References
- Alsenz J., Steffen H., Alex R. Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco‐2 cell monolayers. Pharm. Res. 1998; 15: 423–428, [PUBMED], [INFOTRIEVE]
- Anderle P., Niederer E., Rubas W., Hilgendorf C., Spahn‐Langguth H., Wunderli‐Allenspach H., Merkle H. P., Langguth P. P‐glycoprotein (P‐gp) mediated efflux in Caco‐2 cell monolayers: the influence of culturing conditions and drug exposure on P‐gp expression levels. J. Pharm. Sci. 1998; 87: 757–762, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Bakos E., Evers R., Szakacs G., Tusnady G. E., Welker E., Szabo K., de Haas M., van Deemter L., Borst P., Varadi A., Sarkadi B. Functional multidrug resistance protein (MRP1) lacking the N‐terminal transmembrane domain. J. Biol. Chem. 1998; 273: 32167–32175, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Basson M. D., Turowski G., Emenaker N. J. Regulation of human (Caco‐2) intestinal epithelial cell differentiation by extracellular matrix proteins. Exp. Cell Res. 1996; 225: 301–305, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Benet L. Z., Izumi T., Zhang Y., Silverman J. A., Wacher V. J. Intestinal MDR transport proteins and P‐450 enzymes as barriers to oral drug delivery. J. Control. Release 1999; 62: 25–31, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Bowman P. D., Ennis S. R., Rarey K. E., Betz A. L., Goldstein G. W. Brain microvessel endothelial cells in tissue culture: a model for study of blood–brain barrier permeability. Ann. Neurol. 1983; 14: 396–402, [PUBMED], [INFOTRIEVE]
- Cantz T., Nies A. T., Brom M., Hofmann A. F., Keppler D. MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells. Am. J. Physiol.: Gastrointest. Liver Physiol. 2000; 278: G522–G531
- Cooray H. C., Blackmore C. G., Maskell L., Barrand M. A. Localisation of breast cancer resistance protein in microvessel endothelium of human brain. NeuroReport 2002; 13: 2059–2063, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Cui Y., Konig J., Keppler D. Vectorial transport by double‐transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol. Pharmacol. 2001; 60: 934–943, [PUBMED], [INFOTRIEVE], [CSA]
- Cui Y., Konig J., Nies A. T., Pfannschmidt M., Hergt M., Franke W. W., Alt W., Moll R., Keppler D. Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Lab. Invest. 2003; 83: 527–538, [PUBMED], [INFOTRIEVE], [CSA]
- Davenport E. A., Nettesheim P. Type I collagen gel modulates extracellular matrix synthesis and deposition by tracheal epithelial cells. Exp. Cell Res. 1996; 223: 155–162, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Dehouck M. P., Jolliet‐Riant P., Bree F., Fruchart J. C., Cecchelli R., Tillement J. P. Drug transfer across the blood–brain barrier: correlation between in vitro and in vivo models. J. Neurochem. 1992; 58: 1790–1797, [PUBMED], [INFOTRIEVE]
- Dresser G. K., Bailey D. G., Leake B. F., Schwarz U. I., Dawson P. A., Freeman D. J., Kim R. B. Fruit juices inhibit organic anion transporting polypeptide‐mediated drug uptake to decrease the oral availability of fexofenadine. Clin. Pharmacol. Ther. 2002; 71: 11–20, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Evers R., Kool M., van Deemter L., Janssen H., Calafat J., Oomen L. C. J. M., Paulusma C. C., Elferink R. P. J. O., Baas F., Schinkel A. H., Borst P. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J. Clin. Invest. 1998; 101: 1310–1319, [PUBMED], [INFOTRIEVE], [CSA]
