Effects of Ganopoly^® (A Ganoderma lucidum Polysaccharide Extract) on the Immune Functions in Advanced‐Stage Cancer Patients

References

• Agarwala S. S., Glaspy J., O'Day S. J., Mitchell M., Gutheil J., Whitman E., Gonzalez R., Hersh E., Feun L., Belt R., Meyskens F., Hellstrand K., Wood D., Kirkwood J. M., Gehlsen K. R. Results from a randomized phase III study comparing combined treatment with histamine dihydrochloride plus interleukin‐2 versus interleukin‐2 alone in patients with metastatic melanoma. J. Clin. Oncol. 2002; 20: 125–133
   PubMed Web of Science ®Google Scholar
• Argiles J. M., Lopez‐Soriano F. J. The role of cytokines in cancer cachexia. Med. Res. Rev. 1999; 19: 223–248
   PubMed Web of Science ®Google Scholar
• Battle J., Ha T. Z., Li C. F., Dellabeffa V., Rice P., Kalbfleisch J., Browder W., Williams D. Ligand binding to the (1‐]3)‐beta‐D‐glucan receptor stimulates NF‐kappa B activation, but not apoptosis in U937 cells. Biochem. Biophys. Res. Commun. 1998; 249: 499–504
   PubMed Web of Science ®Google Scholar
• Brittenden J., Heys S. D., Ross J., Eremin O. Natural killer cells and cancer. Cancer 1996; 77: 1226–1243
   PubMed Web of Science ®Google Scholar
• Burnet F. M. Immunological surveillance in neoplasia. Transplant. Rev. 1971; 7: 3–13
   PubMedGoogle Scholar
• Chang R. Effective dose of Ganoderma in humans. Proc 5th Int Mycol Congr, P. K. Buchanan, R. S. Hseu, J. M. Moncalvo. 5th International Mycology Congress Organizing Committee, Vancouver 1994; 117–121
   Google Scholar
• Chang R. The central importance of the beta‐glucan receptor as the basis of immunologic bioactivity of Ganoderma polysaccharides. Reishi, T. Mizuno, B. K. Kim. II Yang Press, Seoul 1996; 177–179
   Google Scholar
• Chen S. In vitro mechanism of PC‐SPES. Urology 2001; 58: 28–35
   Google Scholar
• Cooper M. A., Fehniger T. A., Caligiuri M. A. The biology of human natural killer‐cell subsets. Trend Immunol. 2001; 22: 633–640
   PubMed Web of Science ®Google Scholar
• Czop J. K., Austen K. F. A beta‐glucan inhibitable receptor on human monocytes. J. Immunol. 1985; 134: 2588–2593
   PubMed Web of Science ®Google Scholar
• Diamond M. S., Garcia‐Aguilar J., Bickford J. K., Corbi A. L., Springer T. A. The I domain is a major recognition site on the leukocyte integrin Mac‐1 (CD11b/CD18) for four distinct adhesion ligands. J. Cell Biol. 1993; 120: 1031–1043
   PubMed Web of Science ®Google Scholar
• Gibbs J. B. Mechanism‐based target identification and drug discovery in cancer research. Science 2000; 287: 1969–1973
   PubMed Web of Science ®Google Scholar
• Goto S., Sato M., Kaneko R., Itoh M., Sato S., Takeuchi S. Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunological dysfunction in advanced cancer patients. Cancer Immunol. Immunother. 1999; 48: 435–442
   PubMed Web of Science ®Google Scholar
• Haslett P. A.J. Anticytokine approaches to the treatment of anorexia and cachexia. Semin. Oncol. 1998; 25: 53–57
   PubMed Web of Science ®Google Scholar
• Hwang S. F., Liu K. J., Kuan Y. H., Tung K. S., Su C. H., Tung T. C. The inhibitory effect on artificial pulmonary metastasis of murine S‐180 sarcoma cells by orally administered Ganoderma lucidum culture broth. J. Chin. Oncol. Soc. 1989; 5: 10–15
   Google Scholar
• Jovic V., Konjevic G., Radulovic S., Jelic S., Spuzic I. Impaired perforin‐dependent NK cell cytotoxicity and proliferative activity of peripheral blood T cells is associated with metastatic melanoma. Tumori 2001; 87: 324–329
   PubMed Web of Science ®Google Scholar
