mise au Point sur les Intoxications par les Champignons Supérieurs. Bull. Soc. Mycol. Fr. 1977; 93(3)373–405
  • Piqueras J. Hepatotoxic Mushroom Poisoning: Diagnosis and Management. Mycopathologia 1989; 105: 99–110
  • Piqueras J. Terapeutica de la Intoxicacion por Amanita phalloides. Farm. Clin. 1992; 9(3)221–228
  • Brady L.R., Benedict R.G., Tyler D.E., Stuntz D.E., Malone M.H. Identification of Conocybe filaris as a Toxic Basidiomycete. Lloydia 1975; 38: 172–173
  • Bertault R. Amanites du Maroc. Bull. Soc. Mycol. Fr. 1965; 81: 345–371
  • Bertault R. Amanites du Maroc. Bull. Soc. Mycol. Fr. 1980; 96: 273–284
  • Flegg P.J. Mushroom Poisoning. Cent. Afr. J. Med. 1981; 27(7)125–129
  • Reid D.A., Eicker A. South African Fungi: The Genus Amanita. Mycol. Res. 1991; 95: 80–95
  • D'Agostino D.E., Garcia Roig C., Telenta M., Duca P., Steinberg C.E., de Santibanes E. Liver Transplantation in Amanita phalloides Intoxication. Hepatology 1998; 28: 744A, (2326)
  • Villegas M., Cifuentes J., Aroche R.M., Fuentes P. Primer Registro de Amanita phalloides en Mexico. Bol. Soc. Mex. Micol. 1982; 17: 140–146
  • Gurevich L.S., Zhurkovitch I.K. Toxins of Some Species of the Genus Amanita Pers. Mikol. Fitopatol. 1995; 29: 41–50
  • Lim J.G., Kim J.H., Lee S.I., Kim Y.S. Amanita virosa Induced Toxic Hepatitis: Report of Three Cases. Yonsei Med. J. 2000; 41(3)416–421
  • Omidynia E., Rashidpourai R., Quaderi M.T., Ameri E. Mycetismus in Hamadan of West Iran. Southeast Asian J. Trop. Med. Health 1997; 28: 438–439
  • Oztekin-Mat A. Les Intoxications par les Champignons en Turquie. Ann. Pharm. Fr. 1998; 56: 233–235
  • Seeger R., Stijve T. Occurrence of Toxic Amanita Species. Amatoxin, Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 3–17
  • Ying J., Mao X., Ma Q., Zong Y., Wen H. Icones of Medicinal Fungi from China. Science Press, Beijing, China 1987; 575
  • Yin W., Yang Z.R. A Clinical Analysis of Twelve Patients with Galerina autumnalis Poisoning. Chung-hua Nei K'o Tsa Chih 1993; 32(12)810–812
  • Zu Y. Acute Mushroom Poisoning with Amanita virosa. Chung-hua Yu Fang I Hsueh Tsa Chih 1987; 21(6)335–337
  • Edward J.N., Henry J.A. Medical Problems of Mushroom Ingestion. Mycologist 1989; 3(1)13–16
  • Pegler D.N., Watling R. British Toxic Fungi. Bull. Br. Mycol. Soc. 1982; 16: 66–75
  • Barbato M.P. Poisoning from Accidental Ingestion of Mushrooms. Med. J. Aust. 1993; 158: 842–847
  • Cole F.M. Amanita phalloides in Victoria. Med. J. Aust. 1993; 158(12)849–850
  • Trim G.M., Lepp H., Hall M.J., McKeown R.V., McCaughan G.W., Duggin G.G., Le Couteur D.G. Poisoning by Amanita phalloides (“deathcap”) Mushrooms in the Australian Capital Territory. Med. J. Aust. 1999; 171(5)247–249
  • Chaiear K., Limpaiboon R., Meechai C., Poovorawan Y. Fatal Mushroom Poisoning Caused by Amanita virosa in Thailand. Southeast Asian J. Trop. Med. Public Health 1999; 30(1)157–160
  • Hanrahan J.P., Gordon M.A. Mushroom Poisoning: Case Reports and a Review of Therapy. J. Am. Med. Assoc. 1984; 251(8)1057–1061
  • Olson K.R., Pond S.M., Sewards J., Healey K., Woo F., Becker C.E. Amanita phalloides-Type Mushroom Poisoning. West. J. Med. 1982; 137(4)282–289
  • Bauchet J.M. Poisoning Said to Be Due to Galerina unicolor. Bull. Br. Mycol. Soc. 1983; 17: 51
  • Furia A., Bernicchia A., Alberton F. Intossicazione Parafalloidea da Lepiota brunneoincarnata. Micol. Ital. 1982; 3: 29–33
  • Calonge F.D., Lopez-Herce J.A. Tres Casos de Envenenamiento Grave en Madrid por Ingestion de Lepiota brunneo-incarnata Chodat & Martin (Three Cases of Poisoning by Lepiota brunneo-incarnata Chodat & Martin in Madrid). Bol. Soc. Micol. Madrid 1987; 11(2)287–290
  • Gúzman G. Un Caso Especial de Evenamiento Mortal Producido por Hongos en el Estado de Veracruz. Rev. Mex. Micol. 1987; 3: 203–209
  • McClain J.L., Hausse D.W., Clark M.A. Amanita phalloides Mushroom Poisoning: A Cluster of Four Fatalities. J. Forensic Sci. 1989; 34: 83–87
  • Boudjema K., Wolf P., Burtscher A., Juif J.G., Steib A., Ellero B., Jaeck D., Cinqualbre J. Hépatite Fulminante par Intoxication Phalloïdienne. Une Indication d'Allotransplantation Hépatique. Presse Méd. 1989; 18(18)937
  • Isiloglu M., Watling R. Poisoning by Lepiota helveola Bres. in Southern Turkey. Edinb. J. Bot. 1991; 48(1)91–100
  • Paydas S., Kocak R., Erturk F., Erken E., Zaksu H.S., Gurcay A. Poisoning Due to Amatoxin-Containing Lepiota Species. Br. J. Clin. Pharmacol. 1990; 44(11)450–453
  • Ronzoni G., Vesconi S., Radrizzani D., Corbetta C., Langer M., Iapichino G. Guarigione Dopo Intossicazione Grave da Funghi Selvatici (Encefalopatia di IV Grado) con Sola Terapia Medica Intensiva e Senza Trapianto di Fegato Caso Clinico. Minerva Anestesiol. 1990; 57: 383–387
  • Pérez-Moreno J., Pérez-Moreno A., Ferrara-Cerrato R. Multiple Fatal Mycetism Caused by Amanita virosa in Mexico. Mycopathologia 1994; 125(1)3–5
  • Pérez-Moreno J., Ferrera-Cerrato R. A Review of Mushroom Poisoning in Mexico. Food Addit. Contam. 1995; 12(3)355–360
  • Meunier B.C., Camus C.M., Houssin D.P., Messner M.J.M., Gérault A.M., Launois B.G. Liver Transplantation After Severe Poisoning Due to Amatoxin-Containing Lepiota—Report of Three Cases. Clin. Toxicol. 1995; 33(2)165–171
  • , Kern, C.; Zilker, T.; Van Clarman, M. Successful Liver-Transplantation in a Child After Amanita Poisoning. Congress of Anti-Poisons Centre, Istanbul, Turkey, May 24–27, 1992; 37.
  • Beckurts K.T.E., Hölscher A.H., Heidecke C.D., Zilker T.R., Natrath W., Siewert J.R. Die Rolle der Lebertransplantation im Behandlungskonzept des Akuten Leberversagens nach Knollenblätterpilzvergiftung (The Place of Liver Transplantation in the Treatment of Acute Liver Failure Caused by Amanita phalloides Poisoning). Dtsch. Med. Wochenschr. 1997; 122: 351–355
  • O'Brien B.L., Khuu L. A Fatal Sunday Brunch: Amanita Mushroom Poisoning in a Gulf Coast Family. Am. J. Gastroenterol. 1996; 91(3)581–583
  • Zevin S., Dempsey D., Olson K. Amanita phalloides Mushroom Poisoning—Northern California, January 1997. Morb. Mortal. Wkly Rep. 1997; 46(22)489–492
  • Skaare V.K. Mushroom Poisoning: An Indication for Liver Transplantation. J. Transplant. Coord. 1997; 7(3)141–143
  • Scocco P., Rupolo G., De Leo D. Failed Suicide by Amanita phalloides (Mycetismus) and Subsequent Liver Transplant: Case Report. Arch. Suicide Res. 1998; 4: 201–206
  • Cochran K.W. 1999 Annual Report of the North American Mycological Association's Mushroom Poisoning Case Registry. McIlvainea 2000; 14(2)34–40
  • Chiossi M., Di Pietro P., Marchi A., Messi G., Gallone G., Peisino M.G. Mushroom Poisoning in Children. Vet. Hum. Toxicol. 1993; 35(4)331
  • Elonen E., Härkönen M. Myrkkynääpikän (Galerina marginata) Aiheuttama Myrkytys (Poisoning with Galerina marginata). Duodecim 1978; 94: 1050–1053
  • Belliardo F., Massano G., Accomo S. Amatoxins Do Not Cross the Placental Barrier. Lancet 1983; 1: 1381
  • Kendrick B., Shimizu A. Mushroom Poisoning—Analysis of Two Cases and a Possible New Treatment, Plasmapheresis. Mycologia 1984; 76(3)448–453
  • Fort J., Rodriguez J.A., Cantarell C., Bartolomé J., Boveda J.L., Olmos A., Piera L. Plasmaseparacion en la Intoxicacion por Amanita phalloides. Med. Clin. (Barc.) 1984; 82: 748–775
  • Boron P., Prokopowicz D., Miegoc H. Plazmafereza w Leczeniu Zatruc Grzybami (Plasmapheresis in the Treatment of Poisoning with Mushrooms). Pol. Tyg. Lék. 1987; XLII(39)1215–1219
  • DeSilvestro G., Marson P., Brandolese R., Pittoni G., Ongaro G. A Single Institution's Experience (1982–1999) with Plasma-Exchange Therapy in Patients with Fulminant Hepatic Failure. Int. J. Artif. Organs 2000; 23(7)454–461
  • Ohrn M., Jörgensen B., Gréen K., Karlson-Stiber C., Persson H. Amatoxinanalys vid Svampförgiftning (Amatoxin Analysis in Mushroom Poisoning). Laekartidningen 1987; 84(34)2581–2583
  • Klein A.S., Hart J., Brems J.J., Goldstein L., Lewin K., Busuttil R.W. Amanita Poisoning: Treatment and the Role of Liver Transplantation. Am. J. Med. 1989; 85: 187–193
  • Pouyet M., Caillon P., Ducerf C., Berthaud S., Bouffard Y., Delafosse B., Thomasson A., Pignal C., Pulce C. Transplantation Orthotopique du Foie pour Intoxication Grave par Amanite Phalloïde. Presse Méd. 1991; 20(41)2095–2098
  • Gazzero R.C., Goos R.D. A Case of Mushroom Poisoning Involving Amanita virosa. McIlvainea 1991; 10(1)45–46
  • Pelclova D., Rakovcova H. Intoxikace Houbou Amanita phalloides v Dotazech Toxikologickeho Informacniho Strediska v Praze (Mushroom Amanita phalloides in the Inquiries of the Poison Information Centre). Cas. Lék. Cesk. 1993; 132: 470–472
  • Doepel M., Isoniemi H., Salmela K., Penttilä K., Höckerstedt K. Liver Transplantation in a Patient with Amanita Poisoning. Transplant. Proc. 1994; 26(3)1801–1802
  • , Karakullukçu, F.; Besler, M.; Yurdun, T.; Sifoglu, Z.; Yuksel, K.; Hacikaptan, E.; Onsun, K.; Karakullukçu, B. Hemoperfusion Is Life Saving in Amanita phalloides Intoxication. XXXIIIrd Congress of EDTA, Amsterdam, Holland, 1996; 316.
