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Original Articles

Recent Progress in the Analysis of Pharmaceuticals by Capillary Electrophoresis

Pages 1115-1160 | Received 17 Nov 2004, Accepted 20 Dec 2004, Published online: 06 Feb 2007

References

  • Everaerts , F. M. , Beckers , J. L. and Verheggen , T. P. 1976 . “ Isotachophoresis ” . In Theory, Instrumentation and Applications , Journal of Chromatography Series Vol. 6 , Amsterdam : Elsevier Science .
  • Jorgenson , J. W. and Lukacs , K. D. 1981 . Zone electrophoresis in open‐tubular glass capillaries . Anal. Chem. , 53 : 1298 – 1302 .
  • Jorgenson , J. W. and Lukacs , K. D. 1983 . Capillary zone electrophoresis . Science , 222 : 266 – 272 .
  • Baker , D. R. 1995 . Capillary Electrophoresis 244 New York : John Wiley & Sons, Inc .
  • Jenkins , M. A. 2004 . Quality control and quality assurance aspects of the routine use of capillary electrophoresis for serum and urine proteins in clinical laboratories . Electrophoresis , 25 : 1555 – 1560 .
  • Kuhn , R. and Hoffstetter‐Kuhn , S. 1993 . Capillary Electrophoresis: Principles and Practice 375 Berlin : Springer‐Verlag .
  • Weinberger , R. 1993 . Practical Capillary Electrophoresis 312 San Diego : Academic Press, Inc .
  • Altria , K. 1998 . Analysis of Pharmaceuticals by Capillary Electrophoresis 300 Wiesbaden : Friedrich Vieweg & Sohn Verlag .
  • Khaledi , M. G. , ed. 1998 . High Performance Capillary Electrophoresis: Theory, Techniques, and Applications 1047 New York : John Wiley & Sons, Inc .
  • Chankvetadze , B. 1997 . Capillary Electrophoresis in Chiral Analysis 572 New York : John Wiley & Sons, Inc .
  • Hernandez‐Borges , J. , Neusub , C. , Cifuentes , A. and Pelzing , M. 2004 . On‐line capillary electrophoresis‐mass spectrometry for the analysis of biomolecules . Electrophoresis , 25 : 2257 – 2281 .
  • Kaiser , T. , Wittke , S. , Just , I. , Krebs , R. , Bartel , S. , Fliser , D. , Mischak , H. and Weissinger , E. M. 2004 . Capillary electrophoresis coupled to mass spectrometer for automated and robust polypeptide determination in body fluids for clinical use . Electrophoresis , 25 : 2044 – 2055 .
  • Smyth , W. F. and Brooks , P. 2004 . A critical evaluation of high performance liquid chromatography‐electrospray ionisation‐mass spectrometry and capillary electrophoresis‐electrospray‐mass spectrometry for the detection and determination of small molecules of significance in clinical and forensic science . Electrophoresis , 25 : 1413 – 1446 .
  • Soga , T. , Kakazu , Y. , Robert , M. , Tomita , M. and Nishioka , T. 2004 . Qualitative and quantitative analysis of amino acids by capillary electrophoresis‐electrospray ionization‐tandem mass spectrometry . Electrophoresis , 25 : 1964 – 1972 .
  • Caslavska , J. and Thormann , W. 2004 . Monitoring of drugs and metabolites in body fluids by capillary electrophoresis with XeHg lamp‐based and laser‐induced fluorescence detection . Electrophoresis , 25 : 1623 – 1631 .
  • Tsukagoshi , K. , Nakahama , K. and Nakajima , R. 2004 . Direct detection of biomolecules in a capillary electrophoresis‐chemiluminescence detection system . Anal. Chem. , 76 : 4410 – 4415 .
  • Jayawickrama , D. A. and Sweedler , J. V. 2003 . Hyphenation of capillary separations with nuclear magnetic resonance spectroscopy . J. Chromatogr. A , 1000 : 819 – 840 .
  • Jayawickrama , D. A. and Sweedler , J. V. 2004 . Dual microcoil NMR probe coupled to cyclic CE for continuous separation and analyte isolation . Anal. Chem. , 76 : 4894 – 4900 .
  • Krull , I. S. , Stevenson , R. L. , Mistry , K. and Swartz , M. E. 2000 . Capillary Electrochromatography and Pressurized Flow Capillary Electrochromatography An Introduction 240 New York : HNB Publishing .
  • Zhang , K. , Jiang , Z. , Yao , C. , Zhang , Z. , Wang , Q. , Gao , R. and Yan , C. 2003 . Separation of peptides by pressurized capillary electrochromatography . J. Chromatogr. A , 987 : 453 – 458 .
  • Mistry , K. , Krull , I. and Grinberg , N. 2002 . Capillary electrochromatography: an alternative to HPLC and CE . J. Sep. Sci. , 25 : 935 – 958 .
