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Original Articles

Determination of Leflunomide in Pharmaceutical Tablets by Flow‐Injection Analysis

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Pages 1693-1701 | Received 20 Jan 2005, Accepted 28 Feb 2005, Published online: 20 Aug 2006

References

  • Prakash , A. and Jarvis , B. 1999 . Leflunomide a review of its use in active rheumatoid arthritis . Drugs , 58 ( 6 ) : 1137 – 1164 .
  • Dias , V. C. , Lucien , J. , Legatt , D. F. and Yatscoff , R. W. 1995 . Measurement of the active leflunomide metabolite (A77 1726) by reverse‐phase high‐performance liquid chromatography . Ther. Drug Monit. , 17 : 84 – 88 .
  • Lucien , J. , Dias , V. C. , Legatt , D. F. and Yatscoff , R. W. 1995 . Blood distribution and single‐dose pharmacokinetics of leflunomide . Ther. Drug Monit. , 17 : 454 – 459 .
  • Fairbanks , L. D. , Carrey , E. A. , Ruckemann , K. , Swaminathan , R. , Kirschbaum , B. and Simmonds , H. A. 1999 . Simultaneous separation by high performance liquid chromatography of carbamoyl aspartate, carbamoyl phosphate, and dihydroorotic acid . J. Chromatogr. B , 732 : 487 – 493 .
  • Schmidt , A. , Schwind , B. , Gillich , M. , Brune , K. and Hinz , B. 2003 . Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high performance liquid chromatography . Biomed. Chromatogr. , 17 : 276 – 281 .
  • Chan , V. , Charles , B. G. and Tett , S. E. 2004 . Rapid determination of the active leflunomide metabolite A77 1726 in human plasma by high performance liquid chromatography . J. Chromatogr. B , 803 : 331 – 335 .
  • Roon , E. N. , Yska , J. P. , Raemaekers , J. , Jansen , T. L.Th.A. , Wanrooy , M. and Brouwers , J. R.B.J. 2004 . A rapid and simple determination of A77 1726 in human serum by high performance liquid chromatography and its application for optimization of leflunomide theraphy . J. Pharm. Biom. Anal. , 36 : 17 – 22 .
  • Zhang , Q. , Pang , W. L. , Chen , H. , Cherrington , J. , Lipson , K. , Antonian , L. and Shawver , L. K. 2002 . Application of LC/MS/MS in the quantitation of SU101 and SU0020 uptake by 3T3/PDGFr cells . J. Pharm. Biom. Anal. , 28 : 701 – 709 .
  • Mangold , U. , Dax , C. I. , Saar , K. , Schwab , W. , Kirschbaum , B. and Mullner , S. 1999 . Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases . Eur. J. Biochem. , 266 : 1184 – 1191 .
  • Caporal‐Gautier , J. , Nivet , J. M. , Algranti , P. , Guilloteau , M. , Histe , M. , Lallier , M. , N'guyen‐Huu , J. J. and Russotto , R. 1992 . Guide de validation analytique. Rapport d'une commission SFSTP, I. Methodolgie . S.T.P. Pharm Prat. , 2 : 205 – 226 .
  • Shabir , G. A. 2003 . Validation of high performance liquid chromatography methods for pharmaceutical analysis. Understanding the differences and similarities between validation requirements of the US Food and Drug Administration, the US Pharmacopeia and the International Conference on Harmonization . J.Chromatogr. A , 987 : 57 – 66 .
  • www.rxlist.com/cgi/generic3/leflunomide.htm
  • Shah , V. P. , Midha , K. K. , Dighe , S. , McGilveray , I. J. , Skelly , J. P. and Jacobi , A. 1992 . Analytical methods validation: bioavailability, bioequivalence, and pharmacokinetic studies . J. Pharm. Sci. , 81 : 309 – 312 .
  • 2000 . The United States Pharmacopeia , 24th Ed. 2001 – 2002 . Rockville, MD : US Pharmacopeial Convention .
  • Tuncel , M. , Yazan , Y. , Dogrukol , D. and Atkoşar , Z. 1991 . A polarographic study on dipyridamole and its determination in commercial tablets . Anal. Lett. , 24 ( 10 ) : 1837 – 1846 .
  • Tuncel , M. and Dogrukol , D. 1992 . A study on the polarographic behaviour and determination of tizanidine . Anal. Lett. , 25 ( 6 ) : 1087 – 1094 .
  • Dogrukol‐Ak , D. and Tuncel , M. 1994 . Determination of cytarabine in ampoules by certain polarographic techniques . Pharmazie , 49 ( 12 ) : 928 – 929 .
  • Dogrukol‐Ak , D. and Tuncel , M. 1995 . Determination of omeprazole in capsules by certain polarographic techniques . Pharmazie , 50 ( 10 ) : 701 – 702 .
  • Tuncel , M. and Dogrukol‐Ak , D. 1997 . Flow‐through spectrophotometric determination of omeprazole in pharmaceutical preparations containing enteric coated pellets . Pharmazie , 52 ( 1 ) : 73 – 74 .
  • Dogrukol‐Ak , D. , Gokoren , N. and Tuncel , M. 1998 . A differential pulse voltammetric determination of nisoldipine using glassy carbon electrode in pharmaceutical preparations . Anal. Lett. , 31 ( 1 ) : 105 – 116 .
  • Dogrukol‐Ak , D. , Tunalıer , Z. and Tuncel , M. 1998 . TLC densitometric determination of omeprazole in pharmaceutical preparations . Pharmazie , 53 ( 4 ) : 272 – 273 .
  • Saurina , J. and Hernandez‐Cassou , S. 2001 . Quantitative determinations in conventional flow injection analysis based on different chemometric calibration strategies: a review . Anal. Chim. Acta , 438 ( 1–2 ) : 335 – 352 .

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