  • Trestail J.H. Mushroom Poisoning Case Registry: NAMA Report 1995. McIlvainea 1996; 12(2)98–104
  • Yamada E.G., Mohle-Boetani J., Olson K.R., Werner S.B. Mushroom Poisoning Due to Amatoxin. West. J. Med. 1998; 169: 380–384
  • Langer M., Gridelli B., Piccolo G., Markovic S., Quarenghi E., Gatti S., Ghio L., Ginevri F. A Liver-Transplant Candidate (Fulminant Hepatic Failure from Amanita phalloides Poisoning) as a Multiorgan Donor. Transplant. Proc. 1997; 29: 3343–3344
  • Splendiani G., Zazzaro D., Di Pietrantonio P.D., Delfino L. Continuous Renal Replacement Therapy and Charcoal Plasmaperfusion in Treatment of Amanita Mushroom Poisoning. Artif. Organs 2000; 24(4)305–308
  • Pomerance H.H., Barness E.G., Kobli-Kumar M., Arnold S.R., Steigelfest J. A 15-Year-Old Boy with Fulminant Hepatic Failure. J. Pediatr. 2000; 137(1)114–118
  • Jaros F. Incidence of Fungal Intoxications Including Amanita phalloides in Last Four Decades in the District of Trencia in Slovakia. Ceska Mykol. 1992; 46(3–4)256–262, (Received 1993)
  • Jaros F., Simurka P., Ehsanova M. Incidencia, Sucasna Liecba a Prognoza Otrav Hubami u Deti a Dospelych (Incidence, Contemporary Treatment and Prognosis of Mushroom Poisoning in Children and Adults). Cs. Pediatr. 1998; 53(2)90–93
  • Cosme Jimenez A., Zabaleta Arrizabalaga S., Izaguirre Boneta A., Diago Ferrero A., Alzate Saez de Heredia L.F., Orive Cura V., Arenas Mirave J.I. Intoxication no Mortal por Amanita phalloides. A Proposito de dos Casos. Rev. Clin. Esp. 1983; 171(4)261–264
  • Montanini S., Sinardi D., Pratico C., Sinardi A.U., Trimarchi G. Use of Acetyl-Cysteine as the Life-Saving Antidote in Amanita phalloides (Death Cap) Poisoning. Case Report on 11 Patients. Arzneim.-Forsch. 1999; 49(12)1044–1047
  • Kacic M., Dujsin M., Puretic Z., Slavicek J. Micetizam u Djece-u Povodu Jedne Epidemije Otrovanja (Mycetismus in Children, with Special Reference to One Outbreak of Mushroom Poisoning). Lijec. Vjesn. 1990; 112(11–12)369–373
  • Trestail J.H. Mushroom Poisoning Case Registry: NAMA Report 1994. McIlvainea 1995; 12(1)68–73
  • Rosenthal P., Roberts J.P., Ascher N.L., Edmond J.C. Auxiliary Liver Transplant in Fulminant Failure. Pediatrics 1997; 100(2)100–111
  • Rosenthal P.R. Auxiliary Liver Transplantation for Toxic Mushroom Poisoning. J. Pediatr. 2001; 138(3)449
  • Beaudreuil S., Sharobeem R., Maître F., Karsenti D., Crezard O., Pierre D. Toxicité Rénale de L'amanite phalloïde. Une Observation avec Ponction Biopsie Rénale. Presse Méd. 1998; 27(28)1434
  • Cochran K.W. 1998 Annual Report of the North American Mycological Association's Mushroom Poisoning Case Registry. McIlvainea 1999; 14(1)93–98
  • Gimson A.E.S., Braude S., Mellon P.J., Canalese J. Earlier Charcoal Haemoperfusion in Fulminant Hepatic Failure. Lancet 1982; 681–683
  • Horn K.D., Wax P., Schneider S.M., Martin T.G., Nine J.S., Moraca M.A., Virji M.A., Aronica P.A., Rao K.N. Biomarkers of Liver Regeneration Allow Early Prediction of Hepatic Recovery After Acute Necrosis. Am. J. Clin. Pathol. 1999; 112: 351–357
  • , Butera, R.; Locatelli, C.; Maccarini, D.; Candura, S.M.; Manzo, L. Emploi de la N-Acetylcystéine dans L'intoxication par Amanita phalloides: Résultats Cliniques. Résumés des Communications. XXXIème Congrès de la Société de Toxicologie Clinique, Nancy, France, Sept 16–17, 1993; 29.
  • Dolfi F., Gonnella R. Intossicazione Acuta da Amanita phalloide nel Secondo Trimestre di Gravidenza. Minerva Anestesiol. 1994; 60: 153–154
  • Hruby K. Knollenblätterpilzvergiftung. Intensivmedizin 1987; 24: 269–274
  • , Hruby, K. Treatment of Death Cap Fungus with Silibinin. 10th Congress of the International Society for Human and Animal Mycology, Barcelona, Spain, Jun 1988; 361–363.
  • Plackova S., Caganova B. Acute Intoxications by Mushrooms and Plants in Slovakia. Clin. Toxicol. 1998; 36: 452–453
  • Zilker T.R., Felgenhauer N.J., Michael H., Strange-Hesse A. Grading of Severity and Therapy of 154 Cases of Amanita Poisoning. Vet. Hum. Toxicol. 1993; 35(4)331
  • Russo G.E., Giusti S., Maurici M., Bosco M., Vitaliano E., Caramiello M.S., Bauco B., De Marco C.M., Marigliano V. Plasmapheresi e Avvelenamento da Funghi: Presentazione di un Caso di Intossicazione da Amanita phalloides. Clin. Ter. 1997; 148(5–6)277–280
  • Plotzker R., Jensen D.M., Payne J.A. Case Report Amanita virosa Acute Hepatic Necrosis: Treatment with Thioctic Acid. Am. J. Med. Sci. 1982; 283(2)79–81
  • Bektas H., Schlitt H.J., Böker K., Brunkhorst R., Oldhafer K.J., Pichlmayr R. Indikationsstellung zur Lebertransplantation bei Schwerer Knollenblätterpilzvergiftung (Indication for Liver Transplantation in Severe Amanita phalloides Mushroom Poisoning). Chirurg 1996; 67: 996–1001
  • Pehlivanoglu E., Lawrence R.A., Canpolat C. Treatment of Amanita phalloides Intoxication. A Report of 3 Cases and Review of the Literature. Int. Pediatr. 1991; 6(4)366–370
  • Aji D.Y., Caliskan S., Nayir A., Mat A., Can B., Yasar Z., Ozsahin H., Cullu F., Sever L. Haemoperfusion in Amanita phalloides Poisoning. J. Trop. Pediatr. 1995; 41: 371–374
  • Favarel-Garrigues J.C., Saric J., Janvier F., Wickers F., Masson B., Winnock S., Couzigou P., Lugrin D., Penouil F., De Mascarel A. Intoxication Phalloïdienne Grave—Transplantation Hépatique: Un Recours Possible (à Propos d'une Observation). Soc. Fr. Toxicol. 1988; 8: 62
  • Rangé Grasland L. Intoxication Volontaire par L'amanite phalloïde (à Propos d'un Cas). Université de Rennes 1, France 1986; 96
  • Pescador Guiral C. Intoxications Phalloïdiennes: À Propos de 29 Cas Recensés par le Centre Anti-Poisons de Toulouse Entre 1983 et 1994. Propositions Thérapeutiques. Université de Toulouse III, France 1995; 179
  • Cappell M.S., Hassan T. Gastrointestinal and Hepatic Effects of Amanita phalloides Ingestion. J. Clin. Gastroenterol. 1992; 15(3)225–228
  • Feinfeld D.A., Mofenson H.C., Caraccio T., Kee M. Poisoning by Amatoxin-Containing Mushrooms in Suburban New York—Report of Four Cases. Clin. Toxicol. 1994; 32(6)715–721
  • Mullins M.E., Horowitz B.Z. The Futility of Hemoperfusion and Hemodialysis in Amanita phalloides Poisoning. Vet. Hum. Toxicol. 2000; 42(2)90–91
  • Saltik I.N., Soysal A., Sarikayalar F., Topalgu R., Gurakan F. Amanita Poisoning in a Child Treated with Plasma Exchange. Indian Pediatr. 2000; 37: 1028–1029
  • Locatelli C., Maccarini D., Ferruzi M., Olibet G., Ruggerone M.L. Intossicazioni Acute da Amanita phalloides: Proposta di Terapia con N-Acetilcisteina. Ann. Mus. Civ. Rovereto 1989; 4(1988, Suppl.)211–212
  • Locatelli C., Travaglia A., Sala G., Maccarini D., Ruggerone M.L. Ruolo Dell' N-Acetilcisteinia e Della Diuresi Forzata nel Trattamento Dell'intossicazione Falloidea: Casistica Clinica. Minerva Anestesiol. 1990; 56: 1361–1363
  • Locatelli C., Maccarini D., Travaglia A., Manzo L. Prolonged High Dose N-Acetylcysteine Treatment of Amanita phalloides and Chlorinated Hydrocarbon Poisoning. Pharmacol. Res. 1992; 26: 201
  • , Gayol, S.; Tournoud, C.; Flesch, F.; Berton, C.; Rusterholtz, T.; Raguin, O.; Liegeon, M.N.; Sauder, P.; Jaeger, A. Amatoxin Poisoning Due to Lepiota brunneoincarnata. Congrès Européen de Toxicologie, Marseille, France, Jun 4–7, 1966; 14.
