Omega-6/Omega-3 Essential Fatty Acid Ratio and Chronic Diseases

References

• Bartram , H.-P. , Bostner , A. , Scheppach , W. , Reddy , B. S. , Rao , C. V. , Dusel , G. , Richter , F. , Richteer , A. and Kasper , H. 1993 . Effects of fish oil on rectal cell proliferation, mucosal fatty acids, and prostaglandin E2 release in healthy subjects . Gastroenterology , 105 : 1317 – 1322 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Bartram , H.-P. , Gostner , A. , Reddy , B. S. , Rao , C. V. , Scheppach , W. , Dusal , G. , Richter , A. , Richter , F. and Kasper , H. 1995 . Missing anti-proliferative effect of fish oil on rectal epithelium in healthy volunteers consuming a high-fat diet: potential role of the n-3:n-6 fatty acid ratio . Eur. J. Cancer Prev. , 4 : 231 – 237 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Broughton , K. S. , Johnson , C. S. , Pace , B. K. , Liebman , M. and Kleppinger , K. M. 1997 . Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production . Am. J. Clin. Nutr. , 65 ( 4 ) : 1011 – 1017 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• Cleland , L. G. , James , M. J. , Neumann , M. A. , D’Angelo , M. and Gibson , R. A. 1992 . Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects . Am. J. Clin. Nutr. , 55 : 395 – 399 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• de Lorgeril , M. , Renaud , S. , Mamelle , N. , Salen , P. , Martin , J.-L. , Monjaud , I. , Guidollet , J. , Touboul , P. and Delaye , J. 1994 . Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease . Lancet , 343 : 1454 – 1459 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• de Lorgeril , M. and Salen , P. 2000 . “ Modified Cretan Mediterranean diet in the prevention of coronary heart disease and cancer ” . In Mediterranean Diets Edited by: Simopoulos , A. P. and Visioli , F. Vol. 87 , 1 – 23 . World Rev. Nutr. Diet .
   Google Scholar
• Eaton , S. B. , Eaton , S. B. III , Sinclair , A. J. , Cordain , L. and Mann , N. J. 1998 . “ Dietary intake of long-chain polyunsaturated fatty acids during the Paleolithic ” . In The Return of ω3 Fatty Acids into the Food Supply. I. Land-Based Animal Food products and Their Health Effects Edited by: Simopoulos , A. P. Vol. 83 , 12 – 23 . Karger, Basel : World Rev. Nut. Diet .
   Google Scholar
• Eaton , S. B. and Konner , M. 1985 . Paleolithic nutrition. A consideration of its nature and current implications . New. Engl. J. Med. , 312 : 283 – 289 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Eaton , S. B. , Konner , M. and Shostak , M. 1988 . Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective . Am. J. Med. , 84 : 739 – 749 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ge , Y.-L. , Chen , Z. , Kang , Z. B. , Cluette-Brown , J. , Laposata , M. and Kang , J. X. 2002 . Effects of adenoviral transfer of Caenorhabditis elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells . Anticancer Research , 22 : 537 – 544 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar
• GISSI-Prevenzione Investigators. 1999 . Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial . Lancet , 354 : 447 – 455 . [CROSSREF]
   PubMed Web of Science ®Google Scholar
• James , M. J. and Cleland , L. G. 1997 . Dietary n-3 fatty acids and therapy for rheumatoid arthritis . Semin. Arthritis Rheum. , 27 : 85 – 97 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Kang , Z. B. , Ge , Y. , Chen , Z. , Brown , J. , Lapasota , M. , Leaf , A. and Kang , J. X. 2001 . Adenoviral transfer of Caenorhabditis elegans n-3 fatty acid desaturase optimizes fatty acid composition in mammalian heart cells . Proc. Natl. Acad. Sci. USA , 98 : 4050 – 4054 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Keys , A. , Blackburn , H. and Menotti , A. 1970 . Coronary heart disease in seven countries . Circulation , 41 ( suppl 1 ) : 1 – 211 .
   Web of Science ®Google Scholar
• Laitinen , L. A. , Laitinen , A. and Haahtela , T. 1993 . Airway mucosal inflammation even in patients with newly diagnosed asthma . Am. Rev. Respir. Dis. , 147 ( 3 ) : 697 – 704 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Leaf , A. and Weber , P. C. 1987 . A new era for science in nutrition . Am. J. Clin. Nutr. , 45 : 1048 – 1053 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Li , Y. , Kang , J. X. and Leaf , A. 1997 . Differential effects of various eicosanoids on the contraction of cultured neonatal rat cardiomyocytes . Prostaglandins , 54 : 511 – 530 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Locke , C. A. and Stoll , A. L. 2001 . Omega-3 fatty acids in major depression . World Rev. Nutr. Diet , 89 : 173 – 185 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Maes , M. , Smith , R. , Christophe , A. , Cosyns , P. , Desnyder , R. and Meltzer , H. 1996 . Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20:4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids . J. Affect Disord. , 38 ( 1 ) : 35 – 46 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Maes , M. , Smith , R. , Christophe , A. , Vandoolaeghe , E. , Van Gastel , A. , Neels , H. , Demedts , P. , Wauters , A. and Meltzer , H. Y. 1997 . Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers . Acta Psychiatr. Scand. , 95 ( 3 ) : 212 – 221 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Maillard , V. , Bougnoux , P. , Ferrari , P. , Jourdan , M.-L. , Pinault , M. , Lavillonnieree , F. F. , Body , G. , Le , Floch, O. and Chajes , V. 2002 . n-3 and n-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in tours, France . Int. J. Cancer , 98 : 78 – 83 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Peet , M. , Murphy , B. , Shay , J. and Horrobin , D. 1998 . Depletion of omega-3 fatty acid levels in red blood cell membranes of depressive patients . Biol. Psychiatry , 43 ( 5 ) : 315 – 319 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Pella , D. , Dubnov , G. , Singh , R. B. , Sharma , R. and Berry , E. M. 2003 . “ Effects of an Indo-Mediterranean diet on the omega-6/omega-3 ratio in patients at high risk of coronary artery disease ” . In The Indian Paradox Vol. 92 , 74 – 80 . Basel, Karger : World Rev. Nutr. Diet .
