162
Views
91
CrossRef citations to date
0
Altmetric
Research Article

TESTICULAR GAMETOGENIC AND STEROIDOGENIC ACTIVITIES IN CYCLOPHOSPHAMIDE TREATED RAT: A CORRELATIVE STUDY WITH TESTICULAR OXIDATIVE STRESS

, , , &
Pages 281-292 | Published online: 07 Oct 2002

REFERENCES

  • Paul C., Bruce A.C. Antineoplastic Agents. Pharmacol. Basis Therapeut. 1991; 1209–1263
  • Handschumacher R.E. Immunosuppressive Agents. Pharmacol. Basis Therapeut. 1991; 1264–1276
  • Kirkland R.T., Bongiovanni A.M., Cornfield D., McCormic J.B., Parks J.S., Tenore A. Gonadotropin Responses to Leutinizing Releasing Factor in Boys Treated with Cyclophosphamide for Nephrotic Syndrome. J. Pediatr. 1976; 89: 941
  • Etteldorf J.N., West C.D., Pitcock J.A., Williams D.L. Gonadal Function, Testicular Histology, and Meiosis Following Cyclophosphamide Therapy in Patients with Nephrotic Syndrome. J. Pediatr. 1976; 88: 206
  • Fukutani K., Ishida H., Shinohara M. Suppression of Spermatogenesis in Patients with Behcet's Disease Treated with Cyclophosphamide and Colchicine. Fertil. Steril. 1981; 36: 76
  • Masala A., Faedda R., Alagna S., Satta A., Chiarelli G., Rovasio P.P., Ivaldi R., Taras M.S., Lai E., Bartoli E. Use of Testosterone to Prevent Cyclophosphamide Induced Azoospermia. Ann. Internat. Med. 1997; 126: 292
  • Kaur D., Sangha G.K., Bilaspuri G.S. Cyclophosphamide Induced Structural and Biochemical Changes in Testis and Epididymidis of Rats. Ind. J. Exp. Biol. 1997; 35: 771
  • Poplador M.S., Rojas C., Raya A., Casares J.A., Apparicio J., Lancho Alonso J.L. The Effects of Cyclophosphamide on the Gonadotrophic Cells of the Normal Rat. Histol. Histopathol. 1990; 5: 173
  • Hoorweg-Nijman J.J., Delemarre-vande-Wall H.A., DeWall F.C., Behrendt H. Cyclophosphamide-induced Disturbance of Gonadotropin Secretion Manifesting Testicular Damage. Acta Endocrinol. 1992; 126: 143
  • Trasler J.M., Hales B.F., Robaire B. Chronic Low Dose Cyclophosphamide Treatment of Adult Male Rats: Effect on Fertility, Pregnancy Outcome and Progeny. Biol. Reprod. 1986; 34: 275
  • Howell S., Shalet S. Gonadal Damage from Chemotherapy and Radiotherapy. Endocrinol. Metab. Clin. North Am. 1998; 27: 927
  • Ghosh S., Ghosh D., Chattopadhyay S., Debnath J. Effect of Ascorbic Acid Supplementation on Liver and Kidney Toxicity in Cyclophosphamide Treated Female Albino Rats. J. Toxicol. Sci. 1999; 24: 141
  • Ghosh S., Chattopadhyay S., Ghosh D., Debnath J. Effect of Ascorbic Acid Supplementation on the Activities of Ovarian Δ5-3β and 17β Hydroxysteroid Dehydrogenase and Ovarian Cholesterol in Cyclophosphamide Treated Albino Rats. Med. Sci. Res. 1998; 26: 517
  • Ghosh S., Misro M.M., Das U.B., Maiti R.K., Debnath J., Ghosh D. Effect of Human Chorionic Gonadotrophin Coadministration on Ovarian Steroidogenic and Folliculogenic Activities in Cyclophosphamide Treated Albino Rats. Reprod. Toxicol. 2001; 15: 221
  • Ahotupa M., Huhtaniemi I. Impaired Detoxification of Reactive Oxygen and Consequent Oxidative Stress in Experimentally Criptorchid Rat Testis. Biol. Reprod. 1992; 46: 1114
  • Georgiou M., Perkins L.M., Payne A.H. Steroid Synthesis Dependent, Oxygen-Mediated Damage of Mitochondrial and Microsomal Cytochrome P-450 Enzymes in Rat Leydig Cell Cultures. Endocrinology 1987; 121: 1390
  • McDermott E.M., Powell R.J. Incidence of Ovarian Failure in Systemic Lupus Erythematosus after Treatment with Pulse Cyclophosphamide. Annu. Rheumatic Dis. 1996; 55: 224
  • Leblond C.P., Clermont Y. Definition of the Stages of the Cycle of Seminiferous Epithelium in the Rat. Annual of the New York Academy of Science 1952; 55: 548