  • Pertile N., Galliani E., Vergerio A., Turrin A., Caddia V. Sindrome Falloidea-Descrizione di un Caso in Una Bambina di due Anni. Ped. Med. Chr. (Med. Surg. Ped.) 1990; 12: 411–414
  • Benvenuto V. Intoxication Phalloïdienne: Aspects Botanique, Toxicologique, Clinique, Thérapeutique et Préventif. Université de Saint Etienne, France 1989; 172
  • Sabeel A.I., Kurkus J., Lindholm T. Intensive Hemodialysis and Hemoperfusion Treatment of Amanita Mushroom Poisoning. Mycopathologia 1995; 131: 107–114
  • Daya M.R., Norton R.L., Fields R.D., Kao R., Lake J.R., Ascher N.L., Pinson C.W., Benner K.G., Keefe E.B. Liver Transplantation in Amanita phalloides Poisoning. Vet. Hum. Toxicol. 1989; 31(4)360
  • Pinson C.W., Daya M.R., Benner K.G., Norton R.L., Deveney K.E., Ascher N.L., Roberts J.P., Lake J.R., Kurkchubasche A.G., Ragsdale J.W., Alexander J.P., Keefe E.B. Liver Transplantation for Severe Amanita phalloides Mushroom Poisoning. Am. J. Surg. 1990; 159: 493–499
  • Iivanainen A., Valtonen Ja Pertti M., Pentikäinen J. Sienimyrkytys—Syksyn Sairaus (Mushroom Poisoning—A Disease of Autumn). Duodecim 1989; 105(15)1313–1317
  • Madsen S., Jenssen K.M. Forgiftning Med Hvit Fluesopp (Amanita virosa)—Symptomer, Diagnose og Behandling. Tidsskr. Nor. Laegeforen. 1990; 110(14)1828–1829
  • Schiodt F.V., Ott P., Bondesen S. Forgiftning Med Gron og Hvid Fluesvamp pä en Hepatologisk Specialafdeling, 1989–1994 (Poisoning with Amanita phalloides and Amanita virosa Treated at a Department of Hepatology, 1989–1994). Ugeskr. Laeg. 1995; 157(31)4350–4354
  • Nieter B., Frille J. Plasmaaustausch bei Knollenblätterpilzvergiftung (Plasma Exchange in Amanita phalloides Mushroom Poisoning—A Case Report). Nieren-Hochdruckkr. 1992; 21(1)8–10
  • Scheurlen C., Spannbrucker N., Spengler U., Zachoval R., Schulte-Witte H., Brensing K.A. Amanita phalloides Intoxications in a Family of Russian Immigrants. Case Reports and Review of the Literature with a Focus on Orthotopic Liver Transplantation. Z. Gastroenterol. 1994; 32: 399–404
  • Rambousek V., Janda J., Sikut M. Severe Amanita phalloides Poisoning in a 7-Year-Old Girl. Cesk. Pediatr. 1993; 48(6)332–333
  • Christen Y., Minazio P., de Moerloose P. Monitoring of Haemostatic Parameters in Five Cases of Amanita phalloides Poisoning. Blood Coagul. Fibrinolysis 1993; 4: 627–630
  • Serné E.H., Toorians A.W.F.T., Gietema J.A., Bronsveld W., Haagsma E.B., Mulder P.O.M. Amanita phalloides, a Potentially Lethal Mushrooms: Its Clinical Presentation and Therapeutic Options. Neth. J. Med. 1996; 49(1)19–23
  • Jaros F., Kascak M. Incidencia a Sucasna Liecba Cytotoxickych Cyclopeptidovych (Faloidnych) Otrav u Gravidnych Zien (Incidence and Contemporary Treatment of Cytotoxic Cyclopeptide (Phalloid) Intoxications in Pregnant Women). Vnitr. Lék. 1996; 42(6)414–417
  • Carducci R., Armellino M.F., Volpe C., Basile G., Caso N., Apicella A., Basile V. Silibinina e Intossicazione Acuta da Amanita phalloides. Minerva Anestesiol. 1996; 62(5)187–193
  • Alves A., Ferreira M.G., Paulo J., França A., Carvalho A. Mushroom Poisoning with Amanita phalloides. Eur. J. Int. Med. 2001; 12: 64–66
  • Marugg D., Reutter F.W. Die Amanita phalloides-Intoxication Moderne Therapeutische Massnahmen und Klinischer Verlauf (Amanita phalloides Poisoning—Modern Therapeutic Procedures and Clinical Course). Schweiz. Rundsch. Med./Prax. 1985; 74(37)972–982
  • Hofer J.F., Egermann G., Mach K., Sommer K. Therapie der Knollenblät-Terpilzergiftung mit Silibinin in Kombination mit Penicillin und Cortison. Wien. Klin. Wochenschr. 1983; 95(7)240–243
  • Hallas J., Jensen K. Forgiftning Med Gron Fluesvamp. Ugeskr. Laeg. 1988; 150(16)975–978
  • Molling J., Pohle W., Klein H., Welte T. Stellenwert Therapeutischer Maßnahmen bei Vergiftung mit dem Grünen Knollenblätterpilz (The Different Stages in the Treatment of Amanita phalloides Poisoning). Intensivmedizin 1995; 32(1)37–42
  • Homann J., Rawer P., Bleyl H., Matthes K.J., Heinrich D. Early Detection of Amatoxins in Human Mushroom Poisoning. Arch. Toxicol. 1986; 59: 190–191
  • Bourgeois F., Bourgeois N., Gelin M., Van de Stadt J., Doutrelepont J.M., Adler M. Hépatite Aiguë et Intoxication à L'amanite Phalloïde. Acta Gastroenterol. Belg. 1992; LV: 358–363
  • , Soyez, C.; Autret, E.; Laugier, J.; Broué P.; Crèche, J. Intoxication Familiale par Lepiota helveola. Résumés des Communications. XXXIème Congrès de la Société de Toxicologie Clinique, Nancy, France, Sept 16–17, 1993; 28.
  • Jankowska I., Malenta G., Rysko J., Socha J., Wozniewicz M. Analiza Kliniczno–Morfologiczna Dzieci Zmarlych z Powodu Zatrucia Muchomorem Sromotnikowym (The Clinical–Morphological Analysis of Children Dying of Intoxication with Amanita phalloides). Wiad. Lék. 1992; XLV: 21–22
  • Ryzko J., Jankowska I., Socha J. Ostra Nierwydolnosci Watroby po Zatruciu Muchomorem Sromotnikowym (Acute Hepatic Liver Failure After Poisoning with Amanita phalloides). Wiad. Lék. 1987; 40(21)1453–1458
  • , Socha, J. Mushroom Poisoning in Children. 10th International Congress of the Society for Human and Animal Mycology, Barcelona, Spain, June, 1988; 356–360.
