Marrow Stem Cells, Mesenchymal Progenitor Cells, and Stromal Progeny

REFERENCES

• Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., Marshak D.R. Multilineage Potential of Adult Human Mesenchymal Stem Cells. Science 1999; 284: 143–147
   PubMed Web of Science ®Google Scholar
• Pereira R.F., Halford K.W., O'Hara M.D., Leeper D.B., Sokolov B.P., Pollard M.D., Bagasra O., Prockop D.J. Cultured Adherent Cells from Marrow can Serve as Long-Lasting Precursor Cells for Bone, Cartilage, and Lung in Irradiated Mice. Proc. Natl Acad. Sci. USA 1995; 92: 4857–4861
   PubMed Web of Science ®Google Scholar
• Awad H.A., Butler D.L., Boivin G.P., Smith F.N., Malaviya P., Huibregtse B., Caplan A.I. Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon. Tissue Engng 1999; 5: 267–277
   PubMedGoogle Scholar
• Wakitani S., Saito T., Caplan A.I. Myogenic Cells Derived from Rat Bone Marrow Mesenchymal Stem Cells Exposed to 5-Azacytidine. Muscle Nerve 1995; 18: 1417–1426
   PubMed Web of Science ®Google Scholar
• Kopen G.C., Prockop D.J., Phinney D.G. Marrow Stromal Cells Migrate Through Forebrain and Cerebellum, and They Differentiate into Astrocytes After Injection into Neonatal Mouse Brains. Proc. Natl Acad. Sci. USA 1999; 96: 10711–10716
   PubMed Web of Science ®Google Scholar
• Azizi S.A., Stokes D., Augelli B.J., DiGirolamo C., Prockop D.J. Engraftment and Migration of Human Bone Marrow Stromal Cells Implanted in the Brains of Albino Rats: Similarities to Astrocyte Grafts. Proc. Natl Acad. Sci. USA 1998; 95: 3908–3913
   PubMed Web of Science ®Google Scholar
• Jackson K.A., Mi T., Goodell M.A. Hematopoietic Potential of Stem Cells Isolated from Murine Skeletal Muscle. PNAS 1999; 96: 14482–14486
   PubMed Web of Science ®Google Scholar
• Ferrari G., Cusella-De Angelis G, Coletta M., Paolucci E., Stornaiuolo A., Cossu G., Mavilio F. Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors. Science 1998; 279: 1528–1530
   PubMed Web of Science ®Google Scholar
• Jackson K.A., Majka S.M., Wang H., Pocius J., Hartley C.J., Majesky M.W., Entman M.L., Michael L.H., Hirschi K.K., Goodell M.A. Regeneration of Ischimic Cardiac Muscle and Vascular Endothelium by Adult Stem Cells. J. Clin. Invest. 2001; 107: 1395–1402
   PubMed Web of Science ®Google Scholar
• Bjornson C.R., Rietze R.L., Reynolds B.A., Magli M.C., Vescovi A.L. Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells In Vivo. Science 1999; 283: 534–537
   PubMed Web of Science ®Google Scholar
• Bartlett P.F. Pluripotential Hemopoietic Stem Cells in Adult Mouse Brain. Proc. Natl Acad. Sci. USA 1982; 79: 2711–2725
   Web of Science ®Google Scholar
• Eglitis M.A., Mezey E. Hematopoietic Cells Differentiate into both Microglia And Macroglia in the Brains of Adult Mice. Proc. Natl Acad. Sci. 1997; 94: 4080–4085
   PubMed Web of Science ®Google Scholar
• Brazelton T.R., Rossi F.M.V., Keshet G.I., Blau H.M. From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice. Science 2000; 290: 1775–1779
   PubMed Web of Science ®Google Scholar
• Krause D., Yheise N., Collector M.I., Henegariu O., Hwang S., Gardner R., Neutzel S., Sharkis S.J. Multi-organ, Multi-lineage Engraftment by a Single Bone Marrow-Derived Stem Cell. Cell 2001; 105: 369–377
   PubMed Web of Science ®Google Scholar
