Regulation of Cytochrome P450 by Posttranslational Modification

References

• Addya, S., Anandatheerthavarada, H. K., Biswas, G., Bhagwat, S. V., Mullick, J., Avadhani, N. G. (1997). Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2.J. Cell. Biol. 139(3):589–599. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Amarneh, B., Corbin, C. J., Peterson, J. A., Simpson, E. R., Graham-Lorence, S. (1993). Functional domains of human aromatase cytochrome P450 characterized by linear alignment and site-directed mutagenesis.Mol. Endocrinol. 7(12):1617–1624. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Anandatheerthavarada, H. K., Addya, S., Dwivedi, R. S., Biswas, G., Mullick, J., Avadhani, N. G. (1997). Localization of multiple forms of inducible cytochromes P450 in rat liver mitochondria: immunological characteristics and patterns of xenobiotic substrate metabolism.Arch. Biochem. Biophys. 339(1):136–150. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Anandatheerthavarada, H. K., Biswas, G., Mullick, J., Sepuri, N. B.V., Otvos, L., Pain, D., Avadhani, N. G. (1999). Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at Ser128.EMBO J. 18(20):5494–5504. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Balthazart, J., Baillien, M., Ball, G. F. (2001a). Phosphorylation processes mediate rapid changes of brain aromatase activity.J. Steroid Biochem. Mol. Biol. 79(1–5):261–277. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Balthazart, J., Baillien, M., Ball, G. F. (2001b). Rapid and reversible inhibition of brain aromatase activity.J. Neuroendocrinol. 13(1):63–73. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Balthazart, J., Baillien, M., Charlier, T. D., Ball, G. F. (2003). Calcium dependent phosphorylation processes control brain aromatase in quail.Eur. J. Neurosci. 17(8):1591–1606. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Banerjee, A., Kocarek, T. A., Novak, R. F. (2000). Identification of a ubiquitination-target/substrate-interaction domain of cytochrome P-450 (CYP) 2E1.Drug Metab. Dispos. 28(2):118–124. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bar-Nun, S., Kreibich, G., Adesnik, M., Alterman, J., Negishi, M., Sabatini, D. D. (1980). Synthesis and insertion of cytochrome P-450 into endoplasmic reticulum membranes.PNAS 77(2):965–969. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Bellino, F. L., Holben, L. (1989). Placental estrogen synthetase (aromatase): evidence for phosphatase-dependent inactivation.Biochem. Biophys. Res. Commun. 162(1):498–504. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Berglund, L., Bjorkhem, I., Angelin, B., Einarsson, K. (1986). Evidence against in vitro modulation of rat liver cholesterol 7 α-hydroxylase activity by phosphorylation-dephosphorylation: comparison with hydroxymethylglutaryl CoA reductase.Acta Chem. Scand. B 40(6):457–461. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Bhagwat, S. V., Mullick, J., Raza, H., Avadhani, N. G. (1999a). Constitutive and inducible cytochromes P450 in rat lung mitochondria: xenobiotic induction, relative abundance, and catalytic properties.Toxicol. Appl. Pharmacol. 156(3):231–240. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Bhagwat, S. V., Biswas, G., Anandatheerthavarada, H. K., Addya, S., Pandak, W., Avadhani, N. G. (1999b). Dual targeting property of the N-terminal signal sequence of P4501A1. Targeting of heterologous proteins to endoplasmic reticulum and mitochondria.J. Biol. Chem. 274(34):24014–24022. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Biason-Lauber, A., Zachmann, M., Schoenle, E. J. (2000). Effect of leptin on CYP17 enzymatic activities in human adrenal cells: new insight in the onset of adrenarche.Endocrinology 141(4):1446–1454. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Burgos-Trinidad, M., Brown, A. J., DeLuca, H. F. (1986). Solubilization and reconstitution of chick renal mitochondrial 25-hydroxyvitamin D3 24-hydroxylase.Biochemistry 25(9):2692–2696. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Caron, M. G., Goldstein, S., Savard, K., Marsh, J. M. (1975). Protein kinase stimulation of a reconstituted cholesterol side chain cleavage enzyme system in the bovine corpus luteum.J. Biol. Chem. 250(13):5137–5143., [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Cohen, P. (2002). Protein kinases—the major drug targets of the twenty-first century?.Nat. Rev. 1(4):309–315.