  • Pach J., Zajac J.J., Chrostek-Maj J., Wiernikowski A. Porownanie Skutecznosci Rosnych Modeli Postepowania Leczniczego w Ostrym Zatruciu Muchomorem Sromotnikowym (Comparison of the Effectiveness of Various Models of Therapeutic Man Amanita Poisoning). Pol. Tyg. Lék. 1987; XLII(11)322–324
  • Ponikvar R., Drinovec J., Kandus A., Varl J., Gucek A., Malovrh M. Plasma Exchange in Management of Severe Acute Poisoning with Amanita phalloides. Apher 1990; 327–329
  • Jankowska I., Grenda R., Rysko J., Litwin M., Prokurat S., Rychlik G., Smirska E., Kaliszan A., Socha J. Ocena Przydatnosci Plazmaferezy w Leczeniu Zatruc Muchomorem Sromotnikowym (Evaluation de la Plasmaphérèse dans le Traitement de l'intoxication par Amanita phalloides). Pol. Tyg. Lék. 1993; XLVII(18–19)427–429
  • Bartoloni St Omer F., Giannini A., Botti P., Caramelli L., Ledda F., Peruzzi S., Zorn M. Amanita Poisoning: A Clinical–Histopathological Study of 64 Cases of Intoxication. Hepatogastroenterology 1985; 32: 229–231
  • Fantozzi R., Ledda F., Caramelli L., Moroni F., Blandina P., Masini E., Botti P., Peruzzi S., Zorn M., Mannaioni P.F. Clinical Findings and Follow-Up Evaluation of an Outbreak of Mushroom Poisoning—Survey of Amanita phalloides Poisoning. Klin. Wochenschr. 1986; 64: 38–43
  • Piering W.F., Bratanow N. Role of the Clinical Laboratory in Guiding Treatment of Amanita virosa Mushroom Poisoning: Report of Two Cases. Clin. Chem. 1990; 36(3)571–574
  • Iliev Y., Andonova S., Akabaliev V. Our Experience in the Treatment of Acute Amanita phalloides Poisoning. Folia Med. 1999; XLI(4)30–37
  • Mydlik M., Derzsiova K., Mizla P., Beno P. Pouzitie Hemoperfuzie pri Otrave Hubami. Klinicky Rozbor 58 Chorych (Use of Haemoperfusion in Mushroom Poisoning. Clinical Analysis of 58 Patients). Cas. Lék. Cesk. 1993; 132(15)464–466
  • Buffoni L., Chiossi M., De Santis L., Galletti A., Lattere M., Pesce F., Reboa E., Renna S., Rosati U., Tarateta A., Tasso L. l'Avvelenamento nell'Infanzia da Amanita velenosa “Mortale”. Minerva Pediatr. 1986; 38: 1155–1179
  • Sanz P., Reig R., Borras L., Martinez J., Manez R., Corbella J. Disseminated Intravascular Coagulation and Mesenteric Venous Thrombosis in Fatal Amanita Poisoning. Hum. Toxicol. 1988; 7: 199–201
  • Sanz P., Reig R., Piqueras J., Marti G., Corbella J. Fatal Mushroom Poisoning in Barcelona, 1986–1988. Mycopathologia 1989; 108: 207–209
  • Sese Torres J., Piqueras Carrasco J., Morlans Molina G. Intoxicacion por Amanita phalloides: Diagnostico por Radioinmunoanalisis y Tratamiento con Diuresis Forzada (Poisoning with Amanita phalloides. Diagnosis by Radioimmunoassay and Treatment with Forced Diuresis). Med. Clin. 1985; 84(16)660–662
  • Vesconi S., Langer M., Iapichino G., Constantino D., Busi C., Fiume L. Therapy of Cytotoxic Mushroom Intoxication. Crit. Care Med. 1985; 13: 402–406
  • Capellaro L., Lupo F., Tiboldo F., Belotti M.T., Spagarino E. Esperienza Riguardo All'uso Della Plasmaferesi in Patologie di Interesse Rianimatorio. Minerva Med. 1987; 78: 1565–1570
  • Lopez A., Jerez V., Rebollo J., Lombardo A.G., Julia J.A. Fulminant Hepatitis and Liver Transplantation. Ann. Intern. Med. 1988; 108: 769
  • Ramirez P., Parrilla P., Bueno F.S., Robles R., Pons J.A., Bixquert V., Nicolas S., Nunez R., Alegria M.S., Miras M., Rodriguez J.M. Fulminant Hepatic Failure After Lepiota Mushroom Poisoning. J. Hematol. 1993; 19: 51–54
  • Castiella A., Lopez Dominguez L., Txoperena G., Cosme A., Aramburu V., Arenas J.I. Indication de la Transplantation du Foie en Cas d'Intoxication par Amanite Phalloïde. Presse Méd. 1993; 22(4)177
  • Van Cauter J., Quarre J.P., Demay M., Pollart C., Ligny C. Intoxication Familiale par Amanite Phalloïde. Acta Gastroenterol. Belg. 1984; XLVII: 47–54
  • Boyer J.C., Hernandez F., Estorc J., De La Coussaye J.E., Bali J.P. Management of Maternal Amanita phalloides Poisoning During the First Trimester of Pregnancy: A Case Report and Review of the Literature. Clin. Chem. 2001; 47(5)971–974
  • Perrier A.L. Syndrome Phalloïdien: à Propos d'une Intoxication chez la Femme Enceinte à Treize Semaines d'Aménorrhée. Université Montpellier I, France 1998; 116
  • Woodle E.S., Moody R.R., Cox K.L., Cannon R.A., Ward R.E. Orthotopic Liver Transplantation in a Patient with Amanita Poisoning. J. Am. Med. Assoc. 1985; 253(1)69–70
  • Dumont A.M., Chennebault J.M., Alquier P., Jardel H. Management of Amanita phalloides Poisoning by Bastien's Regimen. Lancet 1981; 1: 722
  • Boiffard J. Une Intoxication Familiale par Lepiota brunneolilacea. Doc. Mycol. 1987; XVIII(69)21–23
  • Daoudal P., Noirot A., Wagschal G., Neftel K., Hany M., Clément D., Floriot C., Delacour J.L. Traitement de l'intoxication Phalloïdienne par Silymarine et Ceftazidime. Presse Méd. 1989; 18(27)1341–1342
  • Heurtebize P. Intoxication Phalloïdienne: À Propos de Cinq Cas Traités par Ceftazidime et Silymarine. Université de Besançon, France 1990; 192
  • Meunier B., Messner M., Bardaxoglou E., Spiliopoulos G., Terblanche J., Launois B. Liver Transplantation for Severe Lepiota helveola Poisoning. Liver 1994; 14: 158–160
  • Galler G.W., Weisenberg E., Brasitus T.A. Mushroom Poisoning: The Role of Orthotopic Liver Transplantation. J. Clin. Gastroenterol. 1992; 15(3)229–232
  • Haines J.H., Lichstein E., Glickerman D. A Fatal Poisoning from an Amatoxin Containing Lepiota. Mycopathologia 1985; 93: 15–17
  • Jander S., Bischoff J. Treatment of Amanita phalloides Poisoning: I. Retrospective Evaluation of Plasmapheresis in 21 Patients. Ther. Apher. 2000; 4(4)303–307
  • Olesen L.L. Amatoxin Intoxication. Scand. J. Urol. Nephrol. 1990; 24: 231–234
  • Nagy I., Pogatsa-Murray G., Zalanyi S., Komlosi P., Laszlo F., Ungi I. Amanita Poisoning During the Second Trimester of Pregnancy. A Case Report and a Review of the Literature. Clin. Investig. 1994; 72: 794–798
  • Mikos B., Biro E. Amanita phalloides Poisoning in a 15-Year Case Load of a Pediatric Intensive Care Unit. Orv. Hetil. 1993; 134(17)907–910
  • Trestail J.H. Mushroom Poisoning Case Registry: North American Mycological Association Report 1992. McIlvainea 1993; 11(1)51–60
  • Trestail J.H. Mushroom Poisoning Case Registry: NAMA Report 1996. McIlvainea 1997; 13(1)63–67
  • Trestail J.H. 1997 Annual Report of the North American Mycological Association's Mushroom Poisoning Case Registry. McIlvainea 1998; 13(2)86–92
  • Trestail J.H. Mushroom Poisoning Case Registry: North American Mycological Association Report 1993. McIlvainea 1994; 11(2)87–95
  • Trestail J.H. Mushroom Poisoning Case Registry: North American Mycological Association Report 1989–90. McIlvainea 1991; 10(1)36–44
  • , Dimitrov, C.; Nikova, M. Intensive Care Treatment in Patients on Acute Haemodialysis/Haemoperfusion. XXXth Congress of EDTA, Vienna, Austria, 1994; 77.
  • , Hubenova, A.; Stankova, E. Some Recent Problems in Amanita phalloides Poisonings. Congress of Anti-Poisons Centre, Istambul, Turkey, May 24–27, 1992; 37.
  • , De Haro, L.; Jouglard, J.; Hayek, M.; David, J.M.; Arditti, J.; Bourdon, J.H.; Blanchard, M.; Regli, P.; Bechtel, Y.; Bechtel, P. Un Cas d'Intoxication par Amanites Printanières: Étude de l'Atteinte Hépatique. XXXIème Congrès de la Société de Toxicologie Clinique, Nancy, France, Sept 16–17, 1993; 27.
  • Timar L., Czeizel A.E. Birth Weight and Congenital Anomalies Following Poisonous Mushroom Intoxication During Pregnancy. Reprod. Toxicol. 1997; 11(6)861–866
  • Misiuk-Hojio M., Magnowska-Wozniak M. Powiklania Oczne w Zatruciu Muchomorem Sromotnikowym (Ocular Complications in Amanita phalloides Poisoning). Klin. Oczna 1996; 98(1)59–60
  • , Mydlik, M.; Mizla, P.; Derzsiova, K.; Beno, P.; Matheova, E. Extracorporeal Treatment of Acute Renal Failure (ARF) and Acute Poisoning (AP) in Children and Adolescents—27 Year Experiences. XXXth Congress of EDTA, Vienna, Austria, 1994; 82.
  • Brunelli F. Première Suisse à Genève: Un Enfant de 7 ans, Intoxiqué par Amanita phalloides, est Sauvé par une Greffe de Foie. Schweiz. Z. Pilzkd. 1992; 70(4)85–86
  • Römer E. Rapport du Toxicologue de l'USSM pour 1987. Schweiz. Z. Pilzkd. 1988; 66(11)202–203
  • Amanita phalloides Mushroom Poisoning—Northern California, January 1997. J. Am. Med. Assoc. 1997; 278(1)16–17
  • Nordt S.P., Manoguerra A., Clark R.F. 5-Year Analysis of Mushroom Exposures in California. West. J. Med. 2000; 173(5)314–317
  • Jaeger A., Flesch F., Jehl F., Sauder P., Kopferschmitt J. Les Intoxications par Champignons. J. Méd. Strasb. 1988; 19(7)381–384
  • Forgittoni R., Vecchiarelli P., Lepri F., Casagrande G.C., Quadrani G., Meletti M. Le Intossicazioni Esogene Acute Presso il Centro di Rianimazione dell'Ospedale di Viterbo nel Decennio 1-10-1979/31-12-1989 (Acute Poisoning Cases in the Intensive Care Unit of the “Ospedale Grande” in Viterbo from 1-X-79 to 31-XII-89). Acta Anaesthesiol. Ital. 1992; 43: 79–93
  • Pinson C.W., Bradley A.L. A Primer for Clinicians on Mushroom Poisoning in the West. West. J. Med. 1996; 165: 318–319
  • Consensus Thérapeutique Face à l'Intoxication Phalloïdienne. Centre Anti-Poisons de Toulouse. Hôpitaux de Toulouse, Toulouse, France 1995; 7
  • Parish R.C., Doering P.L. Treatment of Amanita Poisoning: A Review. Vet. Hum. Toxicol. 1986; 28(4)318–322
  • Köppel C. Clinical Symptomatology and Management of Mushroom Poisoning. Toxicon 1993; 31(12)1513–1540
  • Barriot P., Masson B., Fournier S. Intoxications par les Champignons. Rev. Prat. 2000; 50: 396–400
  • Basak M., Cosansel S., Ozer A., Bilgi O., Danaci M. Mantar Zehirlenmeleri ve Tedavisi (Mushroom Poisonings and Their Treatment). Sendrom 1998; 10(9)55–59
  • Stetkova A. Errors of Diagnostics and Therapy of Poisoning with Amanita phalloides. Ceska Mykol. 1991; 45: 47
  • Position Statement: Ipecac Syrup. Clin. Toxicol. 1997; 35(7)699–709
  • Position Statement: Gastric Lavage. Clin. Toxicol. 1997; 35(7)711–719
  • , Anonymous. Poisindex® and Identidex® Toxicology Information; Micromedex Health Care Series; Micromedex Inc. Intranet Knowledge Bases 1974–1999; Vol. 99, Expires 3/99.