• Vescovi A.L., Snyder E.Y. Establishment and Properties of Neural Stem Cell Clones: Plasticity In Vitro and In Vivo. Brain Pathol. 1999; 9: 569–598
   PubMed Web of Science ®Google Scholar
• Asahara T., Masuda H., Takahashi T., Kalka C., Pastore C., Silver M., Kearne M., Magner M., Isner J.M. Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization. Circ. Res. 1999; 85: 221–228
   PubMed Web of Science ®Google Scholar
• Petersen B.E., Bowen W.C., Patrene K.D., Mars W.M., Sullivan A.K., Murase N., Boggs S.S., Greenberger J.S., Goff J.P. Bone Marrow as a Potential Source of Hepatic Oval Cells. Science 1999; 284: 1168–1170
   PubMed Web of Science ®Google Scholar
• Alison M.R., Poulsom R., Jeffery R., Dhillon A.P., Quaglia A., Jacob J., Novelli M., Prentice G., Williamson J., Wright N.A. Hepatocytes from Non-hepatic Adult Stem Cells. Nature 2000; 406: 257–262
   PubMed Web of Science ®Google Scholar
• Theise N.D., Badve S., Saxena R., Henegariu O., Sell S., Crawford J.M., Krause D.S. Derivation of Hepatocytes from Bone Marrow Cells in Mice After Radiation-Induced Myeloablation. Hepatology 2000; 31: 235–240
   PubMed Web of Science ®Google Scholar
• Theise N.D., Nimmakayalu M., Gardner M., Illei P.B., Morgan G., Teperman L., Henegariu O., Krause D.S. Liver from Bone Marrow in Humans. Hepatology 2000; 32: 11–16
   PubMed Web of Science ®Google Scholar
• Cohnheim J. Ueber Entzundung und Eiterung. Arch. Path. Anat. Physiol. Klin. Med. 1867; 40: 1–79
   Google Scholar
• Friedenstein A.J., Shapiro-Piatetzky I.I., Petrakova K.V. Osteogenesis in Transplants of Bone Marrow Cells. J. Embryol. Exp Morph. 1966; 16: 381–390
   PubMedGoogle Scholar
• Friedenstein A.J., Petrakova K.V., Kurolesova A.I., Frolova G.P. Heterotopic Transplants of Bone Marrow. Analysis of Precursor Cells for Osteogenic and Hematopoietic Tissues. Transplantation 1968; 6: 230–247
   PubMed Web of Science ®Google Scholar
• Friedenstein A.J., Petrakova K.V., Kurolesova A.I., Frolova G.P. Precursors for Fibroblasts in Different Populations of Hematopoietic Cells as Detected by the In Vitro Colony Assay Method. Exp. Hematol. 1974; 2: 83–92
   PubMed Web of Science ®Google Scholar
• Kuznetsov S.A., Krebsbach P.H., Satomura K., Kerr J., Riminucci M., Benayahu D., Robey P.G. Single-Colony Derived Strains of Human Marrow Fibroblasts form Bone after Transplantation In Vivo. J. Bone Miner. Res. 1997; 12: 1335–1347
   PubMed Web of Science ®Google Scholar
• Conget P.A., Minguell J.J. Phenotypical and Functional Properties of Human Bone Marrow Mesenchymal Progenitor Cells. J. Cell. Physiol. 1999; 181: 67–73
   PubMed Web of Science ®Google Scholar
• Colter D.C., Class R., DiGirolamo C.M., Prockop D.J. Rapid Expansion of Recycling Stem Cells in Cultures of Plastic-Adherent Cells from Human Bone Marrow. Proc. Natl Acad. Sci. 2000; 97: 3213–3218
   PubMed Web of Science ®Google Scholar
• Hall F.L., Han B., Kundu R.K., Yee A., Nimni M.E., Gordon E.M. Phenotypic Differentiation of TGF-β1-Responsive Pluripotent Premesenchymal Prehematopoietic Progenitor (P4 Stem) Cells from Murine Bone Marrow. J. Hemato. Ther. Stem Cell Res. 2001; 10: 261–271
   PubMedGoogle Scholar
