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Research Article

PHOTOPROTECTIVE ACTIONS OF TOPICALLY APPLIED VITAMIN E*

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Pages 413-420 | Published online: 10 Oct 2000

REFERENCES

  • Fryer M. J. Evidence for the photoprotective effects of vitamin E. Photochem. Photobiol. 1993; 58: 304–312
  • Fuchs J. Potentials and limitations of the natural antioxidants RRR-alpha-tocopherol, L-ascorbic acid and β-carotene in cutaneous photoprotection. Free Radical Biol. Med. 1998; 25(7)848–873
  • Jurkiewicz B. A., Bissett D. L., Buettner G. R. Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. J. Invest. Dermatol. 1995; 104: 484–488
  • Franklin W. A., Lo K. M., Haseltine W. A. Alkaline lability of fluorescent photoproducts produced in ultraviolet light-irradiated DNA. J. Biol. Chem. 1982; 257: 13,535–13,543
  • Nakazawa H., English D., Randell P. L., Nakazawa K., Martel N., Armstrong B. K., Yamasaki H. UV and skin cancer: Specific p53 gene mutation in normal skin as a biologically relevant exposure measurement. Proc. Natl. Acad. Sci. USA 1994; 91: 360–364
  • Engelberg D., Klein C., Martinetto H., Struhl K., Karin M. The UV response involving the ras signalling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell 1994; 77: 381–390
  • Devary Y., Rosette C., DiDonato J. A., Karin M. NF-kB activation by ultraviolet light not dependent on a nuclear signal. Science 1993; 261: 1442–1445
  • Liebler D. C. The role of metabolism in the antioxidant function of vitamin E. CRC Crit. Rev. Toxicol. 1993; 23: 147–169
  • Serbinova E. A., Packer L. Tocopherone and epoxytocopherone products of vitamin E oxidation, in Antioxidant Characterization and Assay. Academic Press, New York 1994; 310–316
  • Liebler D. C. Antioxidant properties of α-tocopherol and α-tocotrienol, in Antioxidant Characterization and Assay. Academic Press, New York 1994; 354–366
  • Skinner W. A., Alaupovic P. Oxidation products of vitamin E and its model, 6-hydroxy-2,2,5,7,8-pentamethyl-chroman. V. Studies of the products of alkaline ferricyanide oxidation. J. Org. Chem. 1963; 28: 2854–2858
  • Skinner W. A., Parkhurst R. M. Oxidation products of vitamin E and its model 6-hydroxy-2,2,5,7,8-pentamethylchroman. VIII. Oxidation with benzoyl peroxide. J. Org. Chem. 1963; 31: 1248–1251
  • Suarna C., Craig D. C., Cross K. J., Southwell-Keely P. T. Oxidations of vitamin E (α-tocopherol) and its model compound 2,3,5,7,8-pentamethyl-6-hydroxychroman. A new dimer. J. Org. Chem. 1988; 53: 1281–1284
  • Draper H. H., Csallany A. S., Chiu M. Isolation of a trimer of α-tocopherol from mammalian liver. Lipids 1966; 2: 47–52
  • Suarna C., Southwell–Keely P. T. Effect of alcohols on the oxidation of the vitamin E model compound, 2,2,5,7,8-pentamethyl-6-chromanol. Lipids 1989; 24: 56–60
  • Ha Y. L., Csallany A. S. α-Tocopherol oxidation mediated by superoxide anion (O2−). II. Identification of the stable α-tocopherol oxidation products. Lipids 1992; 27: 201–205
  • Nelan D. R., Robeson C. D. The oxidation product from a-tocopherol and potassium ferricyanide and its reaction with ascorbic and hydrochloric acids. J. Am. Chem. Soc. 1962; 84: 2963–2965
  • Gensler H. L., Magdaleno M. Topical vitamin E inhibition of immunosuppression and tumorigenesis induced by ultraviolet radiation. Nutr. Cancer 1991; 15: 97–106
