References
- Hawton K, Townsend E, Deeks J, Appleby L, Gunnell D, Bennewith O, Cooper J. Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study. BMJ 2001; 322(7296):1203–1207., [PUBMED], [INFOTRIEVE]
- Juurlink D N. The Clinical Epidemiology of Poisoning in Ontario. Toronto, Ontario: University of Toronto, 2003.
- Makin A J, Wendon J, Williams R. A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987–1993). Gastroenterology 1995; 109(6):1907–1916., [PUBMED], [INFOTRIEVE], [CSA]
- Rumack B H, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics 1975; 55(6):871–876., [PUBMED], [INFOTRIEVE]
- Prescott L F, Illingworth R N, Critchley J A, Stewart M J, Adam R D, Proudfoot A T. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J 1979; 2(6198):1097–1100., [PUBMED], [INFOTRIEVE]
- Rumack B H, Peterson R C, Koch G G, Amara I A. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981; 141(3:Spec No):Spec-5.
- Smilkstein M J, Knapp G L, Kulig K W, Rumack B H. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med 1988; 319(24):1557–1562., [PUBMED], [INFOTRIEVE], [CSA]
- Wallace C I, Dargan P I, Jones A L. Paracetamol overdose: an evidence based flowchart to guide management. Emerg Med J 2002; 19(3):202–205 , [erratum appears in Emerg Med J 2002 Jul; 19(4):376]. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Prescott L F. Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med 1981; 141(3:Spec No):Spec-9.
- Schmidt L E, Dalhoff K, Poulsen H E. Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology 2002; 35(4):876–882., [PUBMED], [INFOTRIEVE], [CROSSREF]
- Buckley N A, Srinivasan J. Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case for. Drug Safety 2002; 25(9):619–624., [PUBMED], [INFOTRIEVE], [CSA]
- Dargan P I, Jones A L. Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case against. Drug Safety 2002; 25(9):625–632., [PUBMED], [INFOTRIEVE], [CSA]
- Buckley N A, Whyte I M, O'Connell D L, Dawson A H. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? Clin Toxicol 1999; 37(6):759–767., [CROSSREF]
- Makin A, Williams R. Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose. QJM 2000; 93(6):341–349., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Prescott L F. Paracetamol, alcohol and the liver. Br J Clin Pharmacol 2000; 49(4):291–301., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Kozer E, Koren G. Management of paracetamol overdose: current controversies. Drug Safety 2001; 24(7):503–512., [PUBMED], [INFOTRIEVE], [CSA]
- Anker A L, Smilkstein M J. Acetaminophen. Concepts and controversies. Emerg Med Clin North Am 1994; 12(2):335–349., [PUBMED], [INFOTRIEVE]
- Smilkstein M J, Bronstein A C, Linden C, Augenstein W L, Kulig K W, Rumack B H. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med 1991; 20(10):1058–1063., [PUBMED], [INFOTRIEVE]
- Forrest J A, Clements J A, Prescott L F. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet 1982; 7(2):93–107., [PUBMED], [INFOTRIEVE]
- Rumack B H. Acetaminophen hepatotoxicity: the first 35 years. Clin Toxicol 2002; 40(1):3–20., [CROSSREF]
- Park J M, Lin Y S, Calamia J C, Thummel K E, Slattery J T, Kalhorn T F, Carithers R L, Levy A E, Marsh C L, Hebert M F. Transiently altered acetaminophen metabolism after liver transplantation. Clin Pharmacol Ther 2003; 73(6):545–553., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Manyike P T, Kharasch E D, Kalhorn T F, Slattery J T. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clin Pharmacol Ther 2000; 67(3):275–282., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Slattery J T, Levy G. Acetaminophen kinetics in acutely poisoned patients. Clin Pharmacol Ther 1979; 25(2):184–195., [PUBMED], [INFOTRIEVE]
- Jones A L. Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review. Clin Toxicol 1998; 36(4):277–285.
