126
Views
5
CrossRef citations to date
0
Altmetric
Original

Assessment of Proliferative Activity in Colorectal Carcinomas by Quantitative Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR)

, Ph.D., , M.D., , M.D., , M.D. & , Ph.D.
Pages 588-596 | Published online: 31 Jul 2001

REFERENCES

  • Gerdes J., Schwab U., Lemke H., Stein H. Production of aMouse Monoclonal Antibody Reactive with a Human Nuclear Antigen Associated with Cell Proliferation. Int. J. Cancer 1983; 31: 13–20
  • Key G., Becker M. H., Baron B., Duchrow M., Schlüter C., Flad H. D., Gerdes J. New Ki-67-Equivalent Murine Monoclonal Antibodies (MIB 1–3) Generated Against Bacterially Expressed Parts of the Ki-67 cDNA Containing Three 62 Base Pair Repetitive Elements Encoding for the Ki-67 Epitope. Lab. Invest 1993; 68: 629–636
  • Kubbutat M. H., Key G., Duchrow M., Schlüter C., Flad H. D., Gerdes J. Epitope Analysis of Antibodies Recognising the Cell Proliferation Associated Nuclear Antigen Previously Defined by the Antibody Ki-67 (Ki-67 Protein). J. Clin. Pathol. 1994; 47: 524–528
  • Gerdes J., Lemke H., Baisch H., Wacker H. H., Schwab U., Stein H. Cell Cycle Analysis of a Cell Proliferation-Associated Human Nuclear Antigen Defined by the Monoclonal Antibody Ki-67. J. Immunol. 1984; 133: 1710–1715
  • Brown D. C., Gatter K. C. Monoclonal Antibody Ki-67: Its Use in Histopathology. Histopathology 1990; 17: 489–503
  • Gerdes J. Ki-67 and Other Proliferation Markers Useful for Immunohistological Diagnostic and Prognostic Evaluations in Human Malignancies. Semin. Cancer Biol. 1990; 1: 199–206
  • Gerdes J., Stein H., Pileri S., Rivano M. T., Gobbi M., Ralfkiaer E., Nielsen K. M., Pallesen G., Bartels H., Palestro G., Delsol G. Prognostic Relevance of Tumour-Cell Growth Fraction in Malignant Non-Hodgkin's Lymphomas. Lancet 1987; 2(8556)448–449
  • Hall P. A., Richards M. A., Gregory W. M., d'Ardenne A. J., Lister T. A., Stansfeld A. G. The Prognostic Value of Ki67 Immunostaining in Non-Hodgkin's Lymphoma. J. Pathol. 1988; 154: 223–235
  • Grogan T. M., Spier C. M., Richter L. C., Rangel C. S. Immunologic Approaches to the Classification of Non-Hodgkin's Lymphomas. Cancer Treat. Res. 1988; 38: 31–148
  • Holte H., de Lange Davies C., Beiske K., Stokke T., Marton P. F., Smeland E. B., Hoie J., Kvaloy S. Ki67 and 4F2 Antigen Expression as Well as DNA synthesis Predict Survival at Relapse/Tumour Progression in Low-Grade B-Cell Lymphoma. Int. J. Cancer 1989; 44: 975–980
  • Nicholson R. I., Bouzubar N., Walker K. J., McClelland R., Dixon A. R., Robertson J. F., Ellis I. O., Blamey R. W. Hormone Sensitivity in Breast Cancer: Influence of Heterogeneity of Oestrogen Receptor Expression and Cell Proliferation. Eur. J. Cancer 1991; 27: 908–913
  • Wintzer H. O., Zipfel I., Schulte Monting J., Hellerich U., von Kleist S. Ki-67 Immunostaining in Human Breast Tumors and Its Relationship to Prognosis. Cancer 1991; 67: 421–428
  • Locker A. P., Birrell K., Bell J. A., Nicholson R. I., Elston C. W., Blamey R. W., Ellis I. O. Ki67 Immunoreactivity in Breast Carcinoma: Relationships to Prognostic Variables and Short Term Survival. Eur. J. Surg. Oncol. 1992; 18: 224–229
  • Tungekar M. F., Gatter K. C., Dunnill M. S., Mason D. Y. Ki-67 Immunostaining and Survival in Operable Lung Cancer. Histopathology 1991; 19: 545–550
  • Ueda T., Aozasa K., Tsujimoto M., Ohsawa M., Uchida A., Aoki Y., Ono K., Matsumoto K. Prognostic Significance of Ki-67 Reactivity in Soft Tissue Sarcomas. Cancer 1989; 63: 1607–1611
  • Fontana D., Bellina M., Gubetta L., Fasolis G., Rolle L., Scoffone C., Propiglia F., Colombo M., Tarabuzzi R., Leonardo E. Monoclonal Antibody Ki-67 in the Study of the Proliferative Activity of Bladder Carcinoma. J. Urol. 1992; 148: 1149–1151
  • Gerdes J., Li L., Schlüter C., Duchrow M., Wohlenberg C., Gerlach C., Stahmer I., Kloth S., Brandt E., Flad H. D. Immunobiochemical and Molecular Biologic Characterization of the Cell Proliferation-Associated Nuclear Antigen That Is Defined by Monoclonal Antibody Ki-67. Am. J. Pathol. 1991; 138: 867–873