   Google Scholar
• Correia, M. A. (2003). Hepatic cytochrome P450 degradation: mechanistic diversity of the cellular sanitation brigade.Drug Metab. Rev. 35(2,3):107–143. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Correia, M. A., Davoll, S. H., Wrighton, S. A., Thomas, P. E. (1992). Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: characterization of the proteolytic system.Arch. Biochem. Biophys. 297(2):228–238. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Cross, E., Roselli, C. E. (1999). 17β-estradiol rapidly facilitates chemoinvestigation and mounting in castrated male rats.Am. J. Physiol., Regul. Integr. Comp. Physiol. 276(5 pt. 2):R1346–R1350. [CSA]
   Web of Science ®Google Scholar
• Cutler, G. B., Glenn, M. Jr, Bush, M., Hodgen, G. D., Graham, C. E., Loriaux, D. L. (1978). Adrenarche: a survey of rodents, domestic animals, and primates.Endocrinology 103(6):2112–2118. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Daiber, A., Schöneich, V., Schmidt, P., Jung, C., Ullrich, V. (2000a). Autocatalytic nitration of P450CAM by peroxynitrite.J. Inorg. Biochem. 81(3):213–220. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Daiber, A., Herold, S., Schöneich, C., Namgaladze, D., Peterson, J. A., Ullrich, V. (2000b). Nitration and inactivation of cytochrome P450BM-3 by peroxynitrite: stopped-flow measurements prove ferryl intermediates.Eur. J. Biochem. 267(23):6729–6739. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Defaye, G., Monnier, N., Guidicelli, C., Chambaz, E. M. (1982). Phosphorylation of purified mitochondrial cytochromes P-450 (cholesterol desmolase and 11 β-hydroxylase) from bovine adrenal cortex.Mol. Cell. Endocrinol. 27(2):157–168. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Diven, W. F., Sweeney, J., Warty, V., Sanghvi, A. (1988). Regulation of bile acid synthesis. Isolation and characterization of microsomal phosphatases.Biochem. Biophys. Res. Commun. 155(1):7–13. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Drewett, J. G., Adams-Hays, R. L., Ho, B. Y., Hegge, D. J. (2002). Nitric oxide potently inhibits the rate-limiting enzymatic step in steroidogenesis.Mol. Cell. Endocrinol. 194(1,2):39–50. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Einarsson, K., Angelin, B., Ewerth, S., Nilsell, K., Bjorkhem, I. (1986). Bile acid synthesis in man: assay of hepatic microsomal cholesterol 7 α-hydroxylase activity by isotope dilution-mass spectrometry.J. Lipid. Res. 27(1):82–88. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Eliasson, E., Mkrtchian, S., Halpert, J. R., Ingelman-Sundberg, M. (1994). Substrate-regulated, cAMP-dependent phosphorylation, denaturation, and degradation of glucocorticoid-inducible rat liver cytochrome P450 3A1.J. Biol. Chem. 269(28):18378–18383. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Epstein, P. M., Curti, M., Jansson, I., Huang, C. K., Schenkman, J. B. (1989). Phosphorylation of cytochrome P450: regulation by cytochrome b5.Arch. Biochem. Biophys. 271(2):424–432. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Estabrook, R. W., Baron, J., Peterson, J., Ishimura, Y. (1972). Oxygenated cytochrome P-450 as an intermediate in hydroxylation reactions.Biochem. Soc. Symp. 34:159–185. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Evans, R. M. (1988). The steroid and thyroid hormone receptor superfamily.Science 240(4854):889–895. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Freeman, J. E., Wolf, C. R. (1994). Evidence against a role for serine 129 in determining murine cytochrome P450 Cyp2e-1 protein levels.Biochemistry 33(47):13963–13966. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ghazarian, J. G., Yanda, D. M. (1985). Inhibition of 25-hydroxyvitamin D 1 α-hydroxylase by renal mitochondrial protein kinase-catalyzed phosphorylation.Biochem. Biophys. Res. Commun. 132(3):1095–1102. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gilmore, R., Walter, P., Blobel, G. (1982). Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.J. Cell. Biol. 95(2 pt. 1):470–477. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gray, R. W., Ghazarian, J. G. (1989). Solubilization and reconstitution of kidney 25-hydroxyvitamin D3 1 α- and 24-hydroxylases from vitamin D-replete pigs.Biochem. J. 259(2):561–568., [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Guengerich, F. P. (2001). Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.Chem. Res. Toxicol. 14(6):611–650. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Han, K. K., Martinage, A. (1992). Post-translational chemical modification(s) of proteins.Int. J. Biochem. 24(1):19–28. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Haugen, D. A., Coon, M. J. (1976). Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450.J. Biol. Chem. 251(24):7929–7939. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hendy, G. N. (1997). Calcium-regulating hormones. In: Conn, P. M. Melmed, S., eds. Endocrinology: Basic and Clinical Principles. Totowa, NJ: Humana Press, pp. 307–323.
   Google Scholar
• Hink, U., Oelze, M., Kolb, P., Bachschmid, M., Zou, M. H., Daiber, A., Mollnau, H., August, M., Baldus, S., Tsilimingas, N., Walter, U., Ullrich, V., Munzel, T. (2003). Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance.J. Am. Coll. Cardiol. 42(10):1826–1834. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hiwatashi, A., Ichikawa, Y. (1980). Purification and organ-specific properties of cholecalciferol 25-hydroxylase system: cytochrome P-450D25-linked mixed function oxidase system.Biochem. Biophys. Res. Commun. 97(4):1443–1449. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hiwatashi, A., Ichikawa, Y. (1981). Purification and reconstitution of the steroid 21-hydroxylase system (cytochrome P-450-linked mixed function oxidase system) of bovine adrenocortical microsomes.Biochim. Biophys. Acta 664(1):33–48. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Hlavica, P., Lewis, D. F.V. (2001). Allosteric phenomena in cytochrome P450-catalyzed monooxygenations.Eur. J. Biochem. 268(18):4817–4832. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Holsztynska, E. J., Waxman, D. J. (1987). Cytochrome P-450 cholesterol 7 α-hydroxylase: inhibition of enzyme deactivation by structurally diverse calmodulin antagonists and phosphatase inhibitors.Arch. Biochem. Biophys. 256(2):543–559. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ichikawa, Y., Hiwatashi, A. (1982). The role of the sugar regions of components of the cytochrome P-450-linked mixed-function oxidase (monooxygenase) system of bovine adrenocortical mitochondria.Biochim. Biophys. Acta 705(1):82–91. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Jansson, I., Curti, M., Epstein, P. M., Peterson, J. A., Schenkman, J. B. (1990). Relationship between phosphorylation and cytochrome P450 destruction.Arch. Biochem. Biophys. 283(2):285–292. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Khatsenko, O. G., Gross, S. S., Rifkind, A. B., Vane, J. R. (1993). Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants.PNAS 90(23):11147–11151. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Koch, J. A., Waxman, D. J. (1989). Posttranslational modification of hepatic cytochrome P-450. Phosphorylation of phenobarbital-inducible P-450 forms PB-4 (IIB1) and PB-5 (IIB2) in isolated rat hepatocytes and in vivo.Biochemistry 28(8):3145–3152. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Korsmeyer, K. K., Davoll, S., Figueiredo-Pereira, M. E., Correia, M. A. (1999). Proteolytic degradation of heme-modified hepatic cytochromes P450: a role for phosphorylation, ubiquitination, and the 26S proteasome?.Arch. Biochem. Biophys. 365(1):31–44. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Korth-Schutz, S., Levine, L. S., New, M. I. (1976). Dehydroepiandrosterone sulfate (DS) levels, a rapid test for abnormal adrenal androgen secretion.J. Clin. Endocrinol. Metab. 42(6):1005–1013. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Liaudet, L., Soriano, F. G., Szabo, C. (2000). Biology of nitric oxide signaling.Crit. Care. Med. 28(4):N37–N52. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lin, H. L., Kent, U. M., Zhang, H., Waskell, L., Hollenberg, P. F. (2003). Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite.Chem. Res. Toxicol. 16(2):129–136. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Löhr, J. B., Kühn-Velten, W. N. (1997). Protein phosphorylation changes ligand-binding efficiency of cytochrome P450c17 (CYP17) and accelerates its proteolytic degradation: putative relevance for hormonal regulation of CYP17 activity.Biochem. Biophys. Res. Commun. 231(2):403–408., [CSA]
   PubMed Web of Science ®Google Scholar
• Lohr, J. W., Willsky, G. R., Acara, M. A. (1998). Renal drug metabolism.Pharmacol. Rev. 50(1):107–142. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Mandel, M. L., Moorthy, B., Ghazarian, J. G. (1990). Reciprocal post-translational regulation of renal 1 α- and 24-hydroxylases of 25-hydroxyvitamin D3 by phosphorylation of ferredoxin. mRNA-directed cell-free synthesis and immunoisolation of ferredoxin.Biochem. J. 266(2):385–392. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Masaki, R., Yamamoto, A., Tashiro, Y. (1987). Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver.J. Cell. Biol. 104(5):1207–1215. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Mehl, M., Daiber, A., Herold, S., Shoun, H., Ullrich, V. (1999). Peroxynitrite reaction with heme proteins.Nitric Oxide 3(2):142–152. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Menez, J. F., Machu, T. K., Song, B. J., Browning, M. D., Deitrich, R. A. (1993). Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin dependent protein kinase, protein kinase C and cAMP dependent protein kinase.Alcohol Alcohol. 28(4):445–451. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Minamiyama, Y., Takemura, S., Imaoka, S., Funae, Y., Tanimoto, Y., Inoue, M. (1997). Irreversible inhibition of cytochrome P450 by nitric oxide.J. Pharmacol. Exp. Ther. 283(3):1479–1485. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Monier, S., Van Luc, P., Kreibich, G., Sabatini, D. D., Adesnik, M. (1988). Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane.J. Cell. Biol. 107(2):457–470. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Monnier, N., Defaye, G., Chambaz, E. M. (1987). Phosphorylation of bovine adrenodoxin. Structural study and enzymatic activity.Eur. J. Biochem. 169(1):147–153. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Morgan, E. T. (1997). Regulation of cytochromes P450 during inflammation and infection.Drug Metab. Rev. 29(3):1129–1188. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Morgan, E. T. (2001). Regulation of cytochrome P450 by inflammatory mediators: why and how?.Drug Metab. Dispos. 29(4):207–212. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Morgan, E. T., Ullrich, V., Daiber, A., Schmidt, P., Takaya, N., Shoun, H., McGiff, J. C., Oyekan, A., Hanke, C. J., Campbell, W. B., Park, C., Kang, J., Yi, H., Cha, Y., Mansuy, D., Boucher, J. (2001). Cytochromes P450 and flavin monooxygenases. Targets and sources of nitric oxide.Drug Metab. Dispos. 29(11):1366–1376. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Moslemi, S., Vibet, A., Papadopoulos, V., Camoin, L., Silberzahn, P., Gaillard, J. L. (1997). Purification and characterization of equine testicular cytochrome P-450 aromatase: comparison with the human enzyme.Comp. Biochem. Physiol., B Biochem. Mol. Biol. 118B(1):217–227. [CSA], [CROSSREF]
   Google Scholar
