Peripheral Blood Th1 and Th2 Profile in Patients with Moderate Asthma: Effect of Inhaled Corticosteroid

REFERENCES

• Robinson D.S., Hamid Q., Ying S., Tsicopoulos A., Barkans J., Bentley A.M., Corrigan C., Durham S.R., Kay A.B. Predominant Th2-like Broncho-alveolar T-Lymphocyte Population in Atopic Asthma. N. Engl. J. Med. 1992; 326: 298
   PubMed Web of Science ®Google Scholar
• Kay A.B., Ying S., Durham S.R. Phenotype of Cells Positive for Interleukin-4 and Interleukin-5 mRNA in Allergic Tissue Reactions. Int. Arch. Allergy Immunol. 1995; 107: 208
   PubMed Web of Science ®Google Scholar
• Ying S., Durham S.R., Corrigan C.J., Hamid Q., Kay A.B. Phenotype of Cells Expressing mRNA for Th2-Type (Interleukin 4 and Interleukin 5) and Th1-Type (Interleukin 2 and Interferon Gamma) Cytokines in Bronchoalveolar Lavage and Bronchial Biopsies from Atopic Asthmatic and Normal Control Subjects. Am. J. Respir. Cell Mol. Biol. 1995; 12: 1477
   Web of Science ®Google Scholar
• Corrigan C.J., Hamid Q., North J., Barkans J., Moqbel R., Durham S., Gemou-Engesaeth V., Kay A.B. Peripheral Blood CD4 But Not CD8 T-Lymphocytes in Patients with Exacerbation of Asthma Transcribe and Translate Messenger RNA Encoding Cytokines Which Prolong Eosinophil Survival in the Context of a Th2-Type Pattern: Effect of Glucocorticoid Therapy. Am. J. Respir. Cell Mol. Biol. 1995; 12: 567
   PubMed Web of Science ®Google Scholar
• Gemou-Engesaeth V., Bush A., Kay A.B., Hamid Q., Corrigan C.J. Inhaled Glucocorticoid Therapy of Childhood is Associated with Reduced Peripheral Blood T Cell Activation and “Th2-Type” Cytokine mRNA Expression. Pediatrics 1997; 99: 695
   PubMed Web of Science ®Google Scholar
• Ying S., Humbert M., Barkans J., Corrigan C.J., Pfister R., Menz G., Larche M., Robinson D.S., Durham S.R., Kay A.B. Expression of IL-4 and IL-5 mRNA and Protein Product by CD4+ and CD8+ T Cells, Eosinophils, and Mast Cells in Bronchial Biopsies Obtained from Atopic and Nonatopic (Intrinsic) Asthmatics. J. Immunol. 1997; 158: 3539
   PubMed Web of Science ®Google Scholar
• Picker L.J., Singh M.K., Zdravwski Z., Treer J.R., Waldrop S.L., Bergstresser P.R., Maino V.C. Direct Demonstration of Cytokine Synthesis Heterogeneity Among Human Memory/Effector T Cells by Flow Cytometry. Blood 1995; 86: 1408
   PubMed Web of Science ®Google Scholar
• Suni M.A., Picker L.J., Maino V.C. Detection of Antigen-Specific T Cell Cytokine Expression in Whole Blood by Flow Cytometry. J. Immunol. Methods. 1998; 212: 89
   PubMed Web of Science ®Google Scholar
• American Thoracic Society. Standards for the Diagnosis and Care of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Asthma. Am. Rev. Respir. Dis. 1987; 136: 225
   PubMed Web of Science ®Google Scholar
• Corrigan C.J., Kay A.B. CD4 T-Lymphocyte Activation in Acute Severe Asthma. Am. Rev. Respir. Dis. 1990; 141: 970
   PubMed Web of Science ®Google Scholar
• Cebrzynska-Nowak M., Szklarz E., Inglot A.D., Teodorczyk-Injeyan J.A. Elevated Release of Tumor Necrosis Factor-Alpha and Interferon-Gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma. Am. Rev. Respir. Dis. 1993; 147: 291
   PubMedGoogle Scholar
• Krug N., Madden J., Redington A.E., Lackie P., Djukanovic R., Schauer U., Holgate S.T., Frew A.J., Howarth P.H. T-cell Cytokine Profile Evaluated at the Single Cell Level in BAL and Blood in Allergic Asthma. Am. J. Respir. Cell Mol. Biol. 1996; 14: 319
   PubMed Web of Science ®Google Scholar
• Magnan A.O., Mély L.G., Camilla C.A., Badier M.M., Montero-Julian F.A., Guillot C.M., Casano B.B., Prato S.J., Fert V., Bongrand P., Vervloet D. Assessment of the Th1/Th2 Paradigm in Whole Blood in Atopy and Asthma. Increased IFN-g-Producing CD8(+) T. Cells in Astham. Am. J. Respir. Crit. Care Med. 2000; 161: 1790
   PubMed Web of Science ®Google Scholar
• Péne J., Rousset F., Briére F., Chrétien I., Bonnefoy J.Y., Spits H., Yokota T., Arai N., Arai K., Banchereau J., Vries A.D., Romagnani S. IgE Production by Normal Human Lymphocytes Is Induced by Interleukin 4 and Suppressed by Interferon γ and α and Prostaglandin E2. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 6880
   PubMed Web of Science ®Google Scholar
• Del Préte G., Maggi E., Parronchi P., Chrétien I., Tiri A., Macchia D., Ricci M., Banchereau J., De Vries J., Romagnani S. IL-4 Is an Essential Factor for the IgE Synthesis Induced in vitro by Human T Cell Clones and Their Supernatants. J. Immunol. 1988; 140: 4193
   PubMed Web of Science ®Google Scholar
• Lai C.K.W., Ho A.S.S., Chan C.H.S., Tang J., Leung J.C.K., Lai K.N. Interleukin-5 Messenger RNA Expression in Peripheral Blood CD4+ Cells in Asthma. J. Allergy Clin. Immunol. 1996; 97: 1320
   PubMed Web of Science ®Google Scholar
• Krug N., Jung T., Napp U., Wagner K., Schultze-Werninghaus G., Heusser C., Rieger C.H., Schauer U., Fabel H. Frequencies of T Cells Expressing Interleukin-4 and Interleukin-5 in Atopic Asthmatic Children. Comparison with Atopic Asthmatic Adults. Am. J. Respir. Crit. Care Med. 1998; 158: 754
   PubMed Web of Science ®Google Scholar
• National Heart, Lung, and Blood Institute and World Health Organization. Global Initiative for Asthma. NIH Publication No. 95-3659. National Institutes of Health, Bethesda, MD. 1995
   Google Scholar
• National Asthma Education and Prevention Program. Expert Panel Report 2:, Guidelines for the Diagnosis and Management of Asthma. NIH Publication No. 97-4051. National Heart,Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 1997
   Google Scholar
• Selroos O., Pietinalho A., Löfroos A.B., Riska H. Effect of Early vs Late Intervention with Inhaled Corticosteroids in Asthma. Chest 1995; 108: 1228
   PubMed Web of Science ®Google Scholar
• Laitinen L.A., Laitinen A. Remodeling of Asthmatic Airways by Glucocorticosteroids. Allergy Clin. Immunol. 1996; 97: 153
   Google Scholar