512
Views
63
CrossRef citations to date
0
Altmetric
Original

Serum Levels of Interleukins (IL)-4, IL-5, IL-13, and Interferon-γ in Acute Asthma

, M.D., Ph.D., , M.D., , M.D., Ph.D. & , M.D., Ph.D.
Pages 665-671 | Published online: 31 Dec 2001

REFERENCES

  • Ollerenshaw S., Woolcock A. J. Characteristics of the Inflammation in Biopsies from Large Airways of Subjects with Asthma and Subjects with Chronic Airflow Limitation. Am. Rev. Respir. Dis. 1992; 145: 922–927
  • Koning H., Baert M. R.M., Oranje A. P., Savelkuol H. F.J., Neijens H. J. Development of Immune Functions Related to Allergic Mechanisms in Young Children. Pediatr. Res. 1996; 40: 363–375
  • Lasky J. A., Brody A. R. Interleukins Involved in the Pathogenesis of Chronic Airway Inflammation. Res. Immunol. 1997; 148: 39–48
  • Pretolani M., Goldman M. Cytokines Involved in the Downregulation of Allergic Airway Inflammation. Res. Immunol. 1997; 148: 33–38
  • Corrigan C. J., Kay A. B. CD4 T Lymphocyte Activation in Acute Severe Asthma: Relationship to Disease Severity and Atopic Status. Am. Rev. Respir. Dis. 1990; 141: 970–977
  • Wilson J. W., Djukanovic R., Howarth P. H., Holgate S. T. Inhaled Beclomethasone Dipropionate Downregulates Airway Lymphocyte Activation in Atopic Asthma. Am. J. Respir. Crit. Care Med. 1994; 149: 86–90
  • Lebmman D. A., Coffman R. L. Interleukin 4 Causes Isotype Switching to IgE in T Cell-Stimulated Clonal B Cell Cultures. J. Exp. Med. 1988; 168: 853–862
  • Pene J. F., Rousset F., Briere I. IgE Production by Normal Human B Cells Induced by Alleroreactive T Cell Clones Is Mediated by IL-4 and Suppressed by IFN-γ. J. Immunol. 1988; 141: 1218–1224
  • Ying S. M., Humbert J., Barkans C. J. Expression of IL-4 and IL-5 mRNA and Protein Produced by CD4+ and CD8+ T Cells, Eosinophils, and Mast Cells in Bronchial Biopsies Obtained from Atopic and Nonatopic Asthmatics. J. Immunol. 1997; 158: 3539–3544
  • Hashimato S. E., Amemiya Y., Tomita T. Elevation of Soluble IL-2 Receptor and IL-4, and Nonelevation of IFN-γ in Sera from Patients with Allergic Asthma. Ann. Allergy 1993; 714: 455–458
  • Robinson D. S., Hamid Q., Ying S. Predominant Th2-Like Bronchoalveolar T-lymphocyte Population in Atopic Asthma. N. Engl. J. Med. 1992; 326: 298–304
  • Tang M. L., Coleman J., Kemp A. S. Interleukin-4 and Interferon-γ Production in Atopic and Non-atopic Children with Asthma. Clin. Exp. Allergy 1995; 25: 515–521
  • Punnonen J., Aversa G., Cocks B. G., de Vries J. E. Role of Interleukin-4 and Interleukin-13 in Synthesis of IgE and Expression of CD23 by Human B Cells. Allergy 1994; 49: 576–586
  • Zhu Z., Homer R. J., Wang Z. Pulmonary Expression of IL-13 Causes Inflammation, Mucus Hypersecretion, Subepithelial Fibrosis, Physiologic Abnormalities and Eotaxin Production. J. Clin. Invest. 1999; 103: 1779–788
  • Koning H., Neijens H. J., Baert M. R.M., Oranje A. P., Savelkoul H. F. T Cell Subsets and Cytokines in Allergic and Nonallergic Children. Cytokine 1997; 9: 427–436
  • American Thoracic Society. Standard for the Diagnosis and Care of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Asthma. Am. Rev. Respir. Dis. 1987; 136: 225–244