• Gossoni E., Soneoka Y., Strickland C.D., Buzney E.A., Khan M.K., Flint A.F., Kunkel L.M., Mulligan R.C. Dystrophin Expression in the mdx Mouse Restored by Stem Cell Transplantation. Nature 1999; 401: 390–394
   PubMed Web of Science ®Google Scholar
• Flamme I., Risau W. Induction of Vasculogenesis and Hematopoiesis In Vitro. Development 1992; 116: 435–439
   PubMed Web of Science ®Google Scholar
• Weiss M., Orkin S.H. In Vitro Differentiation of Murine Embryonic Stem Cells: New Approaches to Old Problems. J. Clin. Invest. 1996; 97: 591–595
   PubMed Web of Science ®Google Scholar
• Yamashita J., Itoh H., Hirashima M., Ogawa M., Nishikawa S., Yurugi T., Naito M., Nakao K., Nishikawa S. Flk 1-Positive Cells Derived from Embryonic Stem Cells Serve as Vascular Progenitors. Nature 2000; 408: 92–96
   PubMed Web of Science ®Google Scholar
• Kallianpur A.R., Jordan J.E., Brandt S.J. The SCL/TAL-1 Gene Is Expressed in Progenitors of both the Hematopoietic and Vascular Systems During Embryogenesis. Blood 1994; 83: 1200–1208
   PubMed Web of Science ®Google Scholar
• Gering M., Rodaway A.R., Gottgens B., Patient R.K., Green A.R. The SCL Gene Specifies Haemangioblast Development from Early Mesoderm. EMBO J. 1998; 17: 4029–4045
   PubMed Web of Science ®Google Scholar
• Drake C.J., Brandt S.J., Trusk T.C., Little C.D. TLA1/SCL Is Expressed in Endothelial Progenitor Cells/Angioblasts and Defines a Dorsal-to-Ventral Gradient of Vasculogenesis. Dev. Biol. 1997; 192: 17–30
   PubMed Web of Science ®Google Scholar
• Drake C.J., Fleming P.A. Vasculogenesis in the Day 6.5 to 9.5 Mouse Embryo. Blood 2000; 95: 1671–1679
   PubMed Web of Science ®Google Scholar
• Cleaver O., Krieg P.A. VEGF Mediates Angioblast Migration During Development of the Dorsal Aorta in Xenopus. Development 1998; 125: 3905–3914
   PubMed Web of Science ®Google Scholar
• Choi K., Kennedy M., Kazarow A., Papadimitriou J.C., Keller G. A Common Precursor for Hematopoietic and Endothelial Cells. Development 1998; 125: 725–732
   PubMed Web of Science ®Google Scholar
• Suri C., Jones P.F., Patan S., Bartunkova S., Maisonpierre P.C., Davis S., Sato T.N., Yancopoulos G.D. Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis. Cell 1996; 87: 1171–1180
   PubMed Web of Science ®Google Scholar
• Papapetropoulos A., Garcia-Cardena G., Dengler T.J., Maisonpierre P.C., Yancopoulos G.D., Sessa W.C. Direct Actions of Angiopoietin-1 on Human Endothelium: Evidence for Network Stabilization, Cell Survival, and Interaction with other Angiogenic Growth Factors. Lab. Invest. 1999; 79: 213–233
   PubMed Web of Science ®Google Scholar
• Lemischka I. The Power of Stem Cells Reconsidered?. Proc. Natl Acad. Sci. USA 1999; 96: 14193–14195
   PubMed Web of Science ®Google Scholar
• Mezey E., Chandross K.J., Harta G., Maki R.A., McKercher S.R. Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated In Vivo from Bone Marrow. Science 2000; 290: 1779–1782
   PubMed Web of Science ®Google Scholar
• Alliot F., Lecain E., Grima B., Pessac B. Microglial Progenitors with a High Proliferative Potential in the Embryonic and Adult Mouse Brain. Proc. Natl Acad. Sci. USA 1991; 88: 1541–1545
   PubMed Web of Science ®Google Scholar
• McKay R. Stem Cells in the Central Nervous System. Science 1997; 276: 66–71
   PubMed Web of Science ®Google Scholar
