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Hemoglobin
international journal for hemoglobin research
Volume 26, 2002 - Issue 1
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Original

IDENTIFICATION OF Hb KENYA (Aγ81Leu-β86Ala) BY ELECTROSPRAY MASS SPECTROMETRY

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Pages 71-75 | Received 11 Jul 2001, Accepted 21 Aug 2001, Published online: 07 Jul 2009

REFERENCES

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  • Kendall A. G., Ojwang P. J., Schroeder W. A., Huisman T. H.J. Hemoglobin Kenya, the product of a γ–β fusion gene: studies of the family. Am. J. Hum. Genet. 1973; 25: 548–563
  • Smith D. H., Clegg J. B., Weatherall D. J., Gilles H. M. Hereditary persistence of foetal haemoglobin associated with γβ fusion variant, Haemoglobin Kenya. Nature New Biol. 1973; 246: 184–186
  • Nute P. E., Wood W. G., Stamatoyannopoulos G., Olweny C., Failkow P. J. The Kenya form of hereditary persistence of foetal haemoglobin: structural studies and evidence for homogenous distribution of Haemoglobin F using fluorescent anti-Haemoglobin F antibodies. Br. J. Haematol. 1976; 32: 55–63
  • Ojwang P. J., Nakatsuji T., Gardiner M. B., Reese A. L., Gilman J. G., Huisman T. H.J. Gene deletion as the molecular basis for the Kenya-Gγ-HPFH condition. Hemoglobin 1983; 7(2)115–123
  • Forget B. G. Molecular basis of hereditary persistence of fetal hemoglobin. Ann. N.Y. Acad. Sci. 1998; 850: 38–44
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  • Landin B., Jeppsson J-O. Rare β chain hemoglobin variants found in Swedish patients during HbA1c analysis. Hemoglobin 1993; 17(4)303–318
  • Rai D. K., Alvelius G., Landin B., Griffiths W. J. Electrospray tandem mass spectrometry in the rapid identification of α-chain haemoglobin variants. Rapid Commun. Mass Spectrom. 2000; 14: 1184–1194
  • Waye J. S., Cai S-P., Eng B., Chui D. H.K., Francombe W. H. Clinical course and molecular characterization of a compound heterozygote for sickle cell hemoglobin and Hemoglobin Kenya. Am. J. Hematol. 1992; 41: 289–291
  • De Caterina M., Esposito P., Grimaldi E., Di Mario G., Scopacasa F., Ferranti P., Parlapiano A., Malorni A., Pucci P., Marino G. Characterization of Hemoglobin Lepore variants by advanced mass-spectrometric procedures. Clin. Chem. 1992; 38: 1444–1448

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