• Murray, B. P., Correia, M. A. (2001). Ubiquitin-dependent 26S proteasomal pathway: a role in the degradation of native human liver CYP3A4 expressed in Saccharomyces cerevisiae?.Arch. Biochem. Biophys. 393(1):106–116. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Murray, B. P., Zgoda, V. G., Correia, M. A. (2002). Native CYP2C11: heterologous expression in Saccharomyces cerevisiae reveals a role for vacuolar proteases rather than the proteasome system in the degradation of this endoplasmic reticulum.Protein Mol. Pharmacol. 61(5):1146–1153. [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Myant, N. B., Mitropoulos, K. A. (1977). Cholesterol 7 α-hydroxylase.J. Lipid Res. 18(2):135–153. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Nakajin, S., Hall, P. F. (1981). Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 α-hydroxylase-C17,20 lyase).J. Biol. Chem. 256(8):3871–3876. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Nakajin, S., Hall, P. F., Onoda, M. (1981). Testicular microsomal cytochrome P-450 for C21 steroid side chain cleavage. Spectral and binding studies.J. Biol. Chem. 256(12):6134–6139. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Narbaitz, R., Stumpf, W. E., Sar, M. (1981). The role of autoradiographic and immunocytochemical techniques in the clarification of sites of metabolism and action of vitamin D.J. Histochem. Cytochem. 29(1):91–100., [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Negishi, M., Jensen, N. M., Garcia, G. S., Nebert, D. W. (1981). Structural gene products of the murine Ah complex. Differences in ontogenesis and glucosamine incorporation between liver microsomal cytochromes P1-450 and P-448 induced by polycyclic aromatic compounds.Eur. J. Biochem. 115(3):585–594. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Nelson, D. R., Kamataki, T., Waxman, D. J., Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J., Gunsalus, I. C., Gotoh, O. (1993). The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.DNA Cell Biol. 12(1):1–51. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., Gunsalus, I. C., Nebert, D. W. (1996). P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.Pharmacogenetics, 6(1):1–42. [PUBMED], [INFOTRIEVE], [CSA]
   PubMedGoogle Scholar
• Nelson, D. R., Zeldin, D. C., Hoffman, S. M., Maltais, L. J., Wain, H. M., Nebert, D. W. (2004). Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.Pharmacogenetics 14(1):1–18. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Neupert, W. (1997). Protein import into mitochondria.Annu. Rev. Biochem. 66:863–917. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Nguyen, L. B., Shefer, S., Salen, G., Chiang, J. Y., Patel, M. (1996). Cholesterol 7α-hydroxylase activities from human and rat liver are modulated in vitro posttranslationally by phosphorylation/dephosphorylation.Hepatology 24(6):1468–1474. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Oesch-Bartlomowicz, B., Oesch, F. (1990). Phosphorylation of cytochrome P450 isoenzymes in intact hepatocytes and its importance for their function in metabolic processes.Arch. Toxicol. 64(4):257–261. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Oesch-Bartlomowicz, B., Padma, P. R., Becker, R., Richter, B., Hengstler, J. G., Freeman, J. E., Wolf, C. R., Oesch, F. (1998). Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement.Exp. Cell. Res. 242(1):294–302. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Oesch-Bartlomowicz, B., Richter, B., Becker, R., Vogel, S., Padma, P. R., Hengstler, J. G., Oesch, F. (2001). cAMP-dependent phosphorylation of CYP2B1 as a functional switch for cyclophosphamide activation and its hormonal control in vitro and in vivo.Int. J. Cancer 94(5):733–742. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Orentreich, N., Brind, J. L., Rizer, R. L., Vogelman, J. H. (1984). Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood.J. Clin. Endocrinol. Metab. 59(3):551–555. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Osawa, Y., Davila, J. C., Nakatsuka, M., Meyer, C. A., Darbyshire, J. F. (1995). Inhibition of P450 cytochromes by reactive intermediates.Drug Metab. Rev. 27(1,2):61–72. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Parker, L. N., Odell, W. D. (1980). Control of adrenal androgen secretion.Endocr. Rev. 1(4):392–410. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Parker, K. L., Schimmer, B. P. (1993). Transcriptional regulation of the adrenal steroidogenic enzymes.Trends Endocrinol. Metab. 4(2):46–50.