  • Position Statement: Whole Bowel Irrigation. Clin. Toxicol. 1997; 35(7)753–762
  • Rabe C., Scheurlen C., Caselmann W.H. Vorgehen bei Knollenblätterpilzergiftung. Dtsch. Med. Wochenschr. 1999; 124: 1073–1076
  • Position Statement: Cathartics. Clin. Toxicol. 1997; 35(7)743–752
  • Ryzko J., Jankowska I., Socha J. Ocena Wybranych Parametrow Gospodarki Wapniowo-Iosioranowej w Ostrej Nierwydolnosci Watroby po Zatruciu Muchomorem Sromotnikowym (Selected Parameters of Calcium and Phosphate Metabolism in the Acute Liver Failure Following Poisoning with Amanita phalloides). Pol. Tyg. Lék. 1990; XLV(49–50)990–992
  • Parra S., Garcia J., Martinez P., De La Pena C., Carrascosa C. Profile of Alkaline Phosphatase Isoenzymes in Ten Patients Poisoned by Mushrooms of the Genus Lepiota. Dig. Dis. Sci. 1992; 37(10)1495–1498
  • Faulstich H., Zobeley S., Trischmann H. A Rapid Radioimmunoassay, Using a Nylon Support, for Amatoxins from Amanita Mushrooms. Toxicon 1982; 20(5)913–924
  • Frei W., Andres R., Gautschi K., Vonderschmitt D. Eine Neue Methode zur Raschen Bestimmung von Knollenblätterpilzgift im Urin und im Plasma (A New Method for the Rapid Detection of Amanita Toxins in the Urine and Plasma). Schweiz. Med. Wochenschr. 1986; 116(26)892–893
  • Dorizzi R., Michelot D., Tagliaro F., Ghielmi S. Methods for Chromatographic Determination of Amanitins and Related Toxins in Biological Samples. J. Chromatogr. (Biomed. Appl.) 1992; 580: 279–291
  • Defendenti C., Bonacina E., Mauroni M., Gelosa L. Validation of a High Performance Liquid Chromatographic Method for Alpha Amanitin Determination in Urine. Forensic Sci. Int. 1998; 92: 59–68
  • Brüggemann O., Meder M., Freitag R. Analysis of Amatoxins α-Amanitin and β-Amanitin in Toadstool Extracts and Body Fluids by Capillary Zone Electrophoresis with Photodiode Array Detection. J. Chromatogr. A 1996; 744: 167–176
  • Fartushnyi A.F., Sukhin A.P., Fartushnaya Y.A. Chemical and Toxicological Studies in Mushroom Poisonings. Sud. Med. Ekspert. 2000; 43(2)21–24
  • Jankowska I., Rysko J., Kuryl T., Socha J. Przydatnosc Oznaczania Amanityny Metoda RIA w Diagnostyce Zatruc Muchomorem Sromotnikowym u Dzieci (Value of Amanitin Determination with RIA Technique for the Diagnosis of Poisoning with Amanita phalloides in Childhood). Pol. Tyg. Lék. 1988; XLIII: 585–588
  • Mas A., Rodés J. Fulminant Hepatic Failure. Lancet 1997; 349: 1081–1085
  • Gill R.Q., Sterling R.K. Acute Liver Failure. J. Clin. Gastroenterol. 2001; 33(3)191–198
  • Vesconi S., Langer M., Costantino D., Iapichino G., Macchi R. Clinical Evaluation of Amatoxin Removal Approach in Amanita phalloides Poisoning. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 232–236
  • Position Statement: Single-Dose Activated Charcoal. Clin. Toxicol. 1997; 35(7)721–741
  • Faulstich H., Talas A., Wellhöner H.H. Toxicokinetics of Labeled Amatoxins in the Dog. Arch. Toxicol. 1985; 56: 190–194
  • Faulstich H. New Aspects of Amanita Poisoning. Klin. Wochenschr. 1979; 57: 1143–1152
  • Floersheim G.L. Treatment of Human Amatoxin Mushroom Poisoning. Myths and Advances in Therapy. Med. Toxicol. 1987; 2: 1–9
  • Buchwald A. Amanita Poisoning. Am. J. Med. 1989; 87: 702
  • Busi C., Fiume L., Costantino D., Langer M., Vesconi F. Amanita Toxins in Gastroduodenal Fluid of Patients Poisoned by the Mushroom, Amanita phalloides. N. Engl. J. Med. 1979; 300: 800
  • Langer M., Vesconi S., Costantino D., Busi C. Pharmacodynamics of Amatoxins in Human Poisoning as the Basis for the Removal Treatment. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 90–97
  • Vesconi S., Langer M., Costantino D. Mushroom Poisoning and Forced Diuresis. Lancet 1980; 854–855
  • Piqueras J., Duran-Suarez J.R., Massuet L., Hernandez-Sanchez J.M. Mushroom Poisoning: Therapeutic Aphereris or Forced Diuresis. Transfusion 1987; 27(1)116–117
  • Jaeger A., Jehl F., Flesch F., Sauder P., Kopferschmitt J., Minck R., Mantz J.M. Cinétique de l'amanitine au Cours des Intoxications Phalloïdiennes. Réanim. Soins Intens. Méd. Urgence 1985; 1: 262
  • Jaeger A., Jehl F., Flesch F., Sauder P., Kopferschmitt J. Kinetics of Amatoxins in Human Poisoning: Therapeutic Implications. Clin. Toxicol. 1993; 31: 63–80
  • Busi C., Fiume L., Costantino D., Borroni M., Ambrosino G., Olivotto A., Bernardini D. Détermination des Amanitines dans le Sérum de Patients Intoxiqués par l'Amanite Phalloïde. Nouv. Presse Méd. 1977; 6(32)2855–2857
  • Wauters J.P., Rossel C., Farquet J.J. Amanita phalloides Poisoning Treated by Early Charcoal Haemoperfusion. Br. Med. J. 1978; 2: 1465
  • Bartels O., Topf G. Amanita phalloides Poisoning—Indication for Early Haemoperfusion. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 147–154
  • Czygan P., Zimmermann R., Leuschner U., Stiehl A., Kommerell B. Clinical, Biochemical and Morphological Alterations in Patients with Amanita phalloides Intoxication. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 131–136
  • Balsam L., Coritsidis G.N., Feinfeld D.A. Role of Hemodialysis and Hemoperfusion in the Treatment of Intoxications. Crit. Care Toxicol. 1991; 1(3)61–79
  • Lambert H., Laprévote-Heully M.C., Manel J., Claude D., Delorme N., Larcan A. Bilan de l'Utilisation de l'Hémoperfusion dans le Traitement des Intoxications Aiguës. A Propos de 23 Observations. Ann. Méd. Nancy Est 1981; 20: 935–946
  • Czygan P., Stiehl A., Kommerell B. Treatment of Acute Amanita phalloides Induced Hepatic Failure by Haemoperfusion. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 155–161
  • Lambert H. Pronostic et Traitement de l'Intoxication. Réanimation des Intoxications Aiguës, F. Baud. Masson, Paris, France 1995; 185–195
  • Langescheid C., Schmitz-Salue H., Faulstich H., Kramer P., Scheler F. In Vitro Elimination of (3H)Methyl-dehydroxymethyl-α-Amanitin by Four Different Extracorporeal Detoxification Methods. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 137–146
  • Monhart V., Balikova M., Tlustakova M. Sorpcni Ucinnost Ceskych Hemoperfuznich Sorbentu pro Amatoxiny (Sorption Effectiveness of Czech Haemoperfusion Sorbents for Amatoxins). Cas. Lék. Cesk. 1994; 6: 181–183
  • Mydlik M., Derzsiova K., Klan J., Zima T. Hemoperfusion with α-Amanitin: An In Vitro Study. Int. J. Artif. Organs 1997; 20(2)105–107
  • Monhart V. Otravy Muchomurkami a Vyznam Sorpcni Hemoperfuze pri Jejich Léceni (Toadstool Intoxications and Importance of Sorption Haemoperfusion in Their Treatment). Vnitr. Lék. 1997; 43(10)686–690
  • Mercuriali F., Sirchia G. Plasma Exchange for Mushroom Poisoning. Transfusion 1977; 17: 644
  • Ariani G., Ciccarelli P., Ghergo G.F., Reverberi R. Qualche Considerazione sul Trattamento Terapeutico di Tre Casi di Avvelenamento Acuto da Amanita Falloide (Remarks on the Therapy of the Three Cases of Acute Amanita phalloides Poisoning). Minerva Anestesiol. 1979; 45: 335–344
  • Pigrau C., Martinez-Vazquez M., Piqueras J. Intoxicacion por Amanita phalloides. Med. Clin. 1984; 83: 342–345
  • Jander S., Bischoff J., Woodcock B.G. Plasmapheresis in the Treatment of Amanita phalloides Poisoning. II. A Review and Recommendations. Ther. Apher. 2000; 4(4)308–312
  • Floersheim G.L., Schneeberger J., Bucher K. Curative Potencies of Penicillin in Experimental Amanita phalloides Poisoning. Agents Actions 1971; 2(3)138–141
  • Floersheim G.L. Antagonistic Effects of Phalloidin α-Amanitin and Extracts of Amanita phalloides. Agents Actions 1971; 2(3)142–149
  • Floersheim G.L., Eberhard M., Tschumi P., Duckert F. Effects of Penicillin and Silymarin on Liver Enzymes and Blood Clotting Factors in Dogs Given a Boiled Preparation of Amanita phalloides. Toxicol. Appl. Pharmacol. 1978; 46: 455–462
  • Jahn W., Faulstich H., Wieland T. Pharmacokinetics of (3H)Methyldehydroxymethyl-α-amanitin in the Isolated Perfused Rat Liver and the Influence of Several Drugs. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 79–87
  • Tamai I., Terasaki T., Tsuji A. Evidence for the Existence of a Common Transport System of β-Lactam Antibiotics in Isolated Rat Hepatocytes. J. Antibiot. 1985; 38(12)1774–1780
  • Kröncke K.D., Fricker G., Meier P., Gerock W., Wieland T., Kurz G. α-Amanitin Uptake into Hepatocytes: Identification of Hepatic Membrane Transport Systems Used by Amatoxins. J. Biol. Chem. 1986; 261(27)12562–12567
  • Floersheim G.L. Toxins and Intoxications from the Toadstool Amanita phalloides. Trends Pharmacol. Sci. 1983; 4: 263–266
  • Fiume L., Serti S., Montanaro L., Busi C., Costantino D. Amanitins Do Not Bind to Serum Albumin. Lancet 1977; 1: 1111
  • Sherlock S., Dooley J. Diseases of the Liver and Biliary System. 10th Ed., Blackwell Science Ltd., Oxford, UK 1997; 87–102, 651–672
  • Cottagnoud P., Neftel K.A. β-Lactams Act on DNA Synthesis in K-562 Cells. Cell Biol. Toxicol. 1986; 2: 523–529
  • Hübscher U., Do Huynh U., Hässig M., Neftel K.A. Effects of β-Lactams on DNA Replication. Cell Biol. Toxicol. 1986; 2(4)541–547
  • Neftel K.A., Hübscher U. Effects of β-Lactam Antibiotics on Proliferating Eucaryotic Cells. Antimicrob. Agents Chemother. 1987; 31(11)1657–1661
  • Neftel K.A., Keusch G., Cottagnoud P., Widmer U., Hany M., Gautschi K., Joos B., Walt H. Sind Cephalosporine bei der Intoxikation mit Knollenblätterpilz Besser Wirksam als Penicillin-G?. Schweiz. Med. Wochenschr. 1988; 118(2)49–51
  • DeSwarte R.D. Drug–Allergy Problems and Strategies. J. Allergy Clin. Immunol. 1984; 74(3)209–221