• Gritti A., Parati E.A., Cova L., Frolichsthal P., Galli R., Wanke E., Faravelli L., Morassutti D.J., Roisen F., Nickel D.D., Vescovi A.L. Multipotential Stem Cells from the Adult Mouse Brain Proliferate and Self Renew in Response to Basic Fibroblast Growth Factor. J. Neurosci. 1996; 16: 1091–1100
   PubMed Web of Science ®Google Scholar
• Doetsch F., Caille I., Lim D.A., Garcia-Verdugo J.M., Alvarez-Buylla A. Subventricular Zone Astrocytes are Neural Stem Cells in the Adult Mammalian Brain. Cell 1999; 97: 703–716
   PubMed Web of Science ®Google Scholar
• Hoogerbrugge P.M., Wagemaker G., van Beckum D.W. Failure to Demonstrate Pluripoential Hemopoietic Stem Cells in Mouse Brains. Proc. Natl Acad. Sci. 1985; 82: 4268–4269
   PubMedGoogle Scholar
• Tonelli Q., Meints R.H. Surface Molecules of Hematopoietic Stem Cells: Requirement for Sialic Acid in Spleen Colony Formation. Science 1977; 195: 897–898
   PubMed Web of Science ®Google Scholar
• Ploemacher R.E., Brons N.H.C., van Soest P.L. Colony Formation by Bone Marrow Cells after Incubation with Neuraminidase. III. Cell Surface Repair, Homing and Growth Characteristics of Colony Forming Cells In Vivo. Exp. Heamtol. 1981; 9: 168–178
   PubMed Web of Science ®Google Scholar
• La Russa V.F., Sieber F., Sensenbrenner L.L., Sharkis S.J. Effects of Neuraminidase on the Regulation of Erythropoiesis. Blood 1984; 63: 784–788
   PubMed Web of Science ®Google Scholar
• Bianco P., Cossu G. Uno, Nessuno e Centomila: Searching for the Identity of Mesodermal Progenitors. Exp. Cell. Res. 1999; 251: 257–263
   PubMed Web of Science ®Google Scholar
• Doherty M.J., Ashton B.A., Walsh S., Beresford J.N., Grant M.E., Canfield A.E. Vascular Pericytes Express Osteogenic Potential In Vitro and In Vivo. J. Bone Miner. Res. 1998; 13: 828–838
   PubMed Web of Science ®Google Scholar
• De Angelis L., Berghella L., Coletta M., Lattanzi L., Zanchi M., Cusella-De Angelis M.G., Ponzetto C., Cossu G. Skeletal Myogenic Progenitors Originating from Embryonic Dorsal Aorta Coexpress Endothelial and Myogenic Markers and Contribute to Postnatal Muscle Growth and Regeneration. J. Cell Biol. 1999; 147: 869–878
   PubMed Web of Science ®Google Scholar
• Bennett J.H., Joyner C.J., Triffitt J.T., Owen M.E. Adipocyte Cells Cultured from Marrow Have Osteogenic Potential. J. Cell Sci. 1991; 99: 131–139
   PubMed Web of Science ®Google Scholar
• Gentili C., Bianco P., Neri M., Malpeli M., Campanile G., Castagnola P., Cancedda R., Cancedda F.D. Cell Proliferation, Extracellular Matrix Mineralization, and Ovotransferin Transient Expression during In Vitro Differentiation of Chick Hypertrophic Chondrocytes into Osteoblast-like Cells. J. Cell Biol. 1993; 122: 703–712
   PubMed Web of Science ®Google Scholar
• Bianco P., Constantini M., Dearden L.C., Bonucci E. Alkaline Phosphatase Positive Precursors of Adipocytes in the Human Bone Marrow. Br. J. Hematol. 1988; 68: 401–403
   PubMed Web of Science ®Google Scholar
• Satomura K., Krebsbach P.A., Bianco P., Gehron Robey P. Osteogenic Imprinting Upstream of Marrow Cell Differentiation. J. Cell Biochem. 2000; 78: 391–403
   PubMed Web of Science ®Google Scholar
• Bianco P., Riminucci M., Kuznetsov S., Robey P.G. Multipotential Cells in the Bone Marrow Stroma: Regulation in the Context of Organ Physiology. Crit. Rev. Eukaryot. Gene Expr. 1999; 9: 159–173