   PubMed Web of Science ®Google Scholar
• Parker, K. L., Schimmer, B. P. (1996). The roles of the nuclear receptor steroidogenic factor 1 in endocrine differentiation and development.Trends Endocrinol. Metab. 7(6):203–207. [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Parker, K. L., Schimmer, B. P. (1997). Steroidogenic factor 1: a key determinant of endocrine development and function.Endocr. Rev. 18(3):361–377. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Porter, T. D., Coon, M. J. (1991). Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms.J. Biol. Chem. 266(21):13469–13472. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Poulos, T. L. (2003). Cytochrome P450 flexibility.PNAS 100(23):13121–13122. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pyerin, W., Taniguchi, H. (1989). Phosphorylation of hepatic phenobarbital-inducible cytochrome P-450.EMBO J. 8(10):3003–3010. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Pyerin, W., Taniguchi, H., Horn, F., Oesch, F., Amelizad, Z., Friedberg, T., Wolf, C. R. (1987). Isoenzyme-specific phosphorylation of cytochromes P-450 and other drug metabolizing enzymes.Biochem. Biophys. Res. Commun. 142(3):885–892. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Roberts, B. J. (1997). Evidence of proteasome-mediated cytochrome P-450 degradation.J. Biol. Chem. 272(15):9771–9778. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Roberts, B. J., Song, B., Soh, Y., Park, S. S., Shoaf, S. E. (1995). Ethanol induces CYP2E1 by protein stabilization.J. Biol. Chem. 270(50):29632–29635., [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Roberts, E. S., Lin, H., Crowley, J. R., Vuletich, J. L., Osawa, Y., Hollenberg, P. F. (1998). Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1.Chem. Res. Toxicol. 11(9):1067–1074. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Robin, M., Anandatheerthavarada, H. K., Fang, J., Cudic, M., Otvos, L., Avadhani, N. G. (2001). Mitochondrial targeted cytochrome P450 2E1 (P450 MT5) contains an intact N terminus and requires mitochondrial specific electron transfer proteins for activity.J. Biol. Chem. 276(27):24680–24689. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Robin, M., Anandatheerthavarada, H. K., Biswas, G., Sepuri, N. B.V., Gordon, D. M., Pain, D., Avadhani, N. G. (2002). Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation.J. Biol. Chem. 277(43):40583–40593. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ronis, M. J., Johansson, I., Hultenby, K., Lagercrantz, J., Glaumann, H., Ingelman-Sundberg, M. (1991). Acetone-regulated synthesis and degradation of cytochrome P4502E1 and cytochrome P4502B1 in rat liver.Eur. J. Biochem. 198(2):383–389. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Sakaguchi, M., Mihara, K., Sato, R. (1984). Signal recognition particle is required for cotranslational insertion of cytochrome P-450 into microsomal membranes.PNAS 81(11):3361–3364. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Sakaguchi, M., Mihara, K., Sato, R. (1987). A short amino-terminal segment of microsomal cytochrome P-450 functions both as an insertion signal and as a stop-transfer sequence.EMBO J. 6(8):2425–2431. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Schmidt, P., Youhnovski, N., Daiber, A., Balan, A., Arsic, M., Bachschmid, M., Przybylski, M., Ullrich, V. (2003). Specific nitration at tyrosine 430 revealed by high resolution mass spectrometry as basis for redox regulation of bovine prostacyclin synthase.J. Biol. Chem. 278(15):12813–12819. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Schoch, G. A., Yano, J. K., Wester, M. R., Griffin, K. J., Stout, C. D., Johnson, E. F. (2004). Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site.J. Biol. Chem. 279(10):9497–9503. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Scott, E. E., He, Y. A., Wester, M. R., White, M. A., Chin, C. C., Halpert, J. R., Johnson, E. F., Stout, C. D. (2003). An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution.PNAS 100(23):13196–13201. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Scott, E. E., White, M. A., He, Y. A., Johnson, E. F., Stout, C. D., Halpert, J. R. (2004). Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9 Å resolution: insight into the range of P450 conformations and coordination of redox partner binding.J. Biol. Chem. 279(26):27294–27301. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Sethumadhavan, K., Bellino, F. L., Thotakura, N. R. (1991). Estrogen synthetase (aromatase). The cytochrome P-450 component of the human placental enzyme is a glycoprotein.Mol. Cell. Endocrinol. 78(1,2):25–32. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Shimozawa, O., Sakaguchi, M., Ogawa, H., Harada, N., Mihara, K., Omura, T. (1993). Core glycosylation of cytochrome P-450 (arom). Evidence for localization of N terminus of microsomal cytochrome P-450 in the lumen.J. Biol. Chem. 268(28):21399–21402. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Siegel, N., Wongsurawat, N., Armbrecht, H. J. (1986). Parathyroid hormone stimulates dephosphorylation of the renoredoxin component of the 25-hydroxyvitamin D3-1 α-hydroxylase from rat renal cortex.J. Biol. Chem. 261(36):16998–17003. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Sonoda, Y., Amano, C., Endo, M., Sato, Y., Sekigawa, Y., Fukuhara, M. (1995). Lanosterol 14-α-demethylase (cytochrome P-45014DM): modulation of its enzyme activity by cholesterol feeding.Biol. Pharm. Bull. 18(7):1009–1011. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Stadler, J., Trockfeld, J., Schmalix, W. A., Brill, T., Siewert, J. R., Greim, H., Doehmer, J. (1994). Inhibition of cytochromes P4501A by nitric oxide.PNAS 91(9):3559–3563. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Stocco, D. M. (2000). The role of the StAR protein in steroidogenesis: challenges for the future.J. Endocrinol. 164(3):247–253. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Szczesna-Skorupa, E., Kemper, B. (1989). NH2-terminal substitutions of basic amino acids inducetranslocation across the microsomal membrane and glycosylation of rabbit cytochrome P450IIC2.J. Cell. Biol. 108(4):1237–1243. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Szczesna-Skorupa, E., Browne, N., Mead, D., Kemper, B. (1988). Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptide.PNAS, 85(3):738–742. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Tang, P. M., Chiang, J. Y. (1986). Modulation of reconstituted cholesterol 7 α-hydroxylase by phosphatase and protein kinase.Biochem. Biophys. Res. Commun. 134(2):797–802. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Tierney, D. J., Haas, A. L., Koop, D. R. (1992). Degradation of cytochrome P450 2E1: selective loss after labilization of the enzyme.Arch. Biochem. Biophys. 293(1):9–16. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ullrich, V., Bachschmid, M. Superoxide as a messenger of endothelial function.Biochem. Biophys. Res. Commun. (2000)278(1):1–8. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Vilgrain, I., Defaye, G., Chambaz, E. M. (1984). Adrenocortical cytochrome P-450 responsible for cholesterol side chain cleavage (P-450scc) is phosphorylated by the calcium-activated, phospholipid-sensitive protein kinase (protein kinase C).Biochem. Biophys. Res. Commun. 125(2):554–561. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wang, H. F., Figueiredo Pereira, M. E., Correia, M. A. (1999). Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes.Arch. Biochem. Biophys. 365(1):45–53. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wang, X., Medzihradszky, K. F., Maltby, D., Correia, M. A. (2001). Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides.Biochemistry 40(38):11318–11326. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Weissman, A. M. (2001). Ubiquitin and proteasomes: themes and variations on ubiquitylation.Nat. Rev. Mol. Cell. Biol. 2(3):169–178. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wester, M. R., Johnson, E. F., Marques-Soares, C., Dansette, P. M., Mansuy, D., Stout, C. D. (2003a). Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes.Biochemistry, 42(21):6370–6379. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wester, M. R., Johnson, E. F., Marques-Soares, C., Dijols, S., Dansette, P. M., Mansuy, D., Stout, C. D. (2003b). Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding.Biochemistry 42(31):9335–9345. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wester, M. R., Yano, J. K., Schoch, G. A., Yang, C., Griffin, K. J., Stout, C. D., Johnson, E. F. (2004). The structure of human microsomal cytochrome P450 2C9 complexed with flurbiprofen at 2.0 A resolution.J. Biol. Chem. 279(34):35630–35637. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Williams, P. A., Cosme, J., Sridhar, V., Johnson, E. F., McRee, D. E. (2000). Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity.Mol. Cell. 5(1):121–131. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Williams, P. A., Cosme, J., Ward, A., Angove, H. C., Matak Vinkovic, D., Jhoti, H. (2003). Crystal structure of human cytochrome P450 2C9 with bound warfarin.Nature 424(6947):464–468. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Williams, P. A., Cosme, J., Vinkovic, D. M., Ward, A., Angove, H. C., Day, P. J., Vonrhein, C., Tickle, I. J., Jhoti, H. (2004). Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.Science 305(5684):683–686. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Wink, D. A., Osawa, Y., Darbyshire, J. F., Jones, C. R., Eshenaur, S. C., Nims, R. W. (1993). Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent.Arch. Biochem. Biophys. 300(1):115–123. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yamazaki, H., Shimada, T., Martin, M. V., Guengerich, F. P. (2001). Stimulation of cytochrome P450 reactions by apo-cytochrome b5. Evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase.J. Biol. Chem. 276(33):30885–30891. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yang, M. X., Cederbaum, A. I. (1997). Characterization of cytochrome P4502E1 turnover intransfected HepG2 cells expressing human CYP2E1.Arch. Biochem. Biophys. 341(1):25–33. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yano, J. K., Griffin, K., Stout, D. C., Johnson, E. F. (2004a). The crystal structure of human microsomal cytochrome P450 2A6 (CYP2A6): the principle nicotine oxidase, In: Abstracts, Microsomes and Drug Oxidations, Mainz, Germany, July 4–9, P4-CH-11.
   Google Scholar
• Yano, J. K., Wester, M. R., Schoch, G. A., Griffin, K. J., Stout, C. D., Johnson, E. F. (2004b). The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05′ resolution.J. Biol. Chem. 279(37):38091–38094. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yue, W., Santen, R. J., Wang, J. P., Hamilton, C. J., Demers, L. M. (1999). Aromatase within the breast.Endocr. Relat. Cancer 6(2):157–164. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Yue, W., Wang, J. P., Conaway, M. R., Li, Y., Santen, R. J. (2003). Adaptive hypersensitivity following long-term estrogen deprivation: involvement of multiple signal pathways.J. Steroid Biochem. Mol. Biol. 86(3–5):265–274. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zhang, L., Rodriguez, H., Ohno, S., Miller, W. L. (1995). Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome.PNAS, 92(23):10619–10623. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar
• Zhukov, A., Werlinder, V., Ingelman-Sundberg, M. (1993). Purification and characterization of two membrane bound serine proteinases from rat liver microsomes active in degradation of cytochrome P450.Biochem. Biophys. Res. Commun. 197(1):221–228. [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Zou, M., Martin, C., Ullrich, V. (1997). Tyrosine nitration as a mechanism of selective inactivation of prostacyclin synthase by peroxynitrite.Biol. Chem. 378(7):707–713. [PUBMED], [INFOTRIEVE], [CSA]
   PubMed Web of Science ®Google Scholar