- Rumack B H, Peterson R G. Acetaminophen overdose: incidence, diagnosis, and management in 416 patients. Pediatrics 1978; 62(5:Pt 2 suppl):t-903.
- Watson W A, Litovitz T L, Rodgers G C Jr, Klein-Schwartz W, Youniss J, Rose S R, Borys D, May M E. 2002 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 2003; 21(5):353–421., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Brok J, Buckley N, Gluud C. Interventions for paracetamol (acetaminophen) overdoses. Cochrane Database Syst Rev 2002, 3:CD003328., [PUBMED], [INFOTRIEVE]
- Thummel K E, Slattery J T, Ro H, Chien J Y, Nelson S D, Lown K E, Watkins P B. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin Pharmacol Ther 2000; 67(6):591–599., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Hazai E, Vereczkey L, Monostory K. Reduction of toxic metabolite formation of acetaminophen. Biochem Biophys Res Commun 2002; 291(4):1089–1094., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Rumack B H. Acetaminophen overdose in young children. Treatment and effects of alcohol and other additional ingestants in 417 cases. Am J Dis Child 1984; 138(5):428–433., [PUBMED], [INFOTRIEVE], [CSA]
- Banda P W, Quart B D. The effect of mild alcohol consumption on the metabolism of acetaminophen in man. Res Commun Chem Pathol Pharmacol 1982; 38(1):57–70., [PUBMED], [INFOTRIEVE]
- Kucukardali Y, Cinan U, Acar H V, Ozkan S, Top C, Nalbant S, Nalbant S, Cermik H, Cankir Z, Danaci M. Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats. Curr Med Res Opin 2002; 18(2):78–81., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Prescott L F, Roscoe P, Wright N, Brown S S. Plasma-paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet 1971; 1(7698):519–522., [PUBMED], [INFOTRIEVE], [CROSSREF]
- Prescott L F, Donovan J W, Jarvie D R, Proudfoot A T. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol 1989; 37(5):501–506., [PUBMED], [INFOTRIEVE], [CROSSREF]
- Kobrinsky N L, Hartfield D, Horner H, Maksymiuk A, Minuk G Y, White D F, Felstein T J. Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest 1996; 14(3):202–210., [PUBMED], [INFOTRIEVE], [CSA]
- Prescott L F, Wright N. The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br J Pharmacol 1973; 49(4):602–613., [PUBMED], [INFOTRIEVE]
- Cannavo J, Hung O, Nelson L, Hoffman R S. A mathematical model highlighting the limitations of a two point acetaminophen half-life (abstract). J Toxicol, Clin Toxicol 1997; 35(5):510.
- Sivilotti M L.A, Montalvo M, Brison R J, Linden C H. Serum alpha-Glutathione S-transferase (aGST) following supratherapeutic dosing of acetaminophen in human volunteers (abstract). Acad Emerg Med 2002; 9:534., [CROSSREF]
- Nimmo W S, Heading R C, Wilson J, Prescott L F. Reversal of narcotic-induced delay in gastric emptying and paracetamol absorption by naloxone. Br Med J 1979; 2(6199):1189., [PUBMED], [INFOTRIEVE]
- Vassallo S, Khan A N, Howland M A. Use of the Rumack-Matthew nomogram in cases of extended-release acetaminophen toxicity. Ann Intern Med 1996; 125(11):940., [PUBMED], [INFOTRIEVE], [CSA]
- Douglas D R, Sholar J B, Smilkstein M J. A pharmacokinetic comparison of acetaminophen products (Tylenol extended relief vs. regular Tylenol). Acad Emerg Med 1996; 3(8):740–744., [PUBMED], [INFOTRIEVE], [CSA]
- Stork C M, Rees S, Howland M A, Kaplan L, Goldfrank L, Hoffman R S. Pharmacokinetics of extended relief vs. regular release tylenol in simulated human overdose. Clin Toxicol 1996; 34(2):157–162.
- Halcomb S E, Sivilotti M L.A, Goklaney A, Mullins M E. Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose. Acad Emerg Med 2005; 12(2):169–172., [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]