- Flexner C. HIV‐protease inhibitors. N. Engl. J. Med. 1998; 338: 1281–1292, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Fuller S. D., Simons K. Transferrin receptor polarity and recycling accuracy in “tight” and “leaky” strains of Madin‐Darby canine kidney cells. J. Cell Biol. 1986; 103: 1767–1779, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Gisslen M., Hagberg L. Antiretroviral treatment of central nervous system HIV‐1 infection: a review. HIV Med. 2001; 2: 97–104, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Glynn S. L., Yazdanian M. In vitro blood–brain barrier permeability of nevirapine compared to other HIV antiretroviral agents. J. Pharm. Sci. 1998; 87: 306–310, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Goh L. B., Spears K. J., Yao D., Ayrton A., Morgan P., Roland W. C., Friedberg T. Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man. Biochem. Pharmacol. 2002; 64: 1569–1578, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Hidalgo I. J., Raub T. J., Borchardt R. T. Characterization of the human colon carcinoma cell line (Caco‐2) as a model system for intestinal epithelial permeability. Gastroenterology 1989; 96: 736–749, [PUBMED], [INFOTRIEVE]
- Huisman M. T., Smit J. W., Schinkel A. H. Significance of P‐glycoprotein for the pharmacology and clinical use of HIV protease inhibitors. Aids 2000; 14: 237–242, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Huisman M. T., Smit J. W., Crommentuyn K. M. L., Zelcer N., Wiltshire H. R., Beijnen J. H., Schinkel A. H. Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. Aids 2002; 16: 2295–2301, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Hunter J., Hirst B. H. Intestinal secretion of drugs. The role of P‐glycoprotein and related drug efflux systems in limiting oral drug absorption. Adv. Drug Deliv. Rev. 1997; 25: 129–157, [CROSSREF], [CROSSREF], [CSA]
- Kakuda T. N., Struble K. A., Piscitelli S. C. Protease inhibitors for the treatment of human immunodeficiency virus infection. Am. J. Health‐Syst. Pharm. 1998; 55: 233–254, [CSA]
- Kim R. B., Fromm M. F., Wandel C., Leake B., Wood A. J., Roden D. M., Wilkinson G. R. The drug transporter P‐glycoprotein limits oral absorption and brain entry of HIV‐1 protease inhibitors. J. Clin. Invest. 1998; 101: 289–294, [PUBMED], [INFOTRIEVE], [CSA]
- Kondo T., Imaizumi S., Kato I., Yoshimoto T. Isolation and culture of brain endothelial cells and establishment of in vitro blood–brain barrier model. Cell Transplant 1994; 3(Suppl. 1)S35–S37, [PUBMED], [INFOTRIEVE]
- Kool M., van der Linden M., de Haas M., Scheffer G. L., de Vree J. M. L., Smith A. J., Jansen G., Peters G. J., Ponne N., Scheper R. J., Elferink R. P. J. O., Baas F., Borst P. MRP3, an organic anion transporter able to transport anti‐cancer drugs. Proc. Natl. Acad. Sci. U. S. A. 1999; 96: 6914–6919, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Kruijtzer C. M., Beijnen J. H., Rosing H., Bokkel Huinink W. W., Schot M., Jewell R. C., Paul E. M., Schellens J. H. Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P‐glycoprotein inhibitor GF120918. J. Clin. Oncol. 2002; 20: 2943–2950, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Murakami H., Takanaga H., Matsuo H., Ohtani H., Sawada Y. Comparison of blood–brain barrier permeability in mice and rats using in situ brain perfusion technique. Am. J. Physiol., Heart Circ. Physiol. 2000; 279: H1022–H1028
- Nakai D., Nakagomi R., Furuta Y., Tokui T., Abe T., Ikeda T., Nishimura K. Human liver‐specific organic anion transporter, LST‐1, mediates uptake of pravastatin by human hepatocytes. J. Pharmacol. Exp. Ther. 2001; 297: 861–867, [PUBMED], [INFOTRIEVE], [CSA]
- Ng K. H., Lim B. G., Wong K. P. Sulfate conjugating and transport functions of MDCK distal tubular cells. Kidney Int. 2003; 63: 976–986, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Plosker G. L., Scott L. J. Saquinavir: a review of its use in boosted regimens for treating HIV infection. Drugs 2003; 63: 1299–1324, [PUBMED], [INFOTRIEVE]
- Ramu A., Ramu N. Resistance to lipophilic cationic compounds in multidrug resistant leukemia cells. Leuk. Lymphoma 1993; 9: 247–253, [PUBMED], [INFOTRIEVE]
- Raub T. J., Kuentzel S. L., Sawada G. A. Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells. Exp. Cell Res. 1992; 199: 330–340, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Rodriguez‐Antona C., Donato M. T., Boobis A., Edwards R. J., Watts P. S., Castell J. V., Gomez‐Lechon M. J. Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells. Xenobiotica 2002; 32: 505–520, [CROSSREF], [CROSSREF], [CSA]