   PubMed Web of Science ®Google Scholar
• Ducy P., Zhang R., Geoffroy V., Ridall A.L., Karsenty G. Osf2/Cbaf 1: a Transcriptional Activator of Osteoblast Differentiation. Cell 1997; 89: 747–754
   PubMed Web of Science ®Google Scholar
• Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., Shimizu Y., Bronson R.T., Gao Y.H., Inada M., Sato M., Okamoto R., Kitamura Y., Yoshiki S., Kishimoto T. Targeted Disruption of Cbfa 1 Results in a Complete Lack of Bone Formation Owing to Maturational Arrest of Osteoblasts. Cell 1997; 89: 755–764
   PubMed Web of Science ®Google Scholar
• Tontonoz P., Hu E., Spiegelman B.M. Stimulation of Adipogenesis in Fibroblasts by PPAR Gamma 2, a Lipid Activated Transcription Factor. Cell 1994; 79: 1147–1156
   PubMed Web of Science ®Google Scholar
• Gori F., Thomas T., Hicok K.C., Spelsberg T.C., Riggs B.L. Differentiation of Human Marrow Stromal Precursor Cells: Bone Morphogenic Protein-2 Increases OSF2/CBFA1, Enhances Osteoblast Commitment, and Inhibits Late Adipocyte Maturation. J. Bone Miner. Res. 1999; 14: 1522–1535
   PubMed Web of Science ®Google Scholar
• Holmbeck K., Bianco P., Caterina J., Yamada S., Kromer M., Kuznetsov S.A., Mankani M., Robey P.G., Poole A.R., Pidoux I., Ward J.M., Birkedal-Hansen H. MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover. Cell 1999; 99: 81–92
   PubMed Web of Science ®Google Scholar
• Rosen J.M., Zahnow C., Kazansky A., Raught B. Composite Response Elements Mediate Hormonal and Developmental Regulation of Milk Protein Gene Expression. Biochem. Soc. Symp. 1998; 63: 101–113
   PubMedGoogle Scholar
• Shivdasani R.A., Orkin S.H. The Transcriptional Control of Hematopoiesis. Blood 1996; 87: 4025–4039
   PubMed Web of Science ®Google Scholar
• Sieweke M.H., Graf T. A Transcription Factor Party During Blood Cell Differentiation. Curr. Opin. Genet. Dev. 1998; 8: 545–551
   PubMed Web of Science ®Google Scholar
• Zahnow C.A., Younes P., Laucirica R., Rosen J.M. Overexpression of C/EBPbeta-LIP, a Naturally Occurring Dominant-Negative Transcription Factor, in Human Breast Cancer. J. Natl Cancer Inst. 1997; 89: 1887–1891
   PubMed Web of Science ®Google Scholar
• Simmons P.J., Przepiorka D., Thomas E.D., Torok-Storb B. Host Origin of Marrow Stromal Cells Following Allogeneic Bone Marrow Transplantation. Nature 1987; 328: 429–432
   PubMed Web of Science ®Google Scholar
• Golde D.W., Hocking W.G., Quan S.G., Sparkes R.S., Gale R.P. Origin of Human Bone Marrow Fibroblasts. Br. J. Haematol. 1980; 44: 183–187
   PubMedGoogle Scholar
• Agematsu K., Nakahori Y. Recipient Origin of Bone Marrow-Derived Fibroblastic Stromal Cells During all Periods Following Marrow Transplantation in Humans. Br. J. Haematol. 1991; 79: 359–365
   PubMed Web of Science ®Google Scholar
• Santucci M.A., Trabetti E., Martinelli G., Buzzi M., Zaccaria A., Pileri S., Farabegoli P., Sabattini E., Tura S., Pignatti P.F. Host Origin of Bone Marrow Fibroblasts Following Allogeneic Bone Marrow Transplantation for Chronic Myeloid Leukemia. Bone Marrow Transplant 1992; 10: 255–259
   PubMed Web of Science ®Google Scholar
• Keating A., Singer J.W., Killen P.D., Striker G.E., Salo A.C., Sanders J., Thomas E.D., Thorning D., Fialkow P.J. Donor Origin of the In Vitro Haematopoietic Microenvironment After Marrow Transplantation in Man. Nature 1982; 298: 280–283