   Google Scholar
• Renaud , S. , de Lorgeril , M. and Delaye , J. 1995 . Cretan Mediterranean diet for prevention of coronary heart disease . Am. J. Clin. Nutr. , 61 ( suppl ) : 1360S – 1367S . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Sanders , T. A. B. 2000 . Polyunsaturated fatty acids in the food chain in Europe . Am. J. Clin. Nutr. , 71 ( suppl ) : S176 – S178 .
   Google Scholar
• Simopoulos , A. P. 1995a . Plants in Human Nutrition Vol. 77 , Karger, Basel : World Rev. Nutr. Diet .
   Google Scholar
• Simopoulos , A. P. 1995b . “ Evolutionary aspects of diet: Fatty acids, insulin resistance and obesity ” . In Obesity: New Directions in Assessment and Management Edited by: VanItallie , T. B. and Simopoulos , A. P. 241 – 261 . Philadelphia : Charles Press .
   Google Scholar
• Simopoulos , A. P. 1999a . Evolutionary aspects of omega-3 fatty acids in the food supply . Prostaglandins, Leukotrienes and Essential Fatty Acids. , 60 ( 5&6 ) : 421 – 429 . [CROSSREF] [CSA]
   PubMedGoogle Scholar
• Simopoulos , A. P. 1999b . “ Genetic variation and evolutionary aspects of diet ” . In Antioxidants in Nutrition and Health Edited by: Papas , A. 65 – 88 . Boca Raton : CRC Press .
   Google Scholar
• Simopoulos , A. P. 2001 . N-3 fatty acids and human health: defining strategies for public policy . Lipids , 36 : S83 – S89 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Simopoulos , A. P. 1999c . New products from the agri-food industry: The return of n-3 fatty acids into the food supply . Lipids , 34 ( suppl ) : S297 – S301 . [PUBMED] [INFOTRIEVE]
   PubMedGoogle Scholar
• Simopoulos , A. P. 1991 . Omega-3 fatty acids in health and disease and in growth and development . Am. J. Clin. Nutr. , 54 : 438 – 463 . [PUBMED] [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Simopoulos , A. P. 1998a . “ Overview of evolutionary aspects of w3 fatty acids in the diet ” . In The Return of w3 Fatty Acids into the Food Supply. I. Land-Based Animal Food Products and Their Health Effects Edited by: Simopoulos , A. P. Vol. 83 , 1 – 11 . Karger, Basel : World Rev. Nutr. Diet .
   Google Scholar
• Simopoulos , A. P. 1995c . The Mediterranean diet: Greek column rather than an Egyptian pyramid . Nutr. Today , 30 ( 2 ) : 54 – 61 .
   Google Scholar
• Simopoulos , A. P. 1995d . “ Trans fatty acids ” . In Handbook of Lipids in Human Nutrition Edited by: Spiller , G. A. 91 – 99 . Boca Raton : CRC Press .
   Google Scholar
• Simopoulos , A. P., ed. 1999d . “ Evolutionary aspects of nutrition and health ” . In Diet Exercise Genetics and Chronic Disease Vol. 84 , Karger, Basel : World Rev. Nutr. Diet .
   Google Scholar
• Simopoulos , A. P. and Sidossis , L. S. 2000 . “ Hat is so special about the traditional diet of Greece. The scientific evidence ” . In Mediterranean Diets Edited by: Simopoulos , A. P. and Visioli , F. Vol. 87 , 24 – 42 . Basel, Karger : World Rev. Nutr. Diet .
   Google Scholar
• Simopoulos , A. P. and Cleland , L. G. 2003 . “ Omega-6/omega-3 essential fatty acid ratio ” . In The Scientific Evidence Vol. 92 , Karger, Basel : World Rev. Nutr. Diet . in press
   Google Scholar
• Simopoulos , A. P. 1998b . “ The return of w3 fatty acids into the food supply. I ” . In Land-Based Animal Food Products and Their Health Effects Vol. 83 , Karger, Basel : World Rev. Nutr. Diet .
   Google Scholar
• Singh , R. B. , Dubnov , G. and Niaz , M. 2002 . Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high-risk patients (Indo-Mediterranean Diet Heart Study): a randomized single-blind trial . Lancet , 360 : 1455 – 1461 . [PUBMED] [INFOTRIEVE] [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Stoll , A. L. , Severus , W. E. , Freeman , M. P. , Rueter , S. , Zboyan , H. A. , Diamond , E. , Cress , K. K. and Marangell , L. B. 1999 . Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial . Arch. Gen. Psychiatry , 56 ( 5 ) : 407 – 412 . [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
   PubMed Web of Science ®Google Scholar
• Sugano , M. and Hirahara , F. 2000 . Polyunsaturated fatty acids in the food chain in Japan . Am. J. Clin. Nutr. , 71 ( suppl ) : 189S – 196S . [PUBMED] [INFOTRIEVE] [CSA]
   PubMedGoogle Scholar
• Tiemeier , H. , van Tuijl , H. R. , Hofman , A. , Kiliaan , A. J. and Breteler , M.M.B. 2003 . Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study . Am. J. Clin. Nutr. , 78 : 40 – 46 . [PUBMED] [INFOTRIEVE] [CSA]
   PubMed Web of Science ®Google Scholar