- Sasaki M., Suzuki H., Ito K., Abe T., Sugiyama Y. Transcellular transport of organic anions across a double‐transfected Madin‐Darby canine kidney II cell monolayer expressing both human organic anion‐transporting polypeptide (OATP2/SLC21A6) and multidrug resistance‐associated protein 2 (MRP2/ABCC2). J. Biol. Chem. 2002; 277: 6497–6503, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Shitara Y., Itoh T., Sato H., Li A. P., Sugiyama Y. Inhibition of transporter‐mediated hepatic uptake as a mechanism for drug–drug interaction between cervastatin and cyclosporin A. J. Pharmacol. Exp. Ther. 2003; 304: 610–616, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Sormunen R., Eskelinen S., Lehto V. P. Bile canaliculus formation in cultured HEPG2 cells. Lab. Invest. 1993; 68: 652–662, [PUBMED], [INFOTRIEVE]
- Stevenson B. R., Anderson J. M., Goodenough D. A., Mooseker M. S. Tight junction structure and ZO‐1 content are identical in two strains of Madin‐Darby canine kidney cells which differ in transepithelial resistance. J. Cell Biol. 1988; 107: 2401–2408, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Takasato Y., Rapoport S. I., Smith Q. R. An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am. J. Physiol. 1984; 247: H484–H493, [PUBMED], [INFOTRIEVE]
- Tang F. X., Horie K., Borchardt R. T. Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?. Pharm. Res. 2002a; 19: 773–779, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Tang F. X., Horie K., Borchardt R. T. Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?. Pharm. Res. 2002b; 19: 765–772, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Tirona R. G., Leake B. F., Wolkoff A. W., Kim R. B. Human organic anion transporting polypeptide‐C (SLC21A6) is a major determinant of rifampin‐mediated pregnane X receptor activation. J. Pharmacol. Exp. Ther. 2003; 304: 223–228, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Treiber A., Schneiter R., Delahaye S., Clozel M. Inhibition of Oatp‐mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat. J. Pharmacol. Exp. Ther. 2004; 308: 1121–1129, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- van Meer G., Stelzer E. H., Wijnaendts‐van‐Resandt R. W., Simons K. Sorting of sphingolipids in epithelial (Madin‐Darby canine kidney) cells. J. Cell Biol. 1987; 105: 1623–1635, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Wang S., Cukierman E., Swaim W. D., Yamada K. M., Baum B. J. Extracellular matrix protein‐induced changes in human salivary epithelial cell organization and proliferation on a model biological substratum. Biomaterials 1999; 20: 1043–1049, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Wijnholds J., Mol C. A. A. M., van Deemter L., de Haas M., Scheffer G. L., Baas F., Beijnen J. H., Scheper R. J., Hatse S., De Clercq E., Balzarini J., Borst P. Multidrug‐resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc. Natl. Acad. Sci. U. S. A. 2000; 97: 7476–7481, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Williams G. C., Sinko P. J. Oral absorption of the HIV protease inhibitors: a current update. Adv. Drug Deliv. Rev. 1999; 39: 211–238, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Williams G. C., Liu A., Knipp G., Sinko P. J. Direct evidence that saquinavir is transported by multidrug resistance‐associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob. Agents Chemother. 2002; 46: 3456–3462, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF], [CSA]
- Williams G. C., Knipp G. T., Sinko P. J. The effect of cell culture conditions on saquinavir transport through, and interactions with, MDCKII cells overexpressing hMDR1. J. Pharm. Sci. 2003; 92: 1957–1967, [PUBMED], [INFOTRIEVE], [CROSSREF], [CROSSREF]
- Zamora J. M., Pearce H. L., Beck W. T. Physical‐chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Mol. Pharmacol. 1988; 33: 454–462, [PUBMED], [INFOTRIEVE]