   PubMed Web of Science ®Google Scholar
• Piersma A.H., Ploemacher R.E., Brockbank K.G. Transplantation of Bone Marrow Fibroblastoid Stromal Cells in Mice Via the Intravenous Route. Br. J. Haematol. 1983; 54: 285–290
   PubMed Web of Science ®Google Scholar
• Anklesaria P., Kase K., Glowacki J., Holland C.A., Sakakeeny M.A., Wright J.A., FitzGerald T.J., Lee C.Y., Greenberger J.S. Engraftment of a Clonal Bone Marrow Stem Cell Line In Vivo Stimulates Hematopoietic Recovery from Total Body Irradiation. Proc. Natl Acad. Sci. USA 1987; 84: 7681–7685
   PubMed Web of Science ®Google Scholar
• Anklesaria P., FitzGerald T.J., Kase K., Ohara A., Greenberger J.S. Improved Hematopoiesis in Anemic Sl/Sld Mice by Splenectomy and Therapeutic Transplantation of a Hematopoietic Microenviornment. Blood 1989; 74: 1144–1151
   PubMed Web of Science ®Google Scholar
• Fukushima N., Ueno K., Ohkawa H., Hayashi Y. Donor Stromal Cells Support Hematopoiesis in CFU-S Colonies. Exp. Hematol. 1994; 22: 1210–1216
   PubMed Web of Science ®Google Scholar
• Simmons P.J., Torok Storb B. CD34 Expression by Stromal Precursors in Normal Human Adult Bone Marrow. Blood 1991; 78: 2848–2853
   PubMed Web of Science ®Google Scholar
• Quirici N., Soligo D., Bossolasco P., Lambertenghi Deliliers G. Isolation of Highly Purified Mesenchymal Cell Progenitors Using Anti-NGFR Antibodies. Blood 2000; 96: 126b
   Google Scholar
• Simmons P.J., Gronthos S., Zannettino A., Ohta S., Graves S. Isolation, Characterization and Functional Activity of Human Marrow Stromal Progenitors in Hemopoiesis. Prog. Clin. Biol. Res. 1994; 389: 271–280
   PubMedGoogle Scholar
• Digirolamo C.M., Stokes D., Colter D., Phinney D.G., Class R., Prockop D.J. Propagation and Senescence of Human Marrow Stromal Cells in Culture: a Simple Colony-Forming Assay Identifies Samples with the Greatest Potential to Propagate and Differentiate. Br. J. Haematol. 1999; 107: 275–281
   PubMed Web of Science ®Google Scholar
• Bruder S.P., Jaiswal N., Hayensworth S.E. Growth Kinetics, Self-renewal, and Osteogenic Potential of Purified Human Mesenchymal Stem Cells During Extensive Subcultivation and Following Cryopreservation. J. Cell. Biochem. 1997; 64: 278–294
   PubMed Web of Science ®Google Scholar
• Lazarus H.M., Haynesworth S.E., Gerson S.L., Rosenthal N.S., Caplan A.I. Ex Vivo Expansion and Subsequent Infusion of Human Bone Marrow-Derived Stromal Progenitor Cells (Mesenchymal Progenitor Cells): Implications for Therapeutic Use. Bone Marrow Transplant 1995; 16: 557–564
   PubMed Web of Science ®Google Scholar
• Koc O.N., Gerson S.L., Cooper B.W., Dyhouse S.M., Haynesworth S.E., Kaplan A., Tainer N., Lazarus H.M. Rapid Hematopoietic Recovery after Co-infusion of Autologous Culture-Expanded Human Mesenchymal Stem Cells (hMesenchymal Stem Cells) and PBPCs in Breast Cancer Patients Receiving High Dose Chemotherapy. Blood 1998; 92: 274a
   Google Scholar
• Periera, O'Hara M.D., Laptev A.V., Halford K.W., Pollard M.D., Class R., Simon D., Livezey K., Prockop D.J. Marrow Stromal Cells as a Source of Progenitors for Nonhematopoietic Tissues in Transgenic Mice with a Phenotype of Osteogenesis Imperfect. Proc. Natl Acad. Sci. USA 1998; 95: 1142–1147
