Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 31, 2002 - Issue 1
40
Views
19
CrossRef citations to date
0
Altmetric
Original

THE EXPRESSION AND SIGNIFICANCE OF INTRACELLULAR T HELPER CYTOKINES IN SYSTEMIC LUPUS ERYTHEMATOSUS

, &
Pages 1-12 | Published online: 07 Jul 2009

References

  • Klinman D.M., Steinberg A.D. Inquiry into Murine and Human Lupus. Immunol. Rev. 1995; 144: 157–193
  • Kotzin B.L. Systemic Lupus Erythematosus. Cell 1996; 85: 303–306
  • Stohl W, Elliott J.E. Differential Human T Cell-Dependent B Cell Differentiation Induced by Staphylococcal Superantigens; Regulatory Role for Sag-Dependent B Cell Cytolysis. J. Immunol. 1995; 155: 1838–1850
  • Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two Types of Murine Helper T Cell Clones. 1. Definition According to Profiles of Lymphokine Activities and Secreted Proteins. J. Immunol. 1986; 136: 2348–2357
  • Ishida H., Muchamuel T., Sakaguchi S., Andrade S., Menon S., Howard M. Continuous Administration of Anti-Interleukin 10 Antibodies Delays Onset of Autoimmunity in NZB/W Mice. J. Exp. Med. 1994; 179: 305–310
  • Rapoport M.J., Jaramillo A., Zipris D., Lazarus A.H., Serreze D.V., Leiter E.H. Interleukin 4 Reverses T Cell Proliferative Unresponsiveness and Prevents the Onset of Diabetes in Nonobese Diabetic Mice. J. Exp. Med. 1994; 178: 87–99
  • Racke M.K., Bonomo A., Scott D.E., Cannella B., Levine A., Raine C.S. Cytokine-Induced Immune Deviation as a Therapy for Inflammatory Autoimmune Disease. J. Exp. Med. 1994; 180: 1961–1966
  • Nicholson L.B., Greer J.M., Sobel R.A., Lees M.B., Kuchroo V.K. An Altered Peptide Ligand Mediates Immune Deviation and Prevents Autoimmune Immunity 1995; 3: 397–405
  • Ogawa N., ltoh M., Goto Y. Abnormal Production of B Cell Growth Factor in Patients with Systemic Lupus Erythematosus. Clin. Exp. Immunol. 1992; 89: 26–31
  • Linker-Israeli M., Deans R.J., Wallace D.J., Prehn J., Ozeri-Chen T., Klinberg J.R. Elevated Levels of Endogenous IL-6 in Systemic Lupus Erythematosus: a Putative Role in Pathogenesis. J. Immunol. 1991; 147: 117–23
  • Llorente L., Richaud-Patin Y., Wijdenes J., Alcocer-Varela J., Maillot M., Durand-Gasselin I. Spontaneous Production of Interleukin-IO by B Lymphocytes and Monocytes in Systemic Lupus Erythematosus. Eur. Cytokine Netw. 1993; 4: 421–430
  • AI-Janadi M., AI-Balla S., AI-Dalaan A., Raziuddin S. Cytokine Profile in Systemic Lupus Erythematosus, Rheumatoid Arthritis, and other Rheumatic Disease. J. Clin. Immunol. 1993; 13: 58–67
  • Takahashi S., Fossati L., lwamoto M., Merino R., Motta R., Kobayakawa T. Imbalance towards Th1 Predominance is Associated with Acceleration of Lupus-Like Autoimmune Syndrome in MRL Mice. J. Clin. Invest. 1996; 97: 1597–1604
  • Peng S.L., Moslehi J., Craft J. Roles of Interferon-y and Interleukin-4 in Murine Lupus. J. Clin. Invest. 1997; 99: 1936–1946
  • Tan E.M., Cohen A.S., Fries J.F., Masi A.T, MeShane D.J, Rothfield N.F. The 1982 Revised Criteria for the Classification of Systemic Lupus Erythematosus. Arthritis Rheum. 1982; 25: 1271–1277
