REFERENCES
- US Department of Health and Human Services. Ninth Special Report to the U.S. Congress on Alcohol and Health. 1997
- Sato A., Nakajima T., Koyama Y. Dose-related effects of a single dose of ethanol on the metabolism in rat liver of some aromatic and chlorinated hydrocarbons. Tox. Appl. Pharm. 1981; 60: 8–15
- Lelbach W. K. Cirrhosis in the alcoholic and its relation to volume of alcohol abuse. N.Y. Acad. Sci. 1975; 252: 85–105
- Abel E. L. An update on the incidence of FAS: FAS is not an equal opportunity birth defect. Neurotox. Teratol. 1995; 17(4)437–443
- Morena A., Pares A., Ortiz J., Enriquez J., Pares X. Alcohol dehydrogenase from human stomach: Variability in normal mucosa and effect of age, gender, ADH3 phenotype and gastric region. Alcoho. Alcoholism 1995; 29(6)663–671
- Frezza A., DiPadova C., Pozzato G., Terpin M., Baraona E., Lieber C. S. High blood alcohol levels in women: role of decreased gastric alcohol dehydrogenase activity and first pass metabolism of ethanol. New Eng. Journ. Med. 1990; 322: 95–99
- Jones B. M., Jones M. R. Male and female intoxication levles for three alcohol doses or do women really get higher than men. Alcohol Tech. Report 1976; 5: 11–14
- Chao Y. C., Young T. H., Tang H. S., Hsu C. T. Alcohol and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. Hepatol 1997; 25(1)112–117
- Agarwal D. P., Harada S., Goedde H. W. Racial differences in biological sensitivity to ethanol: The role of alcohol dehydrogenase and aldehyde dehydrogenase. Alcohol.: CLin. Exper. Res. 1981; 5(1)12–16
- Lieber C. S. Metabolism of ethanol. Medical and nutritional consequences of alcoholism, C. S. Lieber. Plenum Medical Book Company, New York 1992; 1–35
- Bosron W., Li T. K. Genetic polymorphisms of human alcohol and aldehyde dehydrogenases and their relationship to alcohol metabolism and alcoholism. Hepat. 1986; 6(3)502–510
- Agarwal D., Goedde H. Pharmacogenetics of alcohol dehydrogenase. Pharm. Ther. 1990; 45: 69–83
- Kedishvili N. T., Bosron W., Stone C. L., Hurley T. D., Peggs C. F., Thomasson H. R., Popov K. M., Carr L. G., Edenberg H. J., Li T. K. Expression and characterization of recombinant human stomach alcohol dehydrogenase. Jour. Biol. Chem. 1995; 270(10)3625–3630
- Crabb D., Bosron W., Li T. K. Ethanol metabolism. Pharm. Ther. 1987; 34: 59–73
- Yin S. J., Bosron W., Magnes L., Li T. K. Human liver alcohol dehyrogenase: Purification and kinetic characterization of the β2β2, β2β1 αβ2 and β2γ1 “Oriental Isoenzymes. Biochem. 1984a; 23: 5847–5853
- Hurley T., Ehrig T., Edenberg H., Bosron W. Characterization of human alcohol dehydrogenases containing substitutions at amino acids 47 and 51. Enzymol Mol. Bio. of Carbonyl Metabolism 3, H. Weiner. Plenum Press, New York 1990; 271–274
- Ikuta T., Shibuya A., Yoshida A. Direct determination of usual (Caucasian-type) and atypical (Oriental-type) alleles of the class I human alcohol dehydrogenase-s locus. Biochem. Genet. 1988; 26(7/8)519–525
- Buhler R., Hempel J., Wartburg J. P.v., Jornvall H. Human liver alcohol dehydrogenase: the unique properties of the “atypical” isoenzyme β22 can be explained by a single base pair mutation. Alcohol 1985; 2: 47–51
- Burnell J., Li T. K., Bosron W. Purification and steady state kinetic characterization of human b3b3 alcohol dehydrogenase. Biochem. 1989; 28: 6810–6815
- Smith M., Hopkinson D. A., Harris H. Developmetnal changes and polymorphism in human alcohol dehydrogenase. Amer. Jour. Genet. Lond. 1971; 34: 251–271
- Yin S. J., Liao C. S., Wu C. W., Li T. T., Chen L. L., Lai C. L., Tsao T. Y. Human stomach alcohol and aldehyde dehydrogenase: comparison of of expression pattern and activities in alimentary tract. Gastroenterol. 1997; 112: 766–775
- Dohmen K., Baraona E., Ishibashi H., Pozzato G., Moretti M., Matsunaga C., Fujimoto K., Lieber C. S. Ethnic differences in gastric s-alcohol dehydrogenase activity and ethanol first-pass metabolism. Alcohol.: Clin. Exper. Res. 1996; 20(9)1569–1576
- Jornvall H., Hempel J., Vallee B. L., Bosron W., Li T. K. Human liver alcohol dehydrogenase: Amino acid substitution in the β2β2 Oriental enzyme explains functional propeties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme. Proc. Natl. Acad. Scie. 1984; 81: 3024–3028
- Vesell E., Page J., Passananti G. Genetic and environmental factors affecting ethanol metabolism in man. Clin. Pharm. Ther. 1971; 12: 192–201
- Holford N. H. Clincal pharmacokinetics of ethanol. Clin. Pharmacokin. 1987; 13: 273–292
- Pastino G., Asgharian B., Roberts K., Medinsky M., Bond J. Comparison of physiologically based pharmacokinetic model predictions and experimental data for inhaled ethanol in male and female B6C3F1 mice, F344 rats and humans. Tox. Appl. Pharm. 1997; 145: 147–157
- Institute, I.L.S., Institute, R.S. and Agency, U.E.P. Physiological parameter values for PBPK models. Washington, DC 1994
- Kaneko T., Wang P., Sato A. Partition Coefficients of some acetate esters and alcohols in water, blood, olive oil and rat tissues. Occup. Environ. Med. 1994; 51: 68–72
- Abbas R., Fisher J. W. A physiolgically based pharmacokinetic model for trichlorethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice. Tox. Appl. Pharm. 1997; 147: 15–30
- Derr R. Simulation studies on ethanol metabolism in different human populations with a physiologic pharmacokinetic model. Jour. Pharm. Scie. 1993; 82(7)677–682
- Pastino G., Conolly R. Application of a physiologically based pharmacokinetic model for ethanol to quantify the bioavailability in male rats. The Toxicologist 1998
- Wilkinson P. K., Sedman A. J., Sakmar E., Kay D. R., Wagner J. G. Pharmacokinetics of ethanol after oral administration in the fasting state. Jour. Pharmacokin. Biopharm. 1977; 5: 207–224
- Thomason H., Beard J., Li T. K. ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol.: Clin. Exper. Res. 1995; 19(6)1494–1495
- Bosron W., Li T. K. Catalytic properties of human liver alcohol dehydrogenase isozymes. Enzyme 1987; 37: 19–28
- Seitz H. K., Gartner U., Egerer G., Simanowski U. A. Ethanol metabolism in the gastrointestinal tract and its possible consequences. Biology of alcohol related problems, J. B. Saunders, J. B. Whitfield. Pergamon Press, New York 1996; 157–162