  • Erffmeyer J.E. Adverse Reactions to Penicillin. Ann. Allergy 1981; 47: 288–300
  • Al-Ramahi M., Leader A., Léveillé M.C. An Allergic Reaction Following Intrauterine Insemination. Hum. Reprod. 1998; 13(12)3368–3370
  • Hruby K., Csomos G., Furhmann M., Thaler H. Chemotherapy of Amanita phalloides Poisoning with Intravenous Silibinin. Hum. Toxicol. 1983; 2: 183–195
  • Hruby K., Fuhrmann M., Csomos G., Thaler H. Pharmakotherapie der Knollenblätterpilzvergiftung mit Silibinin (Treatment with Silibinin for Amanita phalloides Poisoning). Wien. Klin. Wochenschr. 1983; 95(7)225–231
  • Neftel K.A., Mueller M.R., Waelti M., Erni J., Gugler M., Arrenbrecht S. Penicilin G Degradation Products Inhibit In Vitro Granulopoiesis. Br. J. Haematol. 1983; 54(2)255–260
  • Neftel K.A., Hauser S.P., Mueller M. Inhibition of Granulopoiesis In Vivo and In Vitro by β-Lactam Antibiotics. J. Infect. Dis. 1985; 152(1)90–98
  • Neftel K., Mueller M.R., Widmer U., Huegin A.W. β-Lactam Antibiotics Inhibit In Vitro Granulopoiesis and Proliferation of Some Other Cell Types. Cell Biol. Toxicol. 1986; 2(4)513–521
  • Neftel K.A., Waelti M., Schulthess H.K., Gubler J. Adverse Reactions Following Intravenous Penicillin G Relate to Degradation of the Drug In Vitro. Klin. Wochenschr. 1984; 62(1)25–29
  • Smith H., Lerner P.I., Weinsten L. Neurotoxicity and “Massive” Intravenous Therapy with Penicillin. Arch. Intern. Med. 1967; 120: 47–53
  • Moroni F., Fantozi R., Masini E., Mannaioni P.F. A Trend in the Therapy of Amanita phalloides Poisoning. Arch. Toxicol. 1976; 36: 111–115
  • Floersheim G.L., Weber O., Tschumi P., Ulbrich M. Die Klinische Knollenbblätter-Pilzvergiftung (Amanita phalloides): Prognostische Faktoren und Therapeutische Massnahmen (Clinical Poisoning with Amanita phalloides (Death Cap): Prognostic Factors and Therapeutic Measures). Schweiz. Med. Wochenschr. 1982; 112(34)1164–1177
  • Wagner V.H., Diesel P., Seitz M. Zur Chemie und Analytik von Silymarin, aus Silybum marianum Gaertn. Arzneim.-Forsch. 1974; 24: 466–471
  • Halbach G., Trost W. Zur Chemie und Pharmakologie des Silymarins Untersuchungen an Einigen Umsetzungsprodukten des Silybins. Arzneim.-Forsch. 1974; 24: 866–868
  • The Index Merck. An Encyclopedia of Chemicals, Drugs, and Biologicals, S. Budavari. Merck and Co., Inc., Whitehouse Station, NJ 1996; 139–140, 1464
  • Hahn V.G., Lehmann H.D., Kürten M., Uebel H., Vogel G., Baumann I., Dobberstein I., Eisen E., Ersfeld A., Krüger S., Meier E., Walther H. Zur Pharmakologie und Toxikologie von Silymarin, des Antihepatotoxischen Wirkprinzipes aus Silybum marianum (L.) Gaertn. Arzneim.-Forsch. 1968; 18: 698–704
  • Vogel V.G., Trost W., Braatz R., Odenthal K.P., Brüsewitz G., Antweiler H., Seeger R. Untersuchungen zu Pharmakodynamik, Angriffspunkt und Wirkungsmecha-nismus von Silymarin, dem Antihepatotoxischen Prinzip aus Silybum marianum (L.) Gaertn. (Studies on Pharmacodynamics, Site and Mechanism of Action of Silymarin, the Antihepatotoxic Principle from Silybum marianum (L.) Gaertn.). Arzneim.-Forsch. 1975; 25(2)179–189
  • Floersheim G.L. Treatment of Experimental Poisoning Produced by Extracts of Amanita phalloides. Toxicol. Appl. Pharmacol. 1975; 34: 499–508
  • Vogel G., Tuchweber B., Trost W., Mengs U. Protection by Silibinin Against Amanita phalloides Intoxication in Beagles. Toxicol. Appl. Pharmacol. 1984; 73: 355–362
  • Ramellini G., Meldolesi J. Stabilization of Isolated Rat Liver Plasma Membranes by Treatment In Vitro with Silymarin. Arzneim.-Forsch. 1974; 24(5)806–808
  • Ramellini G., Meldolesi J. Liver Protection by Silymarin: In Vitro Effect on Dissociated Rat Hepatocytes. Arzneim.-Forsch. 1976; 26(1)69–73
  • Vogel G. The Anti-Amanita Effect of Silymarin. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 180–189
  • Choppin J., Desplaces A. The Action of Silybin on the Mouse Liver in α-Amanitine Poisoning. Arzneim.-Forsch. 1979; 29(1)63–68
  • Flora K., Hahn M., Rosen H., Benner K. Milk Thistle (Silybum marianum) for the Therapy of Liver Disease. Am. J. Gastroenterol. 1998; 93(2)139–143
  • Leng-Peschlow E., Strenge-Hesse A. Die Mariendistel (Silybum marianum) und Silymarin als Lebertherapeutikum. Z. Phytother. 1991; 12: 162–174
  • Leng-Peschlow E. Properties and Medical Use of Flavonolignans (Silymarin) from Silybum marianum. Phytother. Res. 1996; 10: S25–S26
  • Luper S. A Review of Plants Used in the Treatment of Liver Disease: Part 1. Altern. Med. Rev. 1998; 3(6)410–421
  • Luyckx F., Scheen A.J. Pharma-Clinics, le Médicament du mois: Le Legalon (Silymarine). Rev. Méd. Liège 1997; 52(12)792–796
  • Wellington K., Jarvis B. Silymarin: A Review of Its Clinical Properties in the Management of Hepatic Disorders. BioDrugs 2001; 15(7)465–489
  • Muriel P., Mourelle M. Prevention by Silymarin of Membrane Alterations in Acute CCl4 Liver Damage. J. Appl. Toxicol. 1990; 10(4)275–279
  • Bosisio E., Cinzia B., Ondina P. Effect of the Flavonolignans of Silybum marianum L. on Lipid Peroxidation in Rat Liver Microsomes and Freshly Isolated Hepatocytes. Pharmacol. Res. 1992; 25(2)147–154
  • Carini R., Comoglio A., Albano E., Poli G. Lipid Peroxidation and Irreversible Damage in the Rat Hepatocyte Model. Biochem. Pharmacol. 1992; 43(10)2111–2115
  • Dehmlow C., Jochen E., De Groot H. Inhibition of Kupffer Cell Functions as an Explanation for the Hepatoprotective Properties of Silybinin. Hepatology 1996; 23(4)749–754
  • De LaPuerta R., Martinez E., Bravo L., Ahumada C. Effect of Silymarin on Different Acute Inflammation Models and on Leucocyte Migration. J. Pharm. Pharmacol. 1996; 48: 968–970
  • Schuppan D., Lang T., Gerling G., Leng-Peschlow E., Krumbiegel G., Riecken E.O., Waldschmidt J. Antifibrotic Effect of Silymarin in Rat Secondary Biliary Fibrosis Induced by Duct Obliteration with Ethiblock. Z. Gastroenterol. 1995; 32: 45–46
  • Fuchs E.C., Gressner A.M., Weyhem Meyer R., Weiner O. Identification of the Antifibrogenic Properties of Silybin: Effect on TGF-β and Matrix Gene Expression of Hepatic Stellate Cells. Hepatology 1995; 22: 286A
  • Boigk G., Stroedter L., Herbst H., Waldschmidt J., Riecken E.O., Schuppan D. Silymarin Retards Collagen Accumulation in Early and Advanced Biliary Fibrosis Secondary to Complete Bile Duct Obliteration in Rats. Hepatology 1997; 26(3)643–649
  • Magliulo E., Scevola D., Carosi G.P. Investigations on the Actions of Silybin on Regenerating Rat Liver: Effects on Kupffer's Cells. Arzneim.-Forsch. 1979; 29(7)1024–1028
  • Machicao F., Sonnenbichler J. Mechanism of the Stimulation of RNA Synthesis in Rat Liver Nuclei by Silybin. Hoppe-Seyler's Z. Physiol. Chem. 1977; 358: 141–147
  • Sonnenbichler J., Zetl I. Mechanism of Silybin Action V. Effect of Silybin on the Synthesis of Ribosomal RNA, mRNA and tRNA in Rat Livers In Vivo. Hoppe-Seyler's Z. Physiol. Chem. 1984; 365(5)555–566
  • Sonnenbichler J., Goldberg M., Hane L., Madubunyi I., Vogl S., Zetl I. Stimulatory Effect of Silybinin on the DNA Synthesis in Partially Hepatectomized Rat Livers: Non-response in Hepatoma and Other Malign Cell Lines. Biochem. Pharmacol. 1986; 35(3)538–541
  • Sonnenbichler J., Zetl I. Influence of the Flavonolignan Derivative Silibinin on Nucleic Acid and Protein Synthesis in Liver Cells. Flavonoids Bioflavonoids 1986; 361–372
  • Sonnenbichler J., Zetl I. Biochemical Effects of the Flavonolignan Silibinin on RNA, Protein and DNA Synthesis in Rat Livers. Prog. Clin. Biol. Res. 1986; 213: 319–331
  • Lorenz D., Lücker P.W., Mennicke W.H., Wetzelsberger N. Pharmacokinetic Studies with Silymarin in Human Serum and Bile. Methods Find. Exp. Clin. Pharmacol. 1984; 6(10)655–661
  • Bulles H., Bulles J., Krumbiegel G., Mennicke W.H., Nitz D. Untersuchungen zur Verstoffwechselung und zur Ausscheidung von Silybin bei der Ratte (Investigation of the Metabolism and Excretion of Silybin in the Rat). Arzneim.-Forsch. 1975; 25: 902–905
  • Flory P.J., Krug G., Lorenz D., Mennicke H. Untersuchungen zur Elimination von Silymarin bei Cholezystektomierten Patienten (Studies on Elimination of Silymarin in Cholecystectomized Patients). Planta Med. 1980; 38: 227–237
  • Faulstich H., Jahn W., Wieland T. Silybin Inhibition of Amatoxin Uptake in the Perfused Rat Liver. Arzneim.-Forsch. 1980; 30(3)452–454
  • Smetana R., Hruby K., Benesch B., Bauer K., Jahn O. Laboratory Diagnosis and Surveillance of Amanitin Intoxication During Silibinin Therapy. Intensivebehandlung 1986; 11(4)170–175
  • Schandalik R., Gatti G., Perucca E. Pharmacokinetics of Silybin in Bile Following Administration of Silipide and Silymarin in Cholecystectomy Patients. Arzneim.-Forsch. 1992; 42(7)964–968
  • Barzaghi N., Crema F., Gatti G., Pifferi G., Perucca E. Pharmacokinetic Studies on IdB 1016, a Silybin–Phosphatidylcholine Complex, in Healthy Human Subjects. Eur. J. Drug Metab. Pharmacokinet. 1990; 15(4)333–338
  • Beer J.H. Der Falsche Pilz (The Wrong Mushroom). Schweiz. Med. Wochenschr. 1993; 123(17)892–905
  • MacPartland J.M., Vilgalys R.J., Cubeta M.A. Mushroom Poisoning. Am. Fam. Physician 1997; 55(5)1797–1809
  • Castiella A., Arenas J.I. Utility of Silymarin in the Cyclopeptide Syndrome. J. Hepatol. 1994; 21: 1148
  • , Kurkin, V.; Lebedev, A.; Zapesochnaya, A.; Avdeeva, E.V.; Simonova, G.V.; Lebedev, P.A.; Egorov, V.A.; Mizina, P.; Bulatova, M.V. The New Possibilities of the Use of Silybum marianum (L.) Gaertn. Fruits. XIXth International Conference on Polyphénols, Lille, France, Sept 1–4, 1998; 29–30.
