Primary Screening of Natural Products Using Micro Fractionation Combined with a Bioassay

References

• Geiger , G. , Bernhagen , J. , Wagner , E. , Bisswanger , H. , Brunner , H. and Vitzthum , F. 2001 . Standardized measurements and differential spectroscopy in microplates . Anal. Biochem. , 296 : 29 – 40 .
   PubMed Web of Science ®Google Scholar
• Smith , A. D. , Morris , V. C. and Levander , O. A. 2001 . Rapid determination of glutathione peroxidase and thioredoxin reductase activities using a 96‐well microplate format: comparison to standard cuvette‐based assay . Int. J. Vitam. Nutr. Res. , 71 ( 1 ) : 87 – 92 .
   PubMed Web of Science ®Google Scholar
• Lussignoli , S. , Fraccaroli , M. , Andrioli , G. , Brocco , G. and Bellavite , P. 1999 . A microplate‐based colorimetric assay of the total peroxyl radical trapping capability of human plasma . Anal. Biochem. , 269 : 38 – 44 .
   PubMed Web of Science ®Google Scholar
• Skyttä , E. and Mattila‐Sandholm , T. 1991 . A quantitative method for assessing bacteriocins and other food antimicrobials by automated turbidometry . J. Microbiol. Methods , 14 : 77 – 88 .
   Web of Science ®Google Scholar
• Bronson , D. , Hentz , N. , Janzen , W. P. , Lister , M. D. , Menke , K. , Wegrzyn , J. and Sittampalam , G. S. 2001 . “ Basic considerations in designing high‐throughput screening assay ” . In Handbook of Drug Screening. Drugs and Pharmaceutical Sciences Edited by: Seethala , R. and Fernandes , P. B. Vol. 114 , 5 – 30 . New York , NY : Marcel Dekker, Inc. .
   Google Scholar
• Newman , D. J. , Cragg , G. M. and Snader , K. M. 2003 . Natural products as sources of new drugs over the period 1981–2002 . J. Nat. Prod. , 66 ( 7 ) : 1022 – 1037 .
   PubMed Web of Science ®Google Scholar
• Bramwell , D. 2002 . How many plant . Plant Talk , 28 : 32 – 33 .
   Google Scholar
• Verpoorte , R. , van der Heijden , R. and Memelink , J. 2000 . Engineering the plant cell factory for metabolite production . Transgenic Res. , 9 : 323 – 343 .
   PubMed Web of Science ®Google Scholar
• Harborne , J. B. and Williams , C. A. 2000 . Advances in flavonoid research since 1992 . Phytochemistry , 55 : 481 – 504 .
   PubMed Web of Science ®Google Scholar
• Hostettmann , K. , Wolfender , J.‐L. and Terreaux , C. 2001 . Modern screening techniques for plant extracts . Pharm. Biol. , 39 : 18 – 32 .
   PubMed Web of Science ®Google Scholar
• Su , B.‐N. , Park , E. J. , Vigo , J. S. , Graham , J. G. , Cabieses , F. , Fong , H. H.S. , Pezzuto , J. M. and Kinghorn , D. A. 2003 . Activity‐guided isolation of the chemical constituents of Muntingia calabura using a quinone reductase induction assay . Phytochemistry , 63 : 335 – 341 .
   PubMed Web of Science ®Google Scholar
• Peadar , C. A. and Lu , Z. 2002 . High‐throughput analysis of natural product compound libraries by parallel LC‐MS evaporation light scattering detection . Anal. Chem. , 74 ( 21 ) : 5492 – 5500 .
   PubMed Web of Science ®Google Scholar
• Bozbin , S. C. , Yang , S. and Kasten , T. P. 2000 . Application of liquid chromatography‐nuclear magnetic resonance spectroscopy to the identification of natural products . J. Chrom. B , 748 : 259 – 267 .
   PubMed Web of Science ®Google Scholar
• Eldridge , G. R. , Vervoort , H. C. , Lee , C. M. , Cremin , P. A. , Williams , C. T. , Hart , S. M. , Goering , M. G. , O'Neil‐Johnson , M. and Zeng , L. 2002 . High‐throughput method for the production and analysis of large natural product libraries for drug discovery . Anal. Chem. , 74 ( 16 ) : 3963 – 3971 .
   PubMed Web of Science ®Google Scholar
• Schenk , T. , Breel , G. J. , Koevoets , P. , van der Berg , S. , Hogenboom , A. C. , Irth , H. , Tjaden , U. R. and van der Greef , J. 2003 . Screening of natural products extracts for the presence of phosphodiesterase inhibitors using liquid chromatography coupled online to parallel biochemical detection and chemical characterization . J. Biomol. Screen. , 8 ( 4 ) : 421 – 429 .