   PubMed Web of Science ®Google Scholar
• Horwitz E.M., Prockop D.J., Fitzpatrick L.A., Koo W.W., Gordon P.L., Neel M., Sussman M., Orchard P., Marx J.C., Pyeritz R.E., Brenner M.K. Transplantability and Therapeutic Effects of Bone Marrow-Derived Mesenchymal Cells in Children with Osteogenesis Imperfect. Nat. Med. 1999; 5: 309–313
   PubMed Web of Science ®Google Scholar
• Galotto M., Berisso G., Delfino L., Podesta M., Ottaggio L., Dallorso S., Dufour C., Ferrara G.B., Abbondandola A., Dini G., Bacigalupo A., Cancedda R., Quarto R. Stromal Damage as Consequence of High-Dose Chemo/Radiotherapy in Bone Marrow Transplant Recipients. Exp. Hematol. 1999; 27: 1460–1466
   PubMed Web of Science ®Google Scholar
• El-Bradi N.S., Wang B.Y., Good R.A. Osteoblasts Promote Engraftment of Allogeneic Hematopoietic Stem Cells. Exp. Hematol. 1998; 26: 110
   PubMed Web of Science ®Google Scholar
• Chuah M.K., Brems H., Vanslembrouck V., Collen D., Vandendriessche T. Bone Marrow Stromal Cells as Targets for Gene Therapy of Hemophilia A. Hum. Gene Ther. 1998; 9: 353–365
   PubMed Web of Science ®Google Scholar
• Chiang G.G., Rubin H.L., Cherington V., Wang T., Sobolewski J., McGrath C.A., Gaffney A., Emami S., Sarver N., Levine P.H., Greenberger J.S., Hurwitz D.R. Bone Marrow Stromal Cell-Mediated Gene Therapy for Hemophilia A: In Vitro Expression of Human Factor VIII with High Biological Activity Requires the Inclusion of the Proteolytic Site at Amino Acid 1648. Hum. Gene Ther. 1997; 10: 61–76
   Web of Science ®Google Scholar
• Chuah M.K., Van Damme A., Zwinnen H., Goovaerts I., Vanslembrouck V., Collen D., Vandendriessche T. Long-Term Persistence of Human Bone Marrow Stromal Cells Transduced with Factor VIII-Retroviral Vectors and Transient Production of Therapeutic Levels of Human Factor VIII in Nonmyeloablated Immunodeficient Mice. Hum. Gene Ther. 2000; 11: 729–738
   PubMed Web of Science ®Google Scholar
• Hurwitz D.R., Kirchgesser M., Merrill W., Galanopoulos T., McGrath C.A., Emami S., Hansen M., Cherington V., Appel J.M., Bizinkauskas C.B., Brackmann H.H., Levine P.H., Greenberger J.S. Systemic Delivery of Human Growth Hormone or Human Factor IX in Dogs by Reintroduced Genetically Modified Autologous Bone Marrow Stromal Cells. Hum. Gene Ther. 1997; 8: 137–156
   PubMed Web of Science ®Google Scholar
• Gordon E.M., Skotzko M., Kundu R.K., Han B., Andrades J., Nimni M., Anderson W.F., Hall F.L. Capture and Expansion of Bone Marrow-Derived Mesenchymal Progenitor Cells With A Transforming Growth Factor-Beta1-von Willebrand's Factor Fusion Protein for Retrovirus-Mediated Delivery of Coagulation Factor IX. Hum. Gene Ther. 1997; 8: 1385–1394
   PubMed Web of Science ®Google Scholar
• Cherington V., Chiang G.G., McGrath C.A., Gaffney A., Galanopoulos T., Merrill W., Bizinkauskas C.B., Hansen M., Sobolewski J., Levine P.H., Greenberger J.S., Hurwitz D.R. Retroviral Vector-Modified Bone Marrow Stromal Cells Secrete Biologically Active Factor IX In Vitro and Transiently Deliver Therapeutic Levels of Human Factor IX to the Plasma of Dogs after Reinfusion. Hum. Gene Ther. 1998; 9: 1397–1407
   PubMed Web of Science ®Google Scholar
