Stability of the Powdered Dosage Form Prepared by Unsealing the Capsules: Water Vapor Sorption and Discoloration of the Powdery Contents of Clorazepate Dipotassium Capsules

Takehisa Hanawa Department of Pharmacy, Yamanashi Medical University, 1110, Tamaho, Nakakoma-gun, Yamanashi, 409-3898, Japan

Tomohiro Ohta Pharmaceutical Department, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan

Fumiko Kimura Nicolet Japan Company, Limited, Moriya, Kanagawa-ku, Yokohama, Kanagawa, 221-0022, Japan

Takanori Tsuchiya Pharmaceutical Department, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan

Rieko Ikoma Pharmaceutical Department, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan

Tomomi Uchida Pharmaceutical Department, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan

Masahiko Suzuki Department of Pharmacy, Yamanashi Medical University, 1110, Tamaho, Nakakoma-gun, Yamanashi, 409-3898, Japan

Shin'ichiro Nakajima Department of Pharmacy, Yamanashi Medical University, 1110, Tamaho, Nakakoma-gun, Yamanashi, 409-3898, Japan

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