A Facile Two‐Column Chromatographic Process for Efficient Purification of Paclitaxel from Crude Extract

References

• Wani , M. C. , Taylor , H. L. , Wall , M. E. , Coggon , P. and McPhail , A. T. 1971 . Plant anti‐tumor agents. VI. The isolation and structure of taxol, a novel anti‐leukemic and anti‐tumor agent from Taxus brevifolia . J. Am. Chem. Soc. , 93 : 2325 – 2327 .
   PubMed Web of Science ®Google Scholar
• Stull , D. P. , Scales , T. A. , Daughenbaugh , R. , Jans , N. A. and Bailey , D. T. 1995 . Taxol (Paclitaxel), strategies to increase the supply of a new anticancer drug . Appl. Biochem. Biotechnol. , 54 : 133 – 140 .
   Web of Science ®Google Scholar
• Nicolaou , K. C. , Yang , Z. , Liu , J.‐J. , Ueno , H. , Nantermet , P. G. , Guy , R. K. , Claiborne , C. F. , Renaud , J. , Couladouros , E. A. , Paulvannan , K. and Sorensen , E. J. 1994 . Total Synthesis of Taxol . Nature , 367 : 630 – 634 .
   PubMed Web of Science ®Google Scholar
• Tadakatsu , M. , Akiyoshi , K. , Hiroshi , O. , Katsuyoshi , N. , Katsuhiko , M. , Ko‐ji , H. and Ko‐zo , H. 2000 . A semisynthesis of paclitaxel via a 10‐deacetylbaccatin III derivative bearing a β‐keto ester appendage . Tetrahedron Lett. , 41 : 243 – 246 .
   Web of Science ®Google Scholar
• Cardellina II , J. H. 1991 . HPLC separation of taxol and cephalomannine . J. Liq. Chromatogr. , 14 ( 4 ) : 659 – 665 .
   Google Scholar
• Castor , T. P. and Tyler , T. A. 1993 . Determination of taxol in Taxus media needles in the presence of interfering components . J. Liq. Chromatogr. , 16 ( 3 ) : 723 – 731 .
   Web of Science ®Google Scholar
• Koppakva , V. R. , Rajendra , S. B. , John , J. and Richard , M. D. 1996 . A large scale process for paclitaxel and other taxanes from the needles of Taxus × media Hicksii and Taxus floridana using reverse phase column chromatography . J. Liq. Chrom. Rel. Technol. , 19 ( 3 ) : 427 – 447 .
   Web of Science ®Google Scholar
• Wu , D.‐J. , Ma , Z. , Au , B. W. and Wang , N.‐HL. 1997 . Recovery and purification of paclitaxel using low‐pressure liquid chromatography . AIChE J. , 43 ( 1 ) : 232 – 242 .
   Web of Science ®Google Scholar
• Keith , M. W. , Sally , A. L. , Michael , W. S. , Thomas , G. M. , Haleem , J. I. and Gary , M. M. 1989 . High performance liquid chromatographic separation of taxol and related compounds from Taxus brevifolia . J. Liq. Chromatogr. , 12 ( 11 ) : 2117 – 2132 .
   Google Scholar
• Lillian , K. S. and David , C. L. 1997 . Determination of paclitaxel and related taxanes in bark drug and injectable dosage forms by reversed phase liquid chromatography . Anal. Chem. , 69 : 2008 – 2016 .
   PubMed Web of Science ®Google Scholar
• Dauh‐Rurng , Wu. , Klaus , L. and Hellen , C. G. 1995 . Preparative separation of taxol in normal‐ and reversed‐phase operations . J. Chromatogr. , 702 : 233 – 241 .
   Web of Science ®Google Scholar
• Guang Hui , Ma , Masatoshi , N. and Shinzo , O. 1997 . Synthesis of uniform microspheres with higher content of 2‐hydroxyethyl methacrylate by employing SPG (Shirasu porous glass) emulsification technique followed by swelling process of droplets . Appl. Polym. Sci. , 66 ( 7 ) : 1325 – 1341 .
   Web of Science ®Google Scholar
• David , G. I.K. , Gunatilaka , A. A.L. and Ivey , C. A. 1992 . Modified Taxols 7: A method for the separation of taxol and cephalomannine . J. Nat. Prod. , 55 : 259 – 261 .
   PubMed Web of Science ®Google Scholar
• John , M. R. , Anthony , A. M. , Mahendra , D. C. , Milind , M. G. and David , G. I.K. 1996 . An improved method for the separation of paclitaxel and cephalomannine . J. Nat. Prod. , 59 : 167 – 168 .
   Web of Science ®Google Scholar
• Steven , L. R. , David , M. T. and Daniel , W. T. 1992 . High‐performance liquid chromatographic assay of taxol . Anal. Chem. , 64 : 2323 – 2326 .
   PubMed Web of Science ®Google Scholar
• Blay , P. K.S. , Thibault , P. , Tiberge , N. , Kiecken , B. , Lebrum , A. and Mercure , C. 1993 . Analysis of taxol and related taxanes from Taxus Canadensis using liquid chromatography combined with mass spectrometry or tandem mass spectrometry . Rapid Commun. Mass Spectrom. , 7 : 626 – 634 .
   Web of Science ®Google Scholar
• Gwendolyn , N. C. , Bruce , D. H. , Susan , B. , Sally , A. L. , Keith , M. W. and John , A. B. 1992 . 1H‐and 13C‐NMR assignments for taxol, 7‐epi‐taxol and cephalomannine . J. Nat. Prod. , 55 : 414 – 423 .
   PubMed Web of Science ®Google Scholar