  • Duchrow M., Gerdes J., Schlüter C. The Proliferation-Associated Ki-67 Protein: Definition in Molecular Terms. Cell Prolif. 1994; 27: 235–242
  • Schlüter C., Duchrow M., Wohlenberg C., Becker M. H., Key G., Flad H. D., Gerdes J. The Cell Proliferation-Associated Antigen of Antibody Ki-67: A Very Large, Ubiquitous Nuclear Protein with Numerous Repeated Elements, Representing a New Kind of Cell Cycle-Maintaining Proteins. J. Cell Biol. 1993; 123: 513–522
  • Duchrow M., Schlüter C., Wohlenberg C., Flad H. D., Gerdes J. Molecular Characterization of the Gene Locus of the Human Cell Proliferation-Associated Nuclear Protein Defined by Monoclonal Antibody Ki-67. Cell Prolif. 1996; 29: 1–12
  • Hermanek P. [1992 Tumor Classification/Developments]. Langenbecks Arch. Chir. Suppl. Kongressbd. 1992; 40–45
  • Cattoretti G., Becker M H., Key G., Duchrow M., Schlüter C., Galle J., Gerdes J. Monoclonal Antibodies Against Recombinant Parts of the Ki-67 Antigen (MIB 1 and MIB 3) Detect Proliferating Cells in Microwave-Processed Formalin-Fixed Paraffin Sections. J. Pathol. 1992; 168: 357–363
  • Chomczynski P., Sacchi N. Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction. Anal. Biochem. 1987; 162: 156–159
  • Kaplan K. P., Meier P. Nonparametric Estimation from Incomplete Observations. J. Am. Stat. Assoc. 1958; 53: 457–481
  • Porschen R., Lohe B., Hengels K. J., Borchard F. Assessment of Cell Proliferation in Colorectal Carcinomas Using the Monoclonal Antibody Ki-67. Correlation with Pathohistologic Criteria and Influence of Irradiation. Cancer 1989; 64: 2501–2505
  • Kubota Y., Petras R. E., Easley K. A., Bauer T. W., Tubbs R. R., Fazio V. W. Ki-67-Determined Growth Fraction Versus Standard Staging and Grading Parameters in Colorectal Carcinoma. A Multivariate Analysis. Cancer 1992; 70: 2602–2609
  • Diebold J., Dopfer K., Lai M., Lohrs U. Comparison of Different Monoclonal Antibodies for the Immunohistochemical Assessment of Cell Proliferation in Routine Colorectal Biopsy Specimens. Scand. J. Gastroenterol. 1994; 29: 47–53
  • Jansson A., Sun X. F. Ki-67 Expression in Relation to Clinicopathological Variables and Prognosis in Colorectal Adenocarcinomas. Acta Pathol. Microbiol. Immunol. Scand. 1997; 105: 730–734
  • Ofner D., Grothaus A., Riedmann B., Larcher P., Maier H., Bankfalvi A., Schmid K. W. MIB1 in Colorectal Carcinomas: Its Evaluation by Three Different Methods Reveals Lack of Prognostic Significance. Anal. Cell Pathol. 1996; 12: 61–70
  • al Sheneber I. F., Shibata H. R., Sampalis J., Jothy S. Prognostic Significance of Proliferating Cell Nuclear Antigen Expression in Colorectal Cancer. Cancer 1993; 71: 1954–1959
  • Mayer A., Takimoto M., Fritz E., Schellander G., Kofler K., Ludwig H. The Prognostic Significance of Proliferating Cell Nuclear Antigen, Epidermal Growth Factor Receptor, and mdr Gene Expression in Colorectal Cancer. Cancer 1993; 71: 2454–2460
  • van Oijen M. G., Medema R. H., Slootweg P. J., Rijksen G. Positivity of the Proliferation Marker Ki-67 in Noncycling Cells. Am. J. Clin. Pathol. 1998; 110: 24–31
  • Hemming A. W., Davis N. L., Kluftinger A., Robinson B., Quenville N. F., Liseman B., LeRiche J. Prognostic Markers of Colorectal Cancer: An Evaluation of DNA Content, Epidermal Growth Factor Receptor, and Ki-67. J. Surg. Oncol. 1992; 51: 147–152
  • Mori M., Kakeji Y., Adachi Y., Moriguchi S., Maehara Y., Sugimachi K., Jessup J. M., Chen L. B., Steele G. D.J. The Prognostic Significance of Proliferating Cell Nuclear Antigen in Clinical Gastric Cancer. Surgery 1993; 113: 683–690
  • Bruno S., Darzynkiewicz Z. Cell Cycle Dependent Expression and Stability of the Nuclear Protein Detected by Ki-67 Antibody in HL-60 Cells. Cell Prolif. 1992; 25: 31–40

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.