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Original Articles

Cancer Prevention and Treatment by Ganoderma, a Mushroom with Medicinal Properties

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Pages 275-325 | Published online: 06 Feb 2007

References

  • Afshari , C. A. , Nuwaysir , E. F. and Barrett , J. C. 1999 . Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation . Cancer Res. , 59 : 4759 – 4760 .
  • Appelbaum , J. W. 1992 . The role of the immune system in the pathogenesis of cancer . Semin. Oncol. Nurs. , 8 : 51 – 62 .
  • Arlt , V. M. , Stiborova , M. and Schmeiser , H. H. 2002 . Aristolochic acid as a probable human cancer hazard in herbal remedies: a review . Mutagenesis , 17 : 265 – 277 .
  • Bachrach , U. and Wang , Y. C. 2002 . Cancer therapy and prevention by green tea: role of ornithine decarboxylase . Amino Acids , 22 : 1 – 13 .
  • Baek , S. J. , Jung , W. T. , Kim , D. Y. and Cho , K. D. 1999 . G009: hepatoprotectant, immunostimulant . Drug Future , 24 : 1068 – 1071 .
  • Bao , X. F. , Duan , J. Y. , Fang , X. Y. and Fang , J. N. 2001a . Chemical modifications of the (1→3)-alpha-D-glucan from spores of Ganoderma lucidum and investigation of their physicochemical properties and immunological activity . Carbohydr. Res. , 336 : 127 – 140 .
  • Bao , X. F. , Liu , C. P. , Fang , J. N. and Li , X. Y. 2001b . Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst . Carbohydr. Res. , 332 : 67 – 74 .
  • Bao , X. F. , Wang , X. S. , Dong , Q. , Fang , J. N. and Li , X. Y. 2002a . Structural features of immunologically active polysaccharides from Ganoderma lucidum . Phytochemistry , 59 : 175 – 181 .
  • Bao , X. F. , Zhen , Y. , Ruan , L. and Fang , J. N. 2002b . Purification, characterization, and modification of T lymphocyte-stimulating polysaccharide from spores of Ganoderma lucidum . Chem. Pharm. Bull. , 50 : 623 – 629 .
  • Barnes , J. , Anderson , L. A. and Phillipson , J. D. 2001 . St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties . J. Pharm. Pharmacol. , 53 : 583 – 600 .
  • Bateman , J. , Chapman , R. D. and Simpson , D. 1998 . Possible toxicity of herbal remedies . Scot. Med. J. , 43 : 7 – 15 .
  • Battle , J. , Ha , T. Z. , Li , C. F. , Dellabeffa , V. , Rice , P. , Kalbfleisch , J. , Browder , W. and Williams , D. 1998 . Ligand binding to the (1→3)-beta-D-glucan receptor stimulates NF-kappa B activation, but not apoptosis in U937 cells . Biochem. Biophys. Res. Commun. , 249 : 499 – 504 .
  • Bello-Fernandez , C. , Packham , G. and Cleveland , J. L. 1993 . The ornithine decarboxylase gene is a transcriptional target of c-Myc . Proc. Natl Acad. Sci. USA , 90 : 7804 – 7808 .
  • Bingham , S. A. 2000 . Diet and colorectal cancer prevention . Biochem. Soc. Trans. , 28 : 12 – 16 .
  • Birt , D. F. , Hendrich , S. and Wang , W. Q. 2001 . Dietary agents in cancer prevention: flavonoids and isoflavonoids . Pharmacol. Ther. , 90 : 157 – 177 .
  • Block , G. , Patterson , B. and Subar , A. 1992 . Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence . Nutr. Cancer , 18 : 1 – 29 .
  • Boik , J. 2001 . Natural Compounds in Cancer Therapy Princeton : Oregon Medical Press .
  • Bonham , M. , Arnold , H. , Montgomery , B. and Nelson , P. S. 2002 . Molecular effects of the herbal compound PC-SPES: identification of activity pathways in prostate carcinoma . Cancer Res. , 62 : 3920 – 3924 .
  • Boullata , J. I. and Nace , A. M. 2000 . Safety issues with herbal medicine . Pharmacotherapy , 20 : 257 – 269 .
  • Breidenbach , T. , Kliem , V. , Burg , M. , Radermacher , J. , Hoffmann , M. W. and Klempnauer , J. 2000 . Profound drop of cyclosporin A whole blood trough levels caused by St. John's wort (Hypericum perforatum) . Transplantation , 69 : 2229 – 2230 .
  • Brekhman , I. 1980 . Man and Biological Active Substances New York : Pergamon Press .
  • Chai , H. , Wang , F. , Zhang , Z. , Yang , J. and Zhang , Y. 1997 . Constituents from the fruiting body of Ganoderma lucidum (Fr.) Karst . Zhongguo Zhongyao Zazhi—Chin. J. Mater. Med. , 22 : 552 – 553 .
  • Chairul , C. S. M. and Hayashi , Y. 1994 . Lanostanoid triterpenes from Ganoderma applanatum . Phytochemistry , 35 : 1305 – 1308 .
  • Chang , R. 1996 . “ The central importance of the beta-glucan receptor as the basis of immunologic bioactivity of Ganoderma polysaccharides ” . In Reishi Edited by: Mizuno , T. and Kim , B. K. 177 – 179 . Seoul : II Yang Press .
  • Chang , S. T. and Mshigeni , K. E. 2000 . Ganoderma lucidum—paramount among medicinal mushrooms . Discov. Innovat. , 12 : 97 – 101 .
  • Chen , W. C. and Hau , D. M. 1995 . Effects of Ganoderma lucidum on cellular immunocompetence in gamma-irradiated mice . Phytother. Res. , 9 : 533 – 535 .
  • Chen , J. H. and Jiang , R. L. 1980 . A pharmacological study of the Chinese drug lingzhi (Ganoderma) . Acta Pharmacol. Sin. , 15 : 234 – 244 .
  • Chen , R. Y. and Yu , D. Q. 1990 . Progress of studies on the chemical constituents of Ganoderma triterpene . Yaoxue Xuebao—Acta Pharm. Sin. , 25 : 940 – 953 .
  • Chen , T. W. , Wong , Y. K. and Lee , S. S. 1991 . In vitro cytotoxicity of Ganoderma lucidum on oral cancer cells . Chung Hua i Hsueh Tsa Chih—Chin. Med. J. (Chin.) , 48 : 54 – 58 .
  • Chen , W. C. , Hau , D. M. and Lee , S. S. 1995a . Effects of Ganoderma lucidum and Krestin on cellular immunocompetence in gamma-ray-irradiated mice . Am. J. Chin. Med. , 23 : 71 – 80 .
  • Chen , W. C. , Hau , D. M. , Wang , C. C. , Lin , I. H. and Lee , S. S. 1995b . Effects of Ganoderma lucidum and Krestin on subset T-cell in spleen of gamma-irradiated mice . Am. J. Chin. Med. , 23 : 289 – 298 .
  • Chen , Y. J. , Shiao , M. S. , Lee , S. S. and Wang , S. Y. 1997 . Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells . Life Sci. , 60 : 2349 – 2359 .
  • Chen , J. H. , Zhou , J. P. , Zhang , L. N. , Nakumura , Y. and Norisuye , T. 1998 . Chemical structure of the water-insoluble polysaccharide isolated from the fruiting body of Ganoderma lucidum . Polym. J. , 30 : 838 – 842 .
  • Chen , J. H. , Zhang , L. N. , Yu , D. S. and Zhu , R. P. 2000 . Chemical components and solution properties of a glycan-protein complex from Ganoderma lucidum mycelium . Chem. J. Chin. Univ. , 21 : 961 – 964 .
  • Chen , R. C. , Su , J. H. , Gao-Liang , O. Y. , Cai , K. X. , Li , J. Q. and Xie , X. G. 2002 . Induction of differentiation in human hepatocarcinoma cells by isoverbascoside . Planta Med. , 68 : 370 – 372 .
  • Cheong , J. , Jung , W. and Park , W. 1999 . Characterization of an alkali-extracted peptidoglycan from Korean Ganoderma lucidum . Arch. Pharm. Res. , 22 : 515 – 519 .
  • Cheung , W. M. W. , Hui , W. S. , Chu , P. W. K. , Chiu , S. W. and Ip , N. Y. 2000 . Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells . FEBS Lett. , 486 : 291 – 296 .
  • Cheung , H. Y. , Ng , C. W. and Hood , D. J. 2001 . Identification and quantification of base and nucleoside markers in extracts of Ganoderma lucidum, Ganoderma japonicum and Ganoderma capsules by micellar electrokinetic chromatography . J. Chromatogr. (A) , 911 : 119 – 126 .
  • Chihara , G. and Taguchi , T. 1982 . Lentinan: biological activities and possible clinical use . J. Immunol. Immunopharmacol. , 2 : 93 – 104 .
  • Chihara , G. , Hamuro , J. , Maeda , W. , Arai , Y. and Fukuoka , F. 1970 . Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from lentinus edodes. (Berk.) Sing. (an edible mushroom) . Cancer Res. , 30 : 2776 – 2781 .
  • Chiu , S. W. , Wang , Z. M. , Leung , T. M. and Moore , D. 2000 . Nutritional value of Ganoderma extract and assessment of its genotoxicity and antigenotoxicity using comet assays of mouse lymphocytes . Food Chem. Toxicol. , 38 : 173 – 178 .
  • Choi , H.-S. and Sa , Y.-S. 2000 . Fibrinolytic and antithrombotic protease from Ganoderma lucidum . Mycologia , 92 : 545 – 552 .