  • Abercrombie M. Estimation of Nuclear Population from Microtome Sections. Anat. Rec. 1947; 99: 239
  • Clermont Y., Morgentaler H. Quantitative Study of Spermatogenesis in Hypophysectomized Rat. Endocrinology 1955; 57: 369
  • Clermont Y., Harvey S.C. Effects of Hormones on Spermatogenesis in the Rat. Ciba Foundation Colloquin on Endocrinology 1967; 16: 173
  • Talalay P. Hydroxysteroid Dehydrogenase. Meth. Enzymol. 1962; 5: 512–516
  • Jarabak J., Adams J.A., Williams–Ashman H.G., Talalay P. Purification of 17β−hydroxysteroid Dehydrogenase of Human Placenta and Studies on its Tanshydrogenae Function. J. Biol. Chem. 1962; 237: 345
  • Beers R.F., Sizer I.W. A Spectrophotometric Method for Measuring the Break Down of Hydrogen Peroxide by Catalase. J. Biol. Chem. 1952; 195: 133
  • Sadasivam S., Manickam A. Peroxidase. Biochem. Meth. 1996; 108–110
  • Slater T.I. Overview of Methods Used for Detecting Lipid Peroxidation. Meth. Enzymol. 1984; 105: 283–293
  • Ohkawa H., Ohishi N., Yagi K. Assay for Lipid Peroxidation in Animal Tissues by Thioberbutric Acid Reaction. Anal. Biochem. 1979; 95: 351
  • Srivastava T.G. Enzyme Linked Immunosorbant Assay for Steroid Hormones. National Institute of Health and Family Welfare, New Delhi 2001; 55–58
  • Das D., Das A. Analysis of Variance. Stat. Biol. Psychol. 1998; 250–282
  • Ghosh D., Jana D., Debnath J.M. Effects of Leaf Extract of Stephania harnandifolia on Testicular Gametogenesis and Androgenesis in Albino Rats: A Dose-Dependent Response Study. Contraception 2002; 65, in press
  • Ghosh D., Biswas N.M., Ghosh P.K. Studies on the Effect of Prolactin Treatment on Testicular Steroidogenesis and Gametogenesis in Lithium-treated Rats. Acta Endocrinol. 1991; 125: 313
  • Means A.R. Biochemical Effect of Follicle Stimulating Hormone on the Testis. Handbook of Physiology. 1975; 203–217
  • Steinberger E. Hormonal Regulation of the Seminiferous Tubule Function. Hormonal Regulation of Spermatogenesis 1975; 337–352
  • Chowdhury A.K. Dependence of Testicular Germ Cells on Hormone. A Quantitative Study in Hypophysectomized Testosterone Treated Rats. J. Endocrinol. 1979; 82: 331
  • Murono E.P., Payne A.H. Testicular Maturation in the Rat. In VivoEffect of Gonadotropins Steroidogenic Enzymes in Hypophysectomized Immature Rats. Biol. Reprod. 1979; 20: 911
  • Shaw M.J., Georgopouls L.E., Payne A.H. Synergistic Effect of FSH and LH and Testicular Δ5, 3β-hydroxysteroid Dehydrogenase Isomerase. Application of a New Method for the Separation of Testicular Compartments. Endocrinology 1979; 104: 912
  • Aitken R.J., Clarkson J.S. Cellular Basis of Defective Sperm Function and its Association with the Genesis of Reactive Oxygen Species by Human Spermatozoa. J. Reprod. Fertil. 1987; 81: 459
  • Debnath D., Mandal T.K. Study of Quinalphos (An Environmental Oestrogenic Insecticide) Formulation (Ekalux 25 E.C.)-Induced Damage of the Testicular Tissues and Antioxidant Defense Systems in Sprague-Dawley Albino Rats. J. Appl. Toxicol. 2000; 20: 197
  • Chainy G.B.N., Samantaray S., Samanta L. Testosterone-induced Changes in Testicular Antioxidant System. Andrologia 1997; 29: 343
  • Landschulz K.T., Pathak R.K., Rigotti A., Krieger M., Hobbs H.H. Regulation of Scavenger Receptor, Class B, Type I, a High Density Lipoprotein Receptor, in Liver and Steroidogenic Tissues of the Rat. J. Clin. Invest. 1996; 98: 984
  • Brinck-Johnson T., Eik-Nes K.B. Effects of Human Chorionic Gonadotropin on the Secretion of Testosterone and 4-androstenedione 3,17-dione by the Canine Testis. Endocrinology 1957; 61: 676

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.