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Hemoglobin
international journal for hemoglobin research
Volume 28, 2004 - Issue 1
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Original Article

The β‐Thalassemia Mutation/Haplotype Distribution in the Moroccan Population

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Pages 25-37 | Received 08 Aug 2003, Accepted 15 Oct 2003, Published online: 24 Aug 2009

References

  • Nadifi S, Beldjord C, Elion J, Labie D, Filali A, Benlmlih M, Bensliman A. Globin gene mutation in Morocco: genetic and anthropological approach. Cell Pharmacol 1996; 3: 129–133
  • Lemsaddek W, Picanço I, Seuanes F, Mahmal L, Benchekroun S, Khattab M, Nogueira P, Osorio‐Almeida L. Spectrum of β thalassemia mutations and Hb F levels in the heterozygous Moroccan population. Am J Hematol 2003; 73(3)161–168
  • Benchemsi N, Quessar A, Azelmat N, Chaouki M, Akalay O, Tiberi J J, Devaux C, Mouaddib A. Enquête epidemiologique sur les hemoglobinopathies au Maroc. Procédés de la 1ére Journée Scientifique de Thalassemie et Drepanocytose, Casablanca 2001; 11–28
  • Glantz S A. Primer of Bio‐Statistics4th ed. McGraw Hill, New York 1997
  • Bennani C, Bouhass R, Perrin‐Percontal P, Tamouza R, Malou M, Elion J, Trabuchet G, Beldjord C, Benadabji M, Labie D. Anthropological approach to the heterogeneity of β‐thalassemia mutations in northern Africa. Hum Biol 1994; 66(3)369–382
  • Faustino P, Pacheco P, Loureiro P, Nogueira P J, Lavinha J. The geographic pattern of β‐thalassaemia mutations in the Portuguese population. Br J Haematol 1999; 107(4)903–904
  • Ribeiro M L, Gonçalves P, Cunha E, Bento C, Almeida H, Pereira J, Nunez G M, Tamagnini G P. Genetic heterogeneity of β‐thalassemia in populations of the Iberian Peninsula. Hemoglobin 1997; 21(3)261–269
  • Magro S, Santilli E, Mancuso R, Puzzonia P, Consarino C, Morgione S, Galati M C, Fersini G, Madonna G, Brancati C. Spectrum of β‐thalassemia mutations in Calabria: implications for prenatal diagnosis. Am J Hematol 1995; 48(2)128–129
  • Rosatelli M C, Tuveri T, Scalas M T, Leoni G B, Sardu R, Faa V, Meloni A, Pischedda M A, Demurtas M, Monni G. Molecular screening and fetal diagnosis of β‐thalassemia in the Italian population. Hum Genet 1992; 89(6)585–589
  • Rady M S, Baffico M, Khalifa A S, Heshmat N M, el‐Moselhy S, Sciarratta G V, Hussein I R, Temtamy S A, Romeo G. Identification of Mediterranean β‐thalassemia mutations by reverse dot‐blot in Italians and Egyptians. Hemoglobin 1997; 21(1)59–69
  • Camaschella C, Mazza U, Roetto A, Gottardi E, Parziale A, Travi M, Fattore S, Bacchiega D, Fiorelli G, Cappellini M D. Genetic interactions in thalassemia intermedia: analysis of β‐mutations, α‐genotype, γ‐promoters, and β‐LCR hypersensitive sites 2 and 4 in Italian patients. Am J Hematol 1995; 48(2)82–87
  • Rouabhi F, Lapouméroulie C, Amselem S, Krishnamoorthy R, Adjrad L, Girot R, Chardin P, Benabdji M, Labie D, Beldjord C. DNA haplotype distribution in Algerian β thalassaemia patients. Hum Genet 1988; 79(4)373–376
  • Faustino P, Osório‐Almeida L, Barbot J, Espírito‐Santo D, Gonçalves J, Romão L, Martins M C, Marques M M, Lavinha J. Novel promoter and splice junction defects add to the genetic, clinical or geographic heterogeneity of β‐thalassaemia in Portuguese population. Hum Genet 1992; 89(5)573–576