  • Chung , K. S. , Kim , S. B. and Chung , S. H. 1997 . Immunoactivities of the protein-polysaccharides of the tips of the growing carpophores of Ganoderma lucidum . Yakhak Hoeji , 41 : 105 – 110 .
  • Craig , W. J . 1997 . Phytochemicals—guardians of our health . J. Am. Diet. Assoc. , 97 : S199 – S204 .
  • Cuella , M. J. J. , Giner , R. M. , Recio , M. C. , Just , M. J. , Manez , S. and Rios , J. L. 1996 . Two fungal lanostane derivatives as phospholipase A2 inhibitors . J. Nat. Prod. , 59 : 977 – 979 .
  • Cutten , A. E. , Hasnain , S. M. , Segedin , B. P. , Bai , T. R. and McKay , E. J. 1988 . The basidiomycete Ganoderma and asthma: collection, quantitation and immunogenicity of the spores . N. Z. Med. J. , 101 : 361 – 363 .
  • Dell , A. and Morris , H. R. 2001 . Glycoprotein structure determination by mass spectrometry . Science , 291 : 2351 – 2356 .
  • Demeule , M. , Brossard , M. , Page , M. , Gingras , D. and Beliveau , R. 2000 . Matrix metalloproteinase inhibition by green tea catechins . Biochim. Biophys. Acta , 1478 : 51 – 60 .
  • Diamond , M. S. , Garcia-Aguilar , J. , Bickford , J. K. , Corbi , A. L. and Springer , T. A. 1993 . The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands . J. Cell Biol. , 120 : 1031 – 1043 .
  • Eckermann , N. , Fettke , J. and Steup , M. 2002 . Identification of polysaccharide binding proteins by affinity electrophoresis in inhomogeneous polyacrylamide gels and subsequent SDS-PAGE/matrix-assisted laser desorption ionization-time of flight analysis . Anal. Biochem. , 304 : 180 – 192 .
  • el-Mekkawy , S. , Meselhy , M. R. , Nakamura , N. , Tezuka , Y. , Hattori , M. , Kakiuchi , N. , Shimotohno , K. , Kawahata , T. and Otake , T. 1998 . Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum . Phytochemistry , 49 : 1651 – 1657 .
  • Eo , S. K. , Kim , Y. S. , Lee , C. K. and Han , S. S. 1999a . Antiherpetic activities of various protein bound polysaccharides isolated from Ganoderma lucidum . J. Ethnopharmacol. , 68 : 175 – 181 .
  • Eo , S. K. , Kim , Y. S. , Lee , C. K. and Han , S. S. 1999b . Antiviral activities of various water and methanol soluble substances isolated from Ganoderma lucidum . J. Ethnopharmacol. , 68 : 129 – 136 .
  • Eo , S. K. , Kim , Y. S. , Lee , C. K. and Han , S. S. 2000 . Possible mode of antiviral activity of acidic protein bound polysaccharide isolated from Ganoderma lucidum on herpes simplex viruses . J. Ethnopharmacol. , 72 : 475 – 481 .
  • Fang , J. N. 1984 . Isolation, purification, identification and molecular weight determination of polysaccharides . Chin. Pharm. J. , 10 : 46 – 49 .
  • Ferreira , C. G. , Epping , M. , Kruyt , F. A. E. and Giaccone , G. 2002 . Apoptosis: target of cancer therapy . Clin. Cancer Res. , 8 : 2024 – 2034 .
  • Fisher , M. and Yang , L. X. 2002 . Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy . Anticancer Res. , 22 : 1737 – 1754 .
  • Fisher , B. , Costantino , J. P. , Wickerham , D. L. , Redmond , C. K. , Kavanah , M. , Cronin , W. M. , Vogel , V. , Robidoux , A. , Dimitrov , N. , Atkins , J. , Daly , M. , Wieand , S. , Tan-Chiu , E. , Ford , L. and Wolmark , N. 1998 . Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 study . J. Natl Cancer Inst. , 90 : 1371 – 1388 .
  • Fugh-Berman , A. 1999 . Herbal medicinals: selected clinical considerations, focusing on known or potential drug–herb interactions . Arch. Intern. Med. , 159 : 1957 – 1958 .
  • Fugh-Berman , A. 2000 . Herb–drug interactions . Lancet , 355 : 134 – 138 .
  • Fugh-Berman , A. and Ernst , E. 2001 . Herb–drug interactions: review and assessment of report reliability . Br. J. Clin. Pharmacol. , 52 : 587 – 595 .
  • Furusawa , E. , Chou , S. C. , Furusawa , S. , Hirazum , A. and Dang , Y. 1992 . Antitumor activity of Ganoderma lucidum, an edible mushroom, on intraperitoneally implanted Lewis lung carcinoma in synergenic mice . Phytother. Res. , 6 : 300 – 304 .
  • Galluzzi , S. , Zanetti , O. , Binetti , G. , Trabucchi , M. and Frisoni , G. B. 2000 . Coma in a patient with Alzheimer's disease taking low dose trazodone and Ginkgo biloba . J. Neurol. Neurosurg. Psychiatr. , 68 : 679 – 680 .
  • Gan , K. H. , Fann , Y. F. , Hsu , S. H. , Kuo , K. W. and Lin , C. N. 1998 . Mediation of the cytotoxicity of lanostanoids and steroids of Ganoderma tsugae through apoptosis and cell cycle . J. Nat. Prod. , 61 : 485 – 487 .
  • Gao , Y. H. 2002 . The Miracle Herb, Scientific Reports of Ganoderma Shanghai : Shanghai Scientific Publisher .
  • Gao , X. X. , Fei , X. F. , Wang , B. X. , Zhang , J. , Gong , Y. J. , Minami , M. , Nagata , T. and Ikejima , T. 2000a . Effects of polysaccharides (FI0-b) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (I) . Acta Pharmacol. Sin. , 21 : 1179 – 1185 .
  • Gao , X. X. , Wang , B. X. , Fei , X. F. , Zhang , J. , Gong , Y. J. , Minami , M. , Nagata , T. and Ikejima , T. 2000b . Effects of polysaccharides (FI0-c) from mycelium, of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (II) . Acta Pharmacol. Sin. , 21 : 1186 – 1192 .
  • Gao , J. J. , Min , B. S. , Ahn , E. M. , Nakamura , N. , Lee , H. K. and Hattori , M. 2002a . New triterpene aldehydes, lucialdehydes A–C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells . Chem. Pharm. Bull. , 50 : 837 – 840 .
  • Gao , Y. H. , Zhou , S. F. , Chen , G. L. , Dai , X. H. and Ye , J. X. 2002b . A phase I/II study of a Ganoderma lucidum extract (Ganopoly) in patients with advanced cancer . Int. J. Med. Mushroom , 4 : 207 – 214 .
  • in press .
  • in press .
  • Gibbs , J. B. 2000 . Mechanism-based target identification and drug discovery in cancer research . Science , 287 : 1969 – 1973 .
  • Giner-Larza , E. M. , Manez , S. , Giner-Pons , R. M. , Recio , M. C. and Rios , J. L. 2000 . On the anti-inflammatory and anti-phospholipase A(2) activity of extracts from lanostane-rich species . J. Ethnopharmacol. , 73 : 61 – 69 .
  • Gohil , K. 2002 . Genomic responses to herbal extracts: lessons from in vitro and in vivo studies with an extract of Ginkgo biloba . Biochem. Pharmacol. , 64 : 913 – 917 .
  • Gohil , K. , Moy , R. K. , Farzin , S. , Maguire , J. J. and Packer , L. 2000 . mRNA expression profile of a human cancer cell line in response to Ginkgo biloba extract: induction of antioxidant response and the Golgi system . Free Radic. Res. , 33 : 831 – 849 .
  • Gong , Y. J. , Fei , X. F. , Gao , X. X. , Zhang , J. , Wang , B. X. , Minami , M. , Nagata , T. and Ikejima , T. 2001 . Effect of polysaccharide F III-2 from Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human peripheral blood mononuclear cells . Zhonghua Yaolixue Yu Dulixue Zazhi—Chin. J. Pharmacol. Toxicol. , 15 : 401 – 407 .
  • Guengerich , F. P. and Shimada , T. 1998 . Activation of procarcinogens by human cytochrome P450 enzymes . Mutat. Res. , 400 : 201 – 213 .
  • Guns , E. S. , Goldenberg , S. L. and Brown , P. N. 2002 . Mass spectral analysis of PC-SPES confirms the presence of diethylstilbestrol . Can. J. Urol. , 9 : 1684 – 1688 .
  • Ha , T. B. T. , Gerhauser , C. , Zhang , W. D. , Ho-Chong-Line , N. and Fouraste , I. 2000 . New lanostanoids from Ganoderma lucidum that induce NAD(P)H: quinone oxidoreductase in cultured hepalclc7 murine hepatoma cells . Planta Med. , 66 : 681 – 684 .
  • Haak-Frendscho , M. , Kino , K. , Sone , T. and Jardieu , P. 1993 . Ling Zhi-8: a novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression . Cell. Immunol. , 150 : 101 – 113 .
  • Han , M. D. , Lee , E. S. , Kim , Y. K. , Lee , J. W. , Jeong , H. and Yoon , K. H. 1998 . Production of nitric oxide in raw 264.7 macrophages treated with ganoderan, the beta-glucan of Ganoderma lucidum . Korean J. Mycol. , 26 : 246 – 255 .
