References
- Adas F., Betthou F., Picart D., Lozac'h P., Beauge F., Amet Y. Involvement of cytochrome P450 2E1 in the (omega‐1)‐hydroxylation of oleic acid in human and rat liver microsomes. J. Lipid Res. 1998; 39: 1210–1219, [PUBMED], [INFOTRIEVE], [CSA]
- Aleynik M. K., Lieber C. S. Dilinoleoylphophatidylcholine decreases ethanol‐induced cytochrome P4502E1. Biochem. Biophys. Res. Commun. 2001; 288: 1047–1051, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Aleynik M. K., Leo M. A., Aleynik S. I., Lieber C. S. Polyenylphosphatidylcholine opposes the increase of cytochrome P4502E1 by ethanol and corrects its iron‐induced decrease. Alcohol. Clin. Exp. Res. 1999; 23: 96–100, [PUBMED], [INFOTRIEVE], [CSA]
- Amet Y., Berthou F., Goasduff T., Salaun J. P., Le Breton L., Menez J. F. Evidence that cytochrome P450 2E1 is involved in the (ω‐1)‐hydroxylation of lauric acid in rat liver microsomes. Biochem. Biophys. Res. Commun. 1994; 203: 1168–1174, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Ariyoshi T., Takabatake E., Remmer H. Drug metabolism in ethanol induced fatty liver. Life Sci. 1970; 9: 361–369, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Asai H., Imaoka S., Kuroki T., Monna T., Funae Y. Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s. J. Pharmacol. Exp. Ther. 1996; 277: 1004–1009, [PUBMED], [INFOTRIEVE], [CSA]
- Badger T. M., Huang J., Ronis M., Lumpkin C. K. Induction of cytochrome P450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high. Biochem. Res. Commun. 1993; 190: 780–785, [CROSSREF]
- Beskid M., Kalinowski B., Sadowski J., Tlalka J. The influence of metronidazole on ultrastructure of rat's liver. Mater. Med. Pol. 1980; 12: 263–265, [PUBMED], [INFOTRIEVE]
- Best C. H., Hartroft W. S., Lucas C. C., Ridout J. H. Liver damage produced by feeding alcohol or sugar and its prevention by choline. Br. Med. J. 1949; 2: 1001–1006
- Carriere V., Berthou F., Baird S., Belloc C., Beaune P., De Waziers I. Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype. Pharmacogenetics 1996; 6: 203–211, [PUBMED], [INFOTRIEVE], [CSA]
- Casazza J. P., Fu J. L. Measurement of acetol in serum. Anal. Biochem. 1985; 148: 344–348, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Casazza J. P., Veech R. L. The production of 1,2 propanediol in ethanol treated rats. Biochem. Biophys. Res. Commun. 1985; 129: 426–430, [PUBMED], [INFOTRIEVE], [CSA]
- Casazza J. P., Felver M. E., Veech R. L. The metabolism of acetone in rat. J. Biol. Chem. 1984; 259: 231–236, [PUBMED], [INFOTRIEVE]
- Chance B. An intermediate compound in the catalase‐hydrogen reaction. Acta Chem. Scand. 1947; 1: 236–267
- Chen L., Lee M., Hong J. Y., Huang W., Wang E., Yang C. S. Relationship between cytochrome P450 2E1 and acetone catabolism in rats as studied with diallyl sulfide as an inhibitor. Biochem. Pharmacol. 1994; 48: 2199–2205, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Dai Y., Rashba‐Step J., Cederbaum Al. Stable expression of human cytochrome P4502E1 in HepG2 cells:characterization of catalytic activities and production of reactive oxygen intermediates. Biochemistry 1993; 32: 6928–6937, [PUBMED], [INFOTRIEVE]
- Dicker E., Cederbaum Al. Increased oxygen radical dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption. FASEB J. 1988; 2: 2901–2906, [PUBMED], [INFOTRIEVE]