  • Cabeda J M, Correia C, Estevinho A, Simões C, Amorim M L, Pinho L, Justiça B. Unexpected pattern of β‐thalassaemia patients from northern Portugal. Br J Haematol 1999; 105(1)68–74
  • Pirastu M, Saglio G, Camaschella C, Loi A, Serra A, Bertero T, Gabutti W, Cao A. Delineation of specific β‐thalassemia mutations in high‐risk areas of Italy: a prerequisite for prenatal diagnosis. Blood 1988; 71(4)983–988
  • Schiliro G, Di Gregorio F, Samperi P, Mirabile E, Liang R, Curuk M A, Ye Z, Huisman T HJ. Genetic heterogeneity of β‐thalassemia in southeast Sicily. Am J Hematol 1995; 48(1)5–11
  • Di Marzo R, Dowling C E, Wong C, Maggio A, Kazazian H H, Jr. The spectrum of β‐thalassaemia mutations in Sicily. Br J Haematol 1988; 69(3)393–397
  • Rosatelli C, Leoni G B, Tuveri T, Scalas M T, Di Tucci A, Cao A. β Thalassaemia mutations in Sardinians: implications for prenatal diagnosis. J Med Genet 1987; 24(2)97–100
  • Galanello R, Dessi E, Melis M A, Addis M, Sanna M A, Rosatelli C, Argiolu F, Giagu N, Turco M P, Cacace E. Molecular analysis of β0‐thalassemia intermedia in Sardinia. Blood 1989; 74(2)823–827
  • Historia de Portugal, J Mattoso. Circulo de Leitores Lda, Lisboa 1992; Vol. 1
  • Cao A. β Thalassaemia mutations in Mediterranean populations. Br J Haematol 1989; 71(3)309–312
  • Antonarakis S E, Kazazian H H, Jr, Orkin S H. DNA polymorphism and molecular pathology of the human globin gene clusters. Hum Genet 1985; 69(1)1–14
  • Lugan B. Histoire du Maroc des Origines à Nos Jours. Perrin, France 2000
  • Tadmouri G O, Basak A N. β‐Thalassemia in Turkey: a review of the clinical, epidemiological, molecular, and evolutionary aspects. Hemoglobin 2001; 25(2)227–239
  • Filon D, Faerman M, Smith P, Oppenheim A. Sequence analysis reveals a β‐thalassaemia mutation in the DNA of skeletal remains from the archaeological site of Akhziv, Israel. Nat Genet 1995; 9(4)365–368
  • Kollia P, Karababa P H, Sinopoulou K, Voskaridou E, Boussiou M, Papadakis M, Loukopoulos D. β‐Thalassaemia mutations and the underlying β gene cluster haplotypes in the Greek population. Gene Geogr 1992; 6(1–2)59–70
  • Gonçalves I, Ducrocq R, Lavinha J, Nogueira P J, Peres M J, Picanço I, Correia Jor E, Reis A B, Silva C, Krishnamoorthy R, Osório‐Almeida L. Combined effect of two different polymorphic sequences within the β globin gene cluster on the level of Hb F. Am J Hematol 1998; 57(4)269–276
  • Gonçalves I, Henriques A, Raimundo A, Picanço I, Reis A, Correia E, Jr, Santos E, Nogueira P, Osório‐Almeida L. Fetal hemoglobin elevation in Hb Lepore heterozygotes and its correlation with β globin cluster linked determinants. Am J Hematol 2002; 69(2)95–102
  • Ragusa A, Lombardo M, Cherif C, Ruberto C, Lombardo T, Elion J, Nagel R L, Krishnamoorthy R. Genetic epidemiology of β‐thalassaemia in Sicily: do sequences 5′ to the Gγ gene and 5′ to the β gene interact to enhance Hb F expression in β‐thalassaemia?. Am J Hematol 1992; 40(3)199–206
  • Vidal‐Naquet P, Bertin J. Atlas Histórico “Da Pré‐Historia aos Nossos Dias.” Paris: Hachette, 1987. Circulo de Leitore, Lda, Lisbao 1990

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