  • Jiskra , J. , Claessens , H. A. and Cramers , C. A. 2003 . Stationary and mobile phases in capillary electrochromatography (CEC) . J. Sep. Sci. , 26 : 1305 – 1330 .
  • Simal‐Gandara , J. 2004 . The place of capillary electrochromatography among separation techniques‐a review . Crit. Rev. Anal. Chem. , 34 : 85 – 94 .
  • Majors , R. E. 2001 . New directions for concentration sensitivity enhancement in CE and microchip technology . LCGC N. Am. , 19 ( 1 ) : 14 – 30 .
  • Hempel , G. 2000 . Strategies to improve the sensitivity in capillary electrophoresis for the analysis of drugs in biological fluids . Electrophoresis , 21 : 691 – 698 .
  • Breadmore , M. C. and Haddad , P. R. 2001 . Approaches to enhancing the sensitivity of capillary electrophoresis methods for the determination of inorganic and small organic anions . Electrophoresis , 22 : 2464 – 2489 .
  • Macia , A. , Borrull , F. , Aguilar , F. , Aguilar , C. and Calull , M. 2003 . Improving sensitivity by large‐volume sample stacking using the electroosmotic flow pump to analyze some nonsteroidal anti‐inflammatory drugs by capillary electrophoresis in water samples . Electrophoresis , 24 : 2779 – 2787 .
  • Stroink , T. , Paarlberg , E. , Waterval , J. C.M. , Bult , A. and Underberg , W. J.M. 2001 . On‐line sample preconcentration in capillary electrophoresis, focused on the determination of proteins and peptides . Electrophoresis , 22 : 2374 – 2383 .
  • Albin , M. , Grossman , P. D. and Moring , S. E. 1993 . Sensitivity enhancement for capillary electrophoresis . Anal. Chem. , 65 ( 10 ) : 489A – 497A .
  • Weinberger , R. and Stevenson , R. 2000 . Capillary electrophoresis: sample preparation . Am. Lab. , 32 ( 8 ) : 48 – 51 .
  • Lim , K. , Kim , S. and Hahn , J. H. 2002 . Enhanced UV‐visible absorbance detection in capillary electrophoresis using modified T‐shaped post‐column flow cell . Bull. Korean Chem. Soc. , 23 ( 2 ) : 2002
  • Flurer , C. L. 2001 . Analysis of antibiotics by capillary electrophoresis . Electrophoresis , 22 : 4249 – 4261 .
  • Aurora Prado , M. S. , Kedor‐Hackmann , E. R.M. , Santoro , M. I.R.M. , Pinto , T. J.A. and Tavares , M. F.M. 2004 . Capillary electrophoretic method for determination of protease inhibitor indinavir sulfate used in human immunodeficiency virus therapy . J. Pharm. Biomed. Anal. , 34 : 441 – 450 .
  • Petsch , M. , Mayer‐Heim , B. X. , Sauermann , R. , Joukhadar , C. and Kenndler , E. 2004 . Capillary electrophoresis analysis of fosfomycin in biological fluids for clinical pharmacokinetic studies . Electrophoresis , 25 : 2292 – 2298 .
  • Ho , Y. H. , Ko , W. K. , Kou , H. S. , Wu , H. L. and Wu , S. M. 2004 . Field‐amplified sample stacking in capillary electrophoresis for the determination of clozapine, clozapine N‐oxide, and desmethylclozapine in schizophrenics' plasma . J. Chromatogr. B , 809 : 111 – 116 .
  • Gutleben , W. , Scherer , K. , Duc Tuan , N. , Stoiber , H. , Dierich , M. P. and Zemann , A. 2003 . Separation of 11 protease and reverse transcriptase inhibitors by capillary zone electrophoresis . J. Sep. Sci. , 26 : 1198 – 1202 .
  • Toro , I. , Dulsat , J. F. , Fabregas , J. L. and Claramunt , J. 2004 . Development and validation of a capillary electrophoresis method with ultraviolet detection for the determination of the related substances in a pharmaceutical compound . J. Chromatogr. A , 1043 : 303 – 315 .
  • Hillaert , S. and Van den Bossche , W. 2003 . Simultaneous determination of hydrochlorothiazide and several angiotensin‐II‐receptor antagonists by capillary electrophoresis . J. Pharm. Biomed. Anal. , 31 : 329 – 339 .
  • Marchesini , A. F. , Williner , M. R. , Mantovani , V. E. , Robles , J. C. and Goicoechea , H. C. 2003 . Simultaneous determination of naphazoline, diphenhydramine and phenylephrine in nasal solutions by capillary electrophoresis . J. Pharm. Biomed. Anal. , 31 : 39 – 46 .
  • Nemutlu , E. and Kir , S. 2003 . Method development and validation for the analysis of meloxicam in tablets by CZE . J. Pharm. Biomed. Anal. , 31 : 393 – 400 .