- Diehl A. M., Bisgaard H. C., Kren B. T., Steer C. J. Ethanol interferes with regeneration‐associated changes in biotransforming enzymes: a potential mechanism underlying ethanol's carcinogenicity?. Hepatology 1991; 13: 722–727, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Ding X., Coon M. J. Purification and characterization of two unique forms of cytochrome P450 from rabbit nasal microsomes. Biochemistry 1988; 27: 8330–8337, [PUBMED], [INFOTRIEVE]
- Ding X., Koop D. R., Crump B. L., Coon M. J. Immunochemical identification of cytochrome P450 isozyme 3a (P‐450ALC) in rabbit nasal and kidney microsomes and evidence for differential induction by alcohol. Mol. Pharmacol. 1986; 30: 370–376, [PUBMED], [INFOTRIEVE], [CSA]
- Dupont I., Lucas D., Clot P., Menez C., Albano E. Cytochrome P4502E1 inducibility and hydroxyethyl radical formation among alcoholics. J. Hepatol. 1998; 28: 564–571, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Farinati F., Zhou Z., Bellah J., Lieber C. S., Garro A. J. Effect of chronic ethanol consumption on activation of nitrosopyrrolidine to a mutagen by rat upper alimentary tract, lung, and hepatic tissue. Drug Metab. Dispos. 1985; 13: 210–214, [PUBMED], [INFOTRIEVE], [CSA]
- Garro A. J., Seitz H. K., Lieber C. S. Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption. Cancer Res. 1981; 41: 120–124, [PUBMED], [INFOTRIEVE]
- Hasumura Y., Teschke R., Lieber C. S. Increased carbon tetrachloride hepatotoxicity, and its mechanism, after chronic ethanol consumption. Gastroenterology 1974; 66: 226–234
- Hawkins R. D., Kalant H., Khanna J. M. Effects of chronic intake of ethanol on rate of ethanol metabolism. Can. J. Physiol. Pharmacol. 1966; 44: 241–257
- Hayashi S., Watanabe J., Kaname K. Genetic polymorphism in the 5′‐flanking region change transcription regulation of the human cytochrome P‐450IIE1 gene. J. Biochem. 1991; 110: 559–565, [PUBMED], [INFOTRIEVE]
- Hetu C., Dumont A., Joly J. G. Effect of chronic ethanol administration on bromobenzene liver toxicity in the rat. Toxicol. Appl. Pharmacol. 1983; 67: 166–167, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Hirvonen A., Husgafvel‐Pursianinen K., Anttila S., Karjalainen A., Vainio H. The human CYP2E1 gene and lung cancer: Dra I and Rsa I restriction fragment length polymorphisms in a finnish study population. Carcinogenesis 1993; 14: 85–88, [PUBMED], [INFOTRIEVE]
- Ingelman‐Sundberg M., Johansson I., Penttila K. E., Glaumann H., Lindros K. O. Centrilobular expression of ethanol‐inducible cytochrome P450 (IIE1) in rat liver. Biochem. Biophys. Res. Commun. 1988; 157: 55–60, [CSA]
- Iseri O. A., Gottlieb L. S., Lieber C. S. The ultrastructure of ethanol‐induced fatty liver. Fed. Proc. 1964; 23: 579A
- Iseri O. A., Lieber C. S., Gottlieb L. S. The ultrastructure of fatty liver induced by prolonged ethanol ingestion. Am. J. Pathol. 1966; 48: 535–555, [PUBMED], [INFOTRIEVE]
- Isselbacher K. J., Carter E. A. Ethanol oxidation by liver microsomes: evidence against a separate and distinct enzymes system. Biochem. Biophys. Res. Commun. 1970; 39: 530–537, [PUBMED], [INFOTRIEVE], [CROSSREF]
- James F. W., Day C. P. Non‐alcoholic steatohepatitis (NASH): a disease of emerging identity and importance. J. Hepatol. 1998; 29: 495–501, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Johansson I. J., Eliasson E., Norsten C., Ingelman‐Sundberg M. Hydroxylation of acetone by ethanol‐ and acetone‐inducible cytochrome P450 in liver microsomes and reconstituted membranes. FEBS Lett. 1986; 196: 59–64, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Kessova I. G., DeCarli L. M., Lieber C. S. Inducibility of cytochromes P4502E1 and P4501A1 in rat pancreas. Alcohol. Clin. Exp. Res. 1998; 22: 501–504, [PUBMED], [INFOTRIEVE], [CSA]
