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Original Articles

Efficient Cleavage of DS DNA by Bleomycin Conjugated via Hexaethylene Glycol Linker to Triplex‐Forming Oligonucleotides

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Pages 1047-1051 | Received 02 Dec 2003, Accepted 23 Apr 2004, Published online: 23 Aug 2006

References

  • Burger , R. M. 1998 . Cleavage of nucleic acids by bleomycin . Chem. Rev. , 98 ( 3 ) : 1153 – 1169 .
  • Sugiyama , H. , Kilkuskie , R. E. , Chang , L.‐H. , Ma , L.‐T. and Hecht , S. M. 1986 . DNA strand scission by bleomycin: catalytic cleavage and strand selectivity . J. Am. Chem. Soc. , 108 : 3852 – 3854 .
  • Stubbe , J. and Kozarich , J. W. 1987 . Mechanism of bleomycin‐induced DNA degradation . Chem. Rev. , 87 : 1107 – 1136 .
  • Sergeev , D. S. , Godovikova , T. S. and Zarytova , V. F. 1995 . Cleavage of double‐strand DNA by bleomycin derivatives of oligonucleotides forming a ternary complex . Bioorg. Khim. , 21 : 188 – 196 .
  • Zarytova , V. F. , Sergeyev , D. S. and Godovikova , T. S. 1993 . Synthesis of bleomycin A5 oligonucleotide derivatives and site‐specific cleavage of the DNA target . Bioconjug. Chem. , 4 : 189 – 193 .
  • Strobel , S. A. and Dervan , P. B. 1990 . Site‐specific cleavage of a yeast chromosome by oligonucleotide‐directed triple‐helix formation . Science , 249 : 73 – 75 .

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