  • Mohammadi , A. , Kanfer , I. and Walker , R. B. 2004 . A capillary zone electrophoresis (CZE) method for the determination of cyclizine hydrochloride in tablets and suppositories . J. Pharm. Biomed. Anal. , 35 : 233 – 239 .
  • Pazourek , J. , Revilla , A. L. , Gajdosova , D. and Havel , J. 2004 . Validation of a capillary zone electrophoresis method for determination of rimantadine hydrochloride in rimantadin100 tablets and the method application to dissolution test monitoring . Drug Dev. Ind. Pharm. , 30 ( 2 ) : 125 – 134 .
  • Perez‐Ruiz , T. , Martinez‐Lozano , C. , Sanz , A. and Bravo , E. 2004 . Development and validation of a quantitative assay for raloxifene by capillary electrophoresis . J. Pharm. Biomed. Anal. , 34 : 891 – 897 .
  • Chang , H. Y. , Kuo , C. H. and Sun , S. W. 2003 . Determination of ursodeoxycholic acid in pharmaceutical preparations by capillary electrophoresis with indirect UV detection . J. Pharm. Biomed. Anal. , 32 : 949 – 956 .
  • Shihabi , Z. K. 2004 . Fenofibrate and fenofibric acid analysis by capillary electrophoresis . Electrophoresis , 25 : 1648 – 1651 .
  • Teshima , D. , Otsubo , K. , Makino , K. , Itoh , Y. and Oishi , R. 2004 . Simultaneous determination of sulfamethoxazole and trimethoprim in human plasma by capillary zone electrophoresis . Biomed. Chromatogr. , 18 : 51 – 54 .
  • Chen , C. C. , Wu , S. M. , Huang , Y. H. , Ko , W. K. , Kou , H. S. and Wu , H. L. 2004 . On‐line field‐amplified sample stacking in capillary electrophoresis for analysis of amitriptyline and its metabolite nortriptyline in plasma . Anal. Chim. Acta , 517 : 103 – 110 .
  • Aboul‐Enein , H. Y. and Ali , I. 2004 . Analysis of cervastatin in human plasma and identification of its lactone metabolite by capillary electrophoresis . Anal. Lett. , 37 ( 4 ) : 667 – 678 .
  • Breadmore , M. C. , Theurillat , R. and Thormann , W. 2004 . Determination of ribavirin in human serum and plasma by capillary electrophoresis . Electrophoresis , 25 : 1615 – 1622 .
  • Bronner , S. , Renault , C. , Hintz , M. , Wiesner , J. , Jomaa , H. , Monteil , H. and Jehl , F. 2004 . Determination of fosmidomycin in human serum and urine by capillary electrophoresis . J. Chromatogr. B , 806 : 255 – 261 .
  • Lehtonen , P. , Siren , H. , Ojanpera , I. and Kostiainen , R. 2004 . Migration behavior and separation of tramadol metabolites and diastereomeric separation of tramadol glucuronides by capillary electrophoresis . J. Chromatogr. A , 1041 : 227 – 234 .
  • Liu , H. and Sunderland , V. B. 2004 . Determination of sulfate in aminoglycoside antibiotics by capillary electrophoresis with indirect UV Detection . J. Liq. Chromatogr. Rel. Technol. , 27 ( 4 ) : 677 – 687 .
  • Zheng , J. , Jann , M. W. , Hon , Y. Y. and Shamsi , S. A. 2004 . Development of capillary zone electrophoresis‐electrospray ionization‐mass spectrometry for the determination of lamotrigine in human plasma . Electrophoresis , 25 : 2033 – 2043 .
  • Le Potier , I. , Franck , G. , Smadja , C. , Varlet , S. and Taverna , M. 2004 . In‐capillary derivatization approach applied to the analysis of insulin by capillary electrophoresis with laser‐induced fluorescence detection . J. Chromatogr. A , 1046 : 271 – 276 .
  • Chang , S. Y. and Wang , F. Y. 2004 . Determination of gabapentin in human plasma by capillary electrophoresis with laser‐induced fluorescence detection and acetonitrile stacking technique . J. Chromatogr. B , 799 : 265 – 270 .
  • Huang , C. Z. , Santa , T. , Okabe , K. and Imai , K. 2003 . Capillary electrophoresis with laser induced‐fluorescence detection of profens derivatized with the water‐soluble fluorogenic reagent 4‐N‐(4‐N'‐aminoethyl)piperazino‐7‐nitro‐2,1,3‐benzoxadiazole . J. Chromatogr. A , 1011 : 193 – 201 .
  • Horstkotter , C. , Schepmann , D. and Blaschke , G. 2003 . Separation and identification of zaleplon metabolites in human urine using capillary electrophoresis with laser‐induced fluorescence detection and liquid chromatography‐mass spectrometry . J. Chromatogr. A , 1014 : 71 – 81 .