- Kim S. G., Novak R. F. Induction of rat hepatic P450IIE1 (CYP 2E1) by pyridine: evidence for a role of protein synthesis in the absence of transcriptional activation. Biochem. Biophys. Res. Commun. 1990; 166: 1072–1079, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Kim S. G., Shehin S. E., States J. C., Novak R. F. Evidence for increased translational efficiency in the induction of P450IIE1 by solvents: analysis of P450IIE1 mRNA polyribosomal distribution. Biochem. Biophys. Res. Commun. 1990; 172: 767–774, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Koivisto T., Mishin V., Mak K. M., Cohen A., Lieber C. S. Induction of cytochrome P‐4502E1 by ethanol in rat Kupffer cells. Alcohol. Clin. Exp. Res. 1996; 20: 207–212, [PUBMED], [INFOTRIEVE], [CSA]
- Koop D. R. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J. 1992; 6: 724–730, [PUBMED], [INFOTRIEVE], [CSA]
- Koop D. R., Casazza J. P. Identification of ethanol‐inducible P450 enzyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. J. Biol. Chem. 1985; 260: 13607–13612, [PUBMED], [INFOTRIEVE]
- Koop D. R., Tierney D. J. Multiple mechanisms in the regulation of ethanol‐inducible cytochrome P‐450IIE1. BioEssays 1990; 9: 429–435
- Kubota S., Lasker J. M., Lieber C. S. Molecular regulation of ethanol inducible cytochrome P450‐IIE1 in hamsters. Biochem. Biophys. Res. Commun. 1988; 150: 304–310, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Kunitoh S., Tanaka T., Imaoka S., Funae Y., Monna Y. Contribution of cytochrome P450s to MEOS (microsomal ethanol‐oxidizing system): a specific and sensitive assay of MEOS activity by hPLC with fluorescence labeling. Alcohol Alcohol. 1993; 28: 63–68
- Laethem R. M., Balaxy M., Falck J. R., Laethem C. L., Koop D. R. Formation of 19(S)‐, 19(R)‐ and 18(R)‐hydroxyeicosatetraenoic acids by alcohol‐inducible cytochrome P4502E1. J. Biol. Chem. 1993; 268: 12912–12918, [PUBMED], [INFOTRIEVE]
- Lane B. P., Lieber C. S. Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets. Am. J. Pathol. 1966; 49: 593–603, [PUBMED], [INFOTRIEVE]
- Lasker J. M., Raucy J., Kubota S., Bloswick B. P., Black M., Lieber C. S. Purification and characterization of human liver cytochrome P450‐ALC. Biochem. Biophys. Res. Commun. 1987; 148: 232–238, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Lieber C. S. Metabolic effects of acetaldehyde. Biochem. Soc. Trans. 1988; 16: 241–247, [PUBMED], [INFOTRIEVE]
- Lieber C. S. Medical and Nutritional Complications of Alcoholism: Mechanisms and Management. Plenum Press, New York 1992; 579
- Lieber C. S. Cytochrome P‐4502E1: its physiological and pathological role. Physiol. Rev. 1997a; 77: 517–544, [PUBMED], [INFOTRIEVE], [CSA]
- Lieber C. S. Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. Advances in Pharmacology, H. Sies. Academic Press, San Diego, CA 1997b; 601–628
- Lieber C. S. Hepatic and other medical disorders of alcoholism: from pathogenesis to treatment. J. Stud. Alcohol 1998; 59: 9–25, [PUBMED], [INFOTRIEVE]
- Lieber C. S. Microsomal ethanol‐oxidizing system (MEOS), the first 30 years (1968–1998)—a review. Alcohol. Clin. Exp. Res. 1999; 23: 991–1007, [PUBMED], [INFOTRIEVE], [CSA]