• Kempf R. A., Mitchell M. S. Effects of chemotherapeutic agents on the immune response. II. Cancer Investig. 1985; 3: 23–33
   PubMed Web of Science ®Google Scholar
• Kishida E., Okuda R., Sone Y., Misaki A. Fractionation structures and antitumor activities of the polysaccharides of Reishi, the fruiting body of Ganoderma lucidum. Osaka Shiritsu Daigaku Seikatsu Kagakubu Kiyo 1988; 35: 1–10
   Google Scholar
• Konopski Z., Smedsrod B., Seljelid R., Eskeland T. A novel immunomodulator soluble aminated β‐1,3‐D‐glucan: binding characteristics to mouse peritoneal macrophages. Biochim. Biophys. Acta, Mol. Cell Res. 1994; 1221: 61–65
   PubMed Web of Science ®Google Scholar
• Lauerova L., Dusek L., Simickova M., Kocak I., Vagundova M., Zaloudik J., Kovarik J. Malignant melanoma associates with Th1/Th2 imbalance that coincides with disease progression and immunotherapy response. Neoplasma 2002; 49: 159–166
   PubMed Web of Science ®Google Scholar
• Lee J. O., Rieu P., Arnaout M. A., Liddington R. Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell 1995a; 80: 631–638
   PubMed Web of Science ®Google Scholar
• Lee S. S., Wei Y. H., Chen C. F., Wang S. Y., Chen K. Y. Antitumor effects of Ganoderma lucidum. J. Chin. Med. 1995b; 6: 1–12
   Google Scholar
• Liu X., Yuan J. P., Chung C. K., Chen X. J. Antitumor activity of the sporoderm‐broken germinating spores of Ganoderma lucidum. Cancer Lett. 2002; 182: 155–161
   PubMed Web of Science ®Google Scholar
• Mihich E., Fefer A. Biological response modifiers: subcommittee report. NCI Monogr. 1983; 63
   Google Scholar
• Miyazaki T., Nishijima M. Studies on fungal polysaccharides. XXVII. Structural examination of a water‐soluble, antitumor polysaccharide of Ganoderma lucidum. Chem. Pharm. Bull. 1981; 29: 3611–3616
   PubMed Web of Science ®Google Scholar
• Moretta L., Bottino C., Pende D., Mingari M. C., Biassoni R., Moretta A. Human natural killer cells: their origin, receptors and function. Eur. J. Immunol. 2002; 32: 1205–1211
   PubMed Web of Science ®Google Scholar
• Mueller A., Raptis J., Rice P. J., Kalbfleisch J. H., Stout R. D., Ensley H. E., Browder W., Williams D. L. The influence of glucan polymer structure and solution conformation on binding to (1‐ > 3)‐beta‐D‐glucan receptors in a human monocyte‐like cell line. Glycobiology 2000; 10: 339–346
   PubMed Web of Science ®Google Scholar
• Muller A., Rice P. J., Ensley H., Coogan P. S., Kalbfleisch J. H., Kelley J. L., Love E. J., Portera C. A., Ha T. Z., Browder I. W., Williams D. L. Receptor binding and internalization of a water‐soluble (1‐]3)‐beta‐D‐glucan biologic response modifier in two monocyte macrophage cell lines. J. Immunol. 1996; 156: 3418–3425
   PubMed Web of Science ®Google Scholar
• Paulsen B. S. Plant polysaccharides with immunostimulatory activities. Curr. Org. Chem. 2001; 5: 939–950
   Web of Science ®Google Scholar
• Ratain M. J. Pharmacology of cancer chemotherapy. Principles and Practice of Oncology, V. T. DeVita, S. Hellman, S. A. Rosenberg. Lippincott‐Raven Publishers, Philadelphia 1997; 375–509
   Google Scholar
• Ratain M. J., Relling M. V. Gazing into a crystal ball—cancer therapy in the post‐genomic era. Nat. Med. 2001; 7: 283–285
   PubMed Web of Science ®Google Scholar
• Robertson M. J., Ritz J. Biology and clinical relevance of human natural killer cells. Blood 1990; 12: 2421–2438
   Google Scholar
• Santin A. D., Hermonat P. L., Ravaggi A., Bellone S., Roman J., Pecorelli S., Cannon M., Parham G. P. Effects of concurrent cisplatinum administration during radiotherapy vs. radiotherapy alone on the immune function of patients with cancer of the uterine cervix. Int. J. Radiat. Oncol. Biol. Phys. 2000; 48: 997–1006