  • van der Hem , L. G. , van der Vliet , J. A. , Bocken , C. F. , Kino , K. , Hoitsma , A. J. and Tax , W. J. 1995 . Ling Zhi-8: studies of a new immunomodulating agent . Transplantation , 60 : 438 – 443 .
  • Hijikata , Y. and Yamada , S. 1998 . Effect of Ganoderma lucidum on postherpetic neuralgia . Am. J. Chin. Med. , 26 : 375 – 381 .
  • Hikino , H. and Mizuno , T. 1989 . Hypoglycemic actions of some heteroglycans of Ganoderma lucidum fruit bodies . Planta Med. , 55 : 385
  • Hikino , H. , Konno , C. , Mirin , Y. and Hayashi , T. 1985 . Isolation and hypoglycemic activity of ganoderans A and B, glycans of Ganoderma lucidum fruit bodies . Planta Med. , 4 : 339 – 340 .
  • Hikino , H. , Ishiyama , M. , Suzuki , Y. and Konno , C. 1989 . Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies . Planta Med. , 55 : 423 – 428 .
  • Honda , K. , Komoda , Y. and Inoue , S. 1988 . Sleep-promoting effects of Ganoderma extracts in rats: comparison between long-term and acute administrations . Tokyo Ika Shika Daigaku Iyo Kizai Kenkyusho Hokoku—Rep. Inst. Med. Dental Eng. (Jpn.) , 22 : 77 – 82 .
  • Horner , W. E. , Helbling , A. and Lehrer , S. B. 1993 . Basidiomycete allergens: comparison of three Ganoderma species . Allergy , 48 : 110 – 116 .
  • Hsieh , T. C. and Wu , J. M. 2002 . Mechanism of action of herbal supplement PC-SPES: elucidation of effects of individual herbs of PC-SPES on proliferation and prostate specific gene expression in androgen-dependent LNCaP cells . Int. J. Oncol. , 20 : 583 – 588 .
  • Hsieh , T. C. , Lu , X. , Chea , J. and Wu , J. M. 2002 . Prevention and management of prostate cancer using PC-SPES: a scientific perspective . J. Nutr. , 132 : S3513 – S3517 .
  • Hsu , H. Y. , Lian , S. L. and Lin , C. C. 1990 . Radioprotective effect of Ganoderma lucidum (Leyss. ex. Fr.) Karst after X-ray irradiation in mice . Am. J. Chin. Med. , 18 : 61 – 69 .
  • Hsu , M. J. , Lee , S. S. and Lin , W. W. 2002 . Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway . J. Leukocyte Biol. , 72 : 207 – 216 .
  • Hughes , D. A. 1999 . Effects of dietary antioxidants on the immune function of middle-aged adults . Proc. Nutr. Soc. , 58 : 79 – 84 .
  • Hung , W. S. , Fang , C. L. , Su , C. H. , Lai , W. F. , Chang , Y. C. and Tsai , Y. H. 2001 . Cytotoxicity and immunogenicity of sacchachitin and its mechanism of action on skin wound healing . J. Biomed. Mater. Res. , 56 : 93 – 100 .
  • Hwang , S. F. , Liu , K. J. , Kuan , Y. H. , Tung , K. S. , Su , C. H. and Tung , T. C. 1989 . The inhibitory effect on artificial pulmonary metastasis of murine S-180 sarcoma cells by orally administered Ganoderma lucidum culture broth . J. Chin. Oncol. Soc. , 5 : 10 – 15 .
  • Hyun , J. W. , Choi , E. C. and Kim , B. K. 1990 . Studies on constituents of higher fungi of Korea IXII antitumor components of the basidiocarp of Ganoderma-lucidum . Korean J. Mycol. , 18 : 58 – 69 .
  • Ikekawa , T. , Nakanishi , M. and Uehara , N. 1968 . Anti-tumor action of some basidiomycetes, especially Phellinus linteus . Jpn J. Cancer Res. , 59 : 155 – 157 .
  • Ingram , K. D. , Dragosavac , G. B. , Benner , K. G. and Flora , K. D. 2000 . Risks of drug interactions with St John's wort . Am. J. Gastroenterol. , 95 : 3323 – 3324 .
  • Ito , H. , Naruse , S. and Shimura , K. 1977 . Studies on antitumor activity of basidiomycete polysaccharides: VII. Antitumor effect of the polysaccharide preparations from Ganoderma lucidum on mouse Sarcoma 180 . Mie. Med. J. , 26 : 147 – 152 .
  • Izzo , A. A. and Ernst , E. 2001 . Interactions between herbal medicines and prescribed drugs—a systematic review . Drugs , 61 : 2163 – 2175 .
  • Jacobson , J. S. , Workman , S. B. and Kronenberg , F. 2000 . Research on complementary/alternative medicine for patients with breast cancer: a review of the biomedical literature . J. Clin. Oncol. , 18 : 668 – 683 .
  • Jeong , K. H. , Park , W. B. , Kim , H. W. , Choi , E. C. and Kim , B. K. 1992 . Studies on antitumor components of the cultured mycelia of interspecific protoplast fusant F-2 of Ganoderma lucidum and Ganoderma applanatum . Korean J. Mycol. , 20 : 324 – 336 .
  • Johne , A. , Brockmoller , J. , Bauer , S. , Maurer , A. , Langheinrich , M. and Roots , I. 1999 . Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum) . Clin. Pharmacol. Ther. , 66 : 338 – 345 .
  • Johne , A. , Schmider , J. , Brockmoller , J. , Stadelmann , A. M. , Stormer , E. , Bauer , S. , Scholler , G. , Langheinrich , M. and Roots , I. 2002 . Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort (Hypericum perforatum) . J. Clin. Psychopharmacol. , 22 : 46 – 54 .
  • Jolly , K. , Cheng , K. K. and Langman , M. J. S. 2002 . NSAIDs and gastrointestinal cancer prevention . Drugs , 62 : 945 – 956 .
  • Jones , B. D. and Runikis , A. M. 1987 . Interaction of ginseng with phenelzine . J. Clin. Psychopharmacol. , 7 : 201 – 202 .
  • Jong , S. C. and Birmingham , J. M. 1992 . Medicinal benefits of the mushroom Ganoderma . Adv. Appl. Microbiol. , 37 : 101 – 134 .
  • Kabir , Y. , Kimura , S. and Tamura , T. 1988 . Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR) . J. Nutr. Sci. Vitaminol. , 34 : 433 – 438 .
  • Kang , C. Y. , Shim , M. J. , Choi , E. C. , Lee , Y. N. and Kim , B. K. 1981 . Studies on antineoplastic components of Korean basiomycetes. Mycelial culture and an anti-neoplastic component of Ganoderma lucidum . Hanguk Saenghwa Hakho , 14 : 101 – 122 .
  • Kanmatsuse , K. , Kajiwara , N. , Hayashi , K. , Shimogaichi , S. , Fukinbara , I. , Ishikawa , H. and Tamura , T. 1985 . Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects . Yakugaku Zasshi—J. Pharm. Soc. Jpn , 105 : 942 – 947 .
  • Kasahara , Y. and Hikino , H. 1987 . Validation of the oriental medicines. Part 122. Central actions of adenosine, a nucleotide of Ganoderma lucidum . Phytother. Res. , 1 : 173 – 176 .
  • Kawagishi , H. , Mitsunaga , S. , Yamawaki , M. , Ido , M. , Shimada , A. , Kinoshita , T. , Murata , T. , Usui , T. , Kimura , A. and Chiba , S. 1997 . A lectin from mycelia of the fungus Ganoderma lucidum . Phytochemistry , 44 : 7 – 10 .
  • Kempf , R. A. and Mitchell , M. S. 1985 . Effects of chemotherapeutic agents on the immune response. II . Cancer Investig. , 3 : 23 – 33 .
  • Kerb , R. S. 2000 . Tumor angiogenesis: past, present and the near future . Carcinogenesis , 21 : 505 – 515 .
  • Kim , H. W. and Kim , B. K. 1999 . Biomedicinal triterpenoids of Ganoderma lucidum (Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) . Int. J. Med. Mushroom , 1 : 121 – 138 .
  • Kim , B. K. , Chung , H. S. , Chung , K. S. and Yang , M. S. 1980a . Anti-neoplastic components of Korean basidiomycetes . Korean J. Mycol. , 8 : 107 – 114 .
  • Kim , B. K. , Chung , H. S. , Chung , K. S. and Yang , M. S. 1980b . Studies on the anti-neoplastic components of Korean basidiomycetes . Hanguk Kyunhakhoe Chi , 8 : 107 – 113 .
  • Kim , H. W. , Shim , M. J. , Choi , E. C. and Kim , B. K. 1997a . Inhibition of cytopathic effect of human immunodeficiency virus-1 by water-soluble extract of Ganoderma lucidum . Arch. Pharm. Res. , 20 : 425 – 431 .
  • Kim , R. S. , Kim , H. W. and Kim , B. K. 1997b . Suppressive effects of Ganoderma lucidum on proliferation of peripheral blood mononuclear cells . Mol. Cell. , 7 : 52 – 57 .
  • Kim , D. H. , Shim , S. B. , Kim , N. J. and Jang , I. S. 1999a . Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum . Biol. Pharm. Bull. , 22 : 162 – 164 .
  • Kim , H. S. , Kacew , S. and Lee , B. M. 1999b . In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor) . Carcinogenesis , 20 : 1637 – 1640 .
