Advanced search
Publication Cover
Drug Development and Industrial Pharmacy Volume 27, 2001 - Issue 7
Submit an article Journal homepage
71
Views
29
CrossRef citations to date
0
Altmetric
Original

Preparation and In Vitro Properties of N-Succinylchitosan– or Carboxymethylchitin–Mitomycin C Conjugate Microparticles with Specified Size

Hiraku Onishi Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan; Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan
,
Hiroaki Takahashi Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan
,
Miwa Yoshiyasu Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan
&
Yoshiharu Machida Department of Drug Delivery Research, Hoshi University, 2-4-41, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan
Pages 659-667 | Published online: 02 Jul 2010

REFERENCES

  • Song Y., Onishi H., Nagai T. Conjugate of mitomycin C with N-succinyl-chitosan: in vitro drug release properties, toxicity and antitumor activity. Int. J. Pharm. 1993; 98: 121–130
  • Song Y., Onishi H., Nagai T. Toxicity and antitumor activity of the conjugate of mitomycin C with carboxymethylchitin. Yakuzaigaku 1993; 53: 141–147
  • Izume M. The application of chitin and chitosan to cosmetics. Chitin Chitosan Res. 1998; 4: 12–17
  • Song Y., Onishi H., Nagai T. Synthesis and drug release characteristics of the conjugates of mitomycin C with N-succinyl-chitosan and carboxymethyl-chitin. Chem. Pharm. Bull. 1992; 40: 2822–2825
  • Song Y., Onishi H., Nagai T. Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate. Biol. Pharm. Bull. 1993; 16: 48–54
  • Song Y., Onishi H., Machida Y., Nagai T. Particle characteristics of carboxymethyl-chitin-mitomycin C conjugate and N-succinyl-chitosan-mitomycin C conjugate and histological effect on some tissues after intravenous administration. STP Pharm. Sci. 1995; 5: 162–170
  • Sato M., Onishi H., Kitano M., Machida Y., Nagai T. Preparation and drug release characteristics of the conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan. Biol. Pharm. Bull. 1996; 19: 241–245
  • Sato M., Onishi H., Takahara J., Machida Y., Nagai T. In vivo drug release and antitumor characteristics of water-soluble conjugates of mitomycin C with glycol-chitosan and N-succinyl-chitosan. Biol. Pharm. Bull. 1996; 19: 1170–1177
  • Song Y., Onishi H., Machida Y., Nagai T. Drug release and antitumor characteristics of N-succinyl-chitosan-mitomycin C as an implant. J. Controlled Release 1996; 42: 93–100
  • Sugibayashi K., Morimoto Y., Nadai T., Kato Y., Hasegawa A., Arita T. Drug-carrier property of albumin microspheres in chemotherapy. II. Preparation and tissue distribution in mice of microsphere-entrapped 5-fluorouracil. Chem. Pharm. Bull. 1979; 27: 204–209
  • Kanke M., Simmons G. H., Weiss D. L., Bivins B. A., Deluca P. P. Clearance of 141Ce-labeled microspheres from blood and distribution in specific organs following intravenous and intraarterial administration in beagle dogs. J. Pharm. Sci. 1980; 69: 755–762
  • Yoshioka T., Hashida M., Muranishi S., Sezaki H. Specific delivery of mitomycin C to the liver, spleen and lung: nano- and microspherical carriers of gelatin. Int. J. Pharm. 1981; 31: 131–141
  • Morimoto Y., Sugibayashi K., Kato Y. Drug-carrier property of albumin microspheres in chemotherapy. V. Antitumor effect of microsphere-entrapped adriamycin on liver metastasis of AH 7974 cells in rats. Chem. Pharm. Bull. 1981; 29: 1433–1438
  • Hata H., Onishi H., Machida Y. Evaluation of carboxymethylchitin as a drug carrier: effect of the deacetylation degree on the biodegradation and biodisposition characteristics in mice. STP Pharm. Sci. 1999; 9: 115–121
  • Hata H., Onishi H., Machida Y. Preparation of CM-chitin microspheres by complexation with iron(III) in w/o emulsion and their biodisposition characteristics in mice. Biomaterials 2000; 21: 1779–1788
  • Yamaoka K., Tanigawara Y., Nakagawa Y., Uno T. A pharmacokinetic program (MULTI) for microcomputers. J. Pharmacobio.-Dyn. 1981; 4: 879–885

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.