• Nolta J.A., Hanley M.B., Kohn D.B. Sustained Human Hematopoiesis in Immunodeficient Mice by Cotransplantation of Marrow Stroma Expressing Human Interleukin-3: Analysis of Gene Transduction of Long-Lived Progenitors. Blood 1994; 83: 3041–3051
   PubMed Web of Science ®Google Scholar
• Allay J.A., Dennis J.E., Haynesworth S.E., Majumdar M.K., Clapp D.W., Shultz L.D., Caplan A.I., Gerson S.L. LacZ and Interleukin-3 Expression In Vivo After Retroviral Transduction of Marrow-Derived Human Osteogenic Mesenchymal Progenitors. Hum. Gene Ther. 1997; 8: 1417–1427
   PubMed Web of Science ®Google Scholar
• Bolotin E., Smogorzewska M., Smith S., Widmer M., Weinberg K. Enhancement of Thymopoiesis After Bone Marrow Transplant by In Vivo Interleukin-7. Blood 1996; 88: 1887–1894
   PubMed Web of Science ®Google Scholar
• Matzner U., Harzer K., Learish R.D., Barranger J.A., Gieselmann V. Long-Term Expression and Transfer of Arylsulfatase A into Brain of Arylsulfatase A-Deficient Mice Transplanted with Bone Marrow Expressing the Arylsulfatase A cDNA from a Retroviral Vector. Gene Ther. 2000; 7: 1250–1257
   PubMed Web of Science ®Google Scholar
• Schwarz E.J., Alexander G.M., Prockop D.J., Azizi S.A. Multipotential Marrow Stromal Cells Transduced to Produce l-DOPA: Engraftment in a Rat Model of Parkinson Disease. Hum. Gene Ther. 1999; 10: 2539–2549
   PubMed Web of Science ®Google Scholar
• Ding L., Lu S., Batchu R., III R.S., Munshi N. Bone Marrow Stromal Cells as a Vehicle for Gene Transfer. Gene Ther. 1999; 6: 1611–1616
   PubMed Web of Science ®Google Scholar
• Marx J.C., Allay J.A., Persons D.A., Nooner S.A., Hargrove P.W., Kelly P.F., Vanin E.F., Horwitz E.M. High-Efficiency Transduction and Long-Term Gene Expression with a Murine Stem Cell Retroviral Vector Encoding the Green Fluorescent Protein in Human Marrow Stromal Cells. Hum. Gene Ther. 1999; 10: 1163–1173
   PubMed Web of Science ®Google Scholar
• Jaalouk D.E., Eliopoulos N., Couture C., Mader S., Galipeau J. Glucocorticoid-Inducible Retrovector for Regulated Transgene Expression in Genetically Engineered Bone Marrow Stromal Cells. Hum. Gene Ther. 2000; 11: 1837–1849
   PubMed Web of Science ®Google Scholar
• Miller D.G., Adam M.A., Miller A.D. Gene Transfer by Retrovirus Vectors Occurs Only in Cells That are Actively Replicating at the Time of Infection. Mol. Cell Biol. 1990; 10: 4239–4242
   PubMed Web of Science ®Google Scholar
• Conget P.A., Minguell J.J. Adenoviral-Mediated Gene Transfer into Ex Vivo Expanded Human Bone Marrow Mesenchymal Progenitor Cells. Exp. Hematol. 2000; 28: 382–386
   PubMed Web of Science ®Google Scholar
• Frolova-Jones E.A., Ensser A., Stevenson A.J., Kinsey S.E., Meredith D.M. Stable Marker Gene Transfer into Human Bone Marrow Stromal Cells and Their Progenitors Using Novel Herpesvirus Saimiri-Based Vectors. J. Hematother. Stem Cell Res. 2000; 9: 573–581
   PubMedGoogle Scholar
• Lou J., Tu Y., Ludwig F.J., Zhang J., Manske P.R. Effect of Bone Morphogenic Protein-12 Gene Transfer on Mesenchymal Progenitor Cells. Clin. Ortho Rel. Res. 1999; 369: 333–339
   PubMedGoogle Scholar
• Hodgson G.S., Bradley T.R. Properties of Haematopoietic Stem Cells Surviving 5-fluorouracil Treatment: Evidence for a Pre-CFU-S Cell. Nature 1979; 281: 381–382
   PubMed Web of Science ®Google Scholar