  • Kim , Y. S. , Eo , S. K. , Oh , K. W. , Lee , C. K. and Han , S. S. 2000 . Antiherpetic activities of acidic protein bound polysaccharide isolated from Ganoderma lucidum alone and in combinations with interferons . J. Ethnopharmacol. , 72 : 451 – 458 .
  • Kimura , Y. , Okuda , H. and Arichi , S. 1988 . Effects of the extracts of Ganoderma lucidum on blood glucose level in rats . Planta Med. , 54 : 290 – 294 .
  • Kimura , Y. , Tojima , H. , Fukase , S. and Takeda , K. 1994 . Clinical evaluation of sizofilan as assistant immunotherapy in treatment of head and neck cancer . Acta Oto-Laryngol. , 511 : 92 – 95 .
  • Kino , K. , Yamashita , A. , Yamaoka , K. , Watanabe , J. , Tanaka , S. , Ko , K. , Shimizu , K. and Tsunoo , H. 1989 . Isolation and characterization of a new immunomodulatory protein, ling zhi-8 (LZ-8), from Ganoderma lucidium . J. Biol. Chem. , 264 : 472 – 478 .
  • Kishida , E. , Okuda , R. , Sone , Y. and Misaki , A. 1988 . Fractionation structures and antitumor activities of the polysaccharides of Reishi, the fruiting body of Ganoderma lucidum . Osaka-Shiritsu Daigaku Seikatsukagakubu Kiyo , 35 : 1 – 10 .
  • Knudson , A. G. 2002 . Cancer genetics . Am. J. Med. Genet. , 111 : 96 – 102 .
  • Koepf , M. P. , Janiak , C. and Schumann , H. 1988 . Antitumor properties of organometallic metallocene complexes of tin and germanium . J. Cancer Res. Clin. Oncol. , 114 : 502 – 506 .
  • Kohda , H. , Tokumoto , W. , Sakamoto , K. , Fujii , M. , Hirai , Y. , Yamasaki , K. , Komoda , Y. , Nakamura , H. , Ishihara , S. and Uchida , M. 1985 . The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes . Chem. Pharm. Bull. , 33 : 1367 – 1374 .
  • Komoda , Y. , Nakamura , H. , Ishihara , S. , Uchida , M. , Kohda , H. and Yamasaki , K. 1985 . Structure of new terpenoid constituents of Ganoderma lucidum (Fr.) Karst. (Polyporaceae) . Chem. Pharm. Bull. , 33 : 4829 – 4835 .
  • Komoda , Y. , Shimizu , M. , Sonoda , Y. and Sato , Y. 1989 . Ganoderic acid and its derivatives as cholesterol synthesis inhibitors . Chem. Pharm. Bull. , 37 : 531 – 533 .
  • Konopski , Z. , Smedsrod , B. , Seljelid , R. and Eskeland , T. 1994 . A novel immunomodulator soluble aminated β-1,3-D-glucan: binding characteristics to mouse peritoneal macrophages . Biochim. Biophys. Acta—Mol. Cell. Res. , 1221 : 61 – 65 .
  • Kovacic , P. and Jacintho , J. D. 2001 . Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer . Curr. Med. Chem. , 8 : 773 – 796 .
  • Koyama , K. , Imaizumi , T. , Akiba , M. , Kinoshita , K. , Takahashi , K. , Suzuki , A. , Yano , S. , Horie , S. , Watanabe , K. and Naoi , Y. 1997 . Antinociceptive components of Ganoderma lucidum . Planta Med. , 63 : 224 – 227 .
  • Lai , N. S. , Lin , R. H. , Lai , R. S. , Kun , U. C. and Leu , S. C. 2001 . Prevention of autoantibody formation and prolonged survival in New Zealand Black/New Zealand White F1 mice with an ancient Chinese herb, Ganoderma tsugae . Lupus , 10 : 461 – 465 .
  • Langmead , L. and Rampton , D. S. 2001 . Herbal treatment in gastrointestinal and liver disease—benefits and dangers . Aliment. Pharmacol. Ther. , 15 : 1239 – 1252 .
  • Lee , S. Y. and Rhee , H. M. 1990 . Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action . Chem. Pharm. Bull. , 38 : 1359 – 1364 .
  • Lee , S. S. , Chen , F. D. , Chang , S. C. , Wei , Y. H. , Liu , I. , Chen , C. F. , Wei , R. D. , Chen , K. Y. and Han , R. W. 1984 . In vivo anti-tumor effects of crude extracts from the mycelium of Ganoderma lucidum . J. Chin. Oncol. Soc. , 5 : 22 – 28 .
  • Lee , J. W. , Chung , C. H. , Jeong , H. and Lee , K. H. 1990 . Effects of alkali extract of Ganoderma lucidum IY007 on complement system . Korean J. Mycol. , 18 : 137 – 144 .
  • Lee , J. O. , Rieu , P. , Arnaout , M. A. and Liddington , R. 1995a . Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18) . Cell , 80 : 631 – 638 .
  • Lee , S. S. , Wei , Y. H. , Chen , C. F. , Wang , S. Y. and Chen , K. Y. 1995b . Antitumor effects of Ganoderma lucidum . J. Chin. Med. , 6 : 1 – 12 .
  • Lee , S. , Park , S. , Oh , J. W. and Yang , C. H. 1998 . Natural inhibitors for protein prenyltransferase . Planta Med. , 64 : 303 – 308 .
  • Lee , J. M. , Kwon , H. , Jeong , H. , Lee , J. W. , Lee , S. Y. , Baek , S. J. and Surh , Y. J. 2001 . Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum . Phytother. Res. , 15 : 245 – 249 .
  • Lei , L. S. and Lin , Z. B. 1992 . Effect of Ganoderma polysaccharides on T cell subpopulations and production of interleukin 2 in mixed lymphocyte response . Yaoxue Xuebao—Acta Pharm. Sin. , 27 : 331 – 335 .
  • Lei , L. S. and Lin , Z. B. 1993 . Effects of Ganoderma polysaccharides on the activity of DNA polymerase alpha of splenocytes and immune function in aged mice . Yaoxue Xuebao—Acta Pharm. Sin. , 28 : 577 – 582 .
  • Lei , L. S. , Lin , Z. B. , Chen , Q. , Li , R. Z. and He , Y. Q. 1993 . Antagonistic effect of Ganoderma lucidum polysaccharides on the immunosuppressive response induced by cyclosporin A, hydrocortisone and antitumor agents . Zhonghua Yaolixue Yu Dulixue Zazhi—Chin. J. Pharmacol. Toxicol. , 7 : 183 – 185 .
  • Li , M. C. , Lei , L. S. , Liang , D. S. , Xu , Z. M. , Yuan , J. H. , Yang , S. Q. and Sun , L. S. 2000 . Effect of Ganoderma lucidum polysaccharides on oxygen free radicals in murine peritoneal macrophages . Zhonghua Yaolixue Yu Dulixue Zazhi—Chin. J. Pharmacol. Toxicol. , 14 : 65 – 68 .
  • Lieu , C. W. , Lee , S. S. and Wang , S. Y. 1992 . The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells . Anticancer Res. , 12 : 1211 – 1215 .
  • Lim , U. K. and Choi , K. S. 1991 . The study of chemical components of Ganoderma lucidum . Seoul Natl Univ. J. Agric. Sci. , 16 : 109 – 114 .
  • Lin , D. X. 1997 . Composition and peculiarity of powdered Ganoderma lucidum grown in logs . Zhongguo Shiyongjun Zazhi—Chin. J. Edible Fungus , 16 : 4 – 5 .
  • Lin , L. J. and Shiao , M. S. 1988 . Triterpenes from Ganoderma lucidum . Phytochemistry , 27 : 2269 – 2272 .
  • Lin , X. Y. , Huang , K. L. and Zhu , R. P. 1988 . Therapeutic effect of Ganoderma applonatum (GA) on chronic hepatitis B . Zhonghua Lekezazhi—Chin. J. Intern. Med. , 27 : 652 – 653 .
  • Lin , C. N. , Tome , W. P. and Won , S. J. 1991 . Novel cytotoxic principles of Formosan Ganoderma lucidum . J. Nat. Prod. , 54 : 998 – 1002 .
  • Lin , J. M. , Lin , C. C. , Chiu , H. F. , Yang , J. J. and Lee , S. G. 1993 . Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats . Am. J. Chin. Med. , 21 : 59 – 69 .
  • Lin , J. M. , Lin , C. C. , Chen , M. F. , Ujiie , T. and Takada , A. 1995 . Radical scavenger and antihepatotoxic activity of Ganoderma formosanum, Ganoderma lucidum and Ganoderma neo-japonicum . J. Ethnopharmacol. , 47 : 33 – 41 .
  • Lin , W. H. , Hung , C. H. , Hsu , C. I. and Lin , J. Y. 1997 . Dimerization of the N-terminal amphipathic alpha-helix domain of the fungal immunomodulatory protein from Ganoderma tsugae (Fip-gts) defined by a yeast two-hybrid system and site-directed mutagenesis . J. Biol. Chem. , 272 : 20044 – 20048 .
  • Liu , G. T. 1999a . Pharmacology and clinical application of the spores of Ganoderma lucidum (Curt:Fr.) P.Karst. and mycelium of Ganoderma capense (Lloyd) Teng. (Aphyllophromycitideae) . Int. J. Med. Mushrooms , 1 : 217 – 222 .
  • Liu , G. T. 1999b . Recent advances in research of pharmacology and clinical applications of Ganoderma P. Karst species (Aphyllophoromycetideae) in China . Int. J. Med. Mushrooms , 1 : 63 – 67 .
