Production of Beta-Carotene from Synthetic Medium by Blakeslea trispora in Fed-batch Culture

References

• Ahmad , J. 2001 . Hydrogen peroxide. Free radicals in biology and medicine . Spring , 77 ( 222 ) : 1 – 11 .
   Google Scholar
• Anderson , R. F. , Arnold , M. , Nelson , G. E. N. and Ciegler , A. 1958 . Microbiological production of beta-carotene in shaken flasks . J. Agr. Food Chem. , 6 : 543 – 545 .
   Web of Science ®Google Scholar
• Chan , H. Y. and Ho , K. P. 1999 . Growth and carotenoid production by pH-stat cultures of Phaffia rhodozyma . Biotechnol. Lett. , 21 : 953 – 958 .
   Web of Science ®Google Scholar
• Ciegler , A. 1965 . Microbial carotenogenesis . Adv. in Apl. Microbiol. , 7 : 1 – 34 .
   PubMedGoogle Scholar
• Ciegler , A. , Arnold , M. and Anderson , R. F. 1959 . Microbial production of carotenoids. IV. Effect of various grains on production of beta carotene by mated strains of Blakeslea trispora . Appl. Microbiol. , 7 : 94 – 101 .
   PubMedGoogle Scholar
• Ciegler , A. , Pazola , Z. and Hall , H. H. 1964 . Stimulation of carotenogenesis by microbial cells . Appl. Microbiol. , 12 : 150 – 154 .
   PubMedGoogle Scholar
• Dandekar , S. and Modi , V. V. 1980 . Involvement of cyclic AMP in carotenogenesis and cell differentiation in Blakeslea trispora . Biochim. Biophys. Acta , 628 : 398 – 406 .
   PubMed Web of Science ®Google Scholar
• Deacon , J. W. 1997 . Modern Mycology. , 3rd ed. Oxford : Blackwell .
   Google Scholar
• Dubois , M. , Gilles , K. A. , Hamilton , J. K. , Rebers , P. A. and Smith , F. 1956 . Colorimetric method for determination of sugars and related substances . Anal. Chem. , 28 ( 3 ) : 350 – 356 .
   Web of Science ®Google Scholar
• Ho , K. P. , Tam , C. Y. and Zhou , B. 1999 . Growth and carotenoid production of Phaffia Rhodozyma in fed-batch cultures with different feeding methods . Biotechnol. Lett. , 21 : 175 – 178 .
   Web of Science ®Google Scholar
• Jeong , J. C. , Lee , I. Y. , Kim , S. W. and Park , Y. H. 1999 . Stimulation of β-carotene synthesis by hydrogen peroxide in Blakeslea trispora . Biotechnol. Lett. , 21 : 683 – 686 .
   Web of Science ®Google Scholar
• Johnson , E. A. and Schroeder , W. A. 1995 . Microbial carotenoids . Adv. Biochem. Eng. , 53 : 119 – 178 .
   Google Scholar
• Kim , S. W. , Seo , W. T. and Park , Y. H. 1997 . Enhanced synthesis of trisporic acid and β-carotene production in Blakeslea trispora by addition of a non-ionic surfactant, Span 20 . J. Ferment. Bioeng. , 84 : 330 – 332 .
   Google Scholar
• Kreiner , M. , Harvey , L. M. and Mc Neil , B. 2003 . Morphological and enzymatic responses of a recombinant Aspergillus niger to oxidative stressors in chemostat cultures . J. Biotechnol. , 100 : 251 – 260 .
   PubMed Web of Science ®Google Scholar
• Lampila , L. E. , Wallen , S. E. and Bullerman , L. B. 1985 . A review of factors affecting biosynthesis of carotenoids by the order Mucorales . Mycopathologia , 90 : 65 – 80 .
   PubMed Web of Science ®Google Scholar
• Mantzouridou , F. , Roukas , T. and Kotzekidou , P. 2002a . Optimization of β-carotene production from synthetic medium by Blakeslea trispora in a stirred tank reactor and relationship between morphological changes and pigment formation . Food Biotechnol. , 16 ( 3 ) : 167 – 187 .
   Web of Science ®Google Scholar
• Mantzouridou , F. , Roukas , T. and Kotzekidou , P. 2002b . Effect of the aeration rate and agitation speed on β-carotene production and morphology of Blakeslea trispora in a stirred tank reactor: mathematical modeling . Biochem. Engineer. J. , 10 : 123 – 135 .
   Web of Science ®Google Scholar
• Mantzouridou , F. , Roukas , T. , Kotzekidou , P. and Liakopoulou , M. 2002c . Optimization of β-carotene production from synthetic medium by Blakeslea trispora: a mathematical modeling . Appl. Biochem. Biotechnol. , 101 ( 2 ) : 153 – 175 .
   PubMed Web of Science ®Google Scholar
• Margalith , P. 1993 . Enhancement of carotenoid synthesis by fungal metabolite . Appl. Microbiol. Biotechnol. , 38 : 664 – 666 .
   Web of Science ®Google Scholar
• Mehta , B. J. and Cerda-Olmedo , E. 1995 . Mutants of carotene production in Blakeslea trispora . Appl. Microbiol. Biotechnol. , 42 : 836 – 838 .
   Web of Science ®Google Scholar
• Nelis , H. J. and Lewenheer , A. P. D. 1991 . Microbial sources of carotenoid pigments used in food and feeds . J. Appl. Bacteriol. , 70 : 181 – 191 .
   Google Scholar
• Ninet , L. , Renaut , J. and Tissier , R. 1969 . Activation of the biosynthesis of carotenoids by Blakeslea trispora . Biotechnol. Bioeng. , 11 : 1195 – 1210 .
   Web of Science ®Google Scholar
• Paul , G. C. , Kent , C. A. and Thomas , C. R. 1992 . Quantitative characterization of vacuolization in Penicillium chrysogenum using automatic image analysis . Trans. IchemE. , 70 : 13 – 20 .
   Google Scholar
• Paul , G. C. and Thomas , C. R. 1998 . Characterization of mycelia morphology using image analysis . Adv. Biochem. Eng. Biotechnol. , 60 : 1 – 59 .
   PubMed Web of Science ®Google Scholar
• Rao , S. and Modi , V. V. 1977 . Carotenogenesis: possible mechanism of action of trisporic acid in Blakeslea trispora . Experientia , 33 : 31 – 33 .
   Google Scholar
• Roukas , T. 1996 . Ethanol production from nonsterilized beet molasses by free and immobilized Saccharomyces cerevisiae cells using fed-batch culture . J. Food Eng. , 27 : 87 – 96 .
   Web of Science ®Google Scholar
• Roukas , T. and Mantzouridou , F. 2001 . An improved method for extraction of β-carotene from Blakeslea trispora . Appl. Biochem. Biotechnol. , 90 : 37 – 45 .
   PubMed Web of Science ®Google Scholar
• Spears , K. 1988 . Development in food colouring: the natural alternatives . Trends Biotechnol. , 6 : 283 – 288 .
   Web of Science ®Google Scholar
• Stanbury , P. F. and Whitaker , A. 1984 . Principles of Fermentation Technology Oxford : Pergamon Press .
   Google Scholar
• Storz , G. and Zheng , M. 2000 . “ Oxidative stress ” . In Bacterial Stress Responses Washington : ASM Press .
   Google Scholar