  • Jung T., Schauer U., Hausser C., Neumann C., Reiger C. Detection of Intracellular Cytokines by Flow Cytometry. J. Immunol. Methods 1993; 159: 197–207
  • Maino V.C., Picker L.J. Identification of Functional Subsets by Flow Cytometry: Intracellular Detection of Cytokine Expression. Cytometry 1998; 34: 207–215
  • Picker L.J., Singh M.K., Zdraveski Z., Treer J.R., Waldrop S.L., Bergstresser P.R. Direct Demonstration of Cytokine Synthesis Heterogeneity among Human Memory/Effector T Cells by Flow Cytometry. Blood 1995; 86: 1408–1419
  • Openshaw P., Murphy E.E., Hosken N.A., Mario V., Davis K., Murphy K. Heterogeneity of Intracellular Cytokine Synthesis at the Single-Cell Level in Polarized T Helper 1 and T Helper 2 Populations. J. Exp. Med. 1995; 185: 1357–1367
  • Bombardier C., Gladman D.D., Urowitz M.B., Caron D., Chang C.H. Derivation of the SLEDAI. A Disease Activity Index for Lupus Patients. The Committee on Prognosis Studies in SLE. Arthritis & Rheumatism. 1992; 35(6)630–640
  • Linker-Israeli M., Bakke A.C., Kitridou R.C., Gendler S., Gillis S., Horwitz D.A. Defective Production of Interleukin-1 and Interleukin-2 in Patients with Systemic Lupus Erythematosus (SLE). J. Immunol. 1983; 130: 2651–2655
  • Alcocer-Varela J., Alarcon-Segovia D. Longitudinal Study on the Production of and Cellular Response to Interleukin-2 in Patients with Systemic Lupus Erythematosus. Rheumatol. Int. 1995; 15: 57–63
  • Murakawa Y., Sakane T. Deficient Phytohemagglutinin Induced Interleukin-2 Activity in Patients with Inactive Systemic Lupus Erythematosus is Correctable by the Addition of Phorbol Myristate Acetate. Arthritis Rheum. 1988; 31: 826–833
  • Huang Y.P., Perrin L.H., Miescher P.A., Zubler R.H. Correlation of T and B cell Activities in Vitro and Serum IL-2 Levels in Systemic Lupus Erythematosus. J. Immunol. 1988; 141: 827–833
  • Horwitz D.A., Wang H., Gray J.D. Cytokine Gene Profile in Circulating Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus: Increased Interleukin-2 but not Interleukin-4 mRNA. Lupus 1994; 3: 423–428
  • Celis E., Miller R.W., Wiktor T.J., Dietzschold B., Koprowski H. Isolation and Characterization of Human T Cell Lines and Clones Reactive to Rabies Virus: Antigen Specificity and Production of Interferon-Gamma. J. Immunol. 1986; 136(2)692–697
  • Houssiau F.A., Lefebvre C., Vandan Berghe M., Lambert M., Devogelaer J.P., Renauld J.C. Serum Interleukin-10 Titers in Systemic Lupus Erythematosus Reflect Disease Activity. Lupus 1995; 4: 393–395
  • Llorente L., Richaud-Patin Y., Wijdenes J., Alcocer-Varela J., Maillot M.C., Durand-Gasselin I., Fourrier B.M., Galanaud P., Emilie D. Spontaneous Production of Interleukin-10 by B Lymphocytes and Monocytes in Systemic Lupus Erythematosus. Eur. Cytokine Network 1993; 4: 421–427
  • Hagiwara E., Gourley M.F., Lee S., Klinman D.M. Disease Severity in Patients with Systemic Lupus Erythematosus Correlates with an Increased Ration of IL-10: IFN-rsecreting Cells in the Peripheral Blood. Arthritis Rheum. 1996; 39: 379–385
  • Rengaraju M., Gray J.D., Horwitz D.A., Kubin M., Trinchieri G. Increased Spontaneous IL-10 Production and Decreased Mitogen-Induced IFN-r and TNF-a Production in Untreated Patients with SLE: Role of CD8+ T Cells. Lupus 1995; 4(suppl 2)0
