Advanced search
Publication Cover
Journal of Toxicology: Clinical Toxicology Volume 40, 2002 - Issue 5
Journal homepage
282
Views
38
CrossRef citations to date
0
Altmetric
Research Article

Intrathecal Vincristine: Fatal Myeloencephalopathy Despite Cerebrospinal Fluid Perfusion

Andrés Alcaraz Pediatric Intensive Care Unit, Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain, University of Oviedo, Oviedo, Spain
,
Corsino Rey Hospital Central de Asturias, Corsino Rey, Unidad de Cuidados Intensivos Pediátricos, C/Celestino Villamil s.n. 33006, Oviedo, Spain
,
Andrés Concha Pediatric Intensive Care Unit, Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain, University of Oviedo, Oviedo, Spain
&
Alberto Medina Pediatric Intensive Care Unit, Department of Pediatrics, Hospital Central de Asturias, Oviedo, Spain, University of Oviedo, Oviedo, Spain
Pages 557-561 | Published online: 08 Jan 2002

REFERENCES

  • Csuka O., Sugar J., Palgi I., Somfai-Relle S. The Mode of Action of Vinca Alkaloids. Oncology 1980; 37(Suppl. 1)83–87
  • Johnson I.S., Armstrong J.G., Gorman M., Burnett J.P. The Vinca Alkaloids: A New Class of Oncolytic Agents. Cancer Res. 1963; 23: 1390–1427
  • Rosenthal S., Kaufman S. Vincristine Neurotoxicity. Ann. Intern. Med. 1974; 80: 733–737
  • McLeod J.G., Penny R. Vincristine Neuropathy: An Electrophysiological and Histological Study. J. Neurol. Neurosurg. Psychiatr. 1969; 32: 297–304
  • Jackson D.V., Sethi V.S., Spurr C.L., McWhorter J.M. Pharmacokinetics of Vincristine in the Cerebrospinal Fluid of Humans. Cancer Res. 1981; 41: 1466–1468
  • Schochet S.S., Lampert P.W. Neuronal Changes Induced by Intrathecal Vincristine Sulfate. J. Neuropathol. Exp. Neurol. 1968; 27: 645–658
  • Shepherd D.A., Steuber C.P., Starling K.A., Fernbach D.J. Accidental Intrathecal Administration of Vincristine. Med. Pediatr. Oncol. 1978; 5: 85–88
  • Slyter H., Liwnicz B., Herrick M.K., Mason R. Fatal Myeloencephalopathy Caused by Intrathecal Vincristine. Neurology 1980; 30: 867–871
  • Manelis J., Freundlich E., Ezekiel E., Doron J. Accidental Intrathecal Vincristine Administration. J. Neurol. 1982; 228: 209–213
  • Williams M.E., Walker A.N., Bracikowski J.P., Garner L., Wilson K.D., Carpenter J.T. Ascending Myeloencephalopathy Due to Intrathecal Vincristine Sulfate. A Fatal Chemotherapeutic Error. Cancer 1983; 51: 2041–2047
  • Gaidys W.G., Dickerman J.D., Walters C.L., Young P.C. Intrathecal Vincristine. Report of a Fatal Case Despite CNS Washout. Cancer 1983; 52: 799–801
  • Dyke R.W. Treatment of Inadvertent Intrathecal Injection of Vincristine. N. Engl. J. Med. 1989; 321: 1270–1271
  • Bain P.G., Lantos P.L., Djurovic V., West I. Intrathecal Vincristine: A Fatal Chemotherapeutic Error with Devastating Central Nervous System Effects. J. Neurol. 1991; 238: 230–234
  • Bleck T.P., Jacobsen J. Prolonged Survival Following the Inadvertent Intrathecal Administration of Vincristine: Clinical and Electrophysiologic Analyses. Clin. Neuropharmacol. 1991; 14: 457–462
  • Al Fawaz I.M. Fatal Myeloencephalopathy Due to Intrathecal Vincristine Administration. Ann. Trop. Paediatr. 1992; 12: 339–342
  • Zaragoza M.R., Ritchey M.L., Walter A. Neurourologic Consequences of Accidental Intrathecal Vincristine: A Case Report. Med. Pediatr. Oncol. 1995; 24: 61–62
  • Michelagnoli M.P., Bailey C.C., Wilson I., Livingston J., Kinsey S.E. Potential Salvage Therapy for Inadvertent Intrathecal Administration of Vincristine. Br. J. Haematol. 1997; 99: 364–367
  • Meggs W.J., Hoffman R.S. Fatality Resulting from Intraventricular Vincristine Administration. J. Toxicol. Clin. Toxicol. 1998; 36: 243–246
  • Fernandez C.V., Esau R., Hamilton D., Fitzsimmons B., Pritchard S. Intrathecal Vincristine: An Analysis of Reasons for Recurrent Fatal Chemotherapeutic Error with Recommendations for Prevention. J. Pediatr. Hematol. Oncol. 1998; 20: 587–590
  • Al Ferayan A., Russell N.A., Al Wohaibi M., Awada A., Scherman B. Cerebrospinal Fluid Lavage in the Treatment of Inadvertent intrathecal Vincristine Injection. Child's Nerv. Syst. 1999; 15: 87–89
  • Kwack E.K., Kim D.J., Park T.I., Cho K.R., Kwon I.H., Sohn Y.K. Neural Toxicity Induced by Accidental Intrathecal Vincristine Administration. J. Korean Med. Sci. 1999; 14: 688–692
  • Holland J.F., Scharlan C., Galiani S. Vincristine Treatment of Advanced Cancer, a Cooperative Study of 392 Cases. Cancer Res. 1973; 33: 1258–1264
  • Rieselbach R.E., DiChiro G., Freireich E.J., Rall D.P. Subarachnoid Distribution of Drugs After Lumbar Injection. N. Engl. J. Med. 1962; 267: 1273–1278
  • Jackson D.V., Wells H.B., Atkins J.N., Zekan P.J., White D.R., Richards F., Cruz J.M., Muss H.B. Amelioration of Vincristine Neurotoxicity by Glutamic Acid. Am. J. Med. 1988; 84: 1016–1022
  • Griffin J.W., Watson D.F. Axonal Transport in Neurological Disease. Ann. Neurol. 1988; 23: 3–13
  • Solimando D.A., Wilson J.P. Prevention of Accidental Intrathecal Administration of Vincristine Sulfate. Hosp. Pharm. 1982; 17: 540–542
  • Trinkle R., Wu J.K. Errors Involving Pediatric Patients Receiving Chemotherapy: A Literature Review. Med. Pediatr. Oncol. 1996; 26: 344–351
  • Ozgen U., Soylu H., Onal S.C., Mizrak B., Turkoz Y., Kutlu N.O., Kocak A., Ozcan C., Koltuksuz U., Erten S.F., Akein U. Potential Salvage Therapy for Accidental Intrathecal Vincristine Administration: A Preliminary Experimental Study. Chemotherapy 2000; 46: 322–326
  • Berwick D.M. Not Again. Br. Med. J. 2001; 322: 247–248
  • Root T. Appropriate Training Should Avoid Accidental Intrathecal Injection of Vincristine. Br. Med. J. 2001; 322: 1423

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.