  • Liu , G. T. , Bao , T. T. , Wei , H. L. and Song , Z. Y. 1979a . Some pharmacological actions of Ganoderma lucidum and G. japonicum (FR) Llyod on mouse liver . Yaoxue Xuebao—Acta Pharm. Sin. , 14 : 284 – 287 .
  • Liu , G. T. , Wang , G. F. , Wei , H. L. , Bao , T. T. and Song , Z. Y. 1979b . A comparison of the protective actions of biphenyl dimethyl-dicarboxylate, trans-stilbene, alcoholic extracts of Fructus schizandrae and Ganoderma against experimental liver injury in mice . Yaoxue Xuebao—Acta Pharm. Sin. , 14 : 598 – 604 .
  • Liu , T. L. , Wang , S. H. and Chang , Q. H. 1989 . Isolation, purification and analysis of polysaccharides and proteoglycan of Ganoderma . Chin. J. Biochem. , 5 : 33 – 37 .
  • Liu , P. , Liu , Y. W. and Kwok , Y. S . 1990 . Lingzhi—The Champion of Healthy Food (Chinese) Peiking : China Scientific Press .
  • Liu , F. , Ooi , V. E. C. and Chang , S. T. 1997 . Free radical scavenging activities of mushroom polysaccharide extracts . Life Sci. , 60 : 763 – 771 .
  • Liu , W. B. , Reinmuth , N. , Stoeltzing , O. , Parikh , A. A. , Fan , F. , Ahmad , S. A. , Jung , Y. D. and Ellis , L. M. 2002a . Antiangiogenic therapy targeting factors that enhance endothelial cell survival . Semin. Oncol. , 29 : 96 – 103 .
  • Liu , X. , Yuan , J. P. , Chung , C. K. and Chen , X. J. 2002b . Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum . Cancer Lett. , 182 : 155 – 161 .
  • Lowell , J. A. , Parnes , H. L. and Blackburn , G. L. 1990 . Dietary immunomodulation: beneficial effects on oncogenesis and tumor growth . Crit. Care Med. , 18 : 145 – 148 .
  • Lu , Z. W. 1995 . Psychoneuroimmunological effects of morphine and the immunoprotection of Ganoderma polysaccharides peptide in morphine-dependent mice . Shengli Kexue Zazhi—Chin. J. Physiol. , 26 : 45 – 49 .
  • Lu , H. , Uesaka , T. , Katoh , O. , Kyo , E. and Watanabe , H. 2001 . Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats . Oncol. Rep. , 8 : 1341 – 1345 .
  • Lu , H. , Kyo , E. , Uesaka , T. , Katoh , O. and Watanabe , H. 2002 . Prevention of development of N,N′-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice . Int. J. Mol. Med. , 9 : 113 – 117 .
  • Luo , J. K. , Wang , H. , Feng , K. Y. , Zidek , W. and Nephrol , H. S. 1999 . Effect of Ganoderma lucidum on platelet cytosolic free calcium concentration in rabbit . Chin. Med. J. , 112 : 1067
  • Ma , J. Y. , Ye , Q. , Hua , Y. J. , Zhang , D. C. , Cooper , R. , Chang , M. N. , Chang , J. Y. and Sun , H. H. 2002 . New lanostanoids from the mushroom Ganoderma lucidum . J. Nat. Prod. , 65 : 72 – 75 .
  • de Maat , M. M. , Hoetelmans , R. M. , Mathot , R. A. , van Gorp , E. C. , Meenhorst , P. L. , Mulder , J. W. and Beijnen , J. H. 2001 . Drug interaction between St John's wort and nevirapine . AIDS , 15 : 420 – 421 .
  • Maeda , Y. Y. , Watanabe , S. T. , Chihara , C. and Rokutanda , M. 1988 . Denaturation and renaturation of a β-1,6;1,3-glucan, lentinan, associated with expression of T-cell mediated responses . Cancer Res. , 48 : 671 – 675 .
  • Mao , T. , van De Water , J. , Keen , C. L. , Stern , J. S. , Hackman , R. and Gershwin , M. E. 1999 . Two mushrooms, Grifola frondosa and Ganoderma lucidum, can stimulate cytokine gene expression and proliferation in human T lymphocytes . Int. J. Immunother. , 15 : 13 – 22 .
  • Maruyama , H. , Yamazaki , K. , Murofushi , S. , Konda , C. and Ikekawa , T. 1989 . Antitumor activity of Sarcodon aspratus (Berk.) S. Ito and Ganoderma lucidum (Fr.) Karst . J. Pharmacobio-Dyn. , 12 : 118 – 123 .
  • Masso-Welch , P. A. , Zangani , D. , Ip , C. , Vaughan , M. M. , Shoemaker , S. , Ramirez , R. A. and Ip , M. M. 2002 . Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid . Cancer Res. , 62 : 4383 – 4389 .
  • Maurer , A. , Johne , A. and Bauer , S. 1999 . Interaction of St. John's wort extract with phenprocoumon . Eur. J. Clin. Pharmacol. , 55 : 22
  • in press .
  • Milner , J. A. 2002 . Strategies for cancer prevention: the role of diet . Br. J. Nutr. , 87 : S265 – S272 .
  • Min , B. S. , Gao , J. J. , Nakamura , N. and Hattori , M. 2000 . Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against Meth-A and LLC tumor cells . Chem. Pharm. Bull. , 48 : 1026 – 1033 .
  • Miyazaki , T. and Nishijima , M. 1981 . Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum . Chem. Pharm. Bull. , 29 : 3611 – 3616 .
  • Miyazaki , T. and Nishijima , M. 1982 . Studies on fungal polysaccharides. XXXII. Structural examination of an alkali-soluble, water-soluble heteroglycan of the fungus Ganoderma lucidum . Carbohydr. Res. , 109 : 290 – 294 .
  • Mizuno , T. 1995 . Bioactive biomolecules of mushroom—food, function and medicinal effect of mushroom fungi . Food Rev. Int. , 11 : 7 – 21 .
  • Mizuno , T. 1996 . A development of antitumor polysaccharides from mushroom fungi . Foods Food Ingred. J. Jpn. , 167 : 69 – 85 .
  • Mizuno , T. and Hazama , T. 1986 . Studies on the host-mediated antitumor polysaccharides. X. Fractionation, formolysis and antitumor activity of fibrous polysaccharides (noncellulose) from Reishi, the fruiting body of Ganoderma lucidum . Shizuoka Daigaku Nogakuba Kenkyu Hokoku , 36 : 77 – 83 .
  • Mizuno , T. , Hayashi , K. , Arakawa , M. , Shinkai , K. , Shimizu , M. and Tanaka , M. 1981 . Host-mediated antitumor polysaccharides. III. Fractionation, chemical structure, and antitumor activity of water-soluble homoglucans isolated from kofukisaruno-koshikake, the fruit body of Ganoderma applanatum . Shizuoka Daigaku Nogakuba Kenkyu Hokoku , 31 : 49 – 64 .
  • Mizuno , T. , Usui , T. , Tomoda , M. , Shinkai , K. , Shimizu , M. and Tanaka , M. 1982 . Studies on the host-mediated antitumor polysaccharides. VI. Isolation and characterization of antitumor active beta-D-glucan from mycelial cells of Ganoderma applanatum . Shizuoka Daigaku Nogakuba Kenkyu Hokoku , 32 : 41 – 58 .
  • Moschella , C. and Jaber , B. L. 2001 . Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation . Am. J. Kidney Dis. , 38 : 1105 – 1107 .
  • Mothana , R. , Jansen , R. , Julich , W. D. and Lindequist , U. 2000 . Ganomycins A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi . J. Nat. Prod. , 63 : 416 – 418 .
  • Mueller , A. , Raptis , J. , Rice , P. J. , Kalbfleisch , J. H. , Stout , R. D. , Ensley , H. E. , Browder , W. and Williams , D. L. 2000 . The influence of glucan polymer structure and solution conformation on binding to (1→3)-beta-D-glucan receptors in a human monocyte-like cell line . Glycobiology , 10 : 339 – 346 .
  • Muller , A. , Rice , P. J. , Ensley , H. , Coogan , P. S. , Kalbfleisch , J. H. , Kelley , J. L. , Love , E. J. , Portera , C. A. , Ha , T. Z. , Browder , I. W. and Williams , D. L. 1996 . Receptor binding and internalization of a water-soluble (1→3)-beta-D-glucan biologic response modifier in two monocyte macrophage cell lines . J. Immunol. , 156 : 3418 – 3425 .
  • Nebel , A. , Schneider , B. J. , Baker , R. K. and Kroll , D. J. 1999 . Potential metabolic interaction between St. John's wort and theophylline . Ann. Pharmacother. , 33 : 502
  • Oh , J. Y. and Chung , K. S. 1998 . Flow cytometrical analysis of the antitumor and immunomodulatory activities of GLB-A and GLB-B, the protein-polysaccharide fractions of the growing tips of Ganoderma lucidum . Yakhak Hoeji , 42 : 487 – 493 .
  • Oh , J. Y. , Cho , K. J. , Chung , S. H. , Kim , J. H. , Lillehoj , H. S. and Chung , K. S. 1998 . Activation of macrophages by GLB, a protein-polysaccharide of the growing tips of Ganoderma lucidum . Yakhak Hoeji , 42 : 302 – 306 .
  • Oh , K. W. , Lee , C. K. , Kim , Y. S. , Eo , S. K. and Han , S. S. 2000 . Antiherpetic activities of acidic protein bound polysacchride isolated from Ganoderma lucidum alone and in combinations with acyclovir and vidarabine . J. Ethnopharmacol. , 72 : 221 – 227 .