  • Viallard J.F., Pellegrin J.L., Ranchin V., Schaeverbeke T., Dehais J., Longy-Boursier M., Ragnaud J.M., Leng B., Moreau J.F. Th1 (IL-2, Interferon-Gamma) and Th2 (IL-10, IL-4) Cytokine Production by Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus. Clin. Exp. Immunol. 1999; 115(1)189–195
  • Akahoshi M., Nakashima H., Tanaka Y., Kohsaka T., Nagano S., Ohgami E., Arinobu Y., Yamaoka K., Niiro H., Shinozaki M., Hirakata H., Horiuchi T., Otsuka T., Niho Y. Th1/Th2 Balance of Peripheral T Helper Cells in Systemic Lupus Erythematosus. Arthritis Rheum. 1999; 42: 1644–1648
  • Segal R., Bermas B.L., Dayan M., Kalush F., Shearer G.M., Mozes E. Kinetics of Cytokine Production in Experimental Systemic Lupus Erythematosus: Involvement of T Helper Cell I/T Helper Cell 2-Type Cytokines in Disease. J. Immunol. 1997; 158: 3009–3016
  • Kastner D.L., Steinberg A.D. Determinants of B Cell Hyperactivity in Murine Lupus. Concepts Immunopathol 1988; 6: 22–88
  • Preble O.T. Systemic Lupus Erythematosus;Labile Leukocyte Interferon. Science 1982; 216: 429–431
  • Bankhurst A.D. Interferons in Systemic Lupus Erythematosus. J. Rheumatol. 1987; 14(suppl 13)63–67
  • Firestein G.S., Zvaifler N.J. Peripheral Blood and Synovial Fluid Monocyte Activation in Inflammatory Arthritis. I.A Cytofluorographic Study of Monocyte Differentiation Antigens and Class II Antigens and their Regulation by Interferon-γ. Arthritis Rheum. 1987; 30: 857–863
  • Firestein G.S., Zvaifler N.J. Peripheral Blood and Synovial Fluid Monocyte Activation in Inflammatory Arthritis. Arthritis Rheum. 1987; 30: 864–871
  • Rosenbach T.O., Zor U., Moshonov S., Baratz M., Yaron M. Induction of Acute Synovitis in the Rat by Human Interferon. Clinical & Experimental Rheumatology 1987; 5(1)35–40
  • Schwarting A., Wada T., Kinoshita K., Tesch G., Kelly V.R. IFN-γ Receptor Signaling is Essential for the Initiation, Acceleration, and Destruction of Autoimmune Kidney Disease in MRL-Fas Mice. J. Immunol. 1998; 161: 494–503
  • Jacob C.O., Meide P.H., McDevitt H.O. In Vivo Treatment of NZBXNZWFI Lupus-like Nephritis with Monoclonal Antibody to Interferon-γ. J. Exp. Med. 1987; 166: 798–803
  • Ozmen L., Roman D., Fountoulakis M., Schmid G., Ryffel B., Garotta G. Experimental Therapy of Systemic Lupus Erythematosus: the Treatment of NZB/W Mice with Mouse Soluble Interferon-γ Receptor Inhibits the Onset of Glomerulonephritis. Eur. J. Immunol. 1995; 25: 6–12
  • Matis L.A., Glimcher L.H., Paul W.E., Schwartz R.H. Magnitude of Response of Histocompatibility Restricted T Cell Clones is a Function of the Product of the Concentrations of Antigen and 1a Molecules. Proc. Natl. Acad. Sci. USA 1983; 80: 6019–6023
  • Paul W.E. Interleukin-4/B Cell Stimulatory Factor 1: One Lymphokine, Many Functions. FASEB J. 1987; 1: 456–461
  • Park Y.B., Lee S.K., Kim D.S., Lee J., Lee C.H., Song C.H. Elevated Interleukin-10 Levels Correlated with Disease Activity in Systemic Lupus Erythematosus. Clin. Exp. Rheumtol. 1998; 16(3)283–288

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.