- Lieber C. S. Alcohol: its metabolism and interaction with nutrients. Annu. Rev. Nutr. 2000; 20: 395–430, [PUBMED], [INFOTRIEVE], [CSA]
- Lieber C. S., DeCarli L. M. Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding. Science 1968; 162: 417–418
- Lieber C. S., DeCarli L. M. Hepatic microsomal ethanol oxidizing system: in vitro characteristics and adaptive properties in vivo. J. Biol. Chem. 1970; 245: 2505–2512, [PUBMED], [INFOTRIEVE]
- Lieber C. S., DeCarli L. M. The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo. J. Pharmacol. Exp. Ther. 1972; 181: 279–287, [PUBMED], [INFOTRIEVE]
- Lieber C. S., DeCarli L. M. Oxidation of ethanol by hepatic microsomes of acatalasemic mice. Biochem. Biophys. Res. Commun. 1974; 60: 1187–1192, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Lieber C. S., Jones D. P., Mendelson J., DeCarli L. M. Fatty liver, hyperlipemia and hyperuricemia produced by prolonged alcohol consumption, despite adequate dietary intake. Trans. Assoc. Am. Phys. 1963; 76: 289–300
- Lieber C. S., Garro A., Leo M. A., Mak K. M., Worner T. Alcohol and cancer. Hepatology 1986; 6: 1005–1019, [PUBMED], [INFOTRIEVE]
- Lieber C. S., Robins S. J., Li J., Mak K. M., Fasulo J. M., Leo M. A. Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology 1994; 106: 152–159, [PUBMED], [INFOTRIEVE], [CSA]
- Lieber C. S., Leo M. A., Aleynik S. I., Aleynik M. K., DeCarli L. M. Polyenylphosphatidylcholine decreases alcohol‐induced oxidative stress in the baboon. Alcohol. Clin. Exp. Res. 1997; 21: 375–379, [PUBMED], [INFOTRIEVE], [CSA]
- Lieber C. S., Leo M. A., Mak K. M., Xu Y., Cao Q., Ren C., Ponomarenko A., DeCarli L. M. Model of non‐alcoholic steatohepatitis. Am. J. Clin. Nutr. 2004; 79: 502–509, [PUBMED], [INFOTRIEVE], [CSA]
- Ma X. L., Baraona E., Lieber C. S. Alcohol consumption enhances fatty acid ω‐oxidation, with a greater increase in male than in female rats. Hepatology 1993; 18: 1247–1253, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Mezey E., Potter J. J., Reed W. D. Ethanol oxidation by a component of liver microsomes rich in cytochrome P450. J. Biol. Chem. 1973; 248: 1183–1187, [PUBMED], [INFOTRIEVE]
- Miwa G. T., Levin W., Thomas P. E., Lu A. Y.H. The direct oxidation of ethanol by a catalase‐ and alcohol dehydrogenase‐free reconstituted system containing cytochrome P450. Arch. Biochem. Biophys. 1978; 187: 464–475, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Nakajma T., Okino T., Sato A. Kinetic studies on benzene metabolism in rat liver‐possible presence of three forms of benzene metabolizing enzymes in the liver. Biochem. Pharmacol. 1987; 36: 2799–2804, [CSA], [CROSSREF]
- Nelson D. R., Kamataki T., Waxman D. J., Guengerich F. P., Estabrook R. W., Fetereisen R., Gonzalez F. J., Coon M. J., Gunsalus I. C., Gotoh O., Okuda K., Nebert D. W. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names on enzymes, and nomenclature. DNA Cell Biol. 1993; 12: 1–51, [PUBMED], [INFOTRIEVE], [CSA]
- Norton I. D., Apte M. V., Dixson H., Trent R. J., Haber P. S., Pirola R. C., Wilson J. S. Cystic fibrosis genotypes and alcoholic pancreatitis. J. Gastroenterol. Hepatol. 1998; 13: 496–499, [PUBMED], [INFOTRIEVE], [CSA]
- Ohnishi K., Lieber C. S. Reconstitution of the microsomal ethanol‐oxidizing system: qualitative and quantitative changes of cytochrome P450 after chronic ethanol consumption. J. Biol. Chem. 1977; 252: 7124–7131, [PUBMED], [INFOTRIEVE]