  • Ohno , N. , Miura , N. N. , Sugawara , N. , Tokunaka , K. , Kirigaya , N. and Yadomae , T. 1998 . Immunomodulation by hot water and ethanol extracts of Ganoderma lucidum . Pharm. Pharmacol. Lett. , 8 : 174 – 177 .
  • Okazaki , M. , Adachi , Y. , Ohno , N. and Yadomae , T. 1995 . Structure–activity relationship of (1→3)-beta-D-glucans in the induction of cytokine production from macrophages, in vitro . Biol. Pharm. Bull. , 18 : 1320 – 1327 .
  • Ooi , V. E. C. and Liu , F. 1999 . A review of pharmacological activities of mushroom polysaccharides . Int. J. Med. Mushroom , 1 : 195 – 206 .
  • Ooi , V. E. C. and Liu , F. 2000 . Immunomodulation and anti-cancer activity of polysaccharide–protein complexes . Curr. Med. Chem. , 7 : 715 – 729 .
  • Owuor , E. D. and Kong , A. N. T. 2002 . Antioxidants and oxidants regulated signal transduction pathways . Biochem. Pharmacol. , 64 : 765 – 770 .
  • Pan , S. M. , Jr-Shin , Y. and Hseu , R. S. 1997 . Purification and characterization of manganese superoxide dismutase from Ganoderma microsporum . Biochem. Mol. Biol. Int. , 42 : 1035 – 1043 .
  • Pandha , H. S. and Kirby , R. S. 2002 . PC-SPES: phytotherapy for prostate cancer . Lancet , 359 : 2213 – 2215 .
  • Park , E. J. , Ko , G. N. , Kim , J. B. and Sohn , D. H. 1997 . Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, Glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction . Biol. Pharm. Bull. , 20 : 417 – 420 .
  • Paulsen , B. S. 2001 . Plant polysaccharides with immunostimulatory activities . Curr. Org. Chem. , 5 : 939 – 950 .
  • Pfeifer , B. L. , Pirani , J. F. , Hamann , S. R. and Klippel , K. F. 2000 . PC-SPES, a dietary supplement for the treatment of hormone-refractory prostate cancer . BJU Int. , 85 : 481 – 485 .
  • Piscitelli , S. C. , Burstein , A. H. , Chaitt , D. , Alfaro , R. M. and Falloon , J. 2000 . Indinavir concentrations and St John's wort . Lancet , 355 : 547 – 548 .
  • Prendergast , G. C. and Rane , N. 2001 . Farnesyltransferase inhibitors: mechanism and applications . Expert Opin. Investig. Drug , 10 : 2105 – 2116 .
  • Ratain , M. J. 1997 . “ Pharmacology of cancer chemotherapy ” . In Principles and Practice of Oncology Edited by: DeVita , V. T. , Hellman , S. and Rosenberg , S. A. 375 – 509 . Philadelphia : Lippincott-Raven Publishers .
  • Reddy , B. S. , Rao , C. V. , Rivenson , A. and Kelloff , G. 1993 . Chemoprevention of colon carcinogenesis by organosulfur compounds . Cancer Res. , 53 : 3493 – 3498 .
  • Richardson , M. A. and White , J. D. 2000 . Complementary/alternative medicine and cancer research. A national initiative . Cancer Pract. , 8 : 45 – 48 .
  • Rosecke , J. and Konig , W. A. 2000 . Constituents of various wood-rotting basidiomycetes . Phytochemistry , 54 : 603 – 610 .
  • Ross , G. D. , Vetvicka , V. , Yan , J. , Xia , Y. and Vetvickova , J. 1999 . Therapeutic intervention with complement and beta-glucan in cancer . Immunopharmacology , 42 : 61 – 74 .
  • Ryong , L. H. , Tertov , V. V. , Vasil'ev , A. V. , Tutel'yun , V. A. and Orekhov , A. N. 1989 . Antiatherogenic and antiatherosclerotic effects of mushroom extracts revealed in human aortic intima cell culture . Drug Dev. Res. , 17 : 109 – 118 .
  • Saito , K. , Nishijima , M. , Hayakawa , K. and Miyazaki , T. 1991 . Comparison of the antitumor activity of Ganoderma-lucidum by culture medium used and part of the fruit-body . Nihon Kin Gakkai Kaiho , 32 : 355 – 362 .
  • Salih , A. K. and Fentiman , I. S. 2001 . Breast cancer prevention: present and future . Cancer Treat. Rev. , 27 : 261 – 273 .
  • Sandula , J. , Kogan , G. , Kacurakova , M. and Machova , E. 1999 . Microbial (1→3)-beta-D-glucans, their preparation, physico-chemical characterization and immunomodulatory activity . Carbohydr. Polym. , 38 : 247 – 253 .
  • Santin , A. D. , Hermonat , P. L. , Ravaggi , A. , Bellone , S. , Roman , J. , Pecorelli , S. , Cannon , M. and Parham , G. P. 2000 . Effects of concurrent cisplatinum administration during radiotherapy vs. radiotherapy alone on the immune function of patients with cancer of the uterine cervix . Int. J. Radiat. Oncol. Biol. Phys. , 48 : 997 – 1006 .
  • Sasaki , T. , Arai , Y. , Ikekawa , T. , Chihara , G. and Fukuoka , F. 1971 . Antitumor polysaccharides from some Polyporaceae, Ganoderma applanatum and Phellinus linteus . Chem. Pharm. Bull. , 19 : 821 – 826 .
  • Shi , Y. I. , James , A. E. , Benzie , I. F. F. and Buswell , J. A. 2002 . Mushroom-derived preparations in the prevention of H2O2-induced oxidative damage to cellular DNA . Teratog. Carcinog. Mutagen. , 22 : 103 – 111 .
  • Shiao , M. , Lin , L. J. and Yeh , S. F. 1988a . Triterpenes in Ganoderma lucidum . Phytochemistry , 27 : 873 – 875 .
  • Shiao , M. S. , Lin , L. J. and Yeh , S. F. 1988b . Triterpenes from Ganoderma lucidum . Phytochemistry , 27 : 2911 – 2914 .
  • Shiao , M. S. , Lee , K. R. , Lin , L. J. and Wang , C. T. 1994 . “ Natural products and biological activities of the Chinese medical fungus, Ganoderma lucidum ” . In Food Phytochemicals for Cancer Prevention. II: Teas, Spices, and Herbs Edited by: Ho , C. T. , Osawa , T. , Huang , M. T. and Rosen , R. T. 342 – 354 . Washington, DC : American Chemical Society .
  • Shieh , Y. H. , Liu , C. F. , Huang , Y. K. , Yang , J. Y. , Wu , I. L. , Lin , C. H. and Lin , S. C. 2001 . Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice . Am. J. Chin. Med. , 29 : 501 – 507 .
  • Shimizu , A. , Yano , T. , Saito , Y. and Inada , Y. 1985 . Isolation of an inhibitor of platelet aggregation from a fungus, Ganoderma lucidum . Chem. Pharm. Bull. , 33 : 3012 – 3015 .
  • Shureiqi , I. , Reddy , P. and Brenner , D. E. 2000 . Chemoprevention: general perspective . Crit. Rev. Oncol. Hematol. , 33 : 157 – 167 .
  • Singh , A. B. , Gupta , S. K. , Pereira , B. M. and Prakash , D. 1995 . Sensitization to Ganoderma lucidum in patients with respiratory allergy in India . Clin. Exp. Allergy , 25 : 440 – 447 .
  • Small , E. J. and Vogelzang , N. J. 1997 . Second-line hormonal therapy for advanced prostate cancer: a shifting paradigm . J. Clin. Oncol. , 15 : 382 – 388 .
  • Small , E. J. , Frohlich , M. W. , Bok , R. , Shinohara , K. , Grossfeld , G. , Rozenblat , Z. , Kelly , W. K. , Corry , M. and Reese , D. M. 2000 . Prospective trial of the herbal supplement PC-SPES in patients with progressive prostate cancer . J. Clin. Oncol. , 18 : 3595 – 3603 .
  • de Smet , P. A. 1997 . The role of plant-derived drugs and herbal medicines in healthcare . Drugs , 54 : 801 – 840 .
  • Smith , D. C. , Redman , B. G. , Flaherty , L. E. , Li , L. , Strawderman , M. and Pienta , K. J. 1998 . A phase II trial of oral diethylstilbesterol as a second-line hormonal agent in advanced prostate cancer . Urology , 52 : 257 – 260 .
  • Sone , Y. , Okuda , R. , Wada , N. , Kishida , E. and Misaki , A. 1985 . Structural and anti-tumor activities of polysaccharides isolated from fruiting body and the growing culture of mycelium of Ganoderma lucidum . Agric. Biol. Chem. , 49 : 2641 – 2653 .
  • Song , C. H. , Yang , B. K. , Ra , K. S. , Shon , D. H. , Park , E. J. , Go , G. I. and Kim , Y. H. 1998 . Hepatoprotective effect of extracellular polymer produced by submerged culture of Ganoderma lucidum WK-003 . J. Microbiol. Biotechnol. , 8 : 277 – 279 .
  • Sonoda , Y. , Sekigawa , Y. and Sato , Y. 1988 . In vitro effects of oxygenated lanosterol derivatives on cholesterol biosynthesis from 24,25-dihydrolanosterol . Chem. Pharm. Bull. , 36 : 966 – 973 .
