Evaluation of Major Caffeic Acid Derivatives in Echinacea purpurea Dietary Supplements by HPLC with Photodiode Array Detection and Electrospray Mass Spectrometry

References

• Parnham , M. J. 1996 . Benefit‐risk assessment of the squeezed sap of the purple cornflower (Echinacea purpurea) for long‐term oral immunostimulation . Phytomedicine , 3 : 95 – 102 .
   PubMed Web of Science ®Google Scholar
• Bauer , R. and Wagner , H. 1991 . “ Echinacea species, as potential immunostimulatory drugs ” . In Economic and Medicinal Plant Research Edited by: Wagner , H. and Farnsworth , N. R. Vol. 5 , 253 – 321 . San Diego , CA : Academic Press .
   Google Scholar
• Brinkeborn , R. M. , Shah , D. V. and Degenring , F. H. 1999 . Echnaforce® and other Echinacea fresh plant preparations in the treatment of the common cold: a randomized, placebo controlled, doubled‐blind clinical trial . Phytomedicine , 6 : 1 – 6 .
   PubMed Web of Science ®Google Scholar
• Sloley , B. D. , Urichuk , L. J. , Tywin , C. , Coutts , R. T. , Pang , P. K. and Shan , J. J. 2001 . Comparison of chemical components and antioxidant capacity of different Echinacea species . J. Pharm. Pharmacol. , 53 : 849 – 857 .
   PubMed Web of Science ®Google Scholar
• Nusslein , B. , Kurzmann , M. , Bauer , R. and Kreis , W. 2000 . Enzymatic degradation of cichoric acid in Echinacea purpurea preparations . J. Nat. Prod. , 63 : 1615 – 1618 .
   PubMed Web of Science ®Google Scholar
• Mar , C. and Bent , S. 1999 . An evidence‐based review of the 10 most commonly used herbs . West J. Med. , 171 : 168 – 171 .
   PubMedGoogle Scholar
• Cheminat , A. , Zawatzky , R. , Becker , H. and Brouillard , R. 1988 . Caffeoyl conjugates from Echinacea species: structures and biological activity . Phytochemistry , 27 : 2787 – 2794 .
   Web of Science ®Google Scholar
• Bauer , R. , Remiger , P. and Wagner , H. 1988 . Alkamides from the roots of Echinacea purpurea . Phytochemistry , 27 : 2339 – 2342 .
   Web of Science ®Google Scholar
• Bauer , R. , Remiger , P. , Jurcic , K. and Wagner , H. 1989 . Beeinflussung der phagozytose‐aktivitat durch Echinacea‐Extrakte . Z. Phytother. , 10 : 43 – 48 .
   Google Scholar
• Facino , R. M. , Carini , M. , Aldini , G. , Saibene , L. , Pietta , P. and Mauri , P. 1995 . Echinacoside and caffeoyl conjugates protect collagen from free radical‐induced degradation: a potential use of Echinacea extracts in the prevention of skin photodamage . Planta Med. , 61 : 510 – 514 .
   PubMed Web of Science ®Google Scholar
• McDougall , B. , King , P. J. , Wu , B. W. , Hostomsky , Z. , Reinecke , M. G. and Robinson , W. E. Jr. 1998 . Dicaffeoylquinic acid and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase . Antimicrob. Agents Chemother. , 42 : 140 – 146 .
   PubMed Web of Science ®Google Scholar
• Robinson , W. E. Jr. 1998 . L‐Cichoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV‐1) integrase, improves on the in vitro‐HIV‐1 effect of Zidovudine plus a protease (AG1350) . Antiviral Res. , 39 : 101 – 111 .
   PubMed Web of Science ®Google Scholar
• King , P. J. and Robinson , W. E. Jr. 1998 . Resistance to the anti‐human immunodeficiency virus type 1 compound L‐cichoric acid results from a single mutation at amino acid 140 of integrase . J. Virol. , 72 : 8420 – 8424 .
   PubMed Web of Science ®Google Scholar
• King , P. J. , Ma , G. X. , Miao , W. F. , Ji , Q. , McDougall , B. R. , Reinecke , M. G. , Cornell , C. , Kuan , J. , Kim , T. R. and Robinson , W. E. Jr. 1999 . Structure‐activity relationships: analogues of the decaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication . J. Med. Chem. , 42 : 497 – 509 .
   PubMed Web of Science ®Google Scholar
• Lin , Z. W. , Neamati , N. , Zhao , H. , Kiryu , Y. , Turpin , J. A. , Aberham , C. , Strebel , K. , Kohn , K. , Witvrouw , M. , Pannecouque , C. , Debyser , Z. , De Clerq , E. , Rice , W. G. , Pommier , Y. and Burke , T. R. Jr. 1999 . Cichoric acid analogues as HIV‐1 integrase inhibitors . J. Med. Chem. , 42 : 1401 – 1414 .