- Owen O. E., Trapp V. E., Skutches C. L., Mozzoli M. A., Hoieldtke R. O., Boden G., Reichard G. A., Jr. Acetone metabolism during diabetic ketoacidosis. Diabetes 1982; 31: 242–248, [PUBMED], [INFOTRIEVE]
- Persson I., Johansson I., Bergling H., Dahl M. L., Seidegard J., Rylander R., Rannug A., Hogberg J., Sundberg M. I. Genetic polymorphism of cytochrome P‐4502E1 in a Swedish population: relationship to incidence of lung cancer. FEBS Lett. 1993; 319: 207–211, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
- Rannug A., Alexandrie A. K., Persson I., Ingel‐Sundberg M. Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance. J. Occup. Environ. Med. 1995; 37: 25–36, [PUBMED], [INFOTRIEVE], [CSA]
- Raucy J. L., Lasker J. M., Kraner J. C., Salazer D. E., Lieber C. S., Corcoran G. B. Induction of P450IIE1 in the obese rat. Mol. Pharmacol. 1991; 39: 275–280, [PUBMED], [INFOTRIEVE], [CSA]
- Reichard G. A., Jr., Haff A. C., Skutches C. L., Paul P., Holroyde C. P., Owen O. E. Plasma acetone metabolism in the fasting human. J. Clin. Invest. 1979; 63: 619–626, [PUBMED], [INFOTRIEVE]
- Reichard G. A., Jr., Skutches C. L., Hoeldke R. D., Owen O. W. Acetone metabolism in humans during diabetic ketoacidosis. Diabetes 1986; 35: 668–674, [PUBMED], [INFOTRIEVE]
- Remmer H., Merker H. J. Effect of drugs on the formation of smooth endoplasmic reticulum and drug‐metabolizing enzymes. Ann. N.Y. Acad. Sci. 1965; 123: 79–97, [PUBMED], [INFOTRIEVE]
- Roach M. K., Resse W. N., Jr., Creaven P. J. Ethanol oxidation in the microsomal fraction of rat liver. Biochem. Biophys. Res. Commun. 1969; 36: 596–602, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Ronis M. J., Huang J., Crouch J., Mercado C., Irby D., Valentine C. R., Lumpkin C. K., Ingelman‐Sundberg M., Badger T. M. Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two‐step mechanism associated with blood alcohol concentration in rats. J. Pharmacol. Exp. Ther. 1993; 264: 944–950, [PUBMED], [INFOTRIEVE], [CSA]
- Salaspuro M. P., Lieber C. S. Non‐uniformity of blood ethanol elimination: its exaggeration after chronic consumption. Ann. Clin. Res. 1978; 10: 294–297, [PUBMED], [INFOTRIEVE]
- Salmela K. S., Kessova I. G., Tsyrlov I. B., Lieber C. S. Respective roles of human cytochrome P4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. Alcohol. Clin. Exp. Res. 1998; 22: 2125–2132, [PUBMED], [INFOTRIEVE], [CSA]
- Sato C., Lieber C. S. Mechanism of preventive effect of ethanol on acetaminophen‐induced hepatotoxicity. J. Pharmacol. Exp. Ther. 1981; 218: 811–815, [PUBMED], [INFOTRIEVE]
- Seeff L. B., Cuccherini B. A., Zimmerman H. J., Adler E., Benjamin S. B. Acetaminophen hepatotoxicity in alcoholics a therapeutic misadventure. Ann. Intern. Med. 1986; 104: 399–404, [PUBMED], [INFOTRIEVE], [CSA]
- Seitz H. K., Garro A. J., Lieber C. S. Enhanced pulmonary and intestinal activation of procarcinogens and mutagens after chronic ethanol consumption in the rat. Eur. J. Clin. Investig. 1981; 11: 33–38, [CSA]
- Seitz H. K., Czygan P., Waldherr R., Veith S., Kommerell B. Ethanol and intestinal carcinogenesis in the rat. Alcohol 1985; 2: 491–494, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Shimizu M., Lasker J. M., Tsutsumi M., Lieber C. S. Immunohistochemical localization of ethanol‐inducible P450IIE1 in the rat alimentary tract. Gastroenterology 1990; 99: 1044–1053, [PUBMED], [INFOTRIEVE]