  • Sovak , M. , Seligson , A. L. , Konas , M. , Hajduch , M. , Dolezal , M. , Machala , M. and Nagourney , R. 2002 . Herbal composition PC-SPES for management of prostate cancer: identification of active principles . J. Natl Cancer Inst. , 94 : 1275 – 1281 .
  • Sporn , M. B. and Suh , N. 2000 . Chemoprevention of cancer . Carcinogenesis , 21 : 525 – 530 .
  • Su , C. H. 1991 . Taxonomy and physiologically active compounds of Ganoderma—a review . Bull. Taipei Med. Coll. , 20 : 1 – 16 .
  • Su , C. H. , Sun , C. S. , Juan , S. W. , Hu , C. H. , Ke , W. T. and Sheu , M. T. 1997 . Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes . Biomaterials , 18 : 1169 – 1174 .
  • Su , C. H. , Sun , C. S. , Juan , S. W. , Ho , H. O. , Hu , C. H. and Sheu , M. T. 1999a . Development of fungal mycelia as skin substitutes: effects on wound healing and fibroblast . Biomaterials , 20 : 61 – 68 .
  • Su , C. Y. , Shiao , M. S. and Wang , C. T. 1999b . Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets . Biochem. Pharmacol. , 58 : 587 – 595 .
  • Su , C. , Shiao , M. and Wang , C. 2000a . Potentiation of ganodermic acid S on prostaglandin E(1)-induced cyclic AMP elevation in human platelets . Thromb. Res. , 99 : 135 – 145 .
  • Su , H. J. , Fann , Y. F. , Chung , M. I. , Won , S. J. and Lin , C. N. 2000b . New lanostanoids of Ganoderma tsugae . J. Nat. Prod. , 63 : 514 – 516 .
  • Su , C. H. , Yang , Y. Z. , Ho , H. O. , Hu , C. H. and Sheu , M. T. 2001 . High-performance liquid chromatographic analysis for the characterization of triterpenoids from Ganoderma . J. Chromatogr. Sci. , 39 : 93 – 100 .
  • Sugimoto , K. , Ohmori , M. , Tsuruoka , S. , Nishiki , K. , Kawaguchi , A. , Harada , K. , Arakawa , M. , Sakamoto , K. , Masada , M. , Miyamori , I. and Fujimura , A. 2001 . Different effects of St John's wort on the pharmacokinetics of simvastatin and pravastatin . Clin. Pharmacol. Ther. , 70 : 518 – 524 .
  • Surh , Y. J. 1998 . Cancer chemoprevention by dietary phytochemicals—a mechanistic viewpoint . Cancer J. , 11 : 6 – 10 .
  • Suzuki , H. , Iiyama , K. , Yoshida , O. , Yamazaki , S. , Yamamoto , N. and Toda , S. 1990 . Structural characterization of the immunoactive and antiviral water-solubilized lignin in an extract of the culture medium of Lentinus edodes mycelia (LEM) . Agric. Biol. Chem. , 54 : 479 – 487 .
  • Taguchi , T. 1987 . Clinical efficacy of lentinan on patients with stomach cancer: end point results of four-year follow-up survey . Cancer Detect. Prev. , Suppl. 1 : 333 – 349 .
  • de la Taille , A. , Buttyan , R. , Hayek , O. , Bagiella , E. , Shabsigh , A. , Burchardt , M. , Burchardt , T. , Chopin , D. K. and Katz , A. E. 2000 . Herbal therapy PC-SPES: in vitro effects and evaluation of its efficacy in 69 patients with prostate cancer . J. Urol. , 164 : 1229 – 1234 .
  • Talalay , P. , Fahey , J. W. , Holtzclaw , W. D. , Prestera , T. and Zhang , Y. 1995 . Chemoprotection against cancer by phase 2 enzyme induction . Toxicol. Lett. , 82–83 : 173 – 179 .
  • Tamimi , R. M. , Lagiou , P. , Adami , H. O. and Trichopoulos , D. 2002 . Prospects for chemoprevention of cancer . J. Int. Med. , 251 : 286 – 300 .
  • Tanaka , S. , Ko , K. , Kino , K. , Tsuchiya , K. , Yamashita , A. , Murasugi , A. , Sakuma , S. and Tsunoo , H. 1989 . Complete amino acid sequence of an immunomodulatory protein, ling zhi-8 (LZ-8). An immunomodulator from a fungus, Ganoderma lucidium, having similarity to immunoglobulin variable regions . J. Biol. Chem. , 264 : 16372 – 16377 .
  • Tao , J. and Feng , K. Y. 1990 . Experimental and clinical studies on inhibitory effect of Ganoderma lucidum on platelet aggregation . J. Tongji Med. Univ. , 10 : 240 – 243 .
  • Tasaka , K. , Akagi , M. , Miyoshi , K. , Mio , M. and Makino , T. 1988a . Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effect of oleic acid on histamine release . Agents Actions , 23 : 153 – 156 .
  • Tasaka , K. , Mio , M. , Izushi , K. , Akagi , M. and Makino , T. 1988b . Anti-allergic constituents in the culture medium of Ganoderma lucidum. (II). The inhibitory effect of cyclooctasulfur on histamine release . Agents Actions , 23 : 157 – 160 .
  • Temple , N. J. and Balay-Karperien , A. L. 2002 . Nutrition in cancer prevention: an integrated approach . J. Am. Coll. Nutr. , 21 : 79 – 83 .
  • Thomas , T. and Thomas , T. J. 2001 . Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications . Cell. Mol. Life Sci. , 58 : 244 – 258 .
  • Thorgeirsson , S. S. and Grisham , J. W. 2002 . Molecular pathogenesis of human hepatocellular carcinoma . Nat. Genet. , 31 : 339 – 346 .
  • Thornton , B. P. , Vetvicka , V. , Pitman , M. , Goldman , R. C. and Ross , G. D. 1996 . Analysis of the sugar specificity and molecular location of the beta-glucan-binding lectin site of complement receptor type 3 (CD11b/CD18) . J. Immunol. , 156 : 1235 – 1246 .
  • Tiwari , R. K. , Geliebter , J. , Garikapaty , V. P. , Yedavelli , S. P. , Chen , S. and Mittelman , A. 1999 . Anti-tumor effects of PC-SPES, an herbal formulation in prostate cancer . Int. J. Oncol. , 14 : 713 – 719 .
  • Tomoda , M. , Gonda , R. , Kasahara , Y. and Hikino , H. 1986 . Antidiabetes drugs. Glycan structures of ganoderans B and C, hypoglycemic glycans of Ganoderma lucidum fruit bodies . Phytochemistry , 25 : 2817 – 2820 .
  • Tosetti , F. , Ferrari , N. , De Flora , S. and Albini , A. 2002 . ‘Angioprevention’: angiogenesis is a common and key target for cancer chemopreventive agents . FASEB J. , 16 : 2 – 14 .
  • Trnovec , T. and Hrmova , M. 1993 . Immunomodulator polysaccharides: chemistry, disposition and metabolism . Biopharm. Drug. Dispos. , 14 : 187 – 195 .
  • Tsavaris , N. , Kosmas , C. , Vadiaka , M. , Kanelopoulos , P. and Boulamatsis , D. 2002 . Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes . Br. J. Cancer , 87 : 21 – 27 .
  • Tzianabos , A. O. 2000 . Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function . Clin. Microbiol. Rev. , 13 : 523
  • Ukai , S. , Kiho , T. , Hara , C. , Kuruma , I. and Tanaka , Y. 1983a . Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi . J. Pharmacobio-Dyn. , 6 : 983 – 990 .
  • Ukai , S. , Kiho , T. , Hara , C. , Morita , M. , Goto , A. , Imaizumi , N. and Hasegawa , Y. 1983b . Polysaccharides in fungi. XIII. Antitumor activity of various polysaccharides isolated from Dictyophora indusiata, Ganoderma japonicum, Cordyceps cicadae, Auricularia auricula-judae, and Auricularia species . Chem. Pharm. Bull. , 31 : 741 – 744 .
  • Usui , T. , Iwasaki , Y. , Mizuno , T. , Tanaki , M. , Shinkai , K. and Arakawa , M. 1983 . Isolation and characterization of antitumor active beta-D-glucans from the fruit bodies of Ganoderma applanatum . Carbohydr. Res. , 115 : 273 – 280 .
  • Vimala , S. , Norhanom , A. W. and Yadav , M. 1999 . Anti-tumour promoter activity in Malaysian Ginger rhizobia used in traditional medicine . Br. J. Cancer , 80 : 110 – 116 .
  • Vogel , V. G. 2001 . Reducing the risk of breast cancer with tamoxifen in women at increased risk . J. Clin. Oncol. , 19 : 87S – 92S .
  • Walczak , J. , Wood , H. , Wilding , G. , Williams , T. , Bishop , C. W. and Carducci , M. 2001 . Prostate cancer prevention strategies using antiproliferative or differentiating agents . Urology , 57 : 81 – 85 .
  • Wan , F. and Huang , D. 1992 . Anti-inflammatory and analgesic actions of artificial and fermentative Ganoderma sinense (AFGS) . Zhongguo Zhongyao Zazhi—Chin. J. Mater. Med. , 17 : 619 – 622 .
  • Wang , J. F. , Zhang , J. J. and Chen , W. W. 1985 . Study of the action of Ganoderma lucidum on scavenging hydroxyl radicals from plasma . Zhongyi Zazhi—J. Traditional Chin. Med. , 5 : 55 – 60 .
