Advanced search
Publication Cover
Drug Development and Industrial Pharmacy Volume 30, 2004 - Issue 1
Submit an article Journal homepage
35
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Entry Port Selection for Detecting Particle Size Differences in Metered Dose Inhaler Formulations Using Cascade Impaction

Venkatesh Naini Respiratory Formulation Development, Schering‐Plough Research Institute, K‐11‐2, J5, Kenilworth, New Jersey, 07033, USA
, Ph.D.,
Saeed Chaudhry Respiratory Formulation Development, Schering‐Plough Research Institute, K‐11‐2, J5, Kenilworth, New Jersey, 07033, USA
,
Julianne Berry Respiratory Formulation Development, Schering‐Plough Research Institute, K‐11‐2, J5, Kenilworth, New Jersey, 07033, USA
,
Stefan Sharpe Respiratory Formulation Development, Schering‐Plough Research Institute, K‐11‐2, J5, Kenilworth, New Jersey, 07033, USA
,
John Hart Respiratory Formulation Development, Schering‐Plough Research Institute, K‐11‐2, J5, Kenilworth, New Jersey, 07033, USA
&
Joel Sequeira Respiratory Formulation Development, Schering‐Plough Research Institute, K‐11‐2, J5, Kenilworth, New Jersey, 07033, USA
Pages 75-82 | Published online: 02 Feb 2004

References

  • Mitchell J. P., Nagel M. W. Medical aerosols: techniques for particle size evaluation. Part. Sci. Technol. 1997; 15: 217–241
  • Tzou T.‐Z. Aerodynamic particle size of metered‐dose inhalers determined by the quartz crystal microbalance and the Andersen cascade impactor. Int. J. Pharm. 1999; 186: 71–79
  • LeBelle M. J., Graham S. J., Ormsby E. D., Duhaime R. M., Lawrence R. C., Pike R. K. Metered dose inhalers. II. Particle size measurement variation. Int. J. Pharm. 1997; 151: 209–221
  • Hickey A. J. Sampling inlet considerations in inertial particle‐size analysis of inhalation aerosols. Pharm. Technol. 1995; 3: 58–67
  • Olsson B., Borgstrom L., Asking L., Bondesson E. Effect of inlet throat on the correlation between measured fine particle dose and lung deposition. Respiratory Drug Delivery V, R. N. Dalby, P. R. Byron, S. J. Farr. Interpharm Press, Buffalo Grove, IL 1996; 273–281
  • Stein S. W., Gabrio B. J. Understanding throat deposition during cascade impactor testing. Respiratory Drug Delivery VII, P. R. Byron, R. N. Dalby, J. Peart, S. J. Farr. DHI Publishing, Raleigh, NC 2000; 287–290
  • Velasquez D. J., Gabrio B. Metered dose inhaler aerosol deposition in a model of the human respiratory system and a comparison with clinical deposition studies. J. Aerosol Med. 1998; 11(Suppl. 1)S23–S28
  • USP25‐NF20. <601> General Chapter on Aerosols. United States Pharmacopeial Convention, Rockville, MD, 2002; 1964–1980
  • Graham S. J., Lawrence R. C., Ormsby E. D., Pike R. K. Particle size distribution of single and multiple sprays of salbutamol metered dose inhalers (MDIs). Pharm. Res. 1995; 12: 1380–1384
  • Impaq‐6 Operating Manual. California Measurements, Sierra Madre, CA
  • European Pharmacopoeia. Apparatus A (Glass Impinger). 1997
  • Van Oort M., Gollmar R. O., Bohinski R. J. Effects of chamber volume and geometry on aerodynamic size distributions of metered dose inhalation aerosols measured using cascade impactor. Pharm. Res. 1994; 11: 604–607
  • Midoux N., Hosek P., Pailleres L., Authelin J. R. Micronization of pharmaceutical substances in a spiral jet mill. Powder Technol. 1999; 104: 113–120
  • Phillips E. M., Byron P. R. Surfactant promoted crystal growth of micronized methylprednisolone in trichloromonfluoromethane. Int. J. Pharm. 1994; 110: 9–19

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.