- Siegers C. P., Heidbuchel K., Younes M. Influence of alcohol, dithiocarb and (+)‐catechin on the hepatotoxicity and metabolism of vinylidene in rats. J. Appl. Toxicol. 1983; 3: 90–95, [PUBMED], [INFOTRIEVE], [CSA]
- Slater T. F. Free‐radical mechanisms in tissue injury. Biochem. J. 1984; 222: 1–15, [PUBMED], [INFOTRIEVE]
- Sohda T., Mizuno K., Momose Y., Ikeda H., Fujita T., Meguro K. Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents. J. Med. Chem. 1992; 35: 2617–2626, [PUBMED], [INFOTRIEVE]
- Song B. J., Gelboin H. V., Park S. S., Yang C. S., Gonzalez F. J. Complementary DNA and protein sequences of ethanol‐inducible rat and human cytochrome P450s: transcriptional and posttranscriptional regulation of the rat enzyme. J. Biol. Chem. 1986; 261: 166–189
- Takagi T., Ishii H., Takahashi H., Kato S., Okuno F., Ebihara Y., Yamauchi H., Nagata Y., Tashiro M., Tsuchiya M. Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: an animal model of halothane hepatitis. Pharmacol. Biochem. Behav. 1983; 18: 461–465, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Takahashi T., Lasker J. M., Rosman A. S., Lieber C. S. Induction of cytochrome P4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 1993; 17: 236–245, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Tephly T. R., Tinelli F., Watkins W. D. Alcohol metabolism: role of microsomal oxidation in vivo. Science 1969; 166: 627–628, [PUBMED], [INFOTRIEVE]
- Teschke R., Hasumura Y., Joly J. G., Ishii H., Lieber C. S. Microsomal ethanol‐oxidizing system (MEOS): purification and properties of a rat liver system free of catalase and alcohol dehydrogenase. Biochem. Biophys. Res. Commun. 1972; 49: 1187–1193, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Teschke R., Hasumura Y., Lieber C. S. Hepatic microsomal ethanol oxidizing system: solubilization, isolation and characterization. Arch. Biochem. Biophys. 1974a; 163: 404–415, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Teschke R., Hasumura Y., Lieber C. S. NADPH dependent oxidation of methanol, ethanol, propanol and butanol by hepatic microsomes. Biochem. Biophys. Res. Commun. 1974b; 60: 851–857, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Teschke R., Hasumura Y., Lieber C. S. Hepatic microsomal alcohol oxidizing system in normal and acatalasemic mice: its dissociation from the peroxidatic activity of catalase‐H2O2. Mol. Pharmacol. 1975a; 11: 841–849, [PUBMED], [INFOTRIEVE]
- Teschke R., Hasumura Y., Lieber C. S. Hepatic microsomal alcohol oxidizing system: affinity for methanol, ethanol, propanol and butanol. J. Biol. Chem. 1975b; 250: 7397–7404, [PUBMED], [INFOTRIEVE]
- Teschke R., Matsuzaki S., Ohnishi K., DeCarli L. M., Lieber C. S. Microsomal ethanol oxidizing system (MEOS): current status of its characterization and its role. Alcohol. Clin. Exp. Res. 1977; 1: 7–15, [PUBMED], [INFOTRIEVE]
- Thurman R. G., Brentzel H. J. The role of alcohol dehydrogenase in microsomal ethanol oxidation and the adaptive increase in ethanol metabolism due to chronic treatment with ethanol. Alcohol. Clin. Exp. Res. 1977; 1: 33–38, [PUBMED], [INFOTRIEVE]
- Thurman R. G., Ley H. G., Scholz R. Hepatic microsomal ethanol oxidation: hydrogen peroxide formation and the role of catalase. Eur. J. Biochem. 1972; 25: 420–430, [PUBMED], [INFOTRIEVE]