  • Wang , C. N. , Chen , J. C. , Shiao , M. S. and Wang , C. T. 1991 . The inhibition of human platelet function by ganodermic acids . Biochem. J. , 277 : 189 – 198 .
  • Wang , G. , Zhang , J. , Mizuno , T. , Zhuang , C. , Ito , H. , Mayuzumi , H. , Okamoto , H. and Li , J. 1993 . Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the fruiting body of Ganoderma tsugae . Biosci. Biotechnol. Biochem. , 57 : 894 – 900 .
  • Wang , S. Y. , Hsu , M. L. , Hsu , H. C. , Tzeng , C. H. , Lee , S. S. , Shiao , M. S. and Ho , C. K. 1997 . The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes . Int. J. Cancer , 70 : 699 – 705 .
  • Wang , Z. Q. , Gorski , C. , Hamman , M. A. , Huang , S. M. , Lesko , L. J. and Hall , S. D. 2001 . The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity . Clin. Pharmacol. Ther. , 70 : 317 – 326 .
  • Wang , Y. Y. , Khoo , K. H. , Chen , S. T. , Lin , C. C. , Wong , C. H. and Lin , C. H. 2002 . Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities . Bioorg. Med. Chem. , 10 : 1057 – 1062 .
  • Wargovich , M. J. , Woods , C. , Hollis , D. M. and Zander , M. E. 2001 . Herbals, cancer prevention and health . J. Nutr. , 131 : 3034S – 3036S .
  • Wasser , S. P. and Weis , A. L. 1999 . Therapeutic effects of substances occurring in higher basidiomycetes mushrooms: a modern perspective . Crit. Rev. Immunol. , 19 : 65 – 96 .
  • Watanabe , C. M. H. , Wolffram , S. , Ader , P. , Rimbach , G. , Packer , L. , Maguire , J. J. , Schultz , P. G. and Gohil , K. 2001 . The in vivo neuromodulatory effects of the herbal medicine Ginkgo biloba . Proc. Natl Acad. Sci. USA , 98 : 6577 – 6580 .
  • Watson , W. H. , Cai , J. Y. and Jones , D. P. 2000 . Diet and apoptosis . Ann. Rev. Nutr. , 20 : 485 – 505 .
  • Wentworth , J. M. , Agostini , M. , Love , J. , Schwabe , J. W. and Chatterjee , V. K. 2000 . St John's wort, a herbal antidepressant, activates the steroid X receptor . J. Endocrinol. , 166 : R11 – R16 .
  • Werner , G. H. and Jolles , P. 1996 . Immunostimulating agents—what next—a review of their present and potential medical applications . Eur. J. Biochem. , 242 : 1 – 19 .
  • Willard , T. 1990 . Reishi Mushroom. Herbal of Spiritual Potency and Medical Wonder Vancouver : Issaquah Sylvan Press .
  • Williams , D. L. 1997 . Overview of (1-3)-beta-D-glucan immunobiology . Mediat. Inflamm. , 6 : 247 – 250 .
  • Wills , R. B. H. , Bone , K. and Morgan , M. 2000 . Herbal products: active constituents, modes of action and quality control . Nutr. Res. Rev. , 13 : 47 – 77 .
  • Windrum , P. , Hull , D. R. and Morris , T. C. 2000 . Herb–drug interactions . Lancet , 355 : 1019 – 1120 .
  • Won , S. J. , Lee , S. S. , Ke , Y. H. and Lin , M. T. 1989 . Enhancement of splenic NK cytotoxic activity by the extracts of Ganoderma lucidum mycelium in mice . J. Biomed. Lab. Sci. , 2 : 201 – 213 .
  • Won , S. J. , Lin , M. T. and Wu , W. L. 1992 . Ganoderma tsugae mycelium enhances splenic natural killer cell activity and serum interferon production in mice . Jpn. J. Pharmacol. , 59 : 171 – 176 .
  • Wrighton , C. and Busslinger , M. 1993 . Direct transcriptional stimulation of the ornithine decarboxylase gene by Fos in PC12 cells but not in fibroblasts . Mol. Cell. Biol. , 13 : 4657 – 4669 .
  • Wu , T. S. , Shi , L. S. , Kuo , S. C. , Cherng , C. Y. , Tung , S. F. and Teng , C. M. 1997 . Platelet aggregation inhibitor from Ganoderma lucidum . J. Chin. Chem. Soc. , 44 : 157 – 161 .
  • Wu , T. S. , Shi , L. S. and Kuo , S. C. 2001 . Cytotoxicity of Ganoderma lucidum triterpenes . J. Nat. Prod. , 64 : 1121 – 1122 .
  • Xia , Y. , Vetvicka , V. , Yan , J. , Hanikyrova , M. , Mayadas , T. and Ross , G. D. 1999 . The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells . J. Immunol. , 162 : 2281 – 2290 .
  • in press .
  • Yang , B. K. , Jeon , Y. J. , Jeong , S. C. , Kim , D. H. , Ha , J. Y. , Yun , J. W. , Shon , D. H. , Go , G. I. and Song , C. H. 1999 . Hepatoprotective effect of exo-polysaccharide produced from submerged mycelial culture of Ganoderma lucidum WK-003 by using industrial grade medium . Korean J. Mycol. , 27 : 82 – 86 .
  • Yang , C. S. , Chhabra , S. K. , Hong , J. Y. and Smith , T. J. 2001a . Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic . J. Nutr. , 131 : 1041S – 1045S .
  • Yang , C. S. , Prabhu , S. and Landau , J. 2001b . Prevention of carcinogenesis by tea polyphenols . Drug. Metab. Rev. , 33 : 237 – 253 .
  • Yen , G. C. and Wu , J. Y. 1999 . Antioxidant and radical scavenging properties of extracts from Ganoderma tsugae . Food Chem. , 65 : 375 – 379 .
  • Yeo , K. S. , Shim , M. J. , Bok , J. W. , Kang , C. Y. , Choi , E. C. and Kim , B. K. 1994 . Studies on constituents of higher fungi of Korea (LXXVIII) antitumor components of fusion hybrids between Ganoderma lucidum and Coriolus versicolor . Seoul Univ. J. Pharm. Sci. , 19 : 1 – 29 .
  • Yoon , S. Y. , Eo , S. K. , Kim , Y. S. , Lee , C. K. and Han , S. S. 1994 . Antimicrobial activity of Ganoderma lucidum extract alone and in combination with some antibiotics . Arch. Pharm. Res. , 17 : 438 – 442 .
  • Young , R. C. and Wilson , C. M. 2002 . Cancer prevention: past, present, and future . Clin. Cancer Res. , 8 : 11 – 16 .
  • Yue , Q. Y. , Bergquist , C. and Gerden , B. 2000 . Safety of St John's wort (Hypericum perforatum) . Lancet , 355 : 548 – 549 .
  • Yun , T. K. 1999 . Update from Asia. Asian studies on cancer chemoprevention . Ann. N. Y. Acad. Sci. , 889 : 157 – 192 .
  • Zhang , Q. H. and Lin , Z. B. 1999 . Study on antitumor activity and mechanism of Ganoderma polysaccharides B . Zhonghua Zhongxiyi Jehe Zazhi—Chin. J. Integr. Traditional West. Med. , 19 : 544 – 547 .
  • Zhang , N. L. and Zhang , S. Y. 1997 . Analysis of vitamins and polysaccharides of Ganoderma spores . Chin. J. Biochem. Pharmacol. , 18 : 37 – 39 .
  • Zhang , L. X. , Mong , H. and Zhou , X. B. 1993 . Effect of Japanese Ganoderma lucidum on production of interleukin-2 from murine splenocytes . Zhonghua Zhongxiyi Jehe Zazhi—Chin. J. Integr. Traditional West. Med. , 13 : 613 – 615 .
  • Zhang , J. , Wang , G. , Li , H. , Zhuang , C. , Mizuno , T. , Ito , H. , Mayuzumi , H. , Okamoto , H. and Li , J. 1994 . Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium . Biosci. Biotechnol. Biochem. , 58 : 1202 – 1205 .
  • Zhang , J. S. , Tang , Q. J. , Zimmerman-Kordmann , M. , Reutter , W. and Fan , H. 2002 . Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum . Life Sci. , 71 : 623 – 638 .
  • Zhong , L. , Jiang , D. Z. and Wang , Q. R. 1999 . Effects of Ganoderma lucidum (Leyss ex Fr) Karst compound on the proliferation and differentiation of K562 leukemic cells . Bull. Hunan Med. Univ. , 24 : 521 – 524 .
  • Zhou , S. F. and Gao , Y. H. 2002 . The immunomodulating effects of Ganoderma lucidum (Curt.: Fr) P. Karst (Ling Zhi, Reishi mushroom) (Aphyllophoromycetideae) . Int. J. Med. Mushroom , 4 : 1 – 11 .
  • Zhou , S. F. , Gao , Y. H. , Huang , M. , Xu , A. L. and Paxton , J. W. 2002a . Interactions of herbs with cytochrome P450 . Drug. Metab. Rev. , In press
  • Zhou , S. F. , Kestell , P. , Baguley , B. C. and Paxton , J. W. 2002b . 5,6-Dimethylxanthenone-4-acetic acid: a novel biological response modifier for cancer therapy . Investig. New Drugs , 20 : 281 – 295 .
  • Zhu , H. S. , Yang , X. L. , Wang , L. B. , Zhao , D. X. and Chen , L. 2000 . Effects of extracts from sporoderm-broken spores of Ganoderma lucidum on HeLa cells . Cell Biol. Toxicol. , 16 : 201 – 206 .

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