   PubMed Web of Science ®Google Scholar
• See D., Mason S., Roshan R. Increased tumor necrosis factor alpha (TNF‐alpha) and natural killer cell (NK) function using an integrative approach in late stage cancers. Immunol. Invest. 2002; 31: 137–153
   PubMed Web of Science ®Google Scholar
• Small E. J., Frohlich M. W., Bok R., Shinohara K., Grossfeld G., Rozenblat Z., Kelly W. K., Corry M., Reese D. M. Prospective trial of the herbal supplement PC‐SPES in patients with progressive prostate cancer. J. Clin. Oncol. 2000; 18: 3595–3603
   PubMed Web of Science ®Google Scholar
• Sone Y., Okuda R., Wada N., Kishida E., Misaki A. Structural and anti‐tumor activities of polysaccharides isolated from fruiting body and the growing culture of mycelium of Ganoderma lucidum. Agr. Biol. Chem. 1985; 49: 2641–2653
   Web of Science ®Google Scholar
• Thornton B. P., Vetvicka V., Pitman M., Goldman R. C., Ross G. D. Analysis of the sugar specificity and molecular location of the beta‐glucan‐binding lectin site of complement receptor type 3 (CD11b/CD18). J. Immunol. 1996; 156: 1235–1246
   PubMed Web of Science ®Google Scholar
• Tsavaris N., Kosmas C., Vadiaka M., Kanelopoulos P., Boulamatsis D. Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes. Br. J. Cancer. 2002; 87: 21–27
   PubMed Web of Science ®Google Scholar
• Usui T., Iwasaki Y., Hayashi K., Mizuno T., Tanaki M., Shinkai K., Arakawa M. Antitumor activity of water‐soluble beta‐D‐glucan elaborated by Ganoderma applanatum. Agr. Biol. Chem. 1981; 45: 323–326
   Web of Science ®Google Scholar
• Usui T., Iwasaki Y., Mizuno T., Tanaki M., Shinkai K., Arakawa M. Isolation and characterization of antitumor active beta‐D‐glucans from the fruit bodies of Ganoderma applanatum. Carbohyd. Res. 1983; 115: 273–280
   Web of Science ®Google Scholar
• Vickers A. Recent advances: complementary medicine. Br. Med. J. 2000; 321: 683–686
   PubMed Web of Science ®Google Scholar
• Villegas F. R., Coca S., Villarrubia V. G., Jimenez R., Chillon M. J., Jareno J., Zuil M., Callol L. Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer. Lung Cancer 2002; 35: 23–28
   PubMed Web of Science ®Google Scholar
• Wang S. Y., Hsu M. L., Hsu H. C., Tzeng C. H., Lee S. S., Shiao M. S., Ho C. K. The anti‐tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int. J. Cancer 1997; 70: 699–705
   PubMed Web of Science ®Google Scholar
• Wasser S. P., Weis A. L. Therapeutic effects of substances occurring in higher basidiomycetes mushrooms: a modern perspective. Crit. Rev. Immunol. 1999; 19: 65–96
   PubMed Web of Science ®Google Scholar
• Werner G. H., Jolles P. Immunostimulating agents—what next—a review of their present and potential medical applications. Eur. J. Biochem. 1996; 242: 1–19
   PubMedGoogle Scholar
• Zhang J. S., Tang Q. J., Zimmerman‐Kordmann M., Reutter W., Fan H. Activation of B lymphocytes by GLIS, a bioactive proteoglycan from Ganoderma lucidum. Life Sci. 2002; 71: 623–638
   PubMed Web of Science ®Google Scholar
• Zhou S. F., Gao Y. H. The immunomodulating effects of Ganoderma lucidum (Curt.: Fr) P. Karst (Ling Zhi Reishi mushroom) (Aphyllophoromycetideae). Int. J. Med. Mushroom 2002; 4: 1–11
   Google Scholar
• Zhou S. F., Kestell P., Baguley B. C., Paxton J. W. 5,6‐Dimethylxanthenone‐4‐acetic acid: a novel biological response modifier for cancer therapy. Invest. New Drugs 2002; 20: 281–295
   PubMed Web of Science ®Google Scholar