- Tsutsumi M., Takada A., Takase S., Sugata K. Hepatic aldehyde dehydrogenase isoenzymes: differences with respect to species. Alcohol 1988; 5: 33–38, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Tsutsumi M., Lasker J. M., Shimizu M., Rosman A. S., Lieber C. S. The intralobular distribution of ethanol‐inducible P450IIE1 in rat and human liver. Hepatology 1989; 10: 437–446, [PUBMED], [INFOTRIEVE]
- Tsutsumi R., Leo M. A., Kim C. I., Tsutsumi M., Lasker J. M., Lowe N., Lieber C. S. Interaction of ethanol with enflurane metabolism and toxicity: role of P45011E1. Alcohol. Clin. Exp. Res. 1990; 14: 174–179, [PUBMED], [INFOTRIEVE]
- Tsutsumi M., Lasker J. M., Takahashi T., Lieber C. S. In vivo induction of hepatic P4502E1 by ethanol: role of increased enzyme synthesis. Arch. Biochem. Biophys. 1993; 304: 209–218, [PUBMED], [INFOTRIEVE], [CSA]
- Uematsu F., Kikuchi H., Motomiya M., Abe T., Sagami I., Ohmachi T., Wakui A., Kanamaru R., Watanabe M. Association between restriction fragment length polymorphism of the human cytochrome P‐450IIE1 gene and susceptibility to lung cancer. Jpn. J. Cancer Res. 1991; 82: 254–256, [PUBMED], [INFOTRIEVE]
- Uematsu F., Ikawa S., Kikuchi H., Sagami I., Kanamaru R., Abe T., Satoh K., Motomiya M., Watanabe M. Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P‐450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure. Pharmacogenetics 1994; 4: 58–63, [PUBMED], [INFOTRIEVE], [CSA]
- Ueno T., Gonzalez F. J. Transcriptional control of the rat hepatic CYP2E1 gene. Mol. Cell. Biol. 1990; 10: 4495–4505, [PUBMED], [INFOTRIEVE]
- Vatsis K. P., Schulman M. P. Absence of ethanol metabolism in “acatalatic” hepatic microsomes that oxidize drugs. Biochem. Biophys. Res. Commun. 1973; 52: 588–594, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Vatsis K. P., Schulman M. P. An unidentified constituent of ethanol oxidation in hepatic microsomes. Fed. Proc. 1974; 33: 554A
- Watanabe J., Hayashi S., Kawajiri K. Different regulations and expression of the human CYP2E1 gene due to the Rsa I polymorphism in the 5′ flanking region. J. Biochem. 1994; 116: 321–326, [PUBMED], [INFOTRIEVE]
- Watanabe J., Yang J. P., Eguchi H., Hayashi S., Imai K., Nakachi K., Kawajiri K. An Rsa I polymorphism in the CYP2E1 gene does not affect lung cancer risk in a Japanese population. Jpn. J. Cancer Res. 1995; 86: 245–248, [PUBMED], [INFOTRIEVE], [CSA]
- Weltman M. D., Farrell G. C., Hall P., Ingelman‐Sundberg M., Liddle C. Hepatic cytochrome P4502E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 1998; 27: 128–133, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Wickramasinghe S. N., Gardner B., Barden G. Circulating cytotoxic protein generated after ethanol consumption: identification and mechanism of reaction with cells. Lancet 1987; 2: 122–126, [PUBMED], [INFOTRIEVE], [CROSSREF]
- Wrighton S. A., Thomas P. E., Molowa D. T., Haniu M., Shively J. E., Maines S. L., Watkins P. B., Parker G., Mendez‐Picon G., Levin W., Guzelian P. S. Characterization of ethanol‐inducible human liver N‐nitrosodimethylamine demethylase. Biochemistry 1986; 25: 6731–6735, [PUBMED], [INFOTRIEVE]
- Yang C. S., Yoo J. S., Ishizaki H., Hong J. Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation. Drug Metab. Rev. 1990; 22: 147–159, [PUBMED], [INFOTRIEVE]
- Yu A. S., Keeffe E. B. Nonalcoholic fatty liver disease. Rev. Gastroenterol. Disord. 2002; 2: 11–19, [PUBMED], [INFOTRIEVE], [CSA]
- Ziegler D. M. Discussion in microsomes and drug oxidation. Microsomes and Drug Oxidations, R. W. Estabrook, R. J. Gilletter, K. C. Lieberman. Williams & Wilkins, Baltimore, MD 1972; 458