  • Zhang , J. , Xie , J. , Chen , X. and Hu , Z. 2003 . Sensitive determination of ephedrine and pseudoephedrine by capillary electrophoresis with laser‐induced fluorescence detection . Analyst , 128 : 369 – 372 .
  • Tsai , C. H. , Fang , C. , Liu , J. T. and Lin , C. H. 2004 . Stacking and low‐temperature technique in nonaqueous capillary electrophoresis for the analysis of 3,4‐methylenedioxymethamphetamine . Electrophoresis , 25 : 1601 – 1606 .
  • Delmar Cantu , M. , Hillebrand , S. , Costa Queiroz , M. E. , Mauro Lancas , F. and Carrilho , E. 2004 . Validation of non‐aqueous capillary electrophoresis for simultaneous determination of four tricyclic antidepressants in pharmaceutical formulations and plasma samples . J. Chromatogr. B , 799 : 127 – 132 .
  • Peri‐Okonny , U. L. , Kenndler , E. , Stubbs , R. J. and Guzman , N. A. 2003 . Characterization of pharmaceutical drugs by a modified nonaqueous capillary electrophoresis‐mass spectrometry method . Electrophoresis , 24 : 139 – 150 .
  • Rodriguez Flores , J. , Berzas Nevado , J. J. , Contento Salcedo , A. M. and Cabello Diaz , M. P. 2004 . Non‐aqueous capillary zone electrophoresis method for the analysis of paroxetine, tamoxifen, and their main metabolites in urine . Anal. Chim. Acta , 512 : 287 – 295 .
  • Gong , X. , Shen , Y. and Mao , B. 2004 . Quantitation of ammonium cations in pharmaceutical samples by nonaqueous capillary electrophoresis with indirect UV detection . J. Liq. Chromatogr. Rel. Technol. , 27 ( 4 ) : 661 – 675 .
  • Cherkaoui , S. and Veuthey , J.‐L. 1999 . Separation of selected anesthetic drugs by nonaqueous capillary electrophoresis . Analusis , 27 : 765 – 771 .
  • Rodriguez Flores , J. , Berzas Nevado , J. J. , Contento Salcedo , A. M. and Cabello Diaz , M. P. 2004 . Development and validation method for determination of paroxetine and its metabolites by nonaqueous capillary electrophoresis in human urine. Experimental design for evaluating the ruggedness of the method . Electrophoresis , 25 : 454 – 462 .
  • Servais , A. C. , Fillet , M. , Chiap , P. , Abushoffa , A. M. , Hubert , P. and Crommen , J. 2002 . Optimization of the separation of β‐blockers by ion‐pair capillary electrophoresis in non‐aqueous media using univariate and multivariate approaches . J. Sep. Sci. , 25 : 1087 – 1095 .
  • Xu , L. , Feng , Y. Q. , Shi , Z. G. , Da , S. L. and Gu , J. M. 2004 . Nonaqueous capillary electrophoresis using a zirconia‐coated capillary . Anal. Chim. Acta , 514 : 179 – 184 .
  • Zhou , Q. , Jiang , G. , Liu , G. , Liu , J. and Cai , Y. 2004 . Non‐aqueous capillary electrophoresis with indirect photometric detection for direct analysis of Pb2+, Zn2+ and Cd2+ Ions . Microchim. Acta , 144 : 63 – 67 .
  • Terabe , S. , Otsuka , K. , Ichikawa , K. , Tsuchiya , A. and Ando , T. 1984 . Electrokinetic separations with micellar solutions and open‐tubular capillaries . Anal. Chem. , 56 : 111 – 113 .
  • Terabe , S. , Otsuka , K. and Ando , T. 1985 . Electrokinetic chromatography with micellar solution and open‐tubular capillary . Anal. Chem. , 57 : 834 – 841 .
  • Terabe , S. 2004 . Micellar Electrokinetic Chromatography . Anal. Chem. , 76 ( 13 ) : 240A – 246A .
  • Hillhorst , M. J. , Somsen , G. W. and de Jong , G. J. 2001 . Capillary electrokinetic separation techniques for profiling of drugs and related products . Electrophoresis , 22 : 2542 – 2564 .
  • Harang , V. , Jacobsson , S. P. and Westerlund , D. 2004 . Microemulsion electrokinetic chromatography of drugs varying in charge and hydrophobicity part II: strategies for optimization of separation . Electrophoresis , 25 : 1792 – 1809 .
  • Makino , K. , Itoh , Y. , Teshima , D. and Oishi , R. 2004 . Determination of nonsteroidal anti‐inflammatory drugs in human specimens by capillary zone electrophoresis and micellar electrokinetic chromatography . Electrophoresis , 25 : 1488 – 1495 .
  • Deubner , R. and Hozgrabe , U. 2004 . Micellar electrokinetic capillary chromatography, high performance liquid chromatography and nuclear magnetic resonance‐three orthogonal methods for characterization of critical drugs . J. Pharm. Biomed. Anal. , 35 ( 3 ) : 459 – 467 .