  • Bisset D. L., Chatterjee R., Hannon D. P. Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse. Photodermatol. Photoimmunol. Photomed. 1990; 7: 56–62
  • Werninghaus K., Handjani R.-M., Gilchrest B. A. Protective effect of alpha-tocopherol in carrier liposomes on ultraviolet-mediated human epidermal cell damage. in vitro. Photodermatol. Photoimmunol. Photomed. 1991; 8: 236–242
  • Gerrish K. E., Gensler H. L. Prevention of photocarcinogenesis by dietary vitamin E. Nutr. Cancer 1993; 19: 125–133
  • Record I. R., Dreosti I. E, Konstantinopoulos M., Buckley R. A. The influence of topical and systemic vitamin E on ultraviolet light-induced skin damage in hairless mice. Nutr. Cancer 1991; 16: 219–225
  • Werninghaus K., Meydani M, Bhawan J., Margolis R., Blumberg J. B., Gilchrest B. A. Evaluation of the photoprotective effect of oral vitamin E supplementation. Arch. Dermatol. 1994; 130: 1257–1261
  • McVean M., Liebler D. C. Inhibition of UVB induced photodamage in mouse epidermis by topically applied α-tocopherol. Carcinogenesis 1997; 18: 1617–1622
  • McVean M., Liebler D. C. Prevention of DNA photodamage by vitamin E compounds and sunscreens: Roles of ultraviolet absorbance and cellular uptake. Mol. Carcinogen. 1999; 24: 169–176
  • Berton T. R., Conti C. J., Mitchell D. L., Aldaz C. M., Lubet R. A., Fischer S. M. The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis. Mol. Carcinogen. 1998; 23: 175–184
  • Norkus E. P., Bryce G. F., Bhagavan H. N. Uptake and bioconversion of α-tocopheryl acetate to α-tocopherol in skin of hairless mice. Photochem. Photobiol. 1993; 57: 613–615
  • Alberts D. S., Goldman R., Xu M. J., Dorr R. T., Quinn J., Welch K., Guillen-Rodriguez J., Aickin M., Peng Y. M., Loescher L., Gensler H. Disposition and metabolism of topically administered α-tocopherol acetate: A common ingredient of commercially available sunscreens and cosmetics. Nutr. Cancer 1996; 26: 193–201
  • Kramer-Stickland K. A., Liebler D. C. Effect of UVB on hydrolysis of α-tocopherol acetate to α-tocopherol in mouse skin. J. Invest. Dermatol. 1998; 111(2)302–307
  • Thiele J., Traber M. G., Packer L. Depletion of stratum corneum vitamin E: An early and sensitive in vivo marker of UV-induced photo-oxidation. J. Invest. Dermatol. 1998; 110: 756–761
  • Liebler D. C., Burr J. A. Effects of UV light and tumor promoters on Vitamin E status in mouse skin. Carcinogenesis 2000; 21: 221–225
  • Weber C., Podda M., Rallis M., Thiele J. J., Traber M. G., Packer L. Efficacy of topically applied tocopherols and tocotrienols in protection of murine skin from oxidative damage induced by UV-irradiation. Free Radical Biol. Med. 1997; 22: 761–769
  • Kramer K. A., Liebler D. C. UVB induced photooxidation of vitamin E. Chem. Res. Toxicol. 1997; 10: 219–224
  • Matsuo M., Matsumoto S., Iitaka Y., Niki E. Radical scavenging reactions of vitamin E and its model compound, 2,2,5,7,8-pentamethylchroman-6-ol in a tert-butylperoxyl radical generating system. J. Am. Chem. Soc. 1989; 111: 7179–7185
  • Yamauchi R., Miyake N., Kato K., Ueno Y. Reaction of α-tocopherol with alkyl and alkylperoxyl radicals of methyl linoleate. Lipids 1993; 28: 201–206
  • Traber M. G., Rallis M., Podda M., Weber C., Maibach H. I., Packer L. Penetration and distribution of α-tocopherol, α- or α-tocotrienols applied individually onto murine skin. Lipids 1998; 33: 87–91

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