  • Corbridge T. C., Hall J. B. The Assessment and Management of Adults with Status Asthmaticus. Am. J. Respir. Crit. Care Med. 1995; 151: 1296–1316
  • Hamid Q. Expression of mRNA for IL-5 in Mucosal Bronchial Biopsies from Asthma. J. Clin. Invest. 1991; 87: 1541–1546
  • Ying S., Durham S. R., Corrigan C. J., Hamid Q., Kay A. B. Phenotype of Cells Expressing mRNA for Th2-type and Th1-type Cytokines in Bronchoalveolar Lavage and Bronchial Biopsies from Atopic and Normal Subjects. Am. J. Respir. Cell Mol. Biol. 1995; 12: 477–487
  • Gascan H. Regulation of Human IgE Synthesis. Clin. Exp. Allergy 1994; 21: 162–166
  • Romagnani S. Biology of Human Th1 and Th2 Cells. J. Clin. Immunol. 1995; 15: 121–129
  • Robinson D. S., Ying S., Bentley A. M. Relationships Among Numbers of Bronchoalveolar Lavage Cells Expressing mRNA for Cytokines, Asthma Symptoms, and Airway Methacholine Responsiveness in Atopic Asthma. J. Allergy Clin. Immunol. 1993; 92: 397–403
  • Robinson D. S., Hamid Q., Bentley A. M. Activation of CD4+ T Cells and Increased IL-4, IL-5, and GM-CSF mRNA Positive Cells in BAL 24 Hours After Allergen Inhalation Challenge of Atopic Asthmatic Patients. J. Allergy Clin. Immunol. 1993; 92: 313–324
  • Walker C., Bode E., Boer L. Allergic and Nonallergic Asthmatics Have Distinct Patterns of T Cell Activation and Cytokine Production in Peripheral Blood and BAL. Am. Rev. Respir. Dis. 1992; 146: 109–115
  • Crimi E., Gaffi D., Frittoli E., Borgonovo B., Burastero S. E. Depletion of Circulating Allergen-Specific Th2 T Lymphocytes After Allergen Exposure in Asthma. J. Allergy Clin. Immunol. 1997; 99: 788–797
  • Hakonarson H., Maskeri N., Carter C., Grunstein M. M. Regulation of Th1- and Th2-Type Cytokine Expression and Action in Atopic Asthmatic Sensitized Airway Smooth Muscle. J. Clin. Invest. 1999; 103: 1077–1087
  • Lack G. Nebulized but Not Parenteral IFN-γ Decreases IgE Production and Normalizes Airway Function in a Murine Model of Allergen Sensitization. J. Immunol. 1994; 152: 2546–2554
  • Snapper C. M., Paul W. E. Interferon-γ and B Cells Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production. Science 1987; 236: 944–947
  • Coffman R. L., Carty J. A. T Cell Activity That Enhances Polyclonal IgE Production and Its Inhibition by Interferon-γ. J. Immunol. 1986; 136: 949–954
  • Pene J. IgE Production by Normal Human Lymphocytes Is Induced by Interleukin 4 and Suppressed by Interferons, and Prostaglandin E2. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 6880–6884
  • Hessel E. M. Development of Airway Hyperresponsiveness Is Dependent on Interferon-γ and Independent Eosinophil Infiltration. Am. J. Respir. Cell Mol. Biol. 1987; 16: 325–334
  • Bradley L. M., Yoshimoto K., Swain S. The Cytokines IL-4, IFN-γ, and IL-12 Regulate the Development of Subsets of Memory Effector/Helper T Cells In Vitro. J. Immunol. 1995; 155: 1713–1724
  • Romagnani S. Human Th1 and Th2 Subsets. Eur. Cytokine Netw. 1994; 5: 7–12
  • Zangrill J. G. VCAM-1 Levels After Segmental Antigen Challenge Correlate with Eosinophil Influx, IL-4 and IL-5 Production, and the Late Phase Response. Am. J. Respir. Crit. Care Med. 1998; 151: 1346–1353

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.