Advanced search
Publication Cover
Drug Development and Industrial Pharmacy Volume 30, 2004 - Issue 3
Submit an article Journal homepage
583
Views
88
CrossRef citations to date
0
Altmetric
Research Article

Physicochemical Characterization of Solid Dispersions of Indomethacin with PEG 6000, Myrj 52, Lactose, Sorbitol, Dextrin, and Eudragit® E100

Hadi Valizadeh Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
, Ph. D., Pharm. D.,
Ali Nokhodchi Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Pharmacy Department, King's College London, Franklin–Wilkins Building, 150 Stamford St., London, UK
,
Nahid Qarakhani Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
,
Parvin Zakeri‐Milani Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
,
Shirzad Azarmi Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
,
Davood Hassanzadeh Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
&
Raimar Löbenberg Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
 show all
Pages 303-317 | Published online: 03 Nov 2004

References

  • Löbenberg R., Amidon G. L. Modern bioavailability, bioequivalence and biopharmaceutics classification system; new scientific approaches to international regulatory standards. Eur. J. Pharm. Biopharm. 2000; 50: 3–12, [CSA]
  • Kapsi S. G., Ayres J. W. Processing factors in development of solid solution formulation of itraconazole for enhancement of drug dissolution and bioavailability. Int. J. Pharm. 2001; 229: 193–203
  • Aguiar A. J., Zelmer A. J., Kinkel A. W. Deagglomeration behavior of relatively insoluble benzoic acid and its sodium salt. J. Pharm. Sci. 1967; 56: 1243–1252
  • Finholt P., Solvang S. Dissolution kinetics of drugs in human gastric juice—the role of surface tension. J. Pharm. Sci. 1968; 57: 1322–1326
  • Lin S. L., Menig J., Lachman L. Interdependence of physiological surfactant and drug particle size on the dissolution behavior of water insoluble drugs. J. Pharm. Sci. 1968; 57: 2143–2146
  • Sekiguchi K., Obi N. Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem. Pharm. Bull. 1961; 9: 866–872
  • Chiou W. L., Riegelman S. Pharmaceutical applications of solid dispersion systems. J. Pharm. Sci. 1971; 60: 1281–1302
  • Leuner C., Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur. J. Pharm. Biopharm. 2000; 50: 47–60, [CSA]
  • Sarkari M., Brown J., Chen X., Swinnea S., Williams R. O., Johnston K. P. Enhanced drug dissolution using evaporative precipitation into aqueous solution. Int. J. Pharm. 2002; 243: 17–31
  • Prabhu S., Brocks D. R., Betageri G. V. Enhancement of dissolution of ethopropazine using solid dispersion prepared with phospholipid and/or polyethylene glycol. Drug Dev. Ind. Pharm. 2001; 27(5)413–418, [CSA]
  • Alsaidan S. M., Alsughayer A. A., Eshra A. G. Improved dissolution rate of indomethacin by adsorbents. Drug Dev. Ind. Pharm. 1998; 24(4)389–394, [CSA]
  • Krasowska H. Solubilization of indomethacin and cinmetacin by non‐ionic surfactants of the polyoxyethylene type. Il Farmaco 1976; 31(9)463–472
  • Krasowska H. Effect of micellar solubilization on the gastrointestinal absorption of indomethacin in the rat. Int. J. Pharm. 1980; 7(Dec.)137–143
  • Habib M. J., Akogyeram C., Ahmadi B. Improved dissolution of indomethacin in coprecipitates with phospholipids. Part 1. Drug Dev. Ind. Pharm. 1993; 19(4)499
  • Higuchi T., Connors K. A. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4: 117–210
  • Ford J. L. The current status of solid dispersions. Pharm. Acta Helv. 1986; 61: 69–88
  • Craig D. Q.M. The mechanisms of drug release from solid dispersions in water‐soluble polymers. Int. J. Pharm. 2002; 231: 131–144
  • El‐Zein H., Riad L., El‐Bary A. A. Enhancement of carbamazepine dissolution: in vitro and in vivo evaluation. Int. J. Pharm. 1998; 168: 209–220
  • Sekikawa H., Nakano M., Arita T. Dissolution mechanisms of drug‐polyvinylpyrrolidone coprecipitates in aqueous solution. Chem. Pharm. Bull. 1979; 27: 1223–1230
  • Handbook of Pharmaceutical Excipients, A. Wade, P. J. Weller. Pharmaceutical Press, London 1994
  • Janez K., Milojka M., Stanko S., Bojan K., Jelka S. K. Dissolution study of felodipin solid dispersions. Acta Pharm. 1993; 43: 113–120
  • Zingone G., Rubessa F. Release of carbamazepine from solid dispersions with polyvinyl pyrrolidone: vinylacetate copolymer (PVP:VA). STP Pharma Sci. 1994; 4: 122–127
  • Abd El‐Fattah S., Salib N. N., El‐Assik M. New approach for controlling the release rate of pheniramine aminosalicylate via solid dispersion in different types of Eudragit. Drug Dev. Ind. Pharm. 1984; 10(4)649–666
  • Hancock B. C., Zografi G. Characteristic and significance of the amorphous state in pharmaceutical systems. J. Pharm. Sci. 1997; 86: 1–12
  • Matsumoto T., Zografi G. Physical properties of solid molecular dispersions of indomethacin with poly(vinylpyrrolidone) and poly(vinylpyrrolidone‐co‐vinylacetate) in relation to indomethacin crystallization. Pharm. Res. 1999; 16: 1722–1728
  • Lovrecich M., Nobile F., Rubessa F., Zingone G. Effect of aging on the release of indomethacin from solid dispersions with Eudragits. Int. J. Pharm. 1996; 131: 247–255

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.