  • Kubicka J. Rozbor Smrtelnych Otrav Houbami Lécenych Kyselinou Tioktovou (Analysis of Fatal Intoxications with Mushrooms Treated with Thioctic Acid). Cas. Lék. Cesk. 1969; 108: 790–793
  • Zaffiri O., Centi R., Mastroianni A., Francescato F., Bisiani M. Therapy of Acute Poisoning by Amanita phalloides with High Doses of Thioctic Acid. Minerva Anestesiol. 1970; 36(1)56–57
  • Zanninni L., Carbone G., Stelluti A. l'Attuale Terapia Dell'avvelenamento da Amanita phalloides. Clin. Ter. 1971; 56: 177
  • Dudova V., Kubicka J., Veselky J. Thioctic Acid in the Treatment of Amanita phalloides Intoxication. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 190–191
  • Zulik R., Kassay S.F. The Role of Thioctic Acid in the Treatment of Amanita phalloides Intoxication. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 192–196
  • Finestone A.J., Berman R., Widmer B., Markowitz J., Laquer U.J. Thioctic Acid Treatment of Acute Mushroom Poisoning. PA Med. 1972; 75: 49–51
  • Becker C.E., Tong T.G., Boerner U., Roe R.L., Scott R., MacQuarrie M.B., Bartter F. Diagnosis and Treatment of Amanita phalloides-Type Mushroom Poisoning. West. J. Med. 1976; 125: 100–109
  • Culliton B.J. The Destroying Angel: A Story of a Search for an Antidote. Science 1974; 185: 600–601
  • Bartter F.C., Berkson B., Gallelli J., Hiranaka P. Thioctic Acid in the Treatment of Poisoning with α-Amanitin. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 197–202
  • Berkson B.M. Thioctic Acid in Treatment of Hepatotoxic Mushroom (Phalloides) Poisoning. N. Engl. J. Med. 1979; 300: 371
  • Berkson B.M. Treatment of Four Delayed-Mushroom Poisoning Patients with Thioctic Acid. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 203–210
  • Alleva F.R. Thioctic Acid and Mushroom Poisoning. Science 1975; 187: 216
  • Trost W., Lang W. Effect of Thioctic Acid and Silibinin on the Survival Rate in Amanitin and Phalloidin Poisoned Mice. IRCS Med. Sci. 1984; 12: 1079–1080
  • Roldan E.J., Pérez Lloret A. Thioctic acid in Amanita Poisoning. Crit. Care Med. 1986; 14(8)753–754
  • Monography: α-Lipoic Acid. Altern. Med. Rev. 1998; 3(4)308–311
  • Bustamante J., Lodge J.K., Marcocci L., Tritschler H.J., Packer L., Rihn B.H. α-Lipoic Acid in Liver Metabolism and Disease. Free Radic. Biol. Med. 1988; 24(6)1023–1039
  • Olson K.R., Woo O.F., Pond S.M. Treatment of Mushroom Poisoning. J. Am. Med. Assoc. 1984; 252(22)3130–3131
  • Paaso B., Harrison D.C. A New Look at an Old Problem: Mushroom Poisoning. Am. J. Med. 1975; 58: 505–508
  • Vesconi S., Langer M. Thioctic Acid in Amanita Poisoning. Drs. Vesconi and Langer Reply. Crit. Care Med. 1986; 14(8)754
  • Floersheim G.L. Treatment of Mushroom Poisoning. J. Am. Med. Assoc. 1985; 253(22)3252
  • Hanrahan J.P., Gordon M.A. Reply to Olson: Treatment of Mushroom Poisoning. J. Am. Med. Assoc. 1984; 252(22)3131–3132
  • Mitchel D.H. Amanita Mushroom Poisoning. Ann. Rev. Med. 1980; 31: 51–57
  • Bartter F.C. Thioctic Acid and Mushroom Poisoning. Science 1975; 187: 216
  • Tate M., Tufts E. Treatment of Mushroom Poisoning. J. Am. Med. Assoc. 1985; 253(22)3252
  • Levine M. Review of Biochemistry, Physiology and Clinical Uses of Ascorbic Acid. N. Engl. J. Med. 1986; 314: 892–902
  • , Jaeger, A.; Sauder, P.; Kopferschmitt, J.; Berton, C. Les Cytoprotecteurs Hépatiques. XXXème Congrès de la Société de Toxicologie Clinique, Nancy, France, Sept 16–17, 1993; 2.
  • Monthoux O. Une Intoxication Volontaire par l'Amanite Phalloïde et son Traitement: l'Expérience du Dr Bastien à Genève en 1981. Schweiz. Z. Pilzkd. 1982; 60(11)194–197
  • Bastien P. l'Intoxication Phalloïdienne à l'Aube de 1988. Bull. Trim. Féd. Mycol. Dauphiné-Savoie 1988; 110: 4–7
  • Chabré P.A. Intoxication par l'Amanite Phalloïde: Place du Traitement Bastien. Université Lyon 1, France 1995; 98
  • Symposium on Clinical Efficacy, Cytoprotection and Antifibrinolytic Effects. Scand. J. Gastroenterol. 1986; 21(Suppl. 121)1–62
  • Schneider S.M., Borochovitz D., Krenzelok E.P. Cimetidine Protection Against α-Amanitin Hepatoxicity in Mice: A Potential Model Protection for the Treatment of Amanita phalloides Poisoning. Ann. Emerg. Med. 1987; 16(10)1136–1140
  • Schneider S.M., Vanscoy G.J., Michelson E.A. Combination Therapy with Cimetidine, Penicillin and Ascorbic Acid for Alpha-Amanitin Toxicity in Mice. Ann. Emerg. Med. 1989; 18: 482
  • Dawson J.R., Norbeck K., Anundi I., Moldeus P. The Effectiveness of N-Acetylcysteine in Isolated Hepatocytes Against the Toxicity of Paracetamol, Acrolein and Paraquat. Arch. Toxicol. 1984; 55(1)11–15
  • Flanagan R.J. The Role of Acetylcysteine in Clinical Toxicology. Med. Toxicol. 1987; 2: 93–104
  • Kawaji A., Sone T., Natsuki R., Isobe M., Takabatake E., Yamaura Y. In Vitro Toxicity Test of Poisonous Mushroom Extracts with Isolated Rat Hepatocytes. J. Toxicol. Sci. 1990; 15(3)145–156
  • Schneider S.M., Michelson E.A., Vanscoy G.J. Failure of N-Acetylcysteine to Reduce Alpha-Amanitin Toxicity. J. Appl. Toxicol. 1992; 12(2)141–142
  • Usadel K.H., Wdowinski J., Schwedes U., Faulstich H., Röttger G., Hübner K. Effects of Somatotropin, Insulin, “Liver Growth Factor” and Silybin on Liver Regeneration After α-Amanitin Poisoning in the Rat. Amanita Toxins and Poisonings, H. Faulstich, B. Kommerell, T. Wieland. Lubrecht Cramer, New York 1980; 216–224
  • Harrison P.M., Hughes R.D., Forbes A., Portmann B., Alexander G.J.M., Williams R. Failure of Insulin and Glucagon Infusion to Stimulate Liver Regeneration in Fulminant Hepatic Failure. J. Hepatol. 1990; 10: 332–336
  • Rakeka J. A Double-Blinded Randomized Trial of Hydrocortisone in Acute Hepatic Failure: Acute Hepatic Failure Study Group. Gastroenterology 1979; 76: 1297
  • Chang I.M., Yun H.S., Kim Y.S., Ahn J.W. Aucubin: Potential Antidote for α-Amanitin Poisoning. Clin. Toxicol. 1984; 22(1)77–85
  • Bianco A., Bonini C.C., Iavarone C., Trogolo C. Structure Elucidation of Eucommioside (2″-O-β-D-Glucopyranosyl Eucommiol) from Eucommia ulmoides. Phytochemistry 1982; 21(1)201–203
  • Chang I.M., Yamaura Y. Aucubin: A New Antidote for Poisonous Amanita Mushrooms. Phytother. Res. 1993; 7: 53–56
  • Bernini R., Iavarone C., Trogolo C. 1-O-β-Glucopyranosyleucommiol, an Iridoid Glucoside from Aucuba japonica. Phytochemistry 1984; 23(7)1431–1433
  • Chang I.M. Liver-Protective Activities of Aucubin Derived from Traditional Oriental Medicine. Res. Commun. Mol. Pathol. Pharmacol. 1998; 102(2)189–204
  • Lee D.H., Cho I.G., Park M.S., Kim K.N., Chang I.M., Mar W. Studies on the Possible Mechanisms of Protective Activity Against α-Amanitin Poisoning by Aucubin. Arch. Pharm. Res. 2001; 24(1)55–63
  • Suh N.J., Shim C.K., Lee M.H., Kim S.K., Chang I.M. Pharmacokinetic Study of an Iridoid Glucoside: Aucubin. Pharm. Res. 1991; 8: 1059–1063
  • Weinges K., Kloss P., Henkels W.D. Natural Products from Medicinal Plants. XVII. Pricoside II, a New 6-Vanilloyl-catapol from Picrorhiza kuroa Royle and Benth. Justus Liebigs Ann. Chem. 1972; 759: 173–182
