Advanced search
Publication Cover
Drug Development and Industrial Pharmacy Volume 28, 2002 - Issue 8
Submit an article Journal homepage
396
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Effects of Ethanol to Water Ratio in Feed Solution on the Crystallinity of Spray-Dried Lactose

Päivi Harjunen Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, Kuopio, FIN-70211, Finland
,
Vesa-Pekka Lehto Department of Physics, University of Turku, Vesilinnantie 5, Turku, FIN-20014, Finland
,
Jouni Välisaari Department of Chemistry, University of Jyväskylä, P.O. Box 35, Jyväskylä, FIN-40351, Finland
,
Tapio Lankinen Focus Inhalation Oy, P.O. Box 980, Turku, FIN-20101, Finland
,
Petteri Paronen Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, Kuopio, FIN-70211, Finland
&
Kristiina Järvinen Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, Kuopio, FIN-70211, Finland
Pages 949-955 | Published online: 28 Aug 2002

REFERENCES

  • Broadhead J., Edmond Rouan S.K., Rhodes C.T. The Spray Drying Pharmaceuticals. Drug Dev. Ind. Pharm. 1992; 18(11&12)1169–1206
  • Briggner L.E., Buckton G., Bystrom K., Darcy P. The Use of Isothermal Microcalorimetry in the Study of Changes in Crystallinity Induced During the Processing of Powders. Int. J. Pharm. 1994; 105: 125–135
  • Ueno Y., Yonemochi E., Yamamura S., Tozuka Y., Yamamura S., Oguchi T., Yamamoto K. Characterization of Amorphous Ursodeoxycholic Acid Prerared by Spray-Drying. J. Pharm. Pharmacol. 1998; 50: 1213–1219
  • Hancock B.C., Parks M. What Is the True Solubility Advantage for Amorphous Pharmaceuticals?. Pharm. Res. 2000; 17(4)397–404
  • Buckton G., Darcy P. The Influence of Additives on the Recrystallisation of Amorphous Spray Dried Lactose. Int. J. Pharm. 1995; 121: 81–87
  • Buckton G., Darcy P. Water Mobility in Amorphous Lactose Below and Close to the Glass Transition Temperature. Int. J. Pharm. 1996; 136: 141–146
  • Vidgren P., Vidgren M., Paronen P. Physical Stability and Inhalation Behaviour of Mechanically Micronized and Spray Dried Disodium Cromoglycate in Different Humidities. Acta Pharm. Fenn. 1989; 98: 71–78
  • Buckton G., Darcy P., Greenleaf D., Holbrook P. The Use of Isothermal Microcalorimetry in the Study of Changes in Crystallinity of Spray-Dried Salbutamol Sulphate. Int. J. Pharm. 1995; 116: 113–118
  • Sebhatu T., Angberg M., Ahlneck C. Assessment of the Degree of Disorder in Crystalline Solid by Isothermal Microcalorimetry. Int. J. Pharm. 1994; 104: 135–144
  • Chidavaenzi O.C., Buckton G., Koosha F., Pathak R. The Use of Thermal Techniques to Assess the Impact of feed Concentration on the Amorphous Content and Polymorphic Forms Present in Spray Dried Lactose. Int. J. Pharm. 1997; 159: 67–74
  • Angberg M., Nyström C., Castensson S. Evaluation of Heat-Conduction Microcalorimetry in Pharmaceutical Stability Studies. V. A New Approach for Continuous Measurements in Abundant Water Vapour. Int. J. Pharm. 1992; 81: 153–167
  • Angberg M., Nyström C., Castensson S. Evaluation of Heat-Conduction Microcalorimetry in Pharmaceutical Stability Studies. VI. Continuous Monitoring of the Interaction of Water Vapour with Powders and Powder Mixtures at Various Relative Humidities. Int. J. Pharm. 1992; 83: 11–23
  • Stubberud L., Forbes R.T. The Use of Gravimetry for the Study of the Effect of Additives on the Moisture-Induced Recrystallisation of Amorphous Lactose. Int. J. Pharm. 1998; 163: 145–156
  • Naini V., Byron P.R., Phillips E.M. Physicochemical Stability of Crystalline Sugars and Their Spray-Dried Forms: Dependence upon Relative Humidity and Suitability for Use in Powder Inhalers. Drug Dev. Ind. Pharm. 1998; 24(10)895–909

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.