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Research Article

Insulin‐Loaded Calcium Pectinate Nanoparticles: Effects of Pectin Molecular Weight and Formulation pH

& , Ph.D.
Pages 359-367 | Published online: 31 Mar 2004

References

  • Damge C., Vranckx H., Balschmidt P., Couvreur P. Poly(alkyl cyanoacrylate) nanospheres for oral administration of insulin. J. Pharm. Sci. 1997; 86(12)1403–1409
  • Pan Y., Li Y., Zhao H., Zheng J., Xu H., Wei G., Hao J., Cui F. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int. J. Pharm. 2002; 249(1–2)139–147, [CROSSREF]
  • Davis S. S. Overcoming barriers to the oral administration of peptide drugs. Trends Pharmacol. Sci. 1990; 11(9)353–355, [CROSSREF]
  • Carino G. P., Mathionitz E. Oral insulin delivery. Adv. Drug Deliv. Rev. 1999; 35(2–3)249–253, [CROSSREF]
  • Sriamornsak P. Effect of calcium concentration, hardening agent and drying condition on release characteristics of oral proteins from calcium pectinate gel beads. Eur. J. Pharm. Sci. 1999; 8(3)221–227, [CSA], [CROSSREF]
  • Rolin C., Nielsen B. U., Glaahn P. E. Polysaccharides, S. Dumitriu. Marcel Dekker, Inc., New York 1998; 377–432
  • Pillay V., Fassihi R. In vitro release modulation from crosslinked pellets for site‐specific drug delivery to the gastrointestinal tract II: physicochemical characterization of calcium‐alginate, calcium‐pectinate and calcium‐alginate‐pectinate pellets. J. Control. Release 1999; 59(2)243–256, [CSA], [CROSSREF]
  • Lee Y. C., Yalkowsky S. H. Effect of formulation on the systemic absorption of insulin from enhancer‐free ocular devices. Int. J. Pharm. 1999; 185(2)199–204, [CROSSREF]
  • El‐Gibaly I. Oral delayed‐release system based on Zn‐pectinate gel (ZPG) microparticles as an alternative carrier to calcium pectinate beads for colonic drug delivery. Int. J. Pharm. 2002; 232(1–2)199–211
  • Adkin D. A., Kenyon C. J., Lerner E. I., Landau I., Strauss E., Caron D., Penhasi A., Rubinstein A., Wilding I. R. The use of scintigraphy to provide “proof of concept” for novel polysaccharide preparations designed for colonic drug delivery. Pharm. Res. 1997; 14(1)103–107, [CROSSREF]
  • Rubinstein A., Radai R., Ezra M., Pathak S., Rokem J. S. In vitro evaluation of calcium pectinate: a potential colon‐specific drug delivery carrier. Pharm. Res. 1993; 10(2)258–263, [CROSSREF]
  • Saffran M., Kumar G. S., Savariar C., Burnham J. C., Williams F., Neckers D. C. A new approach to the oral administration of insulin and other peptide drugs. Science 1986; 233(4768)81–84
  • Saffran M., Field J. B., Pena J., Jones R. H., Okuda Y. Insulin and the gastrointestinal tract. J. Endocrinol. 1991; 131(2)267–278
  • Ma Z. S., Yeoh H. H., Lim L. Y. Formulation pH modulates the interaction of insulin with chitosan nanoparticles. J. Pharm. Sci. 2002; 91(6)1396–1404, [CROSSREF]
  • Allemann E., Doelker E., Gurny R. Drug loaded poly(lactic acid) nanoparticles produced by a reversible salting‐out process: purification of an injectable dosage form. Eur. J. Pharm. Biopharm. 1993; 39(1)13–18
  • Allemann E., Gurny R., Doelker E. Drug‐loaded nanoparticles: preparation methods and drug targeting issues. Eur. J. Pharm. Biopharm. 1993; 39(2)173–191
  • Deckers H. A., Olieman C., Rombouts F. M., Pilnik W. Calibration and application of high‐performance size exclusion columns for molecular weight distribution of pectins. Carbohydr. Polym. 1986; 6: 361–378, [CROSSREF]
  • Grant G. T., Morris E. R., Rees D. A., Smith P. J.C., Thom D. Biological interactions between polysaccharides and divalent cations: the egg‐box model. FEBS Lett. 1973; 32: 195, [CROSSREF]
  • Walkinshaw M. D., Amott S. Conformations and interactions of pectins I. X‐ray diffraction analyses of sodium pectinate in neutral and acidified forms. J. Mol. Biol. 1981; 153(4)1055–1073, [CROSSREF]
  • , Copenhagen Pectin A/S, 1998. GENU® Pectin General Description. Denmark
  • Racape E., Thibault J. F., Reitsma J. C.E., Pilnik W. Properties of amidated pectins. II. Polyelectrolyte behaviour and calcium binding of amidated pectins and amidated pectin acids. Biopolymers 1989; 28: 1435–1448
  • Plaschina I. G., Braudo E. E., Tolstoguzov V. B. Circular‐dichroism studies of pectin solutions. Carbohydr. Res. 1978; 60: 1–8, [CROSSREF]
  • Cesaro A., Delben F., Paoletti S. Thermodynamics of the proton dissociation of natural polyuronic acids. Int. J. Biol. Macromol. 1990; 12(3)170–176, [CROSSREF]
  • Sommerfeld P., Sabel B. A., Schroeder U. Long‐term stability of PBCA nanoparticle suspensions. J. Microencapsul. 2000; 17(1)69–79, [CSA], [CROSSREF]
  • Hu F. Q., Yuan H., Zhang H. H., Fang M. Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int. J. Pharm. 2002; 239(1–2)121–128, [CROSSREF]

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