  • Ansari R.A., Aswal B.S., Chander R., Dhawan B.N., Garg N.K., Kapoor N.K., Kulshreshtha D.K., Mehdi H., Mehrotra B.N., Patnaik G.K., Sharma S.K. Hepatoprotective Activity of Kutkin—The Iridoid Glycoside Mixture of Picrorhiza kurrooa. Indian J. Med. Res. 1988; 401–404
  • Dwivedi Y., Rastogi R., Garg N.K., Dhawan B.N. Effects of Picroliv, the Active Principle of Picrorhiza kurroa, on Biochemical Changes in Rat Liver Poisoned by Amanita phalloides. Chung-kuo Yao Li Hsueh Pao 1992; 13(3)197–200
  • Floersheim G.L., Bieri A., Koenig R., Pletscher A. Protection Against Amanita phalloides by the Iridoid Glycoside Mixture of Picrorhiza kurroa (Kutkin). Agents Actions 1990; 29(3/4)386–387
  • Chen N., Bowles M.R., Pond S.M. Polyclonal Amanitin-Specific Antibodies: Production and Cytoprotective Properties In Vitro. Biochem. Pharmacol. 1993; 46(2)327–329
  • Faultstich H., Kirchner K., Derenzini M. Strongly Enhanced Toxicity of the Mushroom Toxin Alpha-Amanitin by an Amatoxin-Specific Fab or Monoclonal Antibody. Toxicon 1998; 26(5)491–499
  • , Tempé J.D.; Lutun, P.; Schneider, F.; Bilbault, P.; Marcoux, L. Hépatites Aiguës Toxiques. Indications et Résultats de la Transplantation Hépatique. XXXIème Congrès de la Société de Toxicologie Clinique, Nancy, France, Sept 16–17, 1993; Part I, 1–29.
  • Gubernatis G., Pichlmayr R., Kemnitz J., Gratz K. Auxiliary Partial Orthotopic Liver Transplantation (APOLT) for Fulminant Hepatic Failure: First Successful Case Report. World J. Surg. 1991; 15: 660–665
  • Boudjema K., Siméoni U., Becmeur F., Schiffer F., Odeh M., Chenard M.P., Bellocq J.P., Wolf P., Gelsert J., Sauvage P., Cinquabre J., Jaeck D. Transplantation Hépatique Auxiliaire dans le Traitement de l'Hépatite Fulminante chez l'Enfant: À Propos d'Une Observation. Réa. Urg. 1993; 3: 316
  • Moritz M.J., Jarrell B.E., Munoz S.J., Maddrey W.C. Regeneration of the Native Liver After Heterotopic Liver Transplantation for Fulminant Hepatic Failure. Transplantation 1992; 55(4)952–954
  • Chenard-Neu M.P., Boudjema K., Bernuau J., Degott C., Belghiti J., Cherqui D., Costes V., Domergue J., Durand F., Ehrard J., De Hemptinne B., Gubernatis G., Hadengue A., Kemnitz J., McCarthy M., Maschek H., Mentha G., Oldhafer K., Portmann B., Praet M., Ringers J., Rogiers X., Rubbia L., Schalm S., Ten Kate F., Terpstra O., Van Hoek B., Williams R., Zafrani E.S., Cinqualbre J., Wolf P., Jaeck D., Bellocq J.P. Auxiliary Liver Transplantation: Regeneration of the Native Liver and Outcome in 30 Patients with Fulminant Hepatic Failure—A Multicenter European Study. Hepatology 1996; 23: 1119–1127
  • Duffy T.J. Liver Transplantation for Victims of Amanita Mushroom Poisoning. McIlvainea 1989; 9(1)4–5
  • Frohburg E., Stölzel U., Lenz K., Schäfer J.H., Tung L.C., Riecken E.O. Prognostic Indicators in Fulminant Hepatic Failure. Z. Gastroenterol. 1992; 30: 571–575
  • Caraceni P., Van Thiel D.H. Acute Liver Failure. Lancet 1995; 345: 163–169
  • Castells A., Salmeron J.M., Navasa M., Rimola A., Salö J., Andreu H., Mas A., Rodès J. Liver Transplantation for Acute Liver Failure: Analysis of Applicability. Gastroenterology 1993; 105: 532–538
  • Chapman R.W., Forman D., Perto R., Smallwood R. Liver Transplantation for Acute Hepatic Failure?. Lancet 1990; 335: 32–35
  • Lake J.R., Sussman N.L. Determining Prognosis in Patients with Fulminant Hepatic Failure: When You Absolutely Positively Have to Know the Answer. Hepatology 1995; 21(3)879–881
  • , Jaeger, A.; Kopferschmitt, J.; Flesch, F.; Berton, C.; Levenos, H.; Sauder, P. Liver Transplantation for Amanita Poisoning. Congress of Anti-Poisons Centre, Istambul, Turkey, May 24–27, 1992; 103.
  • O'Grady J.G., Alexander G.J.M., Hayllar K.M., Williams R. Early Indicators of Prognosis in Fulminant Hepatic Failure. Gastroenterology 1989; 97: 439–445
  • Shakil A.O., Kramer D., Mazariegos G.V., Fung J.J., Rakela J. Acute Liver Failure: Clinical Features, Outcome Analysis, and Applicability of Prognostic Criteria. Liver Transplant. 2000; 6(2)163–169
  • Bernuau J., Samuel D., Durand F., Saliba F., Bourlière M., Adam R., Gugenheim J., Castaing D., Bismuth H., Rueff B., Erfinger S., Benhamou J.P. Criteria for Emergency Liver Transplantation in Patients with Acute Viral Hepatitis and Factor V (FV) Below 50% of Normal: A Prospective Study. Hepatology 1991; 14: 49A
  • Bismuth H., Samuel D., Gugenheim J., Castaing D., Bernuau J., Rueff B., Benhamou J.P. Emergency Liver Transplantation for Fulminant Hepatitis. Ann. Intern. Med. 1987; 107: 337–341
  • Bismuth H., Samuel D., Castaing D., Adam R., Saliba F., Johann M., Azoulay D., Ducot B., Chiche L. Orthotopic Liver Transplantation in Fulminant and Subfulminant Hepatitis. The Paul Brousse Experience. Ann. Surg. 1995; 222(2)109–119
  • Pereira L.M.M.B., Langley P.G., Hayllar K.M., Tredger J.M., Williams R. Coagulation Factor V and VIII/V Ratio as Predictors of Outcome in Paracetamol Induced Fulminant Hepatic Failure: Relation to Other Prognostic Indicators. Gut 1992; 33: 98–102
  • Lee W.M., Galbraith R.M., Watt G.H., Hughes R.D., McIntire D.D., Hoffman B.J., Williams R. Predicting Survival in Fulminant Hepatic Failure Using Serum Gc Protein Concentrations. Hepatology 1995; 21(1)101–105
  • Trey C., Davidson L.S. The Management of Fulminant Hepatic Failure. Progress in Liver Disease, H. Popper, F. Schaffner. Grune and Stratton Publishers, New York 1970; 282–298
  • Bernuau J., Benhamou J.P. Classifying Acute Liver Failure. Lancet 1993; 342: 252–253
  • Edmond J.C., Aran P.P., Whitington P.F., Broelsch C.E., Baker A.L. Liver Transplantation in the Management of Fulminant Hepatic Failure. Gastroenterology 1989; 96: 1583–1588
  • O'Grady J.G., Schalm S.W., Williams R. Acute Liver Failure: Redefining the Syndromes. Lancet 1993; 342: 273–275
  • Bernuau J., Goudeau A., Poynard T., Dubois F., Lesage G., Yvonnet B., Degott C., Bezeaud A., Rueff B., Benhamou J.P. Multivariate Analysis of Prognostic Factors in Fulminant Hepatitis B. Hepatology 1986; 6(4)648–651
  • Pauwels A., Mostefa-Kara N., Florent C., Levy V.G. Emergency Liver Transplantation for Acute Liver Failure. Evaluation of London and Clichy Criteria. J. Hepatol. 1993; 17: 124–127
  • Izumi S., Langley P.G., Wendon J., Ellis A.J., Pernambuco J.R.B., Hughes R.D., Williams R. Coagulation Factor V Levels as a Prognostic Indicator in Fulminant Hepatic Failure. Hepatology 1996; 23(6)1507–1511
  • Harrison P.M., O'Grady J.G.O., Keays R.T., Alexander G.J.M., Williams R. Serial Prothrombin Time as Prognostic Indicator in Paracetamol-Induced Fulminant Hepatic Failure. Br. Med. J. 1990; 301: 964–966
  • Christensen E., Bremmelgaard A., Bahnsen M., Buch Andreasen P., Tygstrup N. Prediction of Fatality in Fulminant Hepatic Failure. Scand. J. Gastroenterol. 1984; 19(1)90–96

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