   PubMed Web of Science ®Google Scholar
• Schobel , U. , Frenay , M. , van Elswijk , D. A. , McAndrews , J. M. , Long , K. R. , Olson , L. M. , Bobzin , S. C. and Irth , H. 2001 . High resolution screening of plant natural product extracts for estrogen receptor α and β binding activity using an online HPLC‐MS biochemical detection system . J. Biomol. Screen. , 5 ( 6 ) : 291 – 303 .
   Google Scholar
• Koleva , I. I. , Niederländer , H. A.G. and van Beek , T. A. 2000 . An on‐line HPLC method for detection of radical scavenging compounds in complex mixtures . Anal. Chem. , 72 ( 10 ) : 2323 – 2328 .
   PubMed Web of Science ®Google Scholar
• Luo , H. , Chen , L. , Li , Z. , Ding , Z. and Xu , X. 2003 . Frontal immunoaffinity chromatography with mass spectrometric detection: a method for finding active compounds from traditional Chinese herbs . Anal. Chem. , 75 ( 16 ) : 3994 – 3998 .
   PubMed Web of Science ®Google Scholar
• Johnston , P. A. 2002 . Cellular platforms for HTS: three case studies . Drug Discov. Today , 7 ( 6 ) : 353 – 363 .
   PubMed Web of Science ®Google Scholar
• Moore , K. and Rees , S. 2001 . Cell‐based versus isolated target screening: how lucky do you feel? . J. Biomol. Screen. , 6 ( 2 ) : 69 – 74 .
   PubMed Web of Science ®Google Scholar
• Brand‐Williams , W. , Cuvelier , M. E. and Berset , C. 1995 . Use of free radical method to evaluate antioxidant activity . Lebensm.‐Wiss. Technol. , 28 : 25 – 30 .
   Web of Science ®Google Scholar
• Wennberg , T. , Rauha , J.‐P. and Vuorela , H. 2001 . Computer assisted scale up from analytical HPLC to preparative MPLC for the separation of phenolic compounds . Chromatographia , 53 ( suppl ) : S‐240 – S‐245 .
   Google Scholar
• Huovinen , K. , Hiltunen , R. and von Schantz , M. 1985 . A high performance liquid chromatographic method for the analysis of lichen compounds from the genera cladina and cladonia . Acta Pharm. Fenn. , 94 : 99 – 112 .
   Google Scholar
• Elix , J. A. 1974 . Synthesis of para‐olivetol depsides . Aust. J. Chem. , 27 : 1767 – 1779 .
   Web of Science ®Google Scholar
• Eloff , J. N. 1998 . A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria . Planta Med. , 64 : 711 – 713 .
   PubMed Web of Science ®Google Scholar
• Sittampalam , G. S. , Iversen , P. W. , Boadt , J. A. , Kahl , S. D. , Bright , S. , Zock , J. M. , Janzen , W. P. and Lister , M. 1997 . Design of signal windows in high throughput screening assays for drug discovery . J. Biomol. Screen. , 2 ( 3 ) : 159 – 169 .
   Web of Science ®Google Scholar
• Vogelman , B. , William , A. and Craig , M. D. 1986 . Kinetics of antimicrobial activity . J. Pediatr. , 108 ( 5/2 ) : 835 – 840 .
   PubMed Web of Science ®Google Scholar
• Kubo , I. , Xiao , P. and Fujita , K. 2002 . Anti‐MRSA activity of alkyl gallates . Bioorg. Med. Chem. Lett. , 12 : 113 – 116 .
   PubMed Web of Science ®Google Scholar
• Giridharan , P. , Somasundaram , S. T. , Perumal , K. , Vishwakarma , R. A. , Karthikeyan , N. P. , Velmurugan , R. and Balakrishnan , A. 2002 . Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c‐myc and caspases leading to apoptosis . Br. J. Cancer , 87 : 98 – 105 .
   PubMed Web of Science ®Google Scholar
• Lin , J. , Opoku , A. R. , Geheeb‐Keller , M. , Hutchings , A. D. , Terblanche , S. E. , Jäger , A. K. and van Staden , J. 1999 . Preliminary screening of some traditional zulu medicinal plants for anti‐inflammatory and anti‐microbial activities . J. Ethnopharmacol. , 68 : 267 – 274 .
   PubMed Web of Science ®Google Scholar
• Pietta , P. , Simonetti , P. and Mauri , P. 1998 . Antioxidant activity of selected medicinal plants . J. Agric. Food Chem. , 46 : 4487 – 4490 .
   Web of Science ®Google Scholar