   PubMed Web of Science ®Google Scholar
• Bauer , R. , Remiger , P. and Wagner , H. 1988 . Echinacea: vergleichende DC‐ und HPLC‐ analyse der Herba‐Drogen von Echinacea purpurea, E. pallida und E. angustifolia . Dtsch. Apoth. Ztg. , 128 : 174 – 180 .
   Google Scholar
• Bauer , R. 1999 . Standardization of Echinacea purpurea expressed juice with reference to cichoric acid and alkamides . J. Herbs, Spices Med. Plants , 6 : 51 – 62 .
   Google Scholar
• Wills , R. B.H. and Stuart , D. L. 1998 . Levels of active constituents in manufactured echinacea products . Chem. Aust. , 65 : 17 – 19 .
   Google Scholar
• Wills , R. B.H. and Stuart , D. L. 1999 . Alkylamide and cichoric acid levels in Echinacea purpurea grown in Australia . Food Chem. , 67 : 385 – 388 .
   Web of Science ®Google Scholar
• Perry , N. B. , Burgess , E. J. and Glennie , V. I. 2001 . Echinacea standardization: analytical methods for phenolic compounds and typical levels in medicinal species . J. Agric. Food Chem. , 49 : 1702 – 1706 .
   PubMed Web of Science ®Google Scholar
• Glowniak , K. , Zgorka , G. and Kozyra , M. 1996 . Solid‐phase extraction and reverse‐phase high‐performance liquid chromatography of free phenolic acids in some Echinacea species . J. Chromatogr. A. , 730 : 25 – 29 .
   Web of Science ®Google Scholar
• Bergeron , C. , Livesey , J. F. , Awang , D. V.C. , Arnason , J. T. , Rana , J. , Baum , B. R. and Letchamo , W. 2000 . A quantitative HPLC method for the quality assurance of Echinacea products on the North American market . Phytochem. Anal. , 11 : 207 – 215 .
   Web of Science ®Google Scholar
• Kim , H. O. , Durance , T. D. , Scaman , C. H. and Kitts , D. D. 2000 . Retention of caffeic acid derivatives in dried Echinacea purpurea . J. Agric. Food Chem. , 48 : 4182 – 4186 .
   PubMed Web of Science ®Google Scholar
• Baum , B. R. , Mechanda , S. , Livesey , J. F. , Binns , S. E. and Arnason , J. T. 2001 . Predicting quantitative phytochemical markers in single Echinacea plants or clones from their DNA fingerprints . Phytochemistry , 56 : 543 – 549 .
   PubMed Web of Science ®Google Scholar
• Mølgaard , P. , Johnsen , S. , Christensen , P. and Cornett , C. 2003 . HPLC method validated for the simultaneous analysis of cichoric acid and alkamides in Echinacea purpurea plants and products . J. Agric. Food Chem. , 51 : 6922 – 6933 .
   PubMed Web of Science ®Google Scholar
• Luo , X. B. , Chen , B. , Yao , S. Z. and Zeng , J. G. 2003 . Simultaneous analysis of caffeic acid derivatives and alkamides in roots and extracts of Echinacea purpurea by high‐performance liquid chromatography‐photodiode array detection‐electrospray mass spectrometry . J. Chromatogr. A , 986 : 73 – 81 .
   PubMed Web of Science ®Google Scholar
• Li , W. K. and Fitzloff , J. F. 2002 . HPLC determination of ginsenosides content in ginseng dietary supplements using ultraviolet detection . J. Liq. Chrom. Rel. Technol. , 25 : 2485 – 2500 .
   Web of Science ®Google Scholar
• Li , W. K. and Fitzloff , J. F. 2002 . HPLC determination of flavonoids and terpene lactones in commercial Ginkgo biloba products . J. Liq. Chrom. Rel. Technol. , 25 : 2501 – 2514 .
   Web of Science ®Google Scholar
• Livesey , J. , Awang , D. V.C. , Arnason , J. T. , Letchamo , W. , Barrett , M. and Pennyroyal , G. 1999 . Effect of temperature on stability of marker constituents in Echinacea purpurea root formulations . Phytomedicine , 6 : 347 – 349 .
   PubMed Web of Science ®Google Scholar
• Muller‐Jakic , B. , Breu , W. , Probstle , A. , Redl , K. , Greger , H. and Bauer , R. 1994 . In vitro inhibition of cyclo‐oxygenase and 5‐lipo‐oxygenase by alkamides from Echinacea and Achillea species . Planta Med. , 60 : 37 – 40 .
   PubMed Web of Science ®Google Scholar
• Clifford , L. J. , Nair , M. G. , Rana , J. and Dewitt , D. L. 2002 . Bioactivity of alkamides isolated from Echinacea purpurea (L.) . Moench. Phytomedicine , 9 : 249 – 253 .
   PubMed Web of Science ®Google Scholar