113
Views
27
CrossRef citations to date
0
Altmetric
Original Article

A Dose-Escalating Pilot Study of Sterically Stabilized, Pegylated Liposomal Doxorubicin (Lipo-Dox®) in Patients with Metastatic Breast Cancer

, M.D., , , , & , M.D., Ph.D.
Pages 837-847 | Published online: 12 Oct 2003

References

  • Hortobagyi G. N. Anthracyclines in the treatment of cancer. An overview. Drugs 1997; 54(suppl 4)1–7
  • Aapro M. S. Combining new agents with anthracyclines in metastatic breast cancer: an overview of recent findings. Semin. Oncol. 1999; 26(suppl 3)17–21
  • Tan A. R., Swain S. M. Adjuvant chemotherapy for breast cancer: an update. Semin. Oncol. 2001; 28(4)359–376
  • Allen T. M. Liposomes. Opportunities in drug delivery. Drugs 1997; 54(suppl 4)8–14
  • Gabizon A., Martin F. Polyethylene glycol-coated (pegylated) liposomal doxorubicin. Rationale for use in solid tumors. Drugs 1997; 54(suppl 4)15–21
  • Muggia F. M. Clinical efficacy and prospects for use of pegylated liposomal doxorubicin in the treatment of ovarian and breast cancers. Drugs 1997; 54(suppl 4)22–29
  • Alberts D. S., Garcia D. J. Safety aspects of pegylated liposomal doxorubicin in patients with cancer. Drugs 1997; 54(suppl 4)30–35
  • Gabizon A., Goren D., Horowitz A. T., Tzemach D., Lossos A., Siegal T. Long-circulating liposomes for drug delivery in cancer therapy: a review of biodistribution studies in tumor-bearing animals. Adv. Drug Deliv. Rev. 1997; 24: 337–344
  • Drummond D. C., Meyer O., Hong K., Kirpotin D. B., Papahadjopoulos D. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol. Rev. 1999; 51(4)691–743
  • Ranson M. R., Cheeseman S., White S., Margison J. Caelyx (stealth liposomal doxorubicin) in the treatment of advanced breast cancer. Crit. Rev. Oncol. Hematol. 2001; 37: 115–120
  • Gabizon A. Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest. 2001; 19(4)424–436
  • Sparano J. A., Winer E. P. Liposomal anthracyclines for breast cancer. Semin. Oncol. 2001; 28(4)32–40, (suppl 12)
  • Ranson M. R., Carmichael J., O'Byrne K., Stewart S., Smith D., Howell A. Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin: results of a multicenter phase II trial. J. Clin. Oncol. 1997; 15(10)3185–3191
  • Hong R. L., Tseng Y. L. Phase I and pharmacokinetic study of a stable, polyethylene-glycolated liposomal doxorubicin in patients with solid tumors. Cancer 2001; 91(9)1826–1833
  • Gianni L. Anthracycline resistance: the problem and its current definition. Semin. Oncol. 1997; 24(4)11–17, (suppl 10)
  • Uziely B., Jeffers S., Isacson R., Kutsch K., Wei-Tsao D., Yehoshua Z., Libson E., Muggia F. M., Babizon A. Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies. J. Clin. Oncol. 1995; 13(7)1777–1785
  • Lyass O., Uziely B., Ben-Yosef R., Tzemach D., Heshing N. I., Lotem M., Brufman G., Gabizon A. Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (doxil) in metastatic breast carcinoma. Cancer 2000; 89(5)1037–1047
  • Smith F. P., Barr F., Hendricks C., Burrell L. Phase II study of DOXIL (pegylated liposomal doxorubicin) in doxorubicin-resistant, metastatic breast cancer. Am. Soc. Clin. Oncol. 1999; 18, abstract 524
  • Cowens J. W., Creaven P. J., Greco W. R., Brenner D. E., Tung Y., Ostro M., Pilkiewicz R., Ginsberg R., Petrelli N. Initial clinical (phase I) trial of TLC D-99 (doxorubicin encapsulated in liposomes). Cancer Res. 1993; 53: 2796–2802
  • Safra T., Muggia F., Jeffers S., Tsao-Wei D. D., Groshen S., Lyass O., Henderson R., Berry G., Gabizon A. Pegylated liposomal doxorubicin (DOXIL): reduced clinical cardiotoxicity in patients reaching or exceeding cumulative doses of 500 mg/m2. Ann. Oncol. 2000; 11: 1029–1033
  • Mustafa M. H. Decreased risk of cardiotoxicity with long-term use of doxil/caelyx at high lifetime cumulative doses in patients with AIDS-related Kaposi's sarcoma (KS). Am. Soc. Clin. Oncol. 2001; 20, abstract 2915
  • Harris L., Batist G., Belt R., Rovira D., Navari R., Azarnia N., Welles L., Winer E., for the TLC D-99 Study Group. Liposome-encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first-line therapy of metastatic breast cacinoma. Cancer 2002; 94(1)25–36

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.