  • Orlandini , S. , Fanali , S. , Furlanetto , S. , Marras , A. M. and Pinzauti , S. 2004 . Micellar electrokinetic chromatography for the simultaneous determination of ketorolac tromethamine and its impurities multivariate optimization and validation . J. Chromatogr. A , 1032 : 253 – 263 .
  • Cao , W. , Yang , X. and Wang , E. 2004 . Determination of reserpine in urine by capillary electrophoresis with electrochemiluminescence detection . Electroanalysis , 16 ( 3 ) : 169 – 174 .
  • Chang , S. Y. and Lin , W. C. 2003 . Determination of vigabatrin by capillary electrophoresis with laser‐induced fluorescence detection . J. Chromatogr. B , 794 : 17 – 22 .
  • Marin , A. and Barbas , C. 2004 . CE versus HPLC for the dissolution test in a pharmaceutical formulation containing acetaminophen, phenylephrine and chlorpheniramine . J. Pharm. Biomed. Anal. , 35 : 769 – 777 .
  • Nepote , A. J. , Vera‐Candiotti , L. , Williner , M. R. , Damiani , P. C. and Olivieri , A. C. 2003 . Development and validation of chemometrics‐assisted spectrophotometry and micellar electrokinetic chromatography for the determination of four‐component pharmaceuticals . Anal. Chim. Acta , 489 : 77 – 84 .
  • Pajchel , G. , Michalska , K. and Tyski , S. 2004 . Application of capillary electrophoresis to the determination of various benzylpenicillin salts . J. Chromatogr. A , 1032 : 265 – 272 .
  • Kitahashi , T. and Furuta , I. 2004 . Development and validation of a MEKC method for the direct determination of cefozopran in human serum . J. Pharm. Biomed. Anal. , 34 : 409 – 414 .
  • Lemus Gallego , J. M. and Arroyo , J. P. 2003 . Determination of prednisolone, naphazoline, and phenylephrine in local pharmaceutical preparations by micellar electrokinetic chromatography . J. Sep. Sci. , 26 : 947 – 952 .
  • Suzuki , Y. , Arakawa , H. and Maeda , M. 2004 . The capillary electrophoresis separation of benzodiazepine drug using dextran sulfate and SDS as running buffer . Biomed. Chromatogr. , 18 : 150 – 154 .
  • Yardimic , C. , Suslu , I. and Ozaltin , N. 2004 . Determination of pirebedil in pharmaceutical formulations by micellar electrokinetic capillary chromatography . Anal. Bioanal. Chem. , 379 : 308 – 311 .
  • Benturquia , N. , Parrot , S. , Sauvinet , V. , Renaud , B. and Denoroy , L. 2004 . Simultaneous determination of vigabatrin and amino acid neurotransmitters in brain microdialysates by capillary electrophoresis with laser‐induced fluorescence detection . J. Chromatogr. B , 806 : 237 – 244 .
  • Guttman , A. 2004 . The evolution of capillary gel electrophoresis: from proteins to DNA sequencing . LCGC N. Am. , 22 ( 9 ) : 896 – 904 .
  • Na , D. H. , Park , E. J. , Youn , Y. S. , Moon , B. W. , Jo , Y. W. , Lee , S. H. , Kim , W. B. , Sohn , Y. and Lee , K. C. 2004 . Sodium dodecyl sulfate‐capillary gel electrophoresis of polyethylene glycolylated interferon alpha . Electrophoresis , 25 : 476 – 479 .
  • Palm , A. K. and Marko‐Varga , G. 2004 . On‐column electroextraction and separation of antisense oligonucleotides in human plasma by capillary gel electrophoresis . J. Pharm. Biomed. Anal. , 35 : 415 – 423 .
  • Yu , R. Z. , Geary , R. S. , Monteith , D. K. , Matson , J. , Truong , L. , Fitchett , J. and Levin , A. A. 2004 . Tissue disposition of 2'‐O‐(2‐methoxy) ethyl modified antisense oligonucleotides in monkeys . J. Pharm. Sci. , 93 ( 1 ) : 48 – 59 .
  • Von Brocke , A. , Freudemann , T. and Bayer , E. 2003 . Performance of capillary gel electrophoretic analysis of oligonucleotides coupled on‐line with electrospray mass spectrometry . J. Chromatogr. A , 991 : 129 – 141 .
  • Flottman , D. , Hins , J. , Meissner , T. , Dietrich , C. and Rettenmaier , C. 2004 . Enhancing sensitivity of CZE by on‐line isotachophoretic sample pretreatment . Chromatographia , 60 : S253 – S256 .
  • Gebauer , P. and Bocek , P. 2002 . Recent progress in capillary isotachophoresis . Electrophoresis , 23 : 3858 – 3864 .
  • Polasek , M. , Pospisilova , M. and Urbanek , M. 2000 . Capillary isotachophoretic determination of flufenamic, mefenamic, niflumic, and tolfenamic acid in pharmaceuticals . J. Pharm. Biomed. Anal. , 23 : 135 – 142 .
  • Pospisilova , M. , Polasek , M. and Jokl , V. 2001 . Determination of ambroxol or bromhexine in pharmaceuticals by capillary isotachophoresis . J. Pharm. Biomed. Anal. , 24 : 421 – 428 .
  • Cakrt , M. , Hercegova , A. , Lesko , J. , Polonsky , J. , Sadecka , J. and Skacani , I. 2001 . Isotachophoretic determination of naproxen in the presence of its metabolite in human serum . J. Chromatogr. A , 916 : 207 – 214 .
  • Urbanek , M. , Pospisilova , M. and Polasek , M. 2002 . Dermination of bopindolol in pharmaceuticals by capillary isotachophoresis . J. Pharm. Biomed. Anal. , 28 : 509 – 515 .
  • Meissner , T. and Niess , M. 2004 . Isotachophoretic separation of alkylsulfonates and determination of methanesulfonic acid as main component and as trace component in pharmaceutical drug substances . J. Chromatogr. A , 1035 : 271 – 275 .
  • Kriikku , P. , Grab , B. , Hokkanen , A. , Stuns , I. and Siren , H. 2004 . Isotachophoresis of β‐blockers in a capillary and on a poly(methyl methacrylate) chip . Electrophoresis , 25 : 1687 – 1694 .
  • Olvecka , E. , Konikova , M. , Grobuschek , N. , Kaniansky , D. and Stanislawski , B. 2003 . Direct determination of valproate in serum by zone electrophoresis‐isotachophoresis on a column coupling chip . J. Sep. Sci. , 26 : 693 – 700 .
  • Scriba , G. K.E. 2003 . Recent advances in enantioseparations of peptides by capillary electrophoresis . Electrophoresis , 24 : 4063 – 4077 .
  • Rizzi , A. 2001 . Fundamental aspects of chiral separations by capillary electrophoresis . Electrophoresis , 22 : 3079 – 3106 .
  • Chankvetadze , B. 2002 . Enantiomer migration order in chiral capillary electrophoresis . Electrophoresis , 23 : 4022 – 4035 .
  • Shamsi , S. A. 2002 . Chiral capillary elecrophoresis‐mass spectrometry: modes and applications . Electrophoresis , 23 : 4036 – 4051 .
  • Amini , A. 2001 . Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis . Electrophoresis , 22 : 3107 – 3130 .
  • Arai , T. 1998 . Chiral separation of pharmaceuticals possessing a carboxy moiety . J. Chromatogr. B , 717 : 295 – 311 .
  • Ward , T. J. , Armstrong , D. W. , Zief , M. and Crane , L. J. 1988 . Chromatographic Chiral Separations Edited by: Ward , T. J. , Armstrong , D. W. , Zief , M. and Crane , L. J. 410 New York : Marcel Dekker .
  • Breadmore , M. C. and Thormann , W. 2003 . Capillary electrophoresis evidence for the stereoselective metabolism of itraconazole in man . Electrophoresis , 24 : 2588 – 2597 .
  • Lelièvre , F. , Gareil , P. , Bahaddi , Y. and Galons , H. 1997 . Intrinsic selectivity in capillary electrophoresis for chiral separations with dual cyclodextrin systems . Anal. Chem. , 69 : 393 – 401 .
  • Fillet , M. , Hubert , P. and Crommen , J. 2000 . Enantiomeric separation of drugs using mixtures of charged and neutral cyclodextrins . J. Chromatogr. A , 875 : 123 – 134 .
  • Abushoffa , A. M. , Fillet , M. , Servais , A. , Hubert , P. and Crommen , J. 2003 . Enhancement of selectivity and resolution in the enantioseparation of uncharged compounds using mixtures of oppositely charged cyclodextrins in capillary electrophoresis . Electrophoresis , 24 : 343 – 350 .
  • Tabi , T. , Magyar , K. and Szoko , E. 2003 . Chiral characterization of deprenyl‐N‐oxide and other deprenyl metabolites by capillary electrophoresis using a dual cyclodextrin system in rat urine . Electrophoresis , 24 : 2665 – 2673 .
  • Servais , A. , Chiap , P. , Hubert , P. , Crommen , J. and Fillet , M. 2004 . Determination of salbutamol enantiomers in human urine using heptakis(2,3‐di‐O‐acetyl‐6‐O‐sulfo)‐β‐cyclodextrin in nonaqueous capillary electrophoresis . Electrophoresis , 25 : 1632 – 1640 .
  • Mertzmann , M. D. and Foley , J. P. 2004 . Chiral cyclodextrin‐modified microemulsion electrokinetic chromatography . Electrophoresis , 25 : 1188 – 1200 .
  • Ludwig , M. , Kohler , F. and Belder , D. 2003 . High‐speed chiral separations on a microchip with UV detection . Electrophoresis , 24 : 3233 – 3238 .
  • Kang , J. , Wistuba , D. and Schurig , V. 2003 . Fast enantiomeric separation with vancomycin as chiral additive by co‐electroosmotic flow capillary electrophoresis: increase of the detection sensitivity by the partial filling technique . Electrophoresis , 24 : 2674 – 2679 .
  • Lee , W. , La , S. , Choi , Y. and Kim , K. R. 2003 . Chiral discrimination of aromatic amino acids by capillary electrophoresis in (+)‐ and (−)‐(18‐crown‐6)‐2,3,11,12‐tetracarboxylic acid selector modes . Bull. Korean Chem. Soc. , 24 ( 8 ) : 1232 – 1234 .
  • Martinez‐Pla , J. J. , Martin‐Biosca , Y. , Sagrado , S. , Villanueva‐Camanas , R. M. and Medina‐Hernandez , M. J. 2004 . Fast enantiomeric separation of propranolol by affinity capillary electrophoresis using human serum albumin as chiral selector: application to quality control of pharmaceuticals . Anal. Chim. Acta , 507 : 171 – 178 .
  • Awadallah , B. , Schmidt , P. C. , Holzgrabe , U. and Wahl , M. A. 2003 . Quantitation of talinolol and other β‐blockers by capillary electrophoresis for in vitro drug absorption studies . Electrophoresis , 24 : 2627 – 2632 .
  • Vaccher , M. P. , Lipka , E. , Bonte , J. P. and Vaccher , C. 2004 . Chiral capillary electrophoretic resolution of baclofen, gabaergic ligand, using highly sulfated cyclodextrins . Electrophoresis , 25 : 1111 – 1120 .
  • Lipka , E. , Selouane , A. , Postel , D. , Len , C. , Vaccher , M. P. , Bonte , J.‐P. and Vaccher , C. 2004 . Enantioseparation of four cis and trans diastereomers of 2′,3′‐didehydro‐2′,3′‐dideoxythymidine analogs, by high‐performance liquid chromatography and capillary electrophoresis . J. Chromatogr. A , 1034 : 161 – 167 .
  • Mandrioli , R. , Fanali , S. , Pucci , V. and Raggi , M. A. 2003 . Enantiomeric separation of citalopram and its metabolites by capillary electrophoresis . Electrophoresis , 24 : 2608 – 2616 .
  • La , S. , Kim , J. , Kim , J. H. , Goto , J. and Kim , K. R. 2003 . Simultaneous chiral discrimination of multiple profens by cyclodextrin‐modified capillary electrophoresis in normal and reversed polarity modes . Electrophoresis , 24 : 2642 – 2649 .
  • Glowka , F. K. and Karazniewicz , M. 2004 . High performance capillary electrophoresis for determination of the enantiomers of 2‐arylpropionic acid derivatives in human serum pharmacokinetic studies of ketoprofen enantiomers following administration of standard and sustained release tablets . J. Pharm. Biomed. Anal. , 35 : 807 – 816 .
  • Wikstrom , H. and Owens , P. K. 2002 . Development and validation of a chiral capillary electrophoresis method for melagatran and ximelagatran drug substances . J. Sep. Sci. , 25 : 1167 – 1174 .
  • Gomez‐Gomar , A. , Ortega , E. , Calvet , C. , Andaluz , B. , Merce , R. and Frigola , J. 2003 . Enantioseparation of basic pharmaceutical compounds by capillary electrophoresis using sulfated cyclodextrins application to E‐6006, a novel antidepressant . J. Chromatogr. A , 990 : 91 – 98 .
  • Ekiert , E. , Garcia‐Ruiz , C. , Garcia , M. A. and Marina , M. L. 2003 . Rapid determination of salbutamol in pharmaceutical preparations by chiral capillary electrophoresis . Electrophoresis , 24 : 2680 – 2686 .
  • Liu , Q. , Inoue , T. , Kirchhoff , J. R. , Huang , C. , Tillekeratne , L. M.V. , Olmstead , K. and Hudson , R. A. 2004 . Chiral separation of highly negative charged enantiomers by capillary electrophoresis . J. Chromatogr. A , 1033 : 349 – 356 .
  • Bonato , P. S. and Paias , F. O. 2004 . Enantioselective analysis of omeprazole in pharmaceutical formulations by chiral high performance liquid chromatography and capillary electrophoresis . J. Braz. Chem. Soc. , 15 ( 2 ) : 318 – 323 .
  • Anderson , S. , Gronhaug Halvorsen , T. , Pedersen‐Bjergaard , S. , Rasmussen , K. E. , Tanum , L. and Refsum , H. 2003 . Stereospecific determination of citalopram and desmethylcitalopram by capillary electrophoresis and liquid‐phase microextraction . J. Pharm. Biomed. Anal. , 33 : 263 – 273 .
  • Hinsmann , P. , Arce , L. , Svasek , P. , Lammerhofer , M. and Lendl , B. 2004 . Separation and on‐line distinction of enantiomers: a non‐aqueous capillary electrophoresis fourier transform infrared spectroscopy study . Appl. Spectrosc. , 58 ( 6 ) : 662 – 666 .
  • Klampfi , C. W. 2004 . Review coupling of capillary electrochromatography to mass spectrometry . J. Chromatogr. A , 1044 : 131 – 144 .
  • Barcelo‐Barrachina , E. , Moyano , E. and Galceran , M. T. 2004 . State‐of‐the‐art of the hyphenation of capillary electrochromatography with mass spectrometry . Electrophoresis , 25 : 1927 – 1948 .
  • Fanali , S. , Catarcini , P. , Blascheke , G. and Chankvetadze , B. 2001 . Enantioseparations by capillary electrochromatography . Electrophoresis , 22 : 3131 – 3151 .
  • Guihen , E. and Glennon , J. D. 2004 . Recent highlights in stationary phase design for open‐tubular capillary electrochromatography . J. Chromatogr. A , 1044 : 67 – 81 .
  • Steiner , F. and Lobert , T. 2003 . Capillary electrochromatography with bare silicas of different pore sizes as stationary phases . J. Sep. Sci. , 26 : 1589 – 1594 .
  • Allen , D. and El Rassi , Z. 2003 . Silica‐based monoliths for capillary electrochromatography: methods of fabrication and their applications in analytical separations . Electrophoresis , 24 : 3962 – 3976 .
  • Hilder , E. F. , Svec , F. and Frechet , J. M.J. 2004 . Development and application of polymeric monolithic stationary phases for capillary electrochromatography . J. Chromatogr. A , 1044 : 3 – 22 .
  • Li , W. , Fries , D. P. and Malik , A. 2004 . Sol‐gel stationary phases for capillary electrochromatography . J. Chromatogr. A , 1044 : 23 – 52 .
  • Miller , M. D. , Baker , G. L. and Bruening , M. L. 2004 . Polymer‐brush stationary phases for open‐tubular capillary electrochromatography . J. Chromatogr. A , 1044 : 323 – 330 .
  • Quaglia , M. , Sellergren , B. and De Lorenzi , E. 2004 . Approaches to imprinted stationary phases for affinity capillary electrochromatography . J. Chromatogr. A , 1044 : 53 – 66 .
  • Stachowiak , T. B. , Svec , F. and Frechet , J. M.J. 2004 . Chip electrochromatography . J. Chromatogr. A , 1044 : 97 – 111 .
  • Bandilla , D. and Skinner , C. D. 2004 . Capillary electrochromatography of peptides and proteins . J. Chromatogr. A , 1044 : 113 – 129 .
  • Orlandini , S. , Furlanetto , S. , Pinzauti , S. , D'Orazio , G. and Fanali , S. 2004 . Analysis of ketorolac and its related impurities by capillary electrochromatography . J. Chromatogr. A , 1044 : 295 – 303 .
  • Ohyama , K. , Wada , M. , Ohba , Y. , Fujishita , O. , Nakashima , K. and Kuroda , N. 2004 . Rapid separation of barbiturates and benzodiazepines for capillary electrochromatography with 3‐(1,8‐naphthalimido)propyl‐modified silyl silica gel . Biomed. Chromatogr. , 18 : 396 – 399 .
  • Zhang , K. , Yan , C. , Zhang , Z. , Wang , Q. and Gao , R. 2003 . Mixed mode of hydrophilic and ionic interaction pressurized capillary electrochromatography for separation of basic compounds . J. Liq. Chromatogr. Rel. Technol. , 26 ( 13 ) : 2119 – 2131 .
  • Zhang , K. , Gao , R. , Jiang , Z. , Yao , C. , Zhang , Z. , Wang , Q. and Yan , C. 2003 . Pressurized capillary electrochromatography separation of peptides with strong cation exchange and hydrophilic interaction . J. Sep. Sci. , 26 : 1389 – 1394 .
  • Bicker , W. , Hebenstreit , D. , Lammerhofer , M. and Lindner , W. 2003 . Enantiomeric impurity profiling in ephedrine samples by enantioselective capillary electrochromatography . Electrophoresis , 24 : 2532 – 2542 .
  • Scriba , G. K.E. 2003 . Pharmaceutical and biomedical applications of chiral capillary electrophoresis and capillary electrochromatography: an update . Electrophoresis , 24 : 2409 – 2421 .
  • Mangelings , D. , Hardies , N. , Maftouh , M. , Suteu , C. , Massart , D. L. and Heyden , Y. V. 2003 . Enantioseparations of basic and bifunctional pharmaceuticals by capillary electrochromatography using polysaccharide stationary phases